UA75828C2 - Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity, pharmaceutical composition based thereon and method for treatment of disorder or disease (variants) - Google Patents

Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity, pharmaceutical composition based thereon and method for treatment of disorder or disease (variants) Download PDF

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Publication number
UA75828C2
UA75828C2 UA20041109704A UA20041109704A UA75828C2 UA 75828 C2 UA75828 C2 UA 75828C2 UA 20041109704 A UA20041109704 A UA 20041109704A UA 20041109704 A UA20041109704 A UA 20041109704A UA 75828 C2 UA75828 C2 UA 75828C2
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Ukraine
Prior art keywords
compound
compound according
solution
compounds
stage
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UA20041109704A
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English (en)
Ukrainian (uk)
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Merck & Co Inc
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Merck & Co Inc, Merck Sharp & Dohme filed Critical Merck & Co Inc
Publication of UA75828C2 publication Critical patent/UA75828C2/uk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
UA20041109704A 2002-04-29 2003-04-25 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity, pharmaceutical composition based thereon and method for treatment of disorder or disease (variants) UA75828C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37629102P 2002-04-29 2002-04-29
PCT/US2003/013042 WO2003093266A1 (fr) 2002-04-29 2003-04-25 Modulateurs de l'activite du recepteur de chimiokine, a base de tetrahydropyranyl cyclopentyl tetrahydropyridopyridine

Publications (1)

Publication Number Publication Date
UA75828C2 true UA75828C2 (en) 2006-05-15

Family

ID=29401326

Family Applications (1)

Application Number Title Priority Date Filing Date
UA20041109704A UA75828C2 (en) 2002-04-29 2003-04-25 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity, pharmaceutical composition based thereon and method for treatment of disorder or disease (variants)

Country Status (23)

Country Link
US (1) US7786305B2 (fr)
KR (1) KR100754760B1 (fr)
CN (1) CN1310917C (fr)
AR (1) AR039489A1 (fr)
AU (1) AU2003234251A1 (fr)
BR (1) BR0309650A (fr)
DO (1) DOP2003000638A (fr)
EC (1) ECSP045392A (fr)
HK (1) HK1081967A1 (fr)
HR (1) HRP20041023A2 (fr)
IL (1) IL164909A (fr)
IS (1) IS7512A (fr)
JO (1) JO2479B1 (fr)
MA (1) MA27119A1 (fr)
MX (1) MXPA04010702A (fr)
MY (1) MY129850A (fr)
NO (1) NO20045235L (fr)
PE (1) PE20040598A1 (fr)
PL (1) PL373401A1 (fr)
RU (1) RU2285004C2 (fr)
TW (1) TWI262077B (fr)
UA (1) UA75828C2 (fr)
WO (1) WO2003093266A1 (fr)

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SI1501507T1 (sl) * 2002-04-29 2008-12-31 Merck & Co Inc Tetrahidropiranil ciklopentil tetrahidropiridopiridin modulatorji s kemokinsko receptorsko aktivnostjo
MY129850A (en) 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
WO2004050024A2 (fr) 2002-11-27 2004-06-17 Incyte Corporation Derives de la 3-aminopyrrolidine modulateurs des recepteurs de la chemoquine
CN1826334A (zh) * 2003-03-18 2006-08-30 麦克公司 趋化因子受体活性的四氢吡喃基环戊基杂环酰胺调节剂
WO2004110376A2 (fr) * 2003-06-06 2004-12-23 Merck & Co., Inc. Antagonistes de ccr-2 permettant de traiter une douleur neuropathique
KR20060101476A (ko) 2003-10-27 2006-09-25 머크 앤드 캄파니 인코포레이티드 Ccr-2 길항제 염
WO2005060665A2 (fr) 2003-12-18 2005-07-07 Incyte Corporation Derives 3-cycloalkylaminopyrrolidine utilises en tant que modulateurs des recepteurs de chimiokine
AU2004313486A1 (en) * 2004-01-02 2005-07-28 Merck & Co., Inc. Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity
EP1742919A4 (fr) * 2004-04-26 2010-04-28 Merck Sharp & Dohme Modulateurs tetrahydropyranyle cyclopentyle de tetrahydroisoquinoline 1 substituee et 1,1-disubstituee de l'activite des recepteurs de chimiokine
WO2005105092A2 (fr) * 2004-04-28 2005-11-10 Merck & Co., Inc. Modulateurs de l'activité de récepteurs de chimiokines en tétrahydropyranylcyclopentylamide disubstitué en position 3,3
MXPA06013112A (es) 2004-05-11 2007-02-14 Incyte Corp 3-(4-heteroarilciclohexilamino)ciclopentanocarboxamidas como moduladores de receptores de quimiocinas.
MXPA06014673A (es) 2004-06-28 2007-03-26 Incyte Corp 3-aminociclopentanocarbozamidas como moduladores de receptores de quimioquinas.
TW200608966A (en) 2004-06-28 2006-03-16 Incyte Corp 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
WO2007053498A1 (fr) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Composés pouvant être employés en tant qu'antagonistes de ccr2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
US7977358B2 (en) 2007-07-26 2011-07-12 Hoffmann-La Roche Inc. Pyrazol derivatives
AU2009321221B2 (en) * 2008-11-26 2013-04-04 Pfizer Inc. 3-aminocyclopentanecarboxamides as chemokine receptor modulators
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
TWI540132B (zh) * 2009-06-08 2016-07-01 亞培公司 Bcl-2族群抑制劑之口服醫藥劑型
JP5779591B2 (ja) * 2009-12-22 2015-09-16 アッヴィ・インコーポレイテッド Abt−263カプセル剤
KR20180059560A (ko) 2010-10-29 2018-06-04 애브비 인코포레이티드 아폽토시스―유도제를 포함하는 고체 분산체
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
UY33746A (es) 2010-11-23 2012-06-29 Abbott Lab Método de tratamiento que usa inhibidores selectivos de bcl-2
AU2011332043C1 (en) 2010-11-23 2016-11-10 Abbvie Inc. Salts and crystalline forms of an apoptosis-inducing agent
US20130345254A1 (en) * 2011-03-17 2013-12-26 Anilkumar G. Nair Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
AR085435A1 (es) 2011-03-17 2013-10-02 Bristol Myers Squibb Co Inhibidores de pirrolopiridazina jak3 y su uso para el tratamiento de enfermedades inflamatorias y autoinmunes
US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
CA2879126A1 (fr) 2012-07-19 2014-01-23 Janssen Pharmaceutica Nv Antagonistes octahydro-cyclopentapyrrolyl anti-ccr2
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
DK3297438T3 (da) 2015-05-21 2022-01-17 Chemocentryx Inc Ccr2-modulatorer
SG11202002119QA (en) 2017-09-25 2020-04-29 Chemocentryx Inc Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
WO2019136368A2 (fr) 2018-01-08 2019-07-11 Chemocentryx, Inc. Procédés de traitement de tumeurs solides au moyen d'antagonistes du ccr2
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists

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US3772308A (en) * 1972-06-02 1973-11-13 Lilly Co Eli Cyclopentanecetamides and cyclopentaneacetonitriles
KR880007441A (ko) * 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제
CA2143143A1 (fr) 1994-03-08 1995-09-09 Toshihiko Tanaka Derives de la 3-phenylpyrrolidine
JPH09291034A (ja) 1996-02-27 1997-11-11 Yoshitomi Pharmaceut Ind Ltd 縮合ピリジン化合物およびその医薬としての用途
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US6312689B1 (en) * 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
AU5473400A (en) 1999-06-11 2001-01-02 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
ES2271063T3 (es) * 2000-08-17 2007-04-16 MERCK & CO., INC. Moduladores ciclopentilos de la actividad del receptor de la quimioquina.
MXPA03008109A (es) * 2001-03-07 2003-12-12 Pfizer Prod Inc Moduladores de la actividad de receptores de quimiocinas.
MY129850A (en) 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
US7166614B2 (en) 2002-04-29 2007-01-23 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity
SI1501507T1 (sl) 2002-04-29 2008-12-31 Merck & Co Inc Tetrahidropiranil ciklopentil tetrahidropiridopiridin modulatorji s kemokinsko receptorsko aktivnostjo
AU2003286701B2 (en) 2002-10-30 2008-12-18 Merck Sharp & Dohme Corp. Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity
KR20060101476A (ko) 2003-10-27 2006-09-25 머크 앤드 캄파니 인코포레이티드 Ccr-2 길항제 염
WO2005105092A2 (fr) 2004-04-28 2005-11-10 Merck & Co., Inc. Modulateurs de l'activité de récepteurs de chimiokines en tétrahydropyranylcyclopentylamide disubstitué en position 3,3

Also Published As

Publication number Publication date
CN1310917C (zh) 2007-04-18
HK1081967A1 (en) 2006-05-26
RU2004134604A (ru) 2005-05-27
PE20040598A1 (es) 2004-10-05
IS7512A (is) 2004-10-18
US7786305B2 (en) 2010-08-31
WO2003093266A1 (fr) 2003-11-13
RU2285004C2 (ru) 2006-10-10
IL164909A (en) 2010-04-15
US20050101628A1 (en) 2005-05-12
HRP20041023A2 (en) 2005-02-28
MXPA04010702A (es) 2005-02-17
KR20050000413A (ko) 2005-01-03
IL164909A0 (en) 2005-12-18
JO2479B1 (en) 2009-01-20
DOP2003000638A (es) 2003-11-30
AR039489A1 (es) 2005-02-23
NO20045235L (no) 2004-11-29
AU2003234251A8 (en) 2003-11-17
BR0309650A (pt) 2005-04-26
MA27119A1 (fr) 2004-12-20
TW200307543A (en) 2003-12-16
KR100754760B1 (ko) 2007-09-04
PL373401A1 (en) 2005-08-22
AU2003234251A1 (en) 2003-11-17
CN1662532A (zh) 2005-08-31
MY129850A (en) 2007-05-31
TWI262077B (en) 2006-09-21
ECSP045392A (es) 2005-01-03

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