UA74315C2 - Способ получения водорастворимого витаминного препарата - Google Patents
Способ получения водорастворимого витаминного препарата Download PDFInfo
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- UA74315C2 UA74315C2 UAA200506901A UAA200506901A UA74315C2 UA 74315 C2 UA74315 C2 UA 74315C2 UA A200506901 A UAA200506901 A UA A200506901A UA A200506901 A UAA200506901 A UA A200506901A UA 74315 C2 UA74315 C2 UA 74315C2
- Authority
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- Prior art keywords
- vitamin
- vitaminizing
- component
- retinol
- carotene
- Prior art date
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- 239000000203 mixture Substances 0.000 title abstract description 113
- 229940088594 vitamin Drugs 0.000 title abstract description 108
- 229930003231 vitamin Natural products 0.000 title abstract description 108
- 235000013343 vitamin Nutrition 0.000 title abstract description 108
- 239000011782 vitamin Substances 0.000 title abstract description 108
- 150000003722 vitamin derivatives Chemical class 0.000 title abstract description 92
- 238000004519 manufacturing process Methods 0.000 title abstract description 3
- 235000013734 beta-carotene Nutrition 0.000 abstract description 155
- 239000011648 beta-carotene Substances 0.000 abstract description 155
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 abstract description 148
- 239000012141 concentrate Substances 0.000 abstract description 138
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 abstract description 85
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 abstract description 85
- 229960002747 betacarotene Drugs 0.000 abstract description 85
- 239000002904 solvent Substances 0.000 abstract description 73
- 239000007864 aqueous solution Substances 0.000 abstract description 64
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 57
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract description 31
- 238000004090 dissolution Methods 0.000 abstract description 20
- 239000000725 suspension Substances 0.000 abstract description 10
- 239000003755 preservative agent Substances 0.000 abstract description 9
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract description 5
- 229930003268 Vitamin C Natural products 0.000 abstract description 5
- 235000019154 vitamin C Nutrition 0.000 abstract description 5
- 239000011718 vitamin C Substances 0.000 abstract description 5
- 238000002156 mixing Methods 0.000 abstract description 4
- 238000005063 solubilization Methods 0.000 abstract description 4
- 230000007928 solubilization Effects 0.000 abstract description 4
- JVKUCNQGESRUCL-UHFFFAOYSA-N 2-Hydroxyethyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCCO JVKUCNQGESRUCL-UHFFFAOYSA-N 0.000 abstract 2
- 229920001304 Solutol HS 15 Polymers 0.000 abstract 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 168
- 239000000543 intermediate Substances 0.000 description 133
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 111
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 101
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 67
- 235000019155 vitamin A Nutrition 0.000 description 60
- 239000011719 vitamin A Substances 0.000 description 60
- 239000011607 retinol Substances 0.000 description 57
- 229960003471 retinol Drugs 0.000 description 57
- 235000020944 retinol Nutrition 0.000 description 57
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 54
- 229940045997 vitamin a Drugs 0.000 description 54
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 52
- 229930003427 Vitamin E Natural products 0.000 description 50
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 50
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 50
- 229940046009 vitamin E Drugs 0.000 description 50
- 235000019165 vitamin E Nutrition 0.000 description 50
- 239000011709 vitamin E Substances 0.000 description 50
- 229940042585 tocopherol acetate Drugs 0.000 description 49
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 48
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 48
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 44
- 238000000034 method Methods 0.000 description 44
- 235000005282 vitamin D3 Nutrition 0.000 description 44
- 239000011647 vitamin D3 Substances 0.000 description 44
- 229940021056 vitamin d3 Drugs 0.000 description 44
- 229940087168 alpha tocopherol Drugs 0.000 description 34
- 238000002360 preparation method Methods 0.000 description 34
- 229960000984 tocofersolan Drugs 0.000 description 34
- 235000004835 α-tocopherol Nutrition 0.000 description 34
- 239000002076 α-tocopherol Substances 0.000 description 34
- 239000000047 product Substances 0.000 description 29
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 27
- SFRPDSKECHTFQA-ONOWFSFQSA-N [(2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] propanoate Chemical compound CCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SFRPDSKECHTFQA-ONOWFSFQSA-N 0.000 description 26
- 229940108325 retinyl palmitate Drugs 0.000 description 26
- 235000019172 retinyl palmitate Nutrition 0.000 description 26
- 239000011769 retinyl palmitate Substances 0.000 description 26
- 238000003756 stirring Methods 0.000 description 26
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 25
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 description 25
- 235000019175 phylloquinone Nutrition 0.000 description 25
- 239000011772 phylloquinone Substances 0.000 description 25
- 229960001898 phytomenadione Drugs 0.000 description 25
- 239000000243 solution Substances 0.000 description 16
- 235000010199 sorbic acid Nutrition 0.000 description 14
- 239000004334 sorbic acid Substances 0.000 description 14
- 239000008389 polyethoxylated castor oil Substances 0.000 description 12
- 229940075582 sorbic acid Drugs 0.000 description 12
- 229940079593 drug Drugs 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 11
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 8
- 239000004094 surface-active agent Substances 0.000 description 8
- ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 description 7
- 235000010323 ascorbic acid Nutrition 0.000 description 6
- 229960005070 ascorbic acid Drugs 0.000 description 6
- 239000011668 ascorbic acid Substances 0.000 description 6
- 125000001409 beta-carotene group Chemical group 0.000 description 6
- 235000013305 food Nutrition 0.000 description 5
- 239000000693 micelle Substances 0.000 description 5
- 239000002736 nonionic surfactant Substances 0.000 description 5
- 230000002335 preservative effect Effects 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000004530 micro-emulsion Substances 0.000 description 4
- 241001211977 Bida Species 0.000 description 3
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000004945 emulsification Methods 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 238000005538 encapsulation Methods 0.000 description 3
- 229960002061 ergocalciferol Drugs 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 235000013373 food additive Nutrition 0.000 description 3
- 239000002778 food additive Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 230000002035 prolonged effect Effects 0.000 description 3
- 235000019156 vitamin B Nutrition 0.000 description 3
- 239000011720 vitamin B Substances 0.000 description 3
- 235000001892 vitamin D2 Nutrition 0.000 description 3
- 239000011653 vitamin D2 Substances 0.000 description 3
- IELOKBJPULMYRW-NJQVLOCASA-N D-alpha-Tocopheryl Acid Succinate Chemical compound OC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C IELOKBJPULMYRW-NJQVLOCASA-N 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- -1 etc. 1) Chemical compound 0.000 description 2
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- JRMXMUCILWKNNW-UHFFFAOYSA-N 1-butoxy-2-methylbenzene Chemical compound CCCCOC1=CC=CC=C1C JRMXMUCILWKNNW-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- XINCECQTMHSORG-UHFFFAOYSA-N Isoamyl isovalerate Chemical compound CC(C)CCOC(=O)CC(C)C XINCECQTMHSORG-UHFFFAOYSA-N 0.000 description 1
- MTUBBMSQXXJFQP-UHFFFAOYSA-N OC(CCCCCCCCCCCCCCCCC(=O)OCC(O)CO)(O)O Chemical compound OC(CCCCCCCCCCCCCCCCC(=O)OCC(O)CO)(O)O MTUBBMSQXXJFQP-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- PLXUFYVBQPIQQH-UHFFFAOYSA-N butoxymethoxybenzene Chemical compound CCCCOCOC1=CC=CC=C1 PLXUFYVBQPIQQH-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 229940099418 d- alpha-tocopherol succinate Drugs 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000005454 flavour additive Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- QIWDGSYHBCMXSI-UHFFFAOYSA-J tetrasodium;(2-methyl-4-phosphonatooxynaphthalen-1-yl) phosphate;hexahydrate Chemical compound O.O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].C1=CC=CC2=C(OP([O-])([O-])=O)C(C)=CC(OP([O-])([O-])=O)=C21 QIWDGSYHBCMXSI-UHFFFAOYSA-J 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 229940019439 vitamin a concentrates Drugs 0.000 description 1
- 235000019195 vitamin supplement Nutrition 0.000 description 1
- 150000003772 α-tocopherols Chemical class 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Способ получения водорастворимого витаминного препарата включает в себя солюбилизацию витаминизирующей составляющей в предварительно нагретом солюбилизаторе с последующим введением полученной суспензии в водный раствор. Выбирают заданную витаминизирующую составляющую из группы жирорастворимых витаминов А, D2, D3, E, K1, бета-каротин (провитамин А). Затем путем солюбилизации выбранной витаминизирующей составляющей в солюбилизаторе получают суспензию в виде нанодисперсной композиции этой витаминизирующей составляющей, после чего полученную нанодисперсную композицию вводят в воду для растворения и получения промежуточного концентрата этой витаминизирующей составляющей для последующего смешивания с водным раствором, который содержит консерванты и/или водорастворимый витамин С, либо с промежуточным концентратом другой витаминизирующей составляющей, либо несколькими промежуточными концентратами других витаминизирующих составляющих в весовом соотношении 0,02-0,5 : 0,02-0,5 для последующего растворения смеси промежуточных концентратов нескольких витаминизирующих составляющих в водном растворе с получением водорастворимого витаминного препарата. В качестве солюбилизатора используют смесь Солютола HS 15 или его аналогов, Кремофора EL или его аналогов и Кремофора RH-40 или его аналогов. При этом смесь кремофоров выбирают в весовом соотношении Кремофора RH-40 и Кремофора EL 2,0-2,5 : 0,5-1,0, а смесь кремофоров с Солютолом HS 15 используют в весовом соотношении 3,0:1,0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAA200506901A UA74315C2 (ru) | 2005-07-13 | 2005-07-13 | Способ получения водорастворимого витаминного препарата |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAA200506901A UA74315C2 (ru) | 2005-07-13 | 2005-07-13 | Способ получения водорастворимого витаминного препарата |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA74315C2 true UA74315C2 (ru) | 2005-11-15 |
Family
ID=74506289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200506901A UA74315C2 (ru) | 2005-07-13 | 2005-07-13 | Способ получения водорастворимого витаминного препарата |
Country Status (1)
| Country | Link |
|---|---|
| UA (1) | UA74315C2 (ru) |
-
2005
- 2005-07-13 UA UAA200506901A patent/UA74315C2/ru unknown
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