UA74811C2 - Спосіб одержання екстракту з cyclamen europaeum l. та екстракт, одержаний в такий спосіб, для лікування синуситу - Google Patents
Спосіб одержання екстракту з cyclamen europaeum l. та екстракт, одержаний в такий спосіб, для лікування синуситу Download PDFInfo
- Publication number
- UA74811C2 UA74811C2 UA2002075675A UA2002075675A UA74811C2 UA 74811 C2 UA74811 C2 UA 74811C2 UA 2002075675 A UA2002075675 A UA 2002075675A UA 2002075675 A UA2002075675 A UA 2002075675A UA 74811 C2 UA74811 C2 UA 74811C2
- Authority
- UA
- Ukraine
- Prior art keywords
- extract
- extraction
- isolated extract
- procedure
- alcohol
- Prior art date
Links
- 239000000284 extract Substances 0.000 title abstract description 35
- 238000000034 method Methods 0.000 title abstract description 17
- 201000009890 sinusitis Diseases 0.000 title abstract description 8
- 241000005119 Cyclamen purpurascens Species 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract description 26
- 238000000605 extraction Methods 0.000 abstract description 24
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 24
- 229940079593 drug Drugs 0.000 description 18
- 235000019441 ethanol Nutrition 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 241000196324 Embryophyta Species 0.000 description 10
- 239000007788 liquid Substances 0.000 description 9
- 238000004140 cleaning Methods 0.000 description 8
- 230000002949 hemolytic effect Effects 0.000 description 8
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 7
- 210000004400 mucous membrane Anatomy 0.000 description 7
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 7
- 229930182490 saponin Natural products 0.000 description 7
- 150000007949 saponins Chemical class 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 210000003928 nasal cavity Anatomy 0.000 description 5
- 239000002594 sorbent Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000003825 pressing Methods 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 241000612153 Cyclamen Species 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 229930186364 cyclamen Natural products 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 230000000622 irritating effect Effects 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 206010001076 Acute sinusitis Diseases 0.000 description 2
- 244000182067 Fraxinus ornus Species 0.000 description 2
- 235000002917 Fraxinus ornus Nutrition 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000001331 nose Anatomy 0.000 description 2
- 210000003695 paranasal sinus Anatomy 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000012261 resinous substance Substances 0.000 description 2
- 239000004576 sand Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 238000003809 water extraction Methods 0.000 description 2
- 101100317041 Caenorhabditis elegans vit-1 gene Proteins 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010022822 Intravascular haemolysis Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000208476 Primulaceae Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000012675 alcoholic extract Substances 0.000 description 1
- LKDRXBCSQODPBY-ZXXMMSQZSA-N alpha-D-fructopyranose Chemical compound OC[C@]1(O)OC[C@@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-ZXXMMSQZSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 229930188466 cyclamiretin Natural products 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- WQLVFSAGQJTQCK-UHFFFAOYSA-N diosgenin Natural products CC1C(C2(CCC3C4(C)CCC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 WQLVFSAGQJTQCK-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 210000001031 ethmoid bone Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000005242 forging Methods 0.000 description 1
- 239000003517 fume Substances 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000035929 gnawing Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 244000005706 microflora Species 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- NWMIYTWHUDFRPL-UHFFFAOYSA-N sapogenin Natural products COC(=O)C1(CO)C(O)CCC2(C)C1CCC3(C)C2CC=C4C5C(C)(O)C(C)CCC5(CCC34C)C(=O)O NWMIYTWHUDFRPL-UHFFFAOYSA-N 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000563 toxic property Toxicity 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200100165A ES2170726B1 (es) | 2001-01-25 | 2001-01-25 | Procedimiento para la obtencion de un extracto aislado de la planta cyclamen europaeum l. y su utilizacion como agente terapeutico. |
| PCT/IB2002/000181 WO2002058713A1 (en) | 2001-01-25 | 2002-01-17 | Method for obtaining an isolated extract of the plant cyclamen europaeum l. and its use as a therapeutic agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA74811C2 true UA74811C2 (uk) | 2006-02-15 |
Family
ID=8496498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2002075675A UA74811C2 (uk) | 2001-01-25 | 2002-01-17 | Спосіб одержання екстракту з cyclamen europaeum l. та екстракт, одержаний в такий спосіб, для лікування синуситу |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7105189B2 (el) |
| EP (1) | EP1353682B1 (el) |
| AT (1) | ATE355070T1 (el) |
| CA (1) | CA2433454C (el) |
| CY (1) | CY1106619T1 (el) |
| DE (1) | DE60218427T2 (el) |
| DK (1) | DK1353682T3 (el) |
| EA (1) | EA005009B1 (el) |
| ES (2) | ES2170726B1 (el) |
| PT (1) | PT1353682E (el) |
| UA (1) | UA74811C2 (el) |
| WO (1) | WO2002058713A1 (el) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2235655B1 (es) * | 2003-12-29 | 2006-03-16 | Hartington Business, S.L. | Extracto aislado de una planta de cyclamen europaeum l. como agente terapeutico. |
| KR101594045B1 (ko) * | 2009-07-20 | 2016-02-15 | 해팅턴 비즈니스 에스, 엘. | 식물 시클라멘 에우로파에움 엘.의 동결-건조 분리된 추출물을 수득하는 방법 및 치료제로서의 이의 용도 |
| US8583990B2 (en) | 2011-11-30 | 2013-11-12 | Spectra Logic Corporation | Error correction in a storage element array |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU554868A1 (ru) * | 1975-07-28 | 1977-04-25 | Институт Фармакохимии Им.И.Г.Кутателадзе Ан Грузинской Сср | Способ получени сапонинов |
| RU2040267C1 (ru) * | 1993-03-02 | 1995-07-25 | Василий Антонович Сеньков | Способ для лечения гайморита |
| RU2125457C1 (ru) * | 1996-07-10 | 1999-01-27 | Ольга Юрьевна Сергеева | Гомеопатическое лекарственное средство для лечения аллергозов "аллергин-arn" |
-
2001
- 2001-01-25 ES ES200100165A patent/ES2170726B1/es not_active Expired - Fee Related
-
2002
- 2002-01-17 EP EP02734880A patent/EP1353682B1/en not_active Expired - Lifetime
- 2002-01-17 PT PT02734880T patent/PT1353682E/pt unknown
- 2002-01-17 AT AT02734880T patent/ATE355070T1/de active
- 2002-01-17 UA UA2002075675A patent/UA74811C2/uk unknown
- 2002-01-17 CA CA2433454A patent/CA2433454C/en not_active Expired - Lifetime
- 2002-01-17 EA EA200200613A patent/EA005009B1/ru not_active IP Right Cessation
- 2002-01-17 WO PCT/IB2002/000181 patent/WO2002058713A1/en active IP Right Grant
- 2002-01-17 ES ES02734880T patent/ES2282419T3/es not_active Expired - Lifetime
- 2002-01-17 DK DK02734880T patent/DK1353682T3/da active
- 2002-01-17 US US10/470,369 patent/US7105189B2/en not_active Expired - Lifetime
- 2002-01-17 DE DE60218427T patent/DE60218427T2/de not_active Expired - Lifetime
-
2007
- 2007-05-23 CY CY20071100700T patent/CY1106619T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2433454C (en) | 2013-04-02 |
| ES2170726A1 (es) | 2002-08-01 |
| US7105189B2 (en) | 2006-09-12 |
| ES2282419T3 (es) | 2007-10-16 |
| EA200200613A1 (ru) | 2003-02-27 |
| EP1353682A1 (en) | 2003-10-22 |
| EA005009B1 (ru) | 2004-10-28 |
| CA2433454A1 (en) | 2002-08-01 |
| DE60218427D1 (de) | 2007-04-12 |
| US20040076697A1 (en) | 2004-04-22 |
| ES2170726B1 (es) | 2003-06-16 |
| PT1353682E (pt) | 2007-05-31 |
| EP1353682B1 (en) | 2007-02-28 |
| DK1353682T3 (da) | 2007-06-04 |
| ATE355070T1 (de) | 2006-03-15 |
| WO2002058713A1 (en) | 2002-08-01 |
| CY1106619T1 (el) | 2012-01-25 |
| WO2002058713A8 (en) | 2003-06-05 |
| DE60218427T2 (de) | 2007-12-20 |
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