HK1081967A1 - Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity - Google Patents

Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Info

Publication number
HK1081967A1
HK1081967A1 HK06102357A HK06102357A HK1081967A1 HK 1081967 A1 HK1081967 A1 HK 1081967A1 HK 06102357 A HK06102357 A HK 06102357A HK 06102357 A HK06102357 A HK 06102357A HK 1081967 A1 HK1081967 A1 HK 1081967A1
Authority
HK
Hong Kong
Prior art keywords
chemokine receptor
receptor activity
modulators
tetrahydropyranyl cyclopentyl
tetrahydropyranyl
Prior art date
Application number
HK06102357A
Other languages
English (en)
Inventor
Richard Jiao
Gregori Morriello
Lihu Yang
Christopher Moyes
Original Assignee
Merck & Co Inc
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Merck Sharp & Dohme filed Critical Merck & Co Inc
Publication of HK1081967A1 publication Critical patent/HK1081967A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK06102357A 2002-04-29 2006-02-22 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity HK1081967A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37629102P 2002-04-29 2002-04-29
PCT/US2003/013042 WO2003093266A1 (fr) 2002-04-29 2003-04-25 Modulateurs de l'activite du recepteur de chimiokine, a base de tetrahydropyranyl cyclopentyl tetrahydropyridopyridine

Publications (1)

Publication Number Publication Date
HK1081967A1 true HK1081967A1 (en) 2006-05-26

Family

ID=29401326

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06102357A HK1081967A1 (en) 2002-04-29 2006-02-22 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Country Status (23)

Country Link
US (1) US7786305B2 (fr)
KR (1) KR100754760B1 (fr)
CN (1) CN1310917C (fr)
AR (1) AR039489A1 (fr)
AU (1) AU2003234251A1 (fr)
BR (1) BR0309650A (fr)
DO (1) DOP2003000638A (fr)
EC (1) ECSP045392A (fr)
HK (1) HK1081967A1 (fr)
HR (1) HRP20041023A2 (fr)
IL (1) IL164909A (fr)
IS (1) IS7512A (fr)
JO (1) JO2479B1 (fr)
MA (1) MA27119A1 (fr)
MX (1) MXPA04010702A (fr)
MY (1) MY129850A (fr)
NO (1) NO20045235L (fr)
PE (1) PE20040598A1 (fr)
PL (1) PL373401A1 (fr)
RU (1) RU2285004C2 (fr)
TW (1) TWI262077B (fr)
UA (1) UA75828C2 (fr)
WO (1) WO2003093266A1 (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE396993T1 (de) * 2002-04-29 2008-06-15 Merck & Co Inc Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität
US20060030582A1 (en) * 2002-04-29 2006-02-09 Demartino Julie Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
JO2479B1 (en) 2002-04-29 2009-01-20 ميرك شارب اند دوم ليمتد Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine
GEP20115290B (en) 2002-11-27 2011-09-26 Incyte Corp 3-aminopyrrolidine derivatives as modulators of chemokine receptors
US7393844B2 (en) * 2003-03-18 2008-07-01 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity
US20060205761A1 (en) * 2003-06-06 2006-09-14 Catherine Abbadie Ccr-2 antagonists for treatment of neuropathic pain
WO2005044264A1 (fr) * 2003-10-27 2005-05-19 Merck & Co., Inc. Sel antagoniste de ccr-2
DK1696919T3 (da) 2003-12-18 2013-12-09 Incyte Corp 3-cycloalkylaminopyrrolidin-derivater som modulatorer af chemokinreceptorer
CN1897941A (zh) * 2004-01-02 2007-01-17 默克公司 趋化因子受体活性的烷基氨基、芳基氨基以及氨磺酰基环戊基酰胺调节剂
JP2007534758A (ja) * 2004-04-26 2007-11-29 メルク　エンド　カムパニー　インコーポレーテッド ケモカイン受容体活性調節物質であるテトラヒドロピラニルシクロペンチル１−置換及び１，１−二置換テトラヒドロイソキノリン
EP1755603A4 (fr) * 2004-04-28 2009-03-11 Merck & Co Inc Modulateurs de l'activité de récepteurs de chimiokines en tétrahydropyranylcyclopentylamide disubstitué en position 3,3
CN1950085A (zh) 2004-05-11 2007-04-18 因赛特公司 作为趋化因子受体调节剂的3－(4－杂芳基环己基氨基)环戊烷羧酰胺
UA83311C2 (en) 2004-06-28 2008-06-25 Инсайт Корпорейшн 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
GEP20094843B (en) 2004-06-28 2009-11-25 Incyte Corp 3-aminocyclopentane carboxamides as modulators of chemokine receptors
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
US7977358B2 (en) 2007-07-26 2011-07-12 Hoffmann-La Roche Inc. Pyrazol derivatives
GEP20146064B (en) 2008-11-26 2014-03-25 Pfizer 3-minocyclopentanecarboxamides as chemokine receptor modulators
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
TWI540132B (zh) * 2009-06-08 2016-07-01 亞培公司 Ｂｃｌ-２族群抑制劑之口服醫藥劑型
EP2515883A4 (fr) * 2009-12-22 2013-07-17 Abbvie Inc Capsule de abt-263
RU2598345C2 (ru) 2010-10-29 2016-09-20 Эббви Инк. Твердые дисперсии, содержащие средства, вызывающие апоптоз
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
EP2642999B1 (fr) 2010-11-23 2016-09-28 AbbVie Bahamas Ltd. Procédés de traitement utilisant des inhibiteurs sélectifs de bcl-2
EP2643322B1 (fr) 2010-11-23 2017-08-30 Abbvie Inc. Sels et formes cristallines d'un agent inducteur d'apoptose
EP2686321B1 (fr) 2011-03-17 2016-11-16 Bristol-Myers Squibb Company Inhibiteurs de jak3 de type pyrrolopyridazine et leur utilisation pour traiter les maladies inflammatoires et auto-immunes
WO2012125663A2 (fr) * 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. Dérivés d'amino cyclopentane substitués par cyclohexane en tant qu'antagonistes utiles de ccr2
US8822460B2 (en) 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
CN105358551A (zh) 2012-07-19 2016-02-24 詹森药业有限公司 Ccr2的八氢环戊并吡咯基拮抗剂
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
EP3297438B1 (fr) 2015-05-21 2021-10-20 ChemoCentryx, Inc. Modulateurs du ccr2
JP7453139B2 (ja) 2017-09-25 2024-03-19 ケモセントリックス，インコーポレイティド ケモカイン受容体２（ｃｃｒ２）アンタゴニスト及びｐｄ－１／ｐｄ－ｌ１阻害剤を使用した併用療法
JP7442141B2 (ja) 2018-01-08 2024-03-04 ケモセントリックス，インコーポレイティド Ｃｃｒ２アンタゴニストによる固形腫瘍の治療方法
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3647804A (en) * 1970-02-27 1972-03-07 Upjohn Co Cycloalkanecarboxamides
US3772308A (en) * 1972-06-02 1973-11-13 Lilly Co Eli Cyclopentanecetamides and cyclopentaneacetonitriles
KR880007441A (ko) * 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제
CA2143143A1 (fr) 1994-03-08 1995-09-09 Toshihiko Tanaka Derives de la 3-phenylpyrrolidine
JPH09291034A (ja) 1996-02-27 1997-11-11 Yoshitomi Pharmaceut Ind Ltd 縮合ピリジン化合物およびその医薬としての用途
GB9812037D0 (en) 1998-06-04 1998-07-29 Pfizer Ltd Piperidones
US6312689B1 (en) * 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
WO2000076512A1 (fr) 1999-06-11 2000-12-21 Merck & Co., Inc. Modulateurs cyclopentyliques de l'activite du recepteur de la chimiokine
JP2004506013A (ja) * 2000-08-17 2004-02-26 メルク　エンド　カムパニー　インコーポレーテッド シクロペンチル系ケモカイン受容体活性調節剤
CA2440803A1 (fr) * 2001-03-07 2002-09-12 Pfizer Products Inc. Modulateurs de l'activite du recepteur de la chimiokine
ATE396993T1 (de) 2002-04-29 2008-06-15 Merck & Co Inc Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität
JO2479B1 (en) 2002-04-29 2009-01-20 ميرك شارب اند دوم ليمتد Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine
US7166614B2 (en) 2002-04-29 2007-01-23 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity
US7390803B2 (en) 2002-10-30 2008-06-24 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity
WO2005044264A1 (fr) 2003-10-27 2005-05-19 Merck & Co., Inc. Sel antagoniste de ccr-2
EP1755603A4 (fr) 2004-04-28 2009-03-11 Merck & Co Inc Modulateurs de l'activité de récepteurs de chimiokines en tétrahydropyranylcyclopentylamide disubstitué en position 3,3

Also Published As

Publication number Publication date
CN1662532A (zh) 2005-08-31
RU2004134604A (ru) 2005-05-27
AU2003234251A8 (en) 2003-11-17
HRP20041023A2 (en) 2005-02-28
BR0309650A (pt) 2005-04-26
TW200307543A (en) 2003-12-16
DOP2003000638A (es) 2003-11-30
MA27119A1 (fr) 2004-12-20
JO2479B1 (en) 2009-01-20
CN1310917C (zh) 2007-04-18
ECSP045392A (es) 2005-01-03
UA75828C2 (en) 2006-05-15
US7786305B2 (en) 2010-08-31
NO20045235L (no) 2004-11-29
KR20050000413A (ko) 2005-01-03
MY129850A (en) 2007-05-31
IS7512A (is) 2004-10-18
WO2003093266A1 (fr) 2003-11-13
IL164909A (en) 2010-04-15
KR100754760B1 (ko) 2007-09-04
TWI262077B (en) 2006-09-21
IL164909A0 (en) 2005-12-18
AU2003234251A1 (en) 2003-11-17
MXPA04010702A (es) 2005-02-17
RU2285004C2 (ru) 2006-10-10
AR039489A1 (es) 2005-02-23
PL373401A1 (en) 2005-08-22
PE20040598A1 (es) 2004-10-05
US20050101628A1 (en) 2005-05-12

Similar Documents

Publication Publication Date Title
HK1081967A1 (en) Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
EP1558243A4 (fr) Modulateurs de l'activite des recepteurs de la chimiokine a base de tetrahydropyranyl-cyclopentyl-benzylamide
EP1558250A4 (fr) Modulateurs gamma-aminoamides de l'activite de recepteur de chimiokine
EP1558253A4 (fr) Modulateur piperidinyl-alpha-aminoamide de l'activite de recepteurs de la chimiokine
EP1558599A4 (fr) Modulateurs d'heteroarylpiperidine de l'activite des recepteurs de la chimiokine
HK1054032A1 (zh) N-酰脲異環烷-六氫吡啶作為化學增活受者活動的抑揚調節劑
MXPA03008109A (es) Moduladores de la actividad de receptores de quimiocinas.
EP1755603A4 (fr) Modulateurs de l'activité de récepteurs de chimiokines en tétrahydropyranylcyclopentylamide disubstitué en position 3,3
EP1718152A4 (fr) Modulateurs aminocyclopentyle pyridopyrazinone de l'activite des recepteurs de chimiokines
AU2002241724A1 (en) Diamines as modulators of chemokine receptor activity
AU2002326948A1 (en) Piperizinones as modulators of chemokine receptor activity
EP1606280A4 (fr) Modulateurs d'amide tetrahydropyranyl cyclopentyl heterocylique de l'activite des recepteurs des chimiokines
EP1656138A4 (fr) Derives de cycloalkyamine substitues en tant que modulateurs de l'activite du recepteur de la chimiokine
AU2003218028A8 (en) Cyclic derivatives as modulators of chemokine receptor activity
AU2002357692A1 (en) Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity
EP1742915A4 (fr) Tetrahydropyranyl cyclopentyl tetrahy-dropyridopyridine modulant l'activite des recepteurs de la chimiokine
EP1140086A4 (fr) N-ureidoalkyl-piperidines utilisees en tant que modulateurs de l'activite des recepteurs des chimiokines
AU5600100A (en) Cyclopentyl modulators of chemokine receptor activity
EP1171122A4 (fr) Pyrrolidines modulateurs de l'activite du recepteur de chimiokine
IL175958A0 (en) Novel tricyclic spiroderivatives as modulators of chemokine receptor activity
EP1173170A4 (fr) Modulateurs de pyrrolidine de l'activite du recepteur des chimiokines
IL159256A0 (en) Piperidine derivatives useful as modulators of chemokine receptor activity
EP1617841A4 (fr) Modulateurs amino cyclobutylamide de l'activite du recepteur de chimiokine
EP1622916A4 (fr) Modulateurs tetrahydroisoquinoline et tetrahydropyridopyridine cyclopentyles heterocycliques de l'activite des recepteurs de chimiokine
AU5473800A (en) Cyclopentyl modulators of chemokine receptor activity

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20150425