UA77999C2 - Thymosin-alpha 1 for treatment of malignant glioblastoma - Google Patents
Thymosin-alpha 1 for treatment of malignant glioblastoma Download PDFInfo
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- UA77999C2 UA77999C2 UA20040705523A UA20040705523A UA77999C2 UA 77999 C2 UA77999 C2 UA 77999C2 UA 20040705523 A UA20040705523 A UA 20040705523A UA 20040705523 A UA20040705523 A UA 20040705523A UA 77999 C2 UA77999 C2 UA 77999C2
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- cells
- thymalfazin
- tumor
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- glioblastoma
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- 210000001541 thymus gland Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000005909 tumor killing Effects 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2292—Thymosin; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Prostheses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33714901P | 2001-12-10 | 2001-12-10 | |
| PCT/US2002/039329 WO2003049697A2 (en) | 2001-12-10 | 2002-12-10 | Treatment of glioblastoma with thymosin-alpha 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA77999C2 true UA77999C2 (en) | 2007-02-15 |
Family
ID=23319320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20040705523A UA77999C2 (en) | 2001-12-10 | 2002-10-12 | Thymosin-alpha 1 for treatment of malignant glioblastoma |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20060166870A1 (ko) |
| EP (1) | EP1461063B1 (ko) |
| JP (1) | JP2005516910A (ko) |
| KR (2) | KR20100029844A (ko) |
| CN (1) | CN1615147A (ko) |
| AT (1) | ATE356628T1 (ko) |
| AU (1) | AU2002357115B2 (ko) |
| BR (1) | BR0214848A (ko) |
| CA (1) | CA2469595A1 (ko) |
| DE (1) | DE60218896T2 (ko) |
| DK (1) | DK1461063T3 (ko) |
| EA (1) | EA005822B1 (ko) |
| ES (1) | ES2283653T3 (ko) |
| IL (1) | IL162434A0 (ko) |
| MX (1) | MXPA04005585A (ko) |
| NO (1) | NO20042927L (ko) |
| NZ (1) | NZ533942A (ko) |
| PL (1) | PL370829A1 (ko) |
| PT (1) | PT1461063E (ko) |
| SI (1) | SI1461063T1 (ko) |
| UA (1) | UA77999C2 (ko) |
| WO (1) | WO2003049697A2 (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2288118B1 (es) | 2006-05-10 | 2008-11-01 | Bcn Peptides, S.A. | Procedimiento para sintetizar timosinas. |
| CN108226016A (zh) * | 2018-01-12 | 2018-06-29 | 浙江普罗亭健康科技有限公司 | 肿瘤免疫细胞亚群精准分型的质谱流式检测试剂盒 |
| CN112147326B (zh) * | 2020-09-04 | 2022-04-08 | 北京大学 | 一种肿瘤免疫细胞亚群分型精准检测试剂盒 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4079127A (en) * | 1976-10-28 | 1978-03-14 | Board Of Regents Of The University Of Texas | Thymosin alpha 1 |
| US4116951A (en) * | 1977-04-22 | 1978-09-26 | Hoffmann-La Roche Inc. | [Asn2 ]-thymosin α1 and analogs thereof |
| US4148786A (en) * | 1978-06-26 | 1979-04-10 | American Home Products Corporation | Analgesic polypeptide |
| DE2919592A1 (de) * | 1979-05-15 | 1981-01-15 | Max Planck Gesellschaft | Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon |
| IT1238231B (it) * | 1989-12-18 | 1993-07-12 | Consiglio Nazionale Ricerche | Impiego di immunomodulanti come agenti sinergici di chemioterapici nella terapia dei tumori |
| FR2793684B1 (fr) * | 1999-05-17 | 2001-08-10 | Ethypharm Lab Prod Ethiques | Utilisation de microspheres biodegradables liberant un agent anticancereux pour le traitement du glioblastome, procede de preparation de ces microspheres et suspension les contenant |
| US6462017B1 (en) * | 2000-05-01 | 2002-10-08 | Sciclone Pharmaceuticals, Inc. | Method of reducing side effects of chemotherapy in cancer patients |
-
2002
- 2002-10-12 UA UA20040705523A patent/UA77999C2/uk unknown
- 2002-12-10 WO PCT/US2002/039329 patent/WO2003049697A2/en active Application Filing
- 2002-12-10 DK DK02804755T patent/DK1461063T3/da active
- 2002-12-10 PL PL02370829A patent/PL370829A1/xx not_active Application Discontinuation
- 2002-12-10 KR KR1020107002516A patent/KR20100029844A/ko not_active Application Discontinuation
- 2002-12-10 CA CA002469595A patent/CA2469595A1/en not_active Abandoned
- 2002-12-10 MX MXPA04005585A patent/MXPA04005585A/es active IP Right Grant
- 2002-12-10 NZ NZ533942A patent/NZ533942A/en unknown
- 2002-12-10 JP JP2003550748A patent/JP2005516910A/ja active Pending
- 2002-12-10 IL IL16243402A patent/IL162434A0/xx unknown
- 2002-12-10 SI SI200230509T patent/SI1461063T1/sl unknown
- 2002-12-10 BR BR0214848-0A patent/BR0214848A/pt not_active IP Right Cessation
- 2002-12-10 CN CNA028270819A patent/CN1615147A/zh active Pending
- 2002-12-10 PT PT02804755T patent/PT1461063E/pt unknown
- 2002-12-10 AT AT02804755T patent/ATE356628T1/de active
- 2002-12-10 EA EA200400755A patent/EA005822B1/ru not_active IP Right Cessation
- 2002-12-10 KR KR10-2004-7008939A patent/KR20040091611A/ko not_active Application Discontinuation
- 2002-12-10 AU AU2002357115A patent/AU2002357115B2/en not_active Ceased
- 2002-12-10 ES ES02804755T patent/ES2283653T3/es not_active Expired - Lifetime
- 2002-12-10 EP EP02804755A patent/EP1461063B1/en not_active Expired - Lifetime
- 2002-12-10 US US10/498,050 patent/US20060166870A1/en not_active Abandoned
- 2002-12-10 DE DE60218896T patent/DE60218896T2/de not_active Expired - Lifetime
-
2004
- 2004-07-08 NO NO20042927A patent/NO20042927L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL162434A0 (en) | 2005-11-20 |
| CA2469595A1 (en) | 2003-06-19 |
| DK1461063T3 (da) | 2007-05-21 |
| KR20040091611A (ko) | 2004-10-28 |
| SI1461063T1 (sl) | 2007-08-31 |
| PL370829A1 (en) | 2005-05-30 |
| MXPA04005585A (es) | 2005-03-23 |
| ATE356628T1 (de) | 2007-04-15 |
| EA200400755A1 (ru) | 2004-12-30 |
| WO2003049697A2 (en) | 2003-06-19 |
| NO20042927L (no) | 2004-09-09 |
| DE60218896T2 (de) | 2007-09-20 |
| CN1615147A (zh) | 2005-05-11 |
| EA005822B1 (ru) | 2005-06-30 |
| ES2283653T3 (es) | 2007-11-01 |
| AU2002357115B2 (en) | 2007-12-13 |
| NZ533942A (en) | 2007-01-26 |
| EP1461063A2 (en) | 2004-09-29 |
| DE60218896D1 (de) | 2007-04-26 |
| AU2002357115A1 (en) | 2003-06-23 |
| EP1461063A4 (en) | 2005-08-31 |
| BR0214848A (pt) | 2004-11-09 |
| WO2003049697A3 (en) | 2004-01-15 |
| EP1461063B1 (en) | 2007-03-14 |
| KR20100029844A (ko) | 2010-03-17 |
| US20060166870A1 (en) | 2006-07-27 |
| JP2005516910A (ja) | 2005-06-09 |
| PT1461063E (pt) | 2007-06-18 |
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