DE602004009796D1 - Imidazolderivate als glutamatrezeptorantagonisten - Google Patents
Imidazolderivate als glutamatrezeptorantagonistenInfo
- Publication number
- DE602004009796D1 DE602004009796D1 DE602004009796T DE602004009796T DE602004009796D1 DE 602004009796 D1 DE602004009796 D1 DE 602004009796D1 DE 602004009796 T DE602004009796 T DE 602004009796T DE 602004009796 T DE602004009796 T DE 602004009796T DE 602004009796 D1 DE602004009796 D1 DE 602004009796D1
- Authority
- DE
- Germany
- Prior art keywords
- receptor agonists
- glutamate receptor
- imidazole derivatives
- imidazole
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03012200 | 2003-06-05 | ||
| EP03012200 | 2003-06-05 | ||
| PCT/EP2004/005881 WO2004108701A1 (en) | 2003-06-05 | 2004-06-01 | Imidazole derivatives as glutmate receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004009796D1 true DE602004009796D1 (de) | 2007-12-13 |
| DE602004009796T2 DE602004009796T2 (de) | 2008-08-28 |
Family
ID=33483899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004009796T Active DE602004009796T2 (de) | 2003-06-05 | 2004-06-01 | Imidazolderivate als glutamatrezeptorantagonisten |
Country Status (39)
| Country | Link |
|---|---|
| US (3) | US7332510B2 (de) |
| EP (1) | EP1636206B1 (de) |
| JP (1) | JP4401384B2 (de) |
| KR (1) | KR100778948B1 (de) |
| CN (1) | CN100408572C (de) |
| AR (1) | AR044478A1 (de) |
| AT (1) | ATE377008T1 (de) |
| AU (1) | AU2004245208B2 (de) |
| BR (1) | BRPI0411095B8 (de) |
| CA (1) | CA2527315C (de) |
| CL (1) | CL2004001347A1 (de) |
| CR (1) | CR8094A (de) |
| CY (1) | CY1107856T1 (de) |
| DE (1) | DE602004009796T2 (de) |
| DK (1) | DK1636206T3 (de) |
| EA (1) | EA010577B1 (de) |
| EC (1) | ECSP056202A (de) |
| ES (1) | ES2294504T3 (de) |
| GT (1) | GT200400117A (de) |
| HK (1) | HK1093070A1 (de) |
| HN (1) | HN2004000208A (de) |
| HR (1) | HRP20070529T3 (de) |
| IL (1) | IL171930A (de) |
| MA (1) | MA27881A1 (de) |
| MX (1) | MXPA05013149A (de) |
| MY (2) | MY137272A (de) |
| NO (1) | NO332143B1 (de) |
| NZ (1) | NZ543637A (de) |
| PA (1) | PA8604101A1 (de) |
| PE (1) | PE20050162A1 (de) |
| PL (1) | PL1636206T3 (de) |
| PT (1) | PT1636206E (de) |
| RS (1) | RS53183B (de) |
| SI (1) | SI1636206T1 (de) |
| TN (2) | TNSN05309A1 (de) |
| TW (1) | TWI338007B (de) |
| UA (1) | UA80888C2 (de) |
| WO (1) | WO2004108701A1 (de) |
| ZA (2) | ZA200509807B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7531529B2 (en) | 2003-06-05 | 2009-05-12 | Roche Palo Alto Llc | Imidazole derivatives |
| UA80888C2 (en) * | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
| US7452909B2 (en) | 2003-09-04 | 2008-11-18 | Hoffman-La Roche Inc. | Imidazole derivatives |
| JP4690395B2 (ja) | 2004-06-01 | 2011-06-01 | エフ．ホフマン−ラ ロシュ アーゲー | ｍＧｌｕ５レセプターアンタゴニストとしてのピリジン−４−エチニル−イミダゾール及びピラゾール |
| GB0514296D0 (en) * | 2005-07-12 | 2005-08-17 | Novartis Ag | Organic compounds |
| DE102006011574A1 (de) | 2006-03-10 | 2007-10-31 | Grünenthal GmbH | Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln |
| AU2007336369B2 (en) * | 2006-12-21 | 2013-01-17 | F. Hoffmann-La Roche Ag | Polymorphs of a mGluR5 receptor antagonist |
| US8334287B2 (en) * | 2009-07-17 | 2012-12-18 | Hoffmann-La Roche Inc. | Imidazoles |
| US20120040008A1 (en) * | 2010-08-11 | 2012-02-16 | Ashish Chatterji | Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists |
| US20120039999A1 (en) | 2010-08-11 | 2012-02-16 | Ashish Chatterji | Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists |
| KR20140018286A (ko) | 2011-03-18 | 2014-02-12 | 노파르티스 아게 | 파킨슨병에서의 도파민 유발 이상운동증에서 사용하기 위한 알파 7 니코틴성 아세틸콜린 수용체 활성화제 및 mGluR5 길항제의 조합물 |
| KR101684816B1 (ko) * | 2012-10-18 | 2016-12-20 | 에프. 호프만-라 로슈 아게 | mGluR5 수용체 활성의 조절제로서 에틴일 유도체 |
| NZ703537A (en) * | 2012-10-18 | 2018-06-29 | Hoffmann La Roche | Ethynyl derivatives |
| EA201891948A1 (ru) * | 2016-03-30 | 2019-04-30 | Синнтаксис Аб | Отрицательные аллостерические модуляторы метаботропного глутаматного рецептора 5 для применения в лечении зрелых повреждений головного мозга |
| WO2021245281A1 (en) | 2020-06-05 | 2021-12-09 | Noema Pharma Ag | Methods of treatment of tuberous sclerosis complex |
| WO2022023519A1 (en) * | 2020-07-30 | 2022-02-03 | Noema Pharma Ag | Methods of treatment of trigeminal neuralgia |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4508560A (en) * | 1981-11-11 | 1985-04-02 | Ciba Geigy Corporation | Certain pyridylacetylene compounds, compositions containing same and herbicidal methods of use |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| CA2383524C (en) | 1999-08-31 | 2010-09-28 | Merck & Co., Inc. | Thiazolyl alkynyl compounds and methods of use thereof |
| US7205297B2 (en) * | 2000-07-24 | 2007-04-17 | Krenitsky Pharmaceuticals, Inc. | Substituted 5-alkynyl pyrimidines having neurotrophic activity |
| CN1257894C (zh) * | 2000-12-04 | 2006-05-31 | 弗·哈夫曼-拉罗切有限公司 | 作为谷氨酸受体拮抗剂的苯基乙烯基或苯基乙炔基衍生物 |
| CA2470612A1 (en) * | 2001-12-19 | 2003-07-03 | Merck & Co., Inc. | Heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5 |
| CA2503245A1 (en) * | 2002-10-24 | 2004-05-06 | Merck & Co., Inc. | Alkyne derivatives as tracers for metabotropic glutamate receptor binding |
| TWI292318B (en) * | 2003-03-10 | 2008-01-11 | Hoffmann La Roche | Imidazol-4-yl-ethynyl-pyridine derivatives |
| UA80888C2 (en) * | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
| US7091222B2 (en) * | 2003-07-03 | 2006-08-15 | Hoffmann-La Roche Inc. | Imidazole derivatives |
-
2004
- 2004-01-06 UA UAA200512695A patent/UA80888C2/uk unknown
- 2004-06-01 PL PL04739484T patent/PL1636206T3/pl unknown
- 2004-06-01 CN CNB2004800156669A patent/CN100408572C/zh active Active
- 2004-06-01 DE DE602004009796T patent/DE602004009796T2/de active Active
- 2004-06-01 PT PT04739484T patent/PT1636206E/pt unknown
- 2004-06-01 EA EA200501887A patent/EA010577B1/ru not_active IP Right Cessation
- 2004-06-01 NZ NZ543637A patent/NZ543637A/en unknown
- 2004-06-01 MX MXPA05013149A patent/MXPA05013149A/es active IP Right Grant
- 2004-06-01 SI SI200430525T patent/SI1636206T1/sl unknown
- 2004-06-01 CA CA2527315A patent/CA2527315C/en active Active
- 2004-06-01 KR KR1020057023137A patent/KR100778948B1/ko active IP Right Grant
- 2004-06-01 BR BRPI0411095A patent/BRPI0411095B8/pt active IP Right Grant
- 2004-06-01 RS YU20050892A patent/RS53183B/en unknown
- 2004-06-01 WO PCT/EP2004/005881 patent/WO2004108701A1/en active IP Right Grant
- 2004-06-01 ES ES04739484T patent/ES2294504T3/es active Active
- 2004-06-01 AU AU2004245208A patent/AU2004245208B2/en active Active
- 2004-06-01 DK DK04739484T patent/DK1636206T3/da active
- 2004-06-01 AT AT04739484T patent/ATE377008T1/de active
- 2004-06-01 JP JP2006508238A patent/JP4401384B2/ja active Active
- 2004-06-01 EP EP04739484A patent/EP1636206B1/de active Active
- 2004-06-02 CL CL200401347A patent/CL2004001347A1/es unknown
- 2004-06-02 TW TW093115811A patent/TWI338007B/zh active
- 2004-06-02 PE PE2004000558A patent/PE20050162A1/es active IP Right Grant
- 2004-06-02 US US10/858,969 patent/US7332510B2/en active Active
- 2004-06-02 PA PA20048604101A patent/PA8604101A1/es unknown
- 2004-06-03 MY MYPI20042150A patent/MY137272A/en unknown
- 2004-06-03 GT GT200400117A patent/GT200400117A/es unknown
- 2004-06-03 HN HN2004000208A patent/HN2004000208A/es unknown
- 2004-06-03 AR ARP040101908A patent/AR044478A1/es active IP Right Grant
-
2005
- 2005-05-27 MY MYPI20052424A patent/MY143353A/en unknown
- 2005-11-13 IL IL171930A patent/IL171930A/en active IP Right Grant
- 2005-11-14 CR CR8094A patent/CR8094A/es unknown
- 2005-11-18 NO NO20055465A patent/NO332143B1/no unknown
- 2005-12-01 TN TNP2005000309A patent/TNSN05309A1/fr unknown
- 2005-12-02 ZA ZA200509807A patent/ZA200509807B/en unknown
- 2005-12-02 EC EC2005006202A patent/ECSP056202A/es unknown
- 2005-12-09 MA MA28648A patent/MA27881A1/fr unknown
-
2006
- 2006-11-21 ZA ZA200609681A patent/ZA200609681B/xx unknown
- 2006-11-27 TN TNP2006000391A patent/TNSN06391A1/fr unknown
- 2006-12-18 HK HK06113874A patent/HK1093070A1/xx unknown
-
2007
- 2007-10-31 US US11/930,258 patent/US8481548B2/en active Active
- 2007-11-20 HR HR20070529T patent/HRP20070529T3/xx unknown
- 2007-12-13 US US11/955,421 patent/US7973165B2/en active Active
-
2008
- 2008-01-11 CY CY20081100047T patent/CY1107856T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |