UA77301C2 - Tetrahydro-naphthalene derivatives - Google Patents
Tetrahydro-naphthalene derivatives Download PDFInfo
- Publication number
- UA77301C2 UA77301C2 UA20041210079A UA20041210079A UA77301C2 UA 77301 C2 UA77301 C2 UA 77301C2 UA 20041210079 A UA20041210079 A UA 20041210079A UA 20041210079 A UA20041210079 A UA 20041210079A UA 77301 C2 UA77301 C2 UA 77301C2
- Authority
- UA
- Ukraine
- Prior art keywords
- still
- hydroxy
- tetrahydro
- urea
- naphthalenyl
- Prior art date
Links
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- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
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- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
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- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- AHWALFGBDFAJAI-UHFFFAOYSA-N phenyl carbonochloridate Chemical compound ClC(=O)OC1=CC=CC=C1 AHWALFGBDFAJAI-UHFFFAOYSA-N 0.000 description 1
- DGTNSSLYPYDJGL-UHFFFAOYSA-N phenyl isocyanate Chemical compound O=C=NC1=CC=CC=C1 DGTNSSLYPYDJGL-UHFFFAOYSA-N 0.000 description 1
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- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
- 125000001325 propanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
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- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
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- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
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- 229920003002 synthetic resin Polymers 0.000 description 1
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- 235000012222 talc Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- QUDDPZNVVUOWRH-UHFFFAOYSA-N tert-butyl n-(7-ethoxynaphthalen-1-yl)carbamate Chemical compound C1=CC=C(NC(=O)OC(C)(C)C)C2=CC(OCC)=CC=C21 QUDDPZNVVUOWRH-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 description 1
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- DKZBBWMURDFHNE-UHFFFAOYSA-N trans-coniferylaldehyde Natural products COC1=CC(C=CC=O)=CC=C1O DKZBBWMURDFHNE-UHFFFAOYSA-N 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- BPLKQGGAXWRFOE-UHFFFAOYSA-M trimethylsulfoxonium iodide Chemical compound [I-].C[S+](C)(C)=O BPLKQGGAXWRFOE-UHFFFAOYSA-M 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000012762 unpaired Student’s t-test Methods 0.000 description 1
- JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 208000009935 visceral pain Diseases 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- CAWZRIXWFRFUQB-IOSLPCCCSA-N α,β Methylene ATP Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)CP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O CAWZRIXWFRFUQB-IOSLPCCCSA-N 0.000 description 1
- 229930195724 β-lactose Natural products 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0210512.0A GB0210512D0 (en) | 2002-05-08 | 2002-05-08 | Tetrahydro-napthalene derivatives |
PCT/EP2003/004395 WO2003095420A1 (fr) | 2002-05-08 | 2003-04-28 | Derives hydroxy-tetrahydro-naphtalenyluree |
Publications (1)
Publication Number | Publication Date |
---|---|
UA77301C2 true UA77301C2 (en) | 2006-11-15 |
Family
ID=9936269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA20041210079A UA77301C2 (en) | 2002-05-08 | 2003-04-28 | Tetrahydro-naphthalene derivatives |
Country Status (13)
Country | Link |
---|---|
KR (1) | KR101000688B1 (fr) |
AR (1) | AR039983A1 (fr) |
CU (1) | CU23422B7 (fr) |
DO (1) | DOP2003000642A (fr) |
EC (1) | ECSP045413A (fr) |
GB (2) | GB0210512D0 (fr) |
GT (1) | GT200300102A (fr) |
MA (1) | MA30728B1 (fr) |
MY (1) | MY155011A (fr) |
PE (1) | PE20040363A1 (fr) |
PT (1) | PT1506167E (fr) |
UA (1) | UA77301C2 (fr) |
ZA (1) | ZA200408993B (fr) |
-
2002
- 2002-05-08 GB GBGB0210512.0A patent/GB0210512D0/en not_active Ceased
- 2002-11-21 GB GBGB0227262.3A patent/GB0227262D0/en not_active Ceased
-
2003
- 2003-04-28 KR KR1020047017969A patent/KR101000688B1/ko not_active IP Right Cessation
- 2003-04-28 UA UA20041210079A patent/UA77301C2/uk unknown
- 2003-04-28 PT PT03722554T patent/PT1506167E/pt unknown
- 2003-05-05 GT GT200300102A patent/GT200300102A/es unknown
- 2003-05-06 MY MYPI20031696A patent/MY155011A/en unknown
- 2003-05-07 PE PE2003000445A patent/PE20040363A1/es not_active Application Discontinuation
- 2003-05-07 DO DO2003000642A patent/DOP2003000642A/es unknown
- 2003-05-08 AR ARP030101614A patent/AR039983A1/es active IP Right Grant
-
2004
- 2004-11-04 CU CU20040254A patent/CU23422B7/es unknown
- 2004-11-05 MA MA27935A patent/MA30728B1/fr unknown
- 2004-11-05 ZA ZA2004/08993A patent/ZA200408993B/en unknown
- 2004-11-08 EC EC2004005413A patent/ECSP045413A/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20040108784A (ko) | 2004-12-24 |
PE20040363A1 (es) | 2004-07-03 |
ECSP045413A (es) | 2005-01-03 |
DOP2003000642A (es) | 2003-11-15 |
KR101000688B1 (ko) | 2010-12-10 |
PT1506167E (pt) | 2007-12-10 |
GB0227262D0 (en) | 2002-12-31 |
AR039983A1 (es) | 2005-03-09 |
MA30728B1 (fr) | 2009-10-01 |
GT200300102A (es) | 2004-03-17 |
MY155011A (en) | 2015-08-28 |
GB0210512D0 (en) | 2002-06-19 |
ZA200408993B (en) | 2006-01-25 |
CU23422B7 (es) | 2009-09-08 |
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