WO2017095352A1

WO2017095352A1 - Use of wax, olive oil, butter mixture and/ or its combination with varying ratios of boron and/ or derivatives thereof, in treatment of wounds, burns, and skin diseases

Info

Publication number: WO2017095352A1
Application number: PCT/TR2016/050471
Authority: WO
Inventors: Yasin BAYIR; Zekai HALICI
Original assignee: Ataturk Universitesi Bilimsel Arastirma Projeleri Birimi
Priority date: 2015-12-01
Filing date: 2016-11-30
Publication date: 2017-06-08

Abstract

Use of a medicine comprising 20 - 50 % by weight wax, 20 - 50 % by weight butter, 20 - 50 % by weight olive oil, and/ or 0.1 - 10 % by weight boron and/ or derivatives thereof in the treatment of wounds, burns, and inflammatory skin diseases.

Description

DESCRIPTION

Use of Wax, Olive Oil, Butter Mixture and/ or its Combination with Varying Ratios of Boron and/ or Derivatives Thereof, in Treatment of Wounds, Burns, and Skin Diseases

The Related Art

The invention relates to the use of wax, olive oil, butter, and/ or boron and/ or derivatives thereof, which ensure quicker treatment without scabbing or scarring in burns, scalds, skin grafts, rashes, infections due to skin diseases, and other infected wounds in treatment of wound, burn, and inflammatory skin diseases, by mixing with bain - marie method.

The invention particularly relates to the use of the combination with pharmaceutical forms (powder, cachet, packages, pillules, extracts, ointments, solutions, potion, cream, lotions etc.) and medical materials (dressings, burn wound cover, burn wound band aids, burn sets, burn clothes, burn pillows, burn cushions) in treatment of wound, burn and inflammatory skin diseases.

The Prior Art

Nowadays, burns, scalds, skin grafts, skin disease - related infections, other infections, rashes, cuts, accidents are the types of burn occurring on the muscle or skin caused by internal or external sources as a result of heat, electricity, chemical materials, friction or radiation.

Both in literature and folk medicine practices, from past to present, there are numerous studies, patent applications and methods that are developed to be used for skin - related wound and burn treatments. In these techniques it is determined that oils from many sources (canola, sunflower seed, olive etc.), many plant extracts or active substances, bee products (pollen, propolis wax etc.), many vitamins, many chemical active substances (diclofenac, mupirocin etc.) are used singly and/ or in various combinations.

There are many natural and herbal examples in this field. Walnut leaf can be included among these. Water that is obtained by boiling the walnut leaf has antiseptic effect in skin diseases and reduces pain when placed on wounds. It is also used in the treatment of infected eczemas. Gypsyweed, a traditional plant, is used as a blood - purifier and when used with fresh dead nettle leaves it heals chronic eczemas. In bloom, fresh plant sap can be prepared, which was recommended for chronic skin diseases and above all for eczema. Success of Gypsyweed in healing infected and difficult - to - cure wounds is also stressed in old herbal books.

One of the applications encountered during the studies in literature is the patent application No. W09805313, entitled: "Composition comprising mupirocin and chlorhexidine". In said application, pharmacy - related compositions that comprise mupirocin and chlorhexidine are used in the treatment of topical (on skin) bacterial infections, especially of infected burn wounds. A similar application is the patent application No. TR 2003/00156, entitled: "Burn Treatment". Said application relates to the topical use of diclofenac or its topically acceptable salts for the treatment of burns (for the production of a topic medication).

Another one is the patent application No. US 2003008830. Said application relates to a gel specifically used for treatment of burns. Said gel is obtained by the partial hydrolysis of sulphated galactose, pectin, and collagen addition of hydroxyethyl cellulose.

Another one is the patent application No. TR2008/00328, entitled: "Dermatologic composition used in the treatment of skin burns, skin diseases, and infected wounds". Said application relates to a composition that consists of elderberry bark extract, sheep tallow, olive oil, wax, gum mastic, and can be used for the healing of operation scars and for the treatment of skin burns and infected wounds as well as in every kind of non - allergic skin lesion, skin cracks, cuts, eczema and fungal infections, and even for the treatment of skin diseases such as onychomycosis, decubitus ulcer, diabetes - related skin ulceration, furuncle and carbuncle when in prolonged use.

A similar one is the patent application No. TR 2010/01 146, entitled: "Wound and burn curing preparation". Said application is a preparation that may include natural olive oil and apple, in addition to wax, fatty acids, paraffin or glycerine. It ensures shortening the length of treatment and completely healing the scar as well as faster treatment of rashes in children and infants.

Patent application No. TR 2012/00429 relates to olive oil, red apple and white wax composition, which is used in the treatment of skin burns and wounds, providing a faster and scar - free cure of wound and burns. Patent application No. TR 2012/10606 relates to a pomade having a herbal combination to be used in burn treatments. It is obtained by combining olive oil, wax, turpentine, frankincense, gum mastic, abies gum, paliurus and alkanet root in particular proportions. Patent application No. TR 2012/1 1 126 is a burn cream that can be used in every skin burn related area and is characterized by consisting of components of extra - virgin olive oil, wax, rivanol powder and camomile essence.

Patent application No. TR 2014/15067 relates to a burn cream that heals burn wounds without any scar while stopping the pain and having a different structure used in skins, and to its manufacturing process, and characterized by having the steps of mixing tail fat, karakovan wax, colophony, white wax, butter alkanet and olive oil until they melt in oven and keeping them after meltdown. In patent application No. KR20030020488, a pharmaceutical composition is described, which has as the active ingredient bamboo extract and a pharmaceutically acceptable carrier. Said composition also includes aloe or cucumber extract or a mixture of these.

Patent application No. CN1915351 consists of coptis root, scutelleria root, phellodendron bark, aloe gel and pharmaceutically acceptable additive, that is used in the treatment of skin diseases such as burn, acne, wound, bedsore and eczema.

Each of them having different purposes and characteristics, wax, olive oil and butter are all known and used materials in both literature and society. However, when it is intended to obtain a mixture of these, it is done with random amounts and methods. In this case, as a result of being unable to provide an effective, able dose to provide the treatment, unintended side effects and complications such as over - inflammation, dryness occur.

One of these is the patent application with publication No. TR201415067, entitled: "Wound cream with a different embodiment and the manufacturing method thereof." The abstract of this application is as follows: "This invention relates to a burn cream that heals burn wounds without any scar while stopping the pain and having a different structure used in skins, and to its manufacturing process, and characterized by having the steps of mixing tail fat, karakovan wax, colophony, white wax, butter alkanet and olive oil until they melt in oven and keeping them after meltdown. Boron is a chemical material that is widely found in nature. It is found in various proportions in many fruits and vegetables. While boric acid and sodium borate (named as borax) exist in nature as sodium tetraborate, disodium tetraborate or as its calcium compound, many compounds with boron are also synthesised by treating boron with different chemical processes. Among these we can include boron nitride. Boric acid and borax that are two of the most important compounds of boron compounds are used as sterile medicine in human medical science because of having antiseptic, antibacterial, anti - fungal and firming properties in treatment of small cuts and burns. Boron nitride is a white coloured compound that has a good chemical, electrical and thermal properties. Boron nitride is generally produced by the reaction of boric acid or boron oxide with carbon and nitrogen or organic carbon and nitrogen carriers. The crystal structure of boron nitride is similar to the one of carbon, thus boron nitride is also called white carbon or white graphite.

Said boron compound is used singly in the current technique. A use with wax, butter and olive oil, which has various advantages, is not included.

As a result, the above said drawbacks and the inadequacy of the prior art solutions about the subject have necessitated an improvement in the technical field of compositions used in treatment of wounds, burns, and skin diseases.

Purpose of the Invention

The invention relates to the use of wax, olive oil, and butter mixed via bain - marie method, in treatment of wounds, burns, and skin diseases, which meets the above said requirements, eliminates all of the drawbacks, and brings some additional advantages.

The primary purpose of the invention is to provide a composition that ensures a scabless, scarless healing that has no side effect on the skin it is applied, does not cause infection, heals the infected wound, provides a faster heal for the wounds and helps skin growing hair, in the treatment of skin diseases and infected wounds.

A purpose of the invention is to ensure that said composition consists of olive oil, wax, and butter having various benefits; and it is mixed by bain - marie method. Obtaining the composition of the invention with bain - marie method provides a homogenous mixture and prevents the potential degradation of materials without being exposed to direct flame temperature. When obtained with direct flame, the risk of degradation and oxidation is high. Another purpose of the invention is adding boron and/ or its derivatives (boric acid, borax, boron nitride) to the mixture that is obtained by bain - marie method. Because of the antibacterial properties of boron products, this provides the development of multi - purposed dermatological pharmaceutical forms and medical materials that provides healing by preventing infections.

A similar purpose of the invention is to provide multi - purposed pharmaceutical forms and medical materials that can be stored for years without losing its characteristic in room temperature but can have an effect when in touch with the body.

Another purpose of the invention is to develop a multi - purposed medical composition that is easy to apply on skin because of its fatty structure, that is absorbed by skin shortly and that is easy to remove during dressing change because of not sticking on to the skin. Another purpose of the invention is to be a composition that speeds up the recovery time of skin burns, skin diseases by 2 - 3 times compared to normal medical treatments, while healing the simple burns and cuts in one or two days.

A similar purpose of the invention is to have practical manufacturing steps and low manufacturing costs.

Another purpose of the invention is to reduce the pain that is caused by burn dressing, with composition and technique. Another purpose of the invention is to be able to apply the obtained composition in all pharmaceutical forms such as powder, cachet, packs, pillule, extracts, ointment, solutions, potion, cream, lotions.

A similar purpose of the invention is to be able to apply the obtained composition in various medical materials such as dressings, burn wound cover, burn wound band aids, burn sets, burn clothes, burn pillows, burn cushions.

Another purpose of the invention is to be able store said pharmaceutical forms and medical materials in room temperature in a scentless way by sterilizing.

In order to achieve the above said purposes, the invention is a dermatological composition for use in the treatment of wounds, burns, and inflammatory skin diseases, and it is characterized in that; it comprises 20 - 50 % by weight wax, 20 - 50 % by weight butter, 20 - 50 % by weight olive oil, and/ or 0.1 - 10 % by weight boron and/ or derivatives thereof.

The structural and characteristic features of the invention and all of its advantages shall be understood better with the figures and the detailed description given below in reference to the figures, and therefore, the assessment should be made by taking into account the said figures and detailed explanations.

Detailed Description of the Invention

In this detailed description, the preferred embodiments of the use of wax, olive oil, and butter mixed via bain - marie method, in treatment of wounds, burns, and skin diseases, according to the invention are only disclosed for better understanding of the subject without forming any limiting effect. The invention is a dermatological composition that can be applied with multi - purposed dermatological pharmaceutical forms and medical materials, that prevents infection during healing and provides a scabless, scarless healing in the treatment of wound, burn and inflammatory skin diseases. The most significant characteristic of the composition according to the invention is comprising olive oil, wax, and butter, which are mixed by bain - marie method. Thanks to the bain - marie method, not only a homogenous mixture is obtained, but also the potential degradation is prevented because the materials are not exposed to direct flame temperature. Another characteristic of the invention is that; the amount of olive, wax, and butter that is used in the mixture is determined scientifically, not randomly. This provides the therapeutical dosage that is effective, adequate and that can provide healing. In this way, undesired side effects and complications such as edema, over - inflammation, dryness are prevented. As another characteristic of the invention is the combination of olive, wax, and butter with boron and/ or its components that are known to have various advantages.

The raw materials of the composition according to the invention and their rates:

Raw material Preferred amount bv weiaht Usable amount bv weiaht

1%1 ί%1 Wax 33.3 20 - 50

Butter 33.3 20 - 50

Olive Oil 33.4 20 - 50

Raw material Preferred amount bv weiaht Usable amount bv weiaht

(%1 (%1

Wax 33 20 - 50

Butter 33 20 - 50

Olive Oil 33 20 - 50

Boron and/ or its derivatives 1 0.1 - 10

Wax should not be synthetically manufactured. It has to be organic wax (karakovan) produced directly by bees. Butter has to be organic and salt - free. Olive oil has to be acid - free and natural extra - virgin. Olive oil that is also used as vegetable oil; also nurtures the skin and by moistening, and prevents distention and drying. Boron and/ or its derivatives has to be 100 % pure. Boron derivatives that are used in a preferred embodiment of invention are boric acid, borax, or boron nitride.

The manufacturing method of the composition according to the invention comprises the operation steps of:

• melting and homogenizing of wax, butter and olive oil, and/ or boron and/ or its derivatives by bain - marie method until a homogenous mixture is obtained bv using the above given rates.

(bain - marie method is prepared by providing homogenous distribution by shaker water bath at 100 Ό independent of time)

The obtained composition can be prepared with medical materials such as dressings, burn wound cover, burn wound band aids, burn sets, burn clothes, burn pillows, burn cushions in all pharmaceutical forms such as powder, cachet, packages, pillule, extracts, ointment, solutions, potion, cream, lotions. After preparation, it is sterilized in a way that can go on without degradation for a long time.

Claims

1. A dermatological composition for use in the treatment of wounds, burns, and inflammatory skin diseases, and it is characterized in comprising 20 - 50 % by weight wax, 20 - 50 % by weight butter, 20 - 50 % by weight olive oil, and/ or 0.1 - 10 % by weight boron and/ or derivatives thereof.

2. A production method of a dermatological composition for use in the treatment of wounds, burns, and inflammatory skin diseases, and it is characterized in comprising the operation step of:

• mixing wax, butter, and olive oil, and/ or boron and/ or derivatives thereof via bain - marie method until a homogenous mixture is obtained.

3. The production method according to Claim 2, characterized in comprising 20 - 50 % by weight wax, 20 - 50 % by weight butter, 20 - 50 % by weight olive oil, and/ or 0.1 - 10 % by weight boron and/ or derivatives thereof.

4. The use of the dermatological composition obtained with the method of claim 2 in the treatment of wounds, burns, and inflammatory skin diseases.