UA45810A - LOCAL MEDICINE "TIM" FOR LOCAL APPLICATION - Google Patents

Abstract

The healing remedy for topical application contains the anti-inflammatory agent, the pig fat, the sunflower-seed oil, corn and walnut oils, the celandine oil, and the hydrochloric anhydrite. The melted butter is employed in the formulation as the anti-inflammatory agent.

Description

Description of the invention

The claimed invention relates to medicine, in particular to therapeutic agents, and can be used in 2 dermatology, surgery, gynecology, otolaryngology, cosmetology for the local treatment of skin diseases, purulent, cut, stab, burn and other wounds.

A well-known medicinal product for local use (1. GolovkinV.A. et al. Farmatsiya, Mo2, 1988

P.31-33), which contains anti-inflammatory substance, castor oil, mebetizol, emulsifier and distilled water.

The known agent has antimicrobial activity against fungi of Avzregayi5 pideg, Tgisporpuyup 70 tepiadhorpuyez, Misgozrott Iapozit, Sapaida aiIrisapz. This ointment can be used for the treatment of mycosis, in which, as a rule, only the epithelial layer of the epidermis is affected. In the case of using a well-known ointment for the treatment of lesions of the skin itself, complicated by bacterial lesions and inflammatory processes (wounds, cracks and other lesions), allergic and sensitizing manifestations occur. In addition, the consistency of the known drug makes it difficult to apply it to the affected areas of the skin and, as a result, impairs the penetration of the active substance 12 to the affected areas, which reduces the effectiveness of the drug's therapeutic effect.

It is also known as a medicinal product for local use |2. New medicines.

Zkspress-information, 1984, Mo3. - P.21-22), including a substance obtained from cotton roots, castor oil, sorbic acid, emulsifier and purified water.

The therapeutic effect of the well-known remedy consists in an antiviral effect against dermatoid strains of the herpes virus and is used for shingles, simple vesicular lichen and psoriasis. In this regard, the qualitative and quantitative composition of the components does not allow to provide a wider spectrum of therapeutic action, which would allow the effective use of this agent for the complex treatment of dermatoses of various etiologies while simultaneously ensuring the norms of microbial insemination during the use of the drug.

The closest in terms of the technical essence of the claimed product is a medicinal product for local use |Z. Register of medicinal products of Russia. M. SP "Infarmkhim", 1993, p.518), which includes "anti-inflammatory active substance, namely chloramphenicol, methyluracil - 4.0, polyethylene oxide-400 - 86.2, polyethylene oxide-1500 - 19.05.

The disadvantage of the known remedy is that it has a relatively low efficiency due to the fact that it does not provide a reliable spectrum of antimicrobial activity and often causes a number of undesirable side effects - allergic reactions after use, thereby complicating the treatment process with very moderate "- anti-inflammatory activity, with a narrow range of diseases.

The basis of the invention is the task of creating a therapeutic agent for local use by changing its composition using natural components (components), multidirectional therapeutic action, which makes it possible to increase the effectiveness of the therapeutic effect in various diseases of the skin and mucous membrane. M

The essence of the invention is that the medicinal agent, which contains an anti-inflammatory substance, additionally contains the visceral fat of pork, sunflower, corn and nut oils, celandine oil and hydrogen chloride anhydrite, and as an anti-inflammatory agent, ghee is used in such a mass ratio. 90: "

Pork visceral fat 30.0-30.5 tons Sunflower oil 10.0-10.5

From" Corn oil 10.0-10.5

Peanut oil 10.0-10.5

Celandine oil 5.0-10.5

Hydrochloric anhydrite 5.0-10.5 o Butter, melted butter, the rest 1

What is new in the claimed invention is that the medicinal product contains pork fat, sunflower, corn and nut oils, celandine oil and hydrochloric anhydrite, and as an anti-inflammatory agent - l 20, melted butter is used in this mass ratio. 96: "2 Visceral pork fat 30.0-30.5

Sunflower oil 10.0-10.5

Corn oil 10.0-10.5

Walnut oil 10.0-10.5 » Celandine oil 5.0-10.5

Hydrochloric anhydrite 5.0-10.5

Clarified butter, remaining 60 Treatment of skin diseases, diseases of the mucous membrane and soft tissues, which is carried out with existing means, such as antibiotics, or other synthetic drugs, is not always effective due to the fact that these means contain drugs of narrowly targeted therapeutic effect. In addition, a significant number of known anti-inflammatory, antibacterial, antiviral agents have side effects, suppress the immunoreactive properties of the macroorganism to most antibiotics. 65 When they are regularly prescribed, the resistance of microorganisms and a decrease in the effectiveness of therapy are noted. In this regard, for the effective treatment of skin and mucous membrane lesions, there is a need to create -D-

a tool that gives a therapeutic effect without side effects. The components of the proposed product are natural, they provide nutrition to tissue cells (skin, mucosa), improve and stimulate metabolic processes, thus increasing the resistance of the body and tissue cells. The claimed agent has anti-inflammatory, antiviral, antimicrobial and anti-allergic properties. The products of animal origin included in it - visceral fat, butter - contain vitamins A, D, E, B b. Vitamin A - this compound includes in its structure a trimethylcyclohexane ring connected to a tetraene linked chain of the isoprenoid series. Vitamin A plays an important role in metabolic processes occurring in the skin.

Vitamin A participates in oxidation-reduction reactions, eliminates dryness of the skin, giving it elasticity. 7/0 Its main function is participation in epithelization of tissues, the integrity of the epithelium, contributes not only to the normal function of the epidermis and its derivatives, but also to the connective tissues of the skin, causes thickening of collagen and elastic fibers. In addition, vitamin B; - nicotinic acid, contained in butter and visceral fat, participates in the process of acetylation, oxidation and synthesis of many substances in the body, including acetylcholine, corticosteroids, etc.

The presence of vitamins, microelements and other biologically active substances has a general beneficial effect on the skin and the body in general by stimulating the processes of growth and regeneration of the skin, the transfer of various substances in the body, and the normalization of biochemical and physiological processes.

Butter (cow's) has the property of being quickly absorbed by tissues, saturating them with vitamins -- A, D, E,

In

Other components - vegetable oils, which include corn, sunflower, nut and celandine oil, include vitamins and microelements, harmonize the biochemical composition of tissue cells, increasing their resistance, and suppress disease-causing organisms. Vitamin E contained in vegetable oils, being a combination of a heterocyclic series of chromone derivatives, has an antioxidant effect, stimulates the processes of nutrition and growth, skin regeneration, normalizes metabolic processes.

Vegetable oils - corn and nut, in addition, also contain vitamin E - irreplaceable polyunsaturated fatty acids, which are used in the treatment of long non-healing ulcers and wounds, which leads to the acceleration of tissue healing.

The declared medicinal product, which includes natural animal fats - butter and pork fat, vegetable oils - sunflower, corn, walnut and celandine with the addition of

From Chloric anhydrite in the ratio of components: pork fat - 30.0-30.5, sunflower oil - 10.0-10.5, corn oil - 10.0-10.5, nut oil -410.0-10, 5, celandine oil - 5.0-10.5, - hydrogen chloride - 5.0-10.5, melted butter - the rest, makes it possible to increase the therapeutic effect in the treatment of many diseases of the skin and mucous membrane. The obtained medicinal product improves the nutrition of tissue and skin cells, accelerates metabolic processes, harmonizing the biochemical balance of the cells, which leads to a significant improvement in the functional activity of the cells of the dermis. The use of therapeutic "E" means "TIM" helps to increase the elasticity of the skin, reduce its dryness, activates the processes of epithelization, swelling, infiltration of tissues, and hyperemia disappear after 2-3 procedures. Implement the invention in this way.

Melted butter (cow's) is prepared by melting it in a water bath to a liquid state.

Pork fat is melted to obtain liquid lard. Then take portions of 100g of sunflower, corn and walnut oil, which are poured into a container, then add 50g of celandine oil. 300g of all vegetable oils are poured into the liquid lard, thoroughly mixed for 10-15 minutes at a temperature of 38-40C, 50g of hydrogen chloride anhydrite and 300g of melted butter are added. stir for another 15-20 minutes, cool to 20-23" (at room temperature) and store at a temperature of t4--872 in a container protected from light.

Example 1. NastyakK., 7 years old, was being treated with a diagnosis of neurodermatitis. In the area of the neck, elbows, and hands, there are pronounced manifestations of neurodermatitis - the skin of the neck is dry, irritated, infiltrated, traces of combing, crusts in some places, in the area of the elbows - cracks, the scrotum is separated. He has been suffering from neurodermatitis since he was an old man. In early childhood - pronounced skin manifestations of exudative diathesis. Rubbed

Go! a thin layer of ointment every day after baths. After the second day of using the ointment, a decrease in skin dryness, pruritus, and infiltration was noted. After the third day, epithelization processes became more active, after the seventh, tissue turgor, skin elasticity, and color improved significantly, wound surfaces under crusts and in the area of cracks were almost completely restored.

Example 2. Patient V., 15 years old, 3rd degree thigh burn. Lubricated with ointment 2 times a day. The pain (burning) stopped 10 minutes after lubrication. Burn wounds smeared with ointment were kept open, not bandaged. Already on the second day, a pronounced therapeutic effect was manifested - the appearance of dense granulations and growth of the marginal epithelium was observed. It is noted that when applying the ointment immediately after a burn (within 1

P hours), does not cause the appearance of burn blisters on the skin. Full treatment of burns of medium degree of burden occurs on 6-7 days. Healing of scabs - on the 12th day.

Example 3. Patient D., 53 years old, diagnosis: trophic ulcer of the right leg with purulent exudation, size 3 x 2 cm, severe pain syndrome, hyperemia, edema. Lubricated with a thin layer of ointment. During the day, the wound is cleaned of pus and granulations appear. A significant decrease in swelling occurs already on the 2nd day, on the 6th day the wound has completely epithelialized. No side effects were observed.

Example 4. Patient B., 38 years old, was admitted with a diagnosis of 3rd degree boiling water burn. A thin layer of ointment is applied to the burn blisters. As the ointment is absorbed, lubrication is repeated until a scab forms, which is continued to be lubricated for 10-12 days until the scab itself falls off. With this treatment, the burn wound healed within 2 weeks.

Example 5. Patient V., diagnosis: optotic stomatitis of the oral mucosa. Treated with a warm solution of furatsilin, mouth rinse, lubricated with the therapeutic agent "TIM". Lubricated the affected oral cavity 3-4 times a day.

Improvement came after a day, and complete healing within 6-7 days.

Example 6. Patient K, diagnosis: streptoderma. Each carousel (ulcer) was smeared with a thin layer of ointment 2 times a day: in the morning and in the evening. The condition improved after a day, the pain passed. Complete recovery occurred after 6-7 days.

Example 7. Patient P., diagnosis: postoperative wound of a cavity operation (appendectomy). The postoperative wound was lubricated with a thin layer of ointment and covered with a thin layer of gauze napkin, which was changed after 2-3 days. 7/0 The improvement came after a day. Redness has passed, swelling subsides, pain passes. The wound heals within a week.

The proposed therapeutic agent "TIM" is a cream-emulsion in consistency and structure with good rheological and thixotropic properties. This ensures good applicability of the drug to the affected skin, contributes to its effective treatment. Ointment wipes do not stick to damaged tissues and are easily removed, 7/5 without injuring the upper layer of the wound surface.

It has been established that this drug has a wide spectrum of action: anti-inflammatory and wound-healing, antibacterial and antiviral activity, antifungal (antimycotic) activity against candida, aspergillus, microsporia, trichophyton fungi, as well as reparative and antiallergic action. As it turned out from practice, all these properties of the drug make it possible to use it for the treatment of pustular skin diseases, neurodermatitis, erysipelas, allergic manifestations, streptoderma, constipation, fungal diseases, postoperative wounds, burns of the 1st, 2nd, 3rd degrees, hemorrhoids, inflammation of the gums and other lesions of the skin and mucous membrane.

Claims (1)

The formula of the invention " Medicinal agent for local use, containing an anti-inflammatory substance, which is distinguished by the fact that it additionally contains the internal fat of pork, sunflower, corn and nut oils, celandine oil and hydrogen chloride anhydrite, and as an anti-inflammatory agent, ghee is used in this ratio , mass 90: - Internal pork fat 30.0-30.5 so Sunflower oil 10.0-10.5 Corn oil 10.0-10.5 And c) Walnut oil 10.0-10.5 moa « Celandine oil 5, 0-10.5 Hydrochloric anhydrite 5.0-10.5 Butter, melted, the rest. "the first self". ! ! v. c) Official Bulletin "Industrial Property". Book 1 "Inventions, useful models, topographies of integrated microcircuits", 2002, M 4, 15.04.2002. The State Department of Intellectual Property of the Ministry of Education and Science of Ukraine. Cheka" 1 (ee) - 70 (42) 60 b5