UA79824C2 - 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders - Google Patents
4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders Download PDFInfo
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- UA79824C2 UA79824C2 UAA200503861A UA2005003861A UA79824C2 UA 79824 C2 UA79824 C2 UA 79824C2 UA A200503861 A UAA200503861 A UA A200503861A UA 2005003861 A UA2005003861 A UA 2005003861A UA 79824 C2 UA79824 C2 UA 79824C2
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- compound
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- phenyl
- compound according
- methyl
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- 230000036407 pain Effects 0.000 title claims abstract description 12
- -1 phenyl-piperazinyl-methyl Chemical group 0.000 title claims description 59
- 238000011282 treatment Methods 0.000 title claims description 17
- 208000018522 Gastrointestinal disease Diseases 0.000 title claims description 7
- 208000027520 Somatoform disease Diseases 0.000 title claims description 3
- 208000027753 pain disease Diseases 0.000 title claims description 3
- 150000003936 benzamides Chemical class 0.000 title 1
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- 208000002193 Pain Diseases 0.000 claims abstract description 16
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 16
- 150000003839 salts Chemical class 0.000 claims abstract description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 9
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims description 24
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 21
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- 238000004519 manufacturing process Methods 0.000 claims description 7
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- 125000003107 substituted aryl group Chemical group 0.000 claims description 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 5
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Classifications
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- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Anesthesiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0203300A SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Novel Compounds |
| PCT/SE2003/001703 WO2004041800A1 (en) | 2002-11-07 | 2003-11-05 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA79824C2 true UA79824C2 (en) | 2007-07-25 |
Family
ID=20289504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200503861A UA79824C2 (en) | 2002-11-07 | 2003-05-11 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7396834B2 (pt) |
| EP (1) | EP1562922A1 (pt) |
| JP (1) | JP2006507296A (pt) |
| KR (1) | KR20050072794A (pt) |
| CN (1) | CN100471844C (pt) |
| AR (1) | AR041898A1 (pt) |
| AU (1) | AU2003274884B2 (pt) |
| BR (1) | BR0315998A (pt) |
| CA (1) | CA2502733A1 (pt) |
| IS (1) | IS7864A (pt) |
| MX (1) | MXPA05004709A (pt) |
| NO (1) | NO20052699L (pt) |
| NZ (1) | NZ539483A (pt) |
| PL (1) | PL376895A1 (pt) |
| RU (1) | RU2326875C2 (pt) |
| SE (1) | SE0203300D0 (pt) |
| TW (1) | TW200418823A (pt) |
| UA (1) | UA79824C2 (pt) |
| WO (1) | WO2004041800A1 (pt) |
| ZA (1) | ZA200503553B (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03010445A (es) * | 2001-05-18 | 2004-03-09 | Astrazeneca Ab | Derivados de 4(fenil-piperazinil-metil) benzamida y su uso para tratamiento del dolor, ansiedad o trastornos gastrointestinales. |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| NZ546834A (en) | 2003-10-01 | 2010-03-26 | Adolor Corp | Spirocyclic heterocyclic derivatives and methods of their use |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| KR101234421B1 (ko) * | 2004-08-02 | 2013-02-18 | 아스트라제네카 아베 | 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도 |
| EP1856076A1 (en) * | 2005-02-28 | 2007-11-21 | AstraZeneca AB | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| ES2283220B1 (es) * | 2006-04-12 | 2008-11-01 | Consejo Superior Investig. Cientificas | Uso de agonistas del receptor opioide delta en la elaboracion de composiciones farmaceuticas, composiciones farmaceuticas que las contienen y sus aplicaciones en el tratamiento de tumores. |
| NZ590041A (en) * | 2008-05-20 | 2012-11-30 | Astrazeneca Ab | Method of treating anxious major depressive disorder |
| RU2505536C1 (ru) * | 2012-12-29 | 2014-01-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Ярославский государственный технический университет" | 4-(1-гидрокси-1-метил-2-морфолиноэтил)бензойная и 4-(1-гидрокси-2-морфолиноциклогексил)бензойная кислоты, их фармацевтически приемлемые соли, сложные эфиры, обладающие анксиолитической активностью, и способ их получения |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH583713A5 (pt) | 1973-06-29 | 1977-01-14 | Cermol Sa | |
| DE2900810A1 (de) | 1979-01-11 | 1980-07-24 | Cassella Ag | Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung |
| IT1140978B (it) | 1980-05-23 | 1986-10-10 | Selvi & C Spa | 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche |
| GB8320701D0 (en) | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
| IT1196150B (it) | 1984-06-19 | 1988-11-10 | Poli Ind Chimica Spa | Derivati di 1-(bis-(4-fluorofenil)metil)-4-(3-fenil-2-propenil)-esaidro-1h-1,4-diazepina ad attivita' calcio antagonista,sua preparazione e composizioni che lo contengono |
| SE8500573D0 (sv) | 1985-02-08 | 1985-02-08 | Ferrosan Ab | Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain |
| US5028610A (en) | 1987-03-18 | 1991-07-02 | Sankyo Company Limited | N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use |
| US4829065A (en) | 1987-04-24 | 1989-05-09 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
| US4826844A (en) | 1987-09-30 | 1989-05-02 | American Home Products Corporation | Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols |
| US5840896A (en) | 1989-11-22 | 1998-11-24 | Janssen Pharmaceutica, N.V. | Method of preventing or limiting reperfusion damage |
| JP2574585B2 (ja) | 1989-11-22 | 1997-01-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 再潅流損傷の防止又は制限のための薬剤 |
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| SE9904674D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904673D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904675D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE0001209D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0101765D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101766D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| MXPA03010445A (es) | 2001-05-18 | 2004-03-09 | Astrazeneca Ab | Derivados de 4(fenil-piperazinil-metil) benzamida y su uso para tratamiento del dolor, ansiedad o trastornos gastrointestinales. |
| SE0103313D0 (sv) * | 2001-10-03 | 2001-10-03 | Astrazeneca Ab | Novel compounds |
| JP4892654B2 (ja) | 2001-10-29 | 2012-03-07 | マウント クック ファーマ，インコーポレーテッド | デルタレセプターアゴニスト化合物によるうつ病の治療方法 |
| US8476280B2 (en) | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0300105D0 (sv) | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof |
| SE0400027D0 (sv) | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| SE0401968D0 (sv) | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| EP1856076A1 (en) | 2005-02-28 | 2007-11-21 | AstraZeneca AB | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
-
2002
- 2002-11-07 SE SE0203300A patent/SE0203300D0/xx unknown
-
2003
- 2003-05-11 UA UAA200503861A patent/UA79824C2/uk unknown
- 2003-11-04 TW TW092130855A patent/TW200418823A/zh unknown
- 2003-11-05 NZ NZ539483A patent/NZ539483A/en unknown
- 2003-11-05 BR BR0315998-1A patent/BR0315998A/pt not_active IP Right Cessation
- 2003-11-05 KR KR1020057008068A patent/KR20050072794A/ko not_active Application Discontinuation
- 2003-11-05 PL PL376895A patent/PL376895A1/pl not_active Application Discontinuation
- 2003-11-05 WO PCT/SE2003/001703 patent/WO2004041800A1/en active Application Filing
- 2003-11-05 AR ARP030104056A patent/AR041898A1/es unknown
- 2003-11-05 EP EP03759164A patent/EP1562922A1/en not_active Withdrawn
- 2003-11-05 JP JP2004549772A patent/JP2006507296A/ja not_active Abandoned
- 2003-11-05 CN CNB2003801028254A patent/CN100471844C/zh not_active Expired - Fee Related
- 2003-11-05 MX MXPA05004709A patent/MXPA05004709A/es active IP Right Grant
- 2003-11-05 AU AU2003274884A patent/AU2003274884B2/en not_active Ceased
- 2003-11-05 US US10/533,744 patent/US7396834B2/en not_active Expired - Fee Related
- 2003-11-05 RU RU2005111983/04A patent/RU2326875C2/ru not_active IP Right Cessation
- 2003-11-05 CA CA002502733A patent/CA2502733A1/en not_active Abandoned
-
2005
- 2005-05-04 ZA ZA200503553A patent/ZA200503553B/en unknown
- 2005-05-25 IS IS7864A patent/IS7864A/is unknown
- 2005-06-06 NO NO20052699A patent/NO20052699L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004041800A1 (en) | 2004-05-21 |
| RU2005111983A (ru) | 2006-01-20 |
| IS7864A (is) | 2005-05-25 |
| CN1711251A (zh) | 2005-12-21 |
| CN100471844C (zh) | 2009-03-25 |
| AU2003274884A1 (en) | 2004-06-07 |
| NO20052699D0 (no) | 2005-06-06 |
| ZA200503553B (en) | 2006-09-27 |
| US7396834B2 (en) | 2008-07-08 |
| EP1562922A1 (en) | 2005-08-17 |
| CA2502733A1 (en) | 2004-05-21 |
| KR20050072794A (ko) | 2005-07-12 |
| RU2326875C2 (ru) | 2008-06-20 |
| AR041898A1 (es) | 2005-06-01 |
| NO20052699L (no) | 2005-06-06 |
| SE0203300D0 (sv) | 2002-11-07 |
| AU2003274884B2 (en) | 2007-11-15 |
| NZ539483A (en) | 2007-12-21 |
| BR0315998A (pt) | 2005-09-20 |
| JP2006507296A (ja) | 2006-03-02 |
| MXPA05004709A (es) | 2005-08-03 |
| TW200418823A (en) | 2004-10-01 |
| US20060167004A1 (en) | 2006-07-27 |
| PL376895A1 (pl) | 2006-01-09 |
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