RU2256441C1 - Ointment for treatment of burn, suppurative and infected wound of different etiology and method for treatment of burn, suppurative and infected wound - Google Patents

Abstract

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to curative ointments with anti-inflammatory effect and with biostimulating properties for treatment of burns, suppurative and infected wounds of different etiology and to a method for treatment above said diseases using the ointment said. The proposed ointment comprising bee wax and greasy basis comprises colophony additionally. As greasy basis the ointment comprises butter and vegetable oil in the following ratio of components, wt.-%: bee wax, 20-30; butter, 30-40; vegetable oil, 15-25; colophony, 15-25. Method involves applying ointment by thin layer 0.5-3 mm on dense cotton fabric, its applying to damaged site, keeping and removing ointment with change of bandage 1-3 times per 24 h for 3-14 days. Method provides enhancing the therapeutic effectiveness of ointment due to significant acceleration the healing process of suppurative wounds and insidious furuncles being the ointment doesn't cause irritating effect.

EFFECT: improved and valuable medicinal properties of ointment.

2 cl, 4 ex

Description

The group of inventions relates to medicine, in particular to therapeutic ointments of anti-inflammatory action with biostimulating properties for the treatment of burns, purulent and infected wounds of various etiologies and methods of treating the above diseases with the help of this ointment.

Known ointment "Benin" for the treatment of purulent and infected wounds of various etiologies, consisting of fir oil, propolis, resin, spermaceti and penguin fat (RU, patent No. 2058776, class A 61 K 9/06, 1995).

Known ointment can be used to treat purulent and infected wounds of various etiologies, but is not intended to treat burns, in addition, it includes penguin fat, whose availability and raw material base are limited.

The closest in technical essence and the achieved result to the present invention is an ointment for the treatment of burns, purulent and infected wounds of various etiologies, containing beeswax and fat base, as well as ethyl alcohol, glycerin and a hydrophobic hydrocarbon base (RU, patent No. 2125867, class. A 61 K 9/06, 1999).

The disadvantages of the known ointment is the presence in its composition of alcohol-containing components (ethyl alcohol and glycerin - trihydric alcohol), which are able in some patients to cause some complications and allergic manifestations. In addition, the alcohol-containing components contained in the ointment adversely affect burns and cause irritation of various ulcers.

A known method of treating burns, purulent and infected wounds of various etiologies by applying the above ointments to the affected area, maintaining and subsequent removal of the ointment (RU, patent No. 2125867, class A 61 K 9/06, 1999).

The disadvantages of this method is the long duration of treatment and low efficiency associated with complications and allergic manifestations.

The objective of the invention is to create an ointment stable in composition, from products of natural origin without chemical or special synthetic additives with a long shelf life and a wide range of applications and reduction of treatment time.

The technical result, the achievement of which the present invention is directed, is to increase the therapeutic effectiveness of the ointment by increasing the range of therapeutic effects and reducing the duration of treatment with increasing treatment efficiency.

An additional technical result is the expansion of the range of therapeutic ointments that do not have a pronounced irritating side effect.

The specified technical result is achieved in that the ointment for treating burns, purulent and infected wounds of various etiologies, containing beeswax, and the fat base according to the invention additionally contains rosin, and as the fat base, the ointment contains butter and vegetable oil in the following ratio of ingredients, wt.%:

beeswax 20-30,

butter 30-40,

vegetable oil 15-25,

rosin 15-25.

In addition, in the method of treating burns, purulent and infected wounds of various etiologies by applying an ointment to the affected area, maintaining and then removing the ointment, according to the invention, the above ointment is applied with a thin layer of 0.5-3 mm on a dense cotton fabric, applied to the affected area and change the dressing 1-3 times a day for 3-14 days.

Achieving the indicated result is due to the fact that the proposed ointment, due to biologically active substances extracted from beeswax, fat base and rosin, has a multifaceted effect: antimicrobial, analgesic, osmotic. As an ointment base, the composition of the ointment includes vegetable and butter.

Rosin is a glassy substance from light yellow to dark red, obtained by distillation of turpentine from peeled resin (Big Soviet Encyclopedia. Publishing House "Soviet Encyclopedia". - M., 1973, v.11, p. 328). Rosin has protective antiseptic, anti-inflammatory and anti-allergic properties, produces a calming effect on the nerve endings of open wounds and, in combination with beeswax, improves its pharmacological properties. In addition, rosin contributes to the long-term preservation of the healing properties of the ointment and thereby increases its shelf life.

The experiments carried out allowed us to establish the optimal content of the components that make up the ointment, and the thickness of the ointment layer applied to dense cotton fabric, ensuring maximum effectiveness of the ointment.

So, the content of beeswax should be in the range of 20-30 wt.%. An increase in its content over 30 wt.% And a decrease of less than 20 wt.% Leads to a deterioration in the plasticity of the ointment, which is manifested in the inconvenience of using the ointment.

An increase in the content of butter over 40 wt.% Leads to an ointment of liquid consistency spreading over the skin surface, which prevents the creation of a maximum concentration of ointment in the wound, and a decrease in the amount of butter below 30 wt.% Leads to thickening of the ointment, which worsens the uniformity of its application on the affected area of the body.

Changing the amount of vegetable oil in excess of 25 wt.% And less than 15 wt.% Leads to a decrease in the efficiency of dissolution of the components.

With an increase in the amount of rosin in the composition over 25 wt.% Causes a local irritant effect, which leads to pain, and a decrease in the amount of rosin less than 15 wt.% Reduces the effectiveness of the ointment.

The choice of the thickness of the ointment layer applied to a dense cotton cloth (when using a bandage, the effectiveness of the ointment decreases sharply) is due to the greatest effectiveness of its effect on the wound, with a decrease in the thickness of the ointment less than 0.5 mm and an increase in the thickness of the ointment layer more than 3 mm, the effectiveness of the ointment decreases .

Beeswax increases the viscosity of the ointment and its absorption by the skin. The presence of carotene and vitamin A in wax makes it useful for the treatment of many skin diseases, and inhibits the growth of a number of pathogens.

The proposed ointment is prepared as follows.

For the preparation of ointments, it is advisable to use unrefined sunflower oil and butter obtained from cream of 33% fat and above, without flavoring additives.

The components are taken in a predetermined proportion, crushed, placed in an enameled container, and melted, brought to a boil with continuous stirring, filtered, then hot poured into molds of the desired configuration and volume (jars, tubes, etc.) for subsequent cooling in a natural way. The result is a packaged ointment.

The ointment is stored in a dark, cool place for up to 10 years, without loss of initial activity.

Ointment at room temperature is a homogeneous composition of a solid yellow consistency. Upon contact with the body or heating above 25 ° C, the ointment softens and becomes plastic. It does not dissolve in water and alcohol. Non toxic Contraindication to use is individual intolerance (allergy).

A method of treating burns of purulent and infected wounds consists in applying an ointment with a layer of 0.5-3 mm to a dense cotton cloth, after which the tissue is applied to the wound and fixed with a bandage or plaster, the dressing is changed 1-3 times a day for 3-14 days in depending on the degree of skin damage.

A method of treating burns and wounds is illustrated by examples:

Example 1

Patient M., 41 years old. After the bite of the dog there was a laceration on the left leg. The wound festering and did not heal. They began to apply a bandage to their cotton fabric with a layer of ointment 1 mm thick. The dressing was changed 2 times a day, and after 2 days 1 time per day. A week later, the wound cleansed of pus. The pains ceased to bother. The composition of the ointment:

beeswax 30 wt.%,

butter 25 wt.%,

vegetable oil 20 wt.%,

rosin 25 wt.%.

Example 2

Patient 3., 72 years old. She was operated on for appendicitis, but the suture did not heal within a year. Despite taking medications prescribed by your doctor. A bandage with ointment 0.5 mm thick was applied to the wound. The dressing was changed 3 times a day. A week later, the seam began to heal. The composition of the ointment:

beeswax 25 wt.%,

butter 25 wt.%,

vegetable oil 25 wt.%,

rosin 25 wt.%.

Example 3

Patient L., 64 years old. I got a burn of my right hand. Concerned about sharp pains, blisters, redness appeared. Dressings with ointment 3 mm thick were applied to the wound surface. The dressing was changed 1 time per day. Pain decreased and blisters began to dry out. After 5 days, the burned surface of the skin was replaced by a healthy, normal one.

Example 4

Patient A., 30 years old. Received a burn of a palm by electric shock. The surface of the skin turned black, a bubble swelled, a palm tightened, fingers could not be straightened. We applied a bandage made of dense cotton fabric with an ointment layer thickness of 3 mm. The dressing was changed 2 times a day, on the 3rd day the bubble fell off, on the 5th day the palm softened, the fingers began to straighten, within 14 days the affected skin came off and was replaced with a new, healthy one. The composition of the ointment:

beeswax 20 wt.%,

butter 40 wt.%,

vegetable oil 20 wt.%,

rosin 20 wt.%.

The treatment with the proposed ointment was carried out in almost all cases with a positive result; accelerated wound healing was observed without complications and side effects.

The use of the proposed ointment for the treatment of burns and wounds of various etiologies showed the stimulating effect of the ointment on the regenerative processes of connective tissue and epithelium, which indicates the biostimulating effect of the ointment and confirms a reduction in the healing time of the wound while increasing the effectiveness of the treatment.

Thus, the proposed ointment accelerates the rejection of necrotic tissue of the wounds, reduces the healing time and stimulates the development of young granulation tissue with acceleration of its maturation, enhances the proliferation of the epithelium.

From the patent and scientific and technical literature, we do not know therapeutic ointments containing a combination of the above ingredients in the proposed quantitative ratio, which allows us to conclude that the claimed technical solution is new.

Claims (2)

1. An ointment for the treatment of burns, purulent and infected wounds of various etiologies, containing beeswax and a fat base, characterized in that it additionally contains rosin, and as a fat base, the ointment contains cream and vegetable oil in the following ratio of ingredients, wt.%: Beeswax 20-30, Butter 30-40, Vegetable oil 15-25, Rosin 15-25. 2. A method of treating burns, purulent and infected wounds of various etiologies by applying an ointment to the affected area, maintaining and then removing the ointment, characterized in that the ointment according to claim 1 is applied with a thin layer of 0.5-3 mm on a dense cotton fabric, applied to the affected area and change the dressing 1-3 times a day for 3-14 days.