UA49031C2 - Поліциклічні похідні фталазину та лікарський препарат - Google Patents
Поліциклічні похідні фталазину та лікарський препаратInfo
- Publication number
- UA49031C2 UA49031C2 UA99031312A UA99031312A UA49031C2 UA 49031 C2 UA49031 C2 UA 49031C2 UA 99031312 A UA99031312 A UA 99031312A UA 99031312 A UA99031312 A UA 99031312A UA 49031 C2 UA49031 C2 UA 49031C2
- Authority
- UA
- Ukraine
- Prior art keywords
- formula
- phthalazins
- alkyl
- phtalazin
- medication
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Paper (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Описані нові поліциклічні похідні фталазину, зокрема 2-заміщені мадурафталазини (10,12,15,16-тетрагідрокси-8-метокси-11-метил-1,9,14-триоксо-1,2,6,7,9,14-гексагідронафтацено-[1,2-g])(-фталазинум) формули (І) і їх солі. Описані сполуки ефективні проти грампозитивних штамів бактерій, зокрема проти полірезистентних Staphylococci (MRSA) і проти глікопептидрезистентних штамів, наприклад нанкоміцин-резистентним ентерококам, і, таким чином, можуть бути використані для отримання ефективних антибактерійних лікарських засобів. У формулі (І) R1 означає карбоксіалкіл або карбоксіарил, а R2 і R3 незалежно один від одного означають водень, ацил (наприклад СО-алкіл, СОО-алкіл), за умови, що група R1 відрізняється від можливо заміщеної карбоксифенільної групи, якщо R3 являє собою C1-8-алканоїл. Винахід відноситься також до солей, амідів і ефірів сполук формули (І).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19633221 | 1996-08-17 | ||
PCT/EP1997/003632 WO1998007706A1 (de) | 1996-08-17 | 1997-07-09 | Neue polycyclische phthalazinderivate und ihre verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
UA49031C2 true UA49031C2 (uk) | 2002-09-16 |
Family
ID=7802911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA99031312A UA49031C2 (uk) | 1996-08-17 | 1997-07-09 | Поліциклічні похідні фталазину та лікарський препарат |
Country Status (26)
Country | Link |
---|---|
US (1) | US6124290A (uk) |
EP (1) | EP0925284B1 (uk) |
JP (1) | JP2000516236A (uk) |
KR (1) | KR20000068099A (uk) |
CN (1) | CN1099417C (uk) |
AT (1) | ATE202773T1 (uk) |
AU (1) | AU728361B2 (uk) |
BR (1) | BR9714633A (uk) |
CA (1) | CA2261756A1 (uk) |
CZ (1) | CZ53299A3 (uk) |
DE (2) | DE19719522A1 (uk) |
DK (1) | DK0925284T3 (uk) |
ES (1) | ES2160966T3 (uk) |
GR (1) | GR3036531T3 (uk) |
HK (1) | HK1019750A1 (uk) |
HU (1) | HUP0001832A3 (uk) |
IL (1) | IL127752A (uk) |
NO (1) | NO312029B1 (uk) |
NZ (1) | NZ334538A (uk) |
PL (1) | PL331610A1 (uk) |
PT (1) | PT925284E (uk) |
RU (1) | RU2181361C2 (uk) |
SI (1) | SI0925284T1 (uk) |
SK (1) | SK19299A3 (uk) |
UA (1) | UA49031C2 (uk) |
WO (1) | WO1998007706A1 (uk) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19917505A1 (de) * | 1999-04-17 | 2000-10-19 | Dresden Arzneimittel | Verwendung von Maduraphthalazin-Derivaten als Inhibitoren proinflammatorischer Cytokine |
ATE421956T1 (de) * | 2006-09-19 | 2009-02-15 | Leibniz Inst Naturstoff Forsch | Antibiotikum maduraphthalazin-salze mit verzögerter wirkstofffreigabe des wirkstoffs und deren verwendung |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS606194A (ja) * | 1983-06-23 | 1985-01-12 | Meiji Seika Kaisha Ltd | 新規抗生物質sf−2288及びその製造法 |
US4859598A (en) * | 1984-03-26 | 1989-08-22 | American Cyanamid Company | Antibiotic LL-D42067β |
EP0156193B1 (en) * | 1984-03-26 | 1990-12-27 | American Cyanamid Company | Compounds and compositions for treating protozoal infections with a novel antibiotic |
-
1997
- 1997-05-09 DE DE19719522A patent/DE19719522A1/de not_active Withdrawn
- 1997-07-09 EP EP97931802A patent/EP0925284B1/de not_active Expired - Lifetime
- 1997-07-09 AT AT97931802T patent/ATE202773T1/de not_active IP Right Cessation
- 1997-07-09 CZ CZ99532A patent/CZ53299A3/cs unknown
- 1997-07-09 PL PL97331610A patent/PL331610A1/xx unknown
- 1997-07-09 KR KR1019997001112A patent/KR20000068099A/ko not_active Application Discontinuation
- 1997-07-09 DK DK97931802T patent/DK0925284T3/da active
- 1997-07-09 WO PCT/EP1997/003632 patent/WO1998007706A1/de not_active Application Discontinuation
- 1997-07-09 UA UA99031312A patent/UA49031C2/uk unknown
- 1997-07-09 IL IL12775297A patent/IL127752A/xx not_active IP Right Cessation
- 1997-07-09 SI SI9730131T patent/SI0925284T1/xx unknown
- 1997-07-09 SK SK192-99A patent/SK19299A3/sk unknown
- 1997-07-09 PT PT97931802T patent/PT925284E/pt unknown
- 1997-07-09 JP JP10510304A patent/JP2000516236A/ja active Pending
- 1997-07-09 HU HU00018320001832A patent/HUP0001832A3/hu unknown
- 1997-07-09 CA CA002261756A patent/CA2261756A1/en not_active Abandoned
- 1997-07-09 RU RU99105203/04A patent/RU2181361C2/ru not_active IP Right Cessation
- 1997-07-09 NZ NZ334538A patent/NZ334538A/xx unknown
- 1997-07-09 CN CN97197367A patent/CN1099417C/zh not_active Expired - Fee Related
- 1997-07-09 ES ES97931802T patent/ES2160966T3/es not_active Expired - Lifetime
- 1997-07-09 US US09/242,295 patent/US6124290A/en not_active Expired - Fee Related
- 1997-07-09 BR BR9714633-1A patent/BR9714633A/pt not_active IP Right Cessation
- 1997-07-09 AU AU35429/97A patent/AU728361B2/en not_active Ceased
- 1997-07-09 DE DE59703968T patent/DE59703968D1/de not_active Expired - Fee Related
-
1999
- 1999-02-02 NO NO19990483A patent/NO312029B1/no not_active IP Right Cessation
- 1999-11-03 HK HK99105005A patent/HK1019750A1/xx not_active IP Right Cessation
-
2001
- 2001-09-05 GR GR20010401391T patent/GR3036531T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1228085A (zh) | 1999-09-08 |
AU728361B2 (en) | 2001-01-11 |
DK0925284T3 (da) | 2001-09-24 |
US6124290A (en) | 2000-09-26 |
NZ334538A (en) | 1999-08-30 |
DE19719522A1 (de) | 1998-02-19 |
SK19299A3 (en) | 1999-08-06 |
DE59703968D1 (de) | 2001-08-09 |
AU3542997A (en) | 1998-03-06 |
CA2261756A1 (en) | 1998-02-26 |
GR3036531T3 (en) | 2001-12-31 |
EP0925284A1 (de) | 1999-06-30 |
EP0925284B1 (de) | 2001-07-04 |
ES2160966T3 (es) | 2001-11-16 |
IL127752A (en) | 2003-10-31 |
NO312029B1 (no) | 2002-03-04 |
NO990483D0 (no) | 1999-02-02 |
CN1099417C (zh) | 2003-01-22 |
IL127752A0 (en) | 1999-10-28 |
ATE202773T1 (de) | 2001-07-15 |
BR9714633A (pt) | 2000-10-03 |
CZ53299A3 (cs) | 1999-05-12 |
JP2000516236A (ja) | 2000-12-05 |
NO990483L (no) | 1999-02-02 |
RU2181361C2 (ru) | 2002-04-20 |
HUP0001832A2 (hu) | 2001-05-28 |
HUP0001832A3 (en) | 2001-07-30 |
PL331610A1 (en) | 1999-08-02 |
HK1019750A1 (en) | 2000-02-25 |
WO1998007706A1 (de) | 1998-02-26 |
PT925284E (pt) | 2001-10-30 |
SI0925284T1 (en) | 2001-10-31 |
KR20000068099A (ko) | 2000-11-25 |
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