UA73933C2 - Stable irreversible hydrophilic gel and method for its production - Google Patents
Stable irreversible hydrophilic gel and method for its production Download PDFInfo
- Publication number
- UA73933C2 UA73933C2 UA2001096235A UA2001096235A UA73933C2 UA 73933 C2 UA73933 C2 UA 73933C2 UA 2001096235 A UA2001096235 A UA 2001096235A UA 2001096235 A UA2001096235 A UA 2001096235A UA 73933 C2 UA73933 C2 UA 73933C2
- Authority
- UA
- Ukraine
- Prior art keywords
- gel
- hydrophilic
- polyaldehyde
- polyamine
- polyalcohol
- Prior art date
Links
- 230000002427 irreversible effect Effects 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 title claims description 4
- 238000004519 manufacturing process Methods 0.000 title description 4
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- 229920002647 polyamide Polymers 0.000 claims abstract description 22
- 229920001744 Polyaldehyde Polymers 0.000 claims description 24
- 229920000768 polyamine Polymers 0.000 claims description 24
- 229920002554 vinyl polymer Polymers 0.000 claims description 23
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- 150000005846 sugar alcohols Polymers 0.000 claims description 20
- 150000001299 aldehydes Chemical class 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 claims description 16
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- 239000007864 aqueous solution Substances 0.000 claims description 11
- 229920001519 homopolymer Polymers 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
- 239000000178 monomer Substances 0.000 claims description 8
- 229920006027 ternary co-polymer Polymers 0.000 claims description 8
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 claims description 6
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- 238000002156 mixing Methods 0.000 claims description 5
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- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 4
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- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 3
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- 238000012876 topography Methods 0.000 claims 1
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- LCPVQAHEFVXVKT-UHFFFAOYSA-N 2-(2,4-difluorophenoxy)pyridin-3-amine Chemical compound NC1=CC=CN=C1OC1=CC=C(F)C=C1F LCPVQAHEFVXVKT-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 1
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- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US09/248,591 US6121375A (en) | 1999-02-11 | 1999-02-11 | Gels formed by the interaction of poly(aldehyde) with various substances |
| PCT/US2000/000763 WO2000047149A1 (en) | 1999-02-11 | 2000-01-12 | Gels formed by the interaction of poly(aldehyde) with various substances |
Publications (1)
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| UA73933C2 true UA73933C2 (en) | 2005-10-17 |
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| UA2001096235A UA73933C2 (en) | 1999-02-11 | 2000-12-01 | Stable irreversible hydrophilic gel and method for its production |
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| US7309498B2 (en) * | 2001-10-10 | 2007-12-18 | Belenkaya Bronislava G | Biodegradable absorbents and methods of preparation |
| US7585516B2 (en) * | 2001-11-12 | 2009-09-08 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices |
| US7621903B2 (en) * | 2002-11-12 | 2009-11-24 | Delegge Rebecca | Anchor for implanted devices and method of using same |
| EP1594421A4 (en) * | 2003-01-17 | 2006-02-08 | Psinergi Corp | ARTIFICIAL NUCLEUS PULPOSUS AND METHOD AT ITS INJECTION |
| US20050112151A1 (en) * | 2003-11-20 | 2005-05-26 | Horng Liou L. | Skin adherent hydrogels |
| US20050191270A1 (en) * | 2004-02-27 | 2005-09-01 | Hydromer, Inc. | Anti-infectious hydrogel compositions |
| CN101035572B (zh) | 2004-10-07 | 2010-12-08 | 纳幕尔杜邦公司 | 用于医疗用途的多糖基聚合物组织粘合剂 |
| US20060173470A1 (en) * | 2005-01-31 | 2006-08-03 | Oray B N | Surgical fastener buttress material |
| DE102005014293A1 (de) * | 2005-03-24 | 2006-09-28 | Basf Ag | Verdickungsmittel auf Basis von Amingruppen enthaltenden Polymeren |
| EP2099845B1 (en) * | 2006-11-27 | 2020-12-23 | Actamax Surgical Materials LLC | Multi-functional polyalkylene oxides, hydrogels and tissue adhesives |
| US20090112141A1 (en) * | 2007-10-31 | 2009-04-30 | Derr Michael J | Method and apparatus for providing a medical dressing |
| WO2009064963A2 (en) * | 2007-11-14 | 2009-05-22 | E. I. Du Pont De Nemours And Company | Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use |
| CL2008000156A1 (es) | 2008-01-18 | 2008-08-01 | Igloo Zone Chile S A | Gel estable hidrofilo en base a un polimero para aplicacion topica porque comprende quitosano disuelto en un solvente; proceso para obtener el gel para uso topico antes mencionado; uso del gel. |
| CN101224310B (zh) * | 2008-01-18 | 2010-11-03 | 中国人民解放军第四军医大学 | 一种载有抗菌药物纳米微粒的医用创伤敷料 |
| US20100015231A1 (en) * | 2008-07-17 | 2010-01-21 | E.I. Du Pont De Nemours And Company | Low swell, long-lived hydrogel sealant |
| US8551136B2 (en) | 2008-07-17 | 2013-10-08 | Actamax Surgical Materials, Llc | High swell, long-lived hydrogel sealant |
| US8466327B2 (en) | 2008-11-19 | 2013-06-18 | Actamax Surgical Materials, Llc | Aldehyde-functionalized polyethers and method of making same |
| EP2349357B1 (en) * | 2008-11-19 | 2012-10-03 | Actamax Surgical Materials LLC | Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether |
| US20100160960A1 (en) * | 2008-12-19 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Hydrogel tissue adhesive having increased degradation time |
| JP2012523289A (ja) | 2009-04-09 | 2012-10-04 | アクタマックス サージカル マテリアルズ リミテッド ライアビリティ カンパニー | 減少した分解時間を有するハイドロゲル組織接着剤 |
| US8796242B2 (en) | 2009-07-02 | 2014-08-05 | Actamax Surgical Materials, Llc | Hydrogel tissue adhesive for medical use |
| WO2011002956A1 (en) | 2009-07-02 | 2011-01-06 | E. I. Du Pont De Nemours And Company | Aldehyde-functionalized polysaccharides |
| US8580950B2 (en) | 2009-07-02 | 2013-11-12 | Actamax Surgical Materials, Llc | Aldehyde-functionalized polysaccharides |
| WO2011002888A2 (en) | 2009-07-02 | 2011-01-06 | E. I. Du Pont De Nemours And Company | Hydrogel tissue adhesive for medical use |
| US8859705B2 (en) | 2012-11-19 | 2014-10-14 | Actamax Surgical Materials Llc | Hydrogel tissue adhesive having decreased gelation time and decreased degradation time |
| CN104277111B (zh) * | 2013-07-08 | 2020-06-12 | 百瑞全球有限公司 | 用于制备固定化蛋白质、多肽或寡肽的复合载体、制法及用途 |
| EP3027659B1 (en) | 2013-07-29 | 2020-12-09 | Actamax Surgical Materials LLC | Low swell tissue adhesive and sealant formulations |
| CN105982830A (zh) * | 2015-01-29 | 2016-10-05 | 于杰 | 功能面膜 |
| CN104839198B (zh) * | 2015-03-20 | 2017-05-10 | 山西省农业科学院植物保护研究所 | 一种用于防治桃小食心虫的温敏型农药缓释剂 |
| RU2613112C2 (ru) * | 2015-04-20 | 2017-03-15 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Башкирский государственный университет" | Раневое покрытие на основе хитозана (варианты) |
| CN108187119B (zh) * | 2018-01-16 | 2021-02-12 | 浙江理工大学 | 一种基于纤维素的抗菌止血材料及其制备方法 |
| CN108586831A (zh) * | 2018-04-09 | 2018-09-28 | 长沙秋点兵信息科技有限公司 | 一种高强度纳米复合水凝胶及其制备方法 |
| CN110982022B (zh) * | 2019-12-20 | 2021-07-09 | 中国药科大学 | 一种磁性辣椒碱分子印迹聚合物及其制备方法 |
| KR102409461B1 (ko) * | 2020-04-08 | 2022-06-15 | 울산과학기술원 | 조직 접착용 키토산 하이드로젤 |
| CN113512206A (zh) * | 2021-04-21 | 2021-10-19 | 长沙理工大学 | 一种高吸水性壳聚糖凝胶的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL120957C (id) | 1958-10-04 | |||
| FR1394824A (fr) | 1964-02-14 | 1965-04-09 | Degussa | Procédé pour améliorer et rendre étanches les sols, les formations de sols, les ouvrages d'art, les éléments de construction et les matériaux de construction |
| US4254008A (en) * | 1979-09-13 | 1981-03-03 | Diamond Shamrock Corporation | Crosslinked acrylamide polymer compositions and shaped articles therefrom |
| US4230772A (en) * | 1979-04-02 | 1980-10-28 | Rohm And Haas Company | Amine crosslinked methacrolein copolymers for coatings, binders and adhesives |
| CA1267747A (en) * | 1984-06-25 | 1990-04-10 | Burton Burns Sandiford | Gel and process for preventing carbon dioxide break through |
| DE3903672C1 (id) * | 1989-02-08 | 1990-02-01 | Lohmann Gmbh & Co Kg | |
| US5156601A (en) * | 1991-03-20 | 1992-10-20 | Hydromer, Inc. | Tacky, hydrophilic gel dressings and products therefrom |
| US5206322A (en) * | 1992-05-26 | 1993-04-27 | Isp Investments Inc. | Crosslinkable, functional polymers of vinylpyrrolidone and aminoalkyl acrylamides |
| US5328939A (en) | 1993-04-27 | 1994-07-12 | Alliedsignal Inc. | Rigid materials having high surface area and low density |
| US5420197A (en) * | 1994-01-13 | 1995-05-30 | Hydromer, Inc. | Gels formed by the interaction of polyvinylpyrrolidone with chitosan derivatives |
-
1999
- 1999-02-11 US US09/248,591 patent/US6121375A/en not_active Expired - Lifetime
-
2000
- 2000-01-12 AT AT00904312T patent/ATE446069T1/de not_active IP Right Cessation
- 2000-01-12 KR KR1020017010181A patent/KR20010102071A/ko not_active Application Discontinuation
- 2000-01-12 JP JP2000598103A patent/JP2002536118A/ja not_active Abandoned
- 2000-01-12 SK SK1136-2001A patent/SK11362001A3/sk unknown
- 2000-01-12 AU AU26091/00A patent/AU761930B2/en not_active Ceased
- 2000-01-12 WO PCT/US2000/000763 patent/WO2000047149A1/en active Application Filing
- 2000-01-12 EP EP00904312A patent/EP1164991B1/en not_active Expired - Lifetime
- 2000-01-12 RU RU2001124859/15A patent/RU2225185C2/ru not_active IP Right Cessation
- 2000-01-12 BR BR0008129-9A patent/BR0008129A/pt not_active Application Discontinuation
- 2000-01-12 IL IL14477500A patent/IL144775A0/xx active IP Right Grant
- 2000-01-12 MX MXPA01008099A patent/MXPA01008099A/es not_active IP Right Cessation
- 2000-01-12 PL PL00349812A patent/PL349812A1/xx not_active IP Right Cessation
- 2000-01-12 TR TR2001/02333T patent/TR200102333T2/xx unknown
- 2000-01-12 ID IDW00200101840A patent/ID30281A/id unknown
- 2000-01-12 HU HU0105366A patent/HUP0105366A2/hu unknown
- 2000-01-12 CZ CZ20013008A patent/CZ20013008A3/cs unknown
- 2000-01-12 DE DE60043185T patent/DE60043185D1/de not_active Expired - Fee Related
- 2000-01-12 NZ NZ513492A patent/NZ513492A/xx unknown
- 2000-01-12 CA CA002359872A patent/CA2359872C/en not_active Expired - Fee Related
- 2000-01-12 CN CN00803712A patent/CN1339955A/zh active Pending
- 2000-07-25 US US09/625,464 patent/US6365664B1/en not_active Expired - Lifetime
- 2000-12-01 UA UA2001096235A patent/UA73933C2/uk unknown
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2001
- 2001-08-07 IL IL144775A patent/IL144775A/en not_active IP Right Cessation
- 2001-08-09 IS IS6045A patent/IS6045A/is unknown
- 2001-08-10 NO NO20013913A patent/NO322419B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US6121375A (en) | 2000-09-19 |
| CA2359872A1 (en) | 2000-08-17 |
| RU2225185C2 (ru) | 2004-03-10 |
| CZ20013008A3 (cs) | 2002-02-13 |
| NZ513492A (en) | 2002-11-26 |
| CN1339955A (zh) | 2002-03-13 |
| IL144775A0 (en) | 2002-06-30 |
| NO20013913D0 (no) | 2001-08-10 |
| EP1164991B1 (en) | 2009-10-21 |
| EP1164991A1 (en) | 2002-01-02 |
| HUP0105366A2 (hu) | 2002-04-29 |
| ATE446069T1 (de) | 2009-11-15 |
| WO2000047149A1 (en) | 2000-08-17 |
| AU761930B2 (en) | 2003-06-12 |
| ID30281A (id) | 2001-11-15 |
| DE60043185D1 (de) | 2009-12-03 |
| JP2002536118A (ja) | 2002-10-29 |
| BR0008129A (pt) | 2002-02-05 |
| NO20013913L (no) | 2001-10-10 |
| KR20010102071A (ko) | 2001-11-15 |
| IS6045A (is) | 2001-08-09 |
| MXPA01008099A (es) | 2002-04-24 |
| US6365664B1 (en) | 2002-04-02 |
| TR200102333T2 (tr) | 2002-05-21 |
| CA2359872C (en) | 2008-10-07 |
| SK11362001A3 (sk) | 2002-04-04 |
| EP1164991A4 (en) | 2006-07-19 |
| NO322419B1 (no) | 2006-10-02 |
| PL349812A1 (en) | 2002-09-09 |
| AU2609100A (en) | 2000-08-29 |
| IL144775A (en) | 2006-10-31 |
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