UA78035C2 - Piperazine benzothiazole for treatment of cerebral ischemic disorders or cns disorders - Google Patents
Piperazine benzothiazole for treatment of cerebral ischemic disorders or cns disorders Download PDFInfo
- Publication number
- UA78035C2 UA78035C2 UA20041008647A UA20041008647A UA78035C2 UA 78035 C2 UA78035 C2 UA 78035C2 UA 20041008647 A UA20041008647 A UA 20041008647A UA 20041008647 A UA20041008647 A UA 20041008647A UA 78035 C2 UA78035 C2 UA 78035C2
- Authority
- UA
- Ukraine
- Prior art keywords
- group
- benzothiazol
- pyrimidin
- ylidene
- piperazinebenzothiazole
- Prior art date
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- 230000000302 ischemic effect Effects 0.000 title claims abstract description 12
- 230000002490 cerebral effect Effects 0.000 title claims abstract description 9
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- 238000004262 preparative liquid chromatography Methods 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 229940001470 psychoactive drug Drugs 0.000 description 1
- 239000004089 psychotropic agent Substances 0.000 description 1
- 125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 description 1
- 238000011403 purification operation Methods 0.000 description 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000016515 regulation of signal transduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 150000003555 thioacetals Chemical class 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 210000001578 tight junction Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000007723 transport mechanism Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 125000004953 trihalomethyl group Chemical group 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02100417 | 2002-04-25 | ||
| PCT/EP2003/004323 WO2003091249A1 (en) | 2002-04-25 | 2003-04-25 | Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or cns disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA78035C2 true UA78035C2 (en) | 2007-02-15 |
Family
ID=29265991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20041008647A UA78035C2 (en) | 2002-04-25 | 2003-04-25 | Piperazine benzothiazole for treatment of cerebral ischemic disorders or cns disorders |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7314878B2 (de) |
| EP (1) | EP1501828B1 (de) |
| JP (1) | JP4523289B2 (de) |
| KR (1) | KR100948469B1 (de) |
| CN (1) | CN1310911C (de) |
| AT (1) | ATE383356T1 (de) |
| AU (1) | AU2003233067B2 (de) |
| BR (1) | BRPI0309594A8 (de) |
| CA (1) | CA2481763C (de) |
| CY (1) | CY1107204T1 (de) |
| DE (1) | DE60318567T2 (de) |
| DK (1) | DK1501828T3 (de) |
| EA (1) | EA009682B1 (de) |
| ES (1) | ES2297165T3 (de) |
| HK (1) | HK1075664A1 (de) |
| IL (2) | IL164796A (de) |
| MX (1) | MXPA04010474A (de) |
| PT (1) | PT1501828E (de) |
| RS (1) | RS51407B (de) |
| SI (1) | SI1501828T1 (de) |
| UA (1) | UA78035C2 (de) |
| WO (1) | WO2003091249A1 (de) |
| ZA (1) | ZA200408023B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0309594A8 (pt) | 2002-04-25 | 2017-04-11 | Applied Res Systems Ars Holding N V | Piperazina benzothiazóis como agentes para o tratamento de distúrbios isquêmicos cerebrais ou distúrbios do snc |
| SI1696909T1 (sl) * | 2003-09-12 | 2008-02-29 | Serono Lab | Derivati benzotiazola za zdravljenje diabetesa |
| WO2005118543A1 (ja) * | 2004-06-03 | 2005-12-15 | Ono Pharmaceutical Co., Ltd. | キナーゼ阻害薬およびその用途 |
| ATE411817T1 (de) * | 2004-11-17 | 2008-11-15 | Ares Trading Sa | Benzothiazolformulierungen und ihre verwendung |
| US7838522B2 (en) | 2004-11-17 | 2010-11-23 | Ares Trading S.A. | Benzothiazole formulations and use thereof |
| KR20080044836A (ko) | 2005-07-15 | 2008-05-21 | 라보라뚜와르 세로노 에스. 에이. | 자궁내막증 치료용 ｊｎｋ 억제제 |
| BRPI0613042A2 (pt) * | 2005-07-15 | 2010-12-14 | Serono Lab | inibidores de jnk para o tratamento de endometriose |
| US20100121057A1 (en) * | 2007-04-17 | 2010-05-13 | Merck Serono Sa | Process for the Preparation of Piperazine Benzothiazoles |
| CN102015689B (zh) * | 2008-05-16 | 2014-01-08 | 霍夫曼-拉罗奇有限公司 | Jnk的抑制剂 |
| RU2572247C2 (ru) * | 2010-06-04 | 2016-01-10 | Ф. Хоффманн-Ля Рош Аг | Производные 2-амино-пиримидина в качестве ингибиторов jnk |
| US8471027B2 (en) * | 2011-04-06 | 2013-06-25 | Hoffmann-La Roche Inc. | Adamantyl compounds |
| CN104903331A (zh) * | 2013-01-24 | 2015-09-09 | 山东亨利医药科技有限责任公司 | Jnk抑制剂 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4153574B2 (ja) * | 1997-09-10 | 2008-09-24 | トーアエイヨー株式会社 | 新規なピペリジン誘導体、その製造法およびそれを含有する循環器官用剤 |
| EP1110957A1 (de) * | 1999-12-24 | 2001-06-27 | Applied Research Systems ARS Holding N.V. | Benzazolderivate und ihre Verwendung als JNK Modulatoren |
| EP1193256A1 (de) * | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmazeutisch aktive Benzolsulfonamidderivate als JNK-Proteininhibitoren |
| BRPI0309594A8 (pt) | 2002-04-25 | 2017-04-11 | Applied Res Systems Ars Holding N V | Piperazina benzothiazóis como agentes para o tratamento de distúrbios isquêmicos cerebrais ou distúrbios do snc |
-
2003
- 2003-04-25 BR BRPI0309594A patent/BRPI0309594A8/pt not_active IP Right Cessation
- 2003-04-25 EA EA200401423A patent/EA009682B1/ru not_active IP Right Cessation
- 2003-04-25 US US10/511,438 patent/US7314878B2/en not_active Expired - Lifetime
- 2003-04-25 EP EP03727365A patent/EP1501828B1/de not_active Expired - Lifetime
- 2003-04-25 RS YUP-928/04A patent/RS51407B/en unknown
- 2003-04-25 MX MXPA04010474A patent/MXPA04010474A/es active IP Right Grant
- 2003-04-25 JP JP2003587807A patent/JP4523289B2/ja not_active Expired - Fee Related
- 2003-04-25 IL IL164796A patent/IL164796A/en not_active IP Right Cessation
- 2003-04-25 ES ES03727365T patent/ES2297165T3/es not_active Expired - Lifetime
- 2003-04-25 SI SI200331114T patent/SI1501828T1/sl unknown
- 2003-04-25 PT PT03727365T patent/PT1501828E/pt unknown
- 2003-04-25 UA UA20041008647A patent/UA78035C2/uk unknown
- 2003-04-25 CA CA2481763A patent/CA2481763C/en not_active Expired - Fee Related
- 2003-04-25 DE DE60318567T patent/DE60318567T2/de not_active Expired - Lifetime
- 2003-04-25 AU AU2003233067A patent/AU2003233067B2/en not_active Ceased
- 2003-04-25 WO PCT/EP2003/004323 patent/WO2003091249A1/en active IP Right Grant
- 2003-04-25 KR KR1020047016871A patent/KR100948469B1/ko not_active IP Right Cessation
- 2003-04-25 CN CNB03814493XA patent/CN1310911C/zh not_active Expired - Fee Related
- 2003-04-25 DK DK03727365T patent/DK1501828T3/da active
- 2003-04-25 IL IL16479603A patent/IL164796A0/xx unknown
- 2003-04-25 AT AT03727365T patent/ATE383356T1/de active
-
2004
- 2004-10-05 ZA ZA2004/08023A patent/ZA200408023B/en unknown
-
2005
- 2005-11-10 HK HK05110023A patent/HK1075664A1/xx not_active IP Right Cessation
-
2008
- 2008-02-18 CY CY20081100199T patent/CY1107204T1/el unknown
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