HK1081967A1 - Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity - Google Patents
Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activityInfo
- Publication number
- HK1081967A1 HK1081967A1 HK06102357A HK06102357A HK1081967A1 HK 1081967 A1 HK1081967 A1 HK 1081967A1 HK 06102357 A HK06102357 A HK 06102357A HK 06102357 A HK06102357 A HK 06102357A HK 1081967 A1 HK1081967 A1 HK 1081967A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- chemokine receptor
- receptor activity
- modulators
- tetrahydropyranyl cyclopentyl
- tetrahydropyranyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37629102P | 2002-04-29 | 2002-04-29 | |
PCT/US2003/013042 WO2003093266A1 (fr) | 2002-04-29 | 2003-04-25 | Modulateurs de l'activite du recepteur de chimiokine, a base de tetrahydropyranyl cyclopentyl tetrahydropyridopyridine |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1081967A1 true HK1081967A1 (en) | 2006-05-26 |
Family
ID=29401326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06102357A HK1081967A1 (en) | 2002-04-29 | 2006-02-22 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
Country Status (23)
Country | Link |
---|---|
US (1) | US7786305B2 (fr) |
KR (1) | KR100754760B1 (fr) |
CN (1) | CN1310917C (fr) |
AR (1) | AR039489A1 (fr) |
AU (1) | AU2003234251A1 (fr) |
BR (1) | BR0309650A (fr) |
DO (1) | DOP2003000638A (fr) |
EC (1) | ECSP045392A (fr) |
HK (1) | HK1081967A1 (fr) |
HR (1) | HRP20041023A2 (fr) |
IL (1) | IL164909A (fr) |
IS (1) | IS7512A (fr) |
JO (1) | JO2479B1 (fr) |
MA (1) | MA27119A1 (fr) |
MX (1) | MXPA04010702A (fr) |
MY (1) | MY129850A (fr) |
NO (1) | NO20045235L (fr) |
PE (1) | PE20040598A1 (fr) |
PL (1) | PL373401A1 (fr) |
RU (1) | RU2285004C2 (fr) |
TW (1) | TWI262077B (fr) |
UA (1) | UA75828C2 (fr) |
WO (1) | WO2003093266A1 (fr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE396993T1 (de) * | 2002-04-29 | 2008-06-15 | Merck & Co Inc | Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität |
US20060030582A1 (en) * | 2002-04-29 | 2006-02-09 | Demartino Julie | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
JO2479B1 (en) | 2002-04-29 | 2009-01-20 | ميرك شارب اند دوم ليمتد | Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine |
GEP20115290B (en) | 2002-11-27 | 2011-09-26 | Incyte Corp | 3-aminopyrrolidine derivatives as modulators of chemokine receptors |
US7393844B2 (en) * | 2003-03-18 | 2008-07-01 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity |
US20060205761A1 (en) * | 2003-06-06 | 2006-09-14 | Catherine Abbadie | Ccr-2 antagonists for treatment of neuropathic pain |
WO2005044264A1 (fr) * | 2003-10-27 | 2005-05-19 | Merck & Co., Inc. | Sel antagoniste de ccr-2 |
DK1696919T3 (da) | 2003-12-18 | 2013-12-09 | Incyte Corp | 3-cycloalkylaminopyrrolidin-derivater som modulatorer af chemokinreceptorer |
CN1897941A (zh) * | 2004-01-02 | 2007-01-17 | 默克公司 | 趋化因子受体活性的烷基氨基、芳基氨基以及氨磺酰基环戊基酰胺调节剂 |
JP2007534758A (ja) * | 2004-04-26 | 2007-11-29 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性調節物質であるテトラヒドロピラニルシクロペンチル1−置換及び1,1−二置換テトラヒドロイソキノリン |
EP1755603A4 (fr) * | 2004-04-28 | 2009-03-11 | Merck & Co Inc | Modulateurs de l'activité de récepteurs de chimiokines en tétrahydropyranylcyclopentylamide disubstitué en position 3,3 |
CN1950085A (zh) | 2004-05-11 | 2007-04-18 | 因赛特公司 | 作为趋化因子受体调节剂的3-(4-杂芳基环己基氨基)环戊烷羧酰胺 |
UA83311C2 (en) | 2004-06-28 | 2008-06-25 | Инсайт Корпорейшн | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
GEP20094843B (en) | 2004-06-28 | 2009-11-25 | Incyte Corp | 3-aminocyclopentane carboxamides as modulators of chemokine receptors |
US8067415B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
US8067457B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
US7977358B2 (en) | 2007-07-26 | 2011-07-12 | Hoffmann-La Roche Inc. | Pyrazol derivatives |
GEP20146064B (en) | 2008-11-26 | 2014-03-25 | Pfizer | 3-minocyclopentanecarboxamides as chemokine receptor modulators |
US8728516B2 (en) * | 2009-04-30 | 2014-05-20 | Abbvie Inc. | Stabilized lipid formulation of apoptosis promoter |
TWI532484B (zh) * | 2009-06-08 | 2016-05-11 | 艾伯維有限公司 | 包含凋亡促進劑之固態分散劑 |
TWI540132B (zh) * | 2009-06-08 | 2016-07-01 | 亞培公司 | Bcl-2族群抑制劑之口服醫藥劑型 |
EP2515883A4 (fr) * | 2009-12-22 | 2013-07-17 | Abbvie Inc | Capsule de abt-263 |
RU2598345C2 (ru) | 2010-10-29 | 2016-09-20 | Эббви Инк. | Твердые дисперсии, содержащие средства, вызывающие апоптоз |
UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
EP2642999B1 (fr) | 2010-11-23 | 2016-09-28 | AbbVie Bahamas Ltd. | Procédés de traitement utilisant des inhibiteurs sélectifs de bcl-2 |
EP2643322B1 (fr) | 2010-11-23 | 2017-08-30 | Abbvie Inc. | Sels et formes cristallines d'un agent inducteur d'apoptose |
EP2686321B1 (fr) | 2011-03-17 | 2016-11-16 | Bristol-Myers Squibb Company | Inhibiteurs de jak3 de type pyrrolopyridazine et leur utilisation pour traiter les maladies inflammatoires et auto-immunes |
WO2012125663A2 (fr) * | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | Dérivés d'amino cyclopentane substitués par cyclohexane en tant qu'antagonistes utiles de ccr2 |
US8822460B2 (en) | 2012-04-06 | 2014-09-02 | Janssen Pharmaceutica Nv | Fused cyclopentyl antagonists of CCR2 |
CN105358551A (zh) | 2012-07-19 | 2016-02-24 | 詹森药业有限公司 | Ccr2的八氢环戊并吡咯基拮抗剂 |
US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
EP3297438B1 (fr) | 2015-05-21 | 2021-10-20 | ChemoCentryx, Inc. | Modulateurs du ccr2 |
JP7453139B2 (ja) | 2017-09-25 | 2024-03-19 | ケモセントリックス,インコーポレイティド | ケモカイン受容体2(ccr2)アンタゴニスト及びpd-1/pd-l1阻害剤を使用した併用療法 |
JP7442141B2 (ja) | 2018-01-08 | 2024-03-04 | ケモセントリックス,インコーポレイティド | Ccr2アンタゴニストによる固形腫瘍の治療方法 |
US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3647804A (en) * | 1970-02-27 | 1972-03-07 | Upjohn Co | Cycloalkanecarboxamides |
US3772308A (en) * | 1972-06-02 | 1973-11-13 | Lilly Co Eli | Cyclopentanecetamides and cyclopentaneacetonitriles |
KR880007441A (ko) * | 1986-12-11 | 1988-08-27 | 알렌 제이.스피겔 | 스피로-치환된 글루타르아미드 이뇨제 |
CA2143143A1 (fr) | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | Derives de la 3-phenylpyrrolidine |
JPH09291034A (ja) | 1996-02-27 | 1997-11-11 | Yoshitomi Pharmaceut Ind Ltd | 縮合ピリジン化合物およびその医薬としての用途 |
GB9812037D0 (en) | 1998-06-04 | 1998-07-29 | Pfizer Ltd | Piperidones |
US6312689B1 (en) * | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
WO2000076512A1 (fr) | 1999-06-11 | 2000-12-21 | Merck & Co., Inc. | Modulateurs cyclopentyliques de l'activite du recepteur de la chimiokine |
JP2004506013A (ja) * | 2000-08-17 | 2004-02-26 | メルク エンド カムパニー インコーポレーテッド | シクロペンチル系ケモカイン受容体活性調節剤 |
CA2440803A1 (fr) * | 2001-03-07 | 2002-09-12 | Pfizer Products Inc. | Modulateurs de l'activite du recepteur de la chimiokine |
ATE396993T1 (de) | 2002-04-29 | 2008-06-15 | Merck & Co Inc | Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität |
JO2479B1 (en) | 2002-04-29 | 2009-01-20 | ميرك شارب اند دوم ليمتد | Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine |
US7166614B2 (en) | 2002-04-29 | 2007-01-23 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity |
US7390803B2 (en) | 2002-10-30 | 2008-06-24 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity |
WO2005044264A1 (fr) | 2003-10-27 | 2005-05-19 | Merck & Co., Inc. | Sel antagoniste de ccr-2 |
EP1755603A4 (fr) | 2004-04-28 | 2009-03-11 | Merck & Co Inc | Modulateurs de l'activité de récepteurs de chimiokines en tétrahydropyranylcyclopentylamide disubstitué en position 3,3 |
-
2003
- 2003-04-22 JO JO200343A patent/JO2479B1/en active
- 2003-04-22 TW TW092109364A patent/TWI262077B/zh not_active IP Right Cessation
- 2003-04-22 MY MYPI20031503A patent/MY129850A/en unknown
- 2003-04-25 PL PL03373401A patent/PL373401A1/xx not_active Application Discontinuation
- 2003-04-25 CN CNB038150417A patent/CN1310917C/zh not_active Expired - Fee Related
- 2003-04-25 PE PE2003000418A patent/PE20040598A1/es not_active Application Discontinuation
- 2003-04-25 AU AU2003234251A patent/AU2003234251A1/en not_active Abandoned
- 2003-04-25 MX MXPA04010702A patent/MXPA04010702A/es active IP Right Grant
- 2003-04-25 WO PCT/US2003/013042 patent/WO2003093266A1/fr not_active Application Discontinuation
- 2003-04-25 KR KR1020047017373A patent/KR100754760B1/ko not_active IP Right Cessation
- 2003-04-25 BR BR0309650-5A patent/BR0309650A/pt not_active Application Discontinuation
- 2003-04-25 UA UA20041109704A patent/UA75828C2/uk unknown
- 2003-04-25 RU RU2004134604/04A patent/RU2285004C2/ru not_active IP Right Cessation
- 2003-04-29 DO DO2003000638A patent/DOP2003000638A/es unknown
- 2003-04-29 AR ARP030101487A patent/AR039489A1/es unknown
-
2004
- 2004-05-28 US US10/856,012 patent/US7786305B2/en active Active
- 2004-10-18 IS IS7512A patent/IS7512A/is unknown
- 2004-10-27 EC EC2004005392A patent/ECSP045392A/es unknown
- 2004-10-28 IL IL164909A patent/IL164909A/en not_active IP Right Cessation
- 2004-10-29 HR HR20041023A patent/HRP20041023A2/hr not_active Application Discontinuation
- 2004-11-17 MA MA27955A patent/MA27119A1/fr unknown
- 2004-11-29 NO NO20045235A patent/NO20045235L/no not_active Application Discontinuation
-
2006
- 2006-02-22 HK HK06102357A patent/HK1081967A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1662532A (zh) | 2005-08-31 |
RU2004134604A (ru) | 2005-05-27 |
AU2003234251A8 (en) | 2003-11-17 |
HRP20041023A2 (en) | 2005-02-28 |
BR0309650A (pt) | 2005-04-26 |
TW200307543A (en) | 2003-12-16 |
DOP2003000638A (es) | 2003-11-30 |
MA27119A1 (fr) | 2004-12-20 |
JO2479B1 (en) | 2009-01-20 |
CN1310917C (zh) | 2007-04-18 |
ECSP045392A (es) | 2005-01-03 |
UA75828C2 (en) | 2006-05-15 |
US7786305B2 (en) | 2010-08-31 |
NO20045235L (no) | 2004-11-29 |
KR20050000413A (ko) | 2005-01-03 |
MY129850A (en) | 2007-05-31 |
IS7512A (is) | 2004-10-18 |
WO2003093266A1 (fr) | 2003-11-13 |
IL164909A (en) | 2010-04-15 |
KR100754760B1 (ko) | 2007-09-04 |
TWI262077B (en) | 2006-09-21 |
IL164909A0 (en) | 2005-12-18 |
AU2003234251A1 (en) | 2003-11-17 |
MXPA04010702A (es) | 2005-02-17 |
RU2285004C2 (ru) | 2006-10-10 |
AR039489A1 (es) | 2005-02-23 |
PL373401A1 (en) | 2005-08-22 |
PE20040598A1 (es) | 2004-10-05 |
US20050101628A1 (en) | 2005-05-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20150425 |