KR20030020488A - Pharmaceutical composition for healing burn-injury comprising bamboo extract as active ingredient - Google Patents

Abstract

PURPOSE: Provided are a pharmaceutical composition for healing burn-injury which comprises a bamboo extract as active ingredient and a pharmaceutically acceptable carrier, thereby simplifying treatment procedure of burn-injury and treating it rapidly. CONSTITUTION: The pharmaceutical composition characteristically comprises a bamboo extract as active ingredient and is thus used for healing burn-injury. It further comprises an aloe extract or a cucumber extract, or their mixture. It further comprises antibiotics.

Description

Pharmaceutical Composition for Healing Burn-injury Comprising Bamboo Extract as Active Ingredient}

The present invention relates to a composition for burn treatment comprising the bamboo extract as an active ingredient. More specifically, the present invention relates to a composition for treating burns containing bamboo extract as an active ingredient and comprising a pharmaceutically acceptable carrier.

The skin of an animal is the primary protective film that protects the living body from the external environment, and receives the effects of the external environment without filtering. Among these effects, damage caused by harmful pollutants such as air pollutants or ultraviolet rays is prominent. In the case of ultraviolet rays, an extremely small amount corresponding to 0.5% of the light reaching the earth, erythema, pigmentation, wrinkles and most skin cancers It is known to act as an inducing factor. Recently, due to the imbalance and destabilization of the ecosystem, the amount of ultraviolet rays reaching the surface is gradually increasing as the ozone layer in the atmosphere becomes thinner, and malignant melanoma increases by 0.6% as the ozone layer decreases by 1%. to be.

In general, when a body is injured, the organism has the property of defending itself to some extent and self-healing. If the skin is damaged, the skin damage below a certain level can be recovered by the self-healing ability, but the skin damage above a certain level may spread to other diseases due to other factors such as bacterial infection. In particular, when the skin is damaged by a burn due to ultraviolet rays or other firearms, not only damage to the skin tissue, but also additional damage caused by poisoning, so as to treat this early, a wound treatment composition for burn treatment is used. The electrical composition should be excellent in biocompatibility, so it has little rejection at the wound site, can be in close contact with the wound site, can prevent bacterial infection at the wound site, and should not be reactive even when mixed with other medicines. do.

Skin treatment compositions currently used to aid in the treatment of burns or trauma protect the wound for a limited time until the damaged skin is restored, prevent the leakage of water in the body, and when the exudative fluid is inflamed. In addition to absorbing the collected liquid, it also shares the characteristics of preventing bacterial infection. Looking at them by type, a composition mainly composed of gel having excellent skin absorption property, a composition mainly composed of a polyurethane membrane or a freeze-dried product of pork skin, a composition mainly composed of a porous membrane coated with chitin, a natural polysaccharide, synthetic polymers or functionalities And a composition containing gelatin as a main component. In addition, wound healing compositions using other materials have been developed, but these include synthetic materials as the main ingredients, and these materials help to treat damaged areas of the skin, but side effects to normal tissues exist little by little. Therefore, in order to solve these problems, efforts have been made to develop wound healing compositions containing natural substances as main components. In recent years, it has been found that green tea extract is effective for the treatment of skin damage and skin diseases, and its active ingredient is reported to be a catechin compound, and development of a therapeutic composition using the same has been studied. However, the wound healing composition prepared from most natural products does not overcome the disadvantage that the cost of the material and the cost of the manufacturing process are enormous and economical.

In addition, in the case of using the composition for electrotherapy, it is generally applied directly to the wound, the burn requires a long treatment time and effort compared to the general wound. The reason for this is that the process of removing the poison and the process of removing the blisters caused by the burn are additionally included. Therefore, a treatment for burns is being developed separately from the general wound treatment. However, the therapeutic agent developed in this way is treated after removing the poison and blisters, which can prevent the residual damage caused by the first removed poison and prevent the reoccurrence of the blisters. The situation in the country does not develop much.

Therefore, there is a constant need to develop a method for treating burns efficiently.

Thus, the inventors of the present invention, as a result of research efforts to develop a method for treating burns efficiently, when using a composition for the treatment of burns comprising bamboo extract as an active ingredient, a pharmaceutically acceptable carrier, separate poisons and Without removing the blisters, it was confirmed that the burn can be treated quickly and effectively, and the present invention was completed.

After all, the main object of the present invention is to provide a composition for burn treatment containing bamboo extract as an active ingredient.

The composition for treating burns of the present invention contains a bamboo extract as an active ingredient, and includes a pharmaceutically acceptable carrier: at this time, it may further include aloe extract and cucumber extract, bamboo extract, cucumber extract and aloe extract Silver is preferably mixed at 90: 5: 5 to 70:15:15 (w / w / w).

Bamboo is a preferred plant in Far East Asia because of its ecological characteristics. In particular, bamboo has been greatly loved since ancient times because of its functionality as well as its form. For example, 34 kinds of prescriptions using bamboo have been recorded in the herbaceous cortex, and in the New Nongbyeon Herbal Cultivation and Dongbobogam, the remedy and the tumor, fever, insecticide, vomiting, It is said to be effective in swelling, expectoration, stroke, diabetes, high blood pressure, nervous breakdown, pregnancy anemia, pediatric infectious diseases, epilepsy, insomnia, excessive drinking, fatigue, and eye pain. (下 죽) In Mokbu-chocho, `` Kimchi '' is made by cutting the thin skin of ivy, and has the effect of calming, fever, and hemostasis. It is effective in heavy winds, strokes, tetanus and postpartum fever. Bamboo bamboo is a yellow-white film in bamboo nodes, sweet and tasteless. To overpower the aggression and fever of God. ' The pharmacological effects of bamboo are numerous, such as bamboo charcoal made of bamboo, and bamboo salt baked with sun salt in bamboo. However, the pharmacological effect of the bamboo is a proven effect after most of the bamboo extract orally administered method, the external effect of the bamboo extract was not particularly revealed.

The present inventors studied the external effects of the bamboo extract, it was confirmed that the bamboo extract is excellent in removing poison and blisters. In particular, in the method of removing blisters, even if the moisture contained in the blisters is conventionally removed, the epidermis of the blisters does not adhere to the wound site and thus prevents the smooth treatment. When applied to the surface of, the moisture contained in the blisters was lost, the epidermis of the blisters were brought into close contact with the burned area, and the skin tissue damaged by the burns was quickly recovered. In addition, the conventional method has to be treated with a separate disinfection and antibiotics to prevent infection of external pathogens in the area where the epidermis of the blister is removed, but when using the burn treatment composition of the present invention Since it is not lost, separate disinfection and treatment of antibiotics can be omitted or simplified.

Bamboo extract contained as an active ingredient of the burn treatment composition of the present invention is a pharmaceutically acceptable binder (eg, polyvinylpyrrolidone, hydroxypropyl cellulose), disintegrant (eg, carboxymethyl cellulose calcium, starch glycolic acid Sodium), diluents (e.g. corn starch, lactose, soybean oil, crystalline cellulose, mannitol), lubricants (e.g. magnesium stearate, talc), stabilizers (sodium carboxymethylcellulose, alpha or beta cyclodextrin, vitamin C, citric acid, white lead) ), Preservatives (e.g. methyl paraoxybenzoate, propyl paraoxybenzoate, sodium benzoate) or flavorings (e.g. ethyl vanillin, masking flavors, menthol flavono, herbal flavors), tablets, porous membranes, powders, It may be prepared as a pharmaceutical preparation such as gels, ointments, creams, solutions. In addition, in order to prevent further dermal infection by external infectious bacteria, it may further comprise a normal dose of known antibiotics.

Dosage

The dosage of the composition for the treatment of burns varies depending on the age, weight, and the degree of wound of the patient, but in the case of adults (based on 60 kg body weight), usually in an amount of 0.01 to 0.06 g / cm ² 1-5 times a day parenterally. It is preferable to apply to the burned area, and may be appropriately determined by the experience of those skilled in the art.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it will be apparent to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. .

Example 1 Preparation of Burn Treatment Composition

10 kg of 4 year-old bamboo cut to a size of 20 cm is placed in a pressure cooker designed to collect steam, sealed, heated to 120 ° C. for 24 hours, and the generated steam is collected and cooled to obtain 1 kg of bamboo extract. It was. 800 g of the obtained bamboo extract, 100 g of cucumber juice and 100 g of aloe juice were mixed with stirring, and dried at 50 ° C. for 5 hours to prepare an oily burn composition.

Example 2 Burn Treatment Effect of Burn Composition

The burn treatment effect of the burn treatment composition of the present invention was compared with the burn treatment effect by various burn treatment methods.

Example 2-1 : Effect of the composition for burn treatment (I)

A healthy male New Zealand white rabbit (8 kg body weight) of 8 weeks old (weight 2 kg) was bred under unlimited conditions of feeding (drinking feed) and drinking water. Subsequently, 2 × 2cm wide skin located 5% horizontally from the inferior border of scapular of the experimental animal skin was designated as an image processing site, and the designated area was disinfected, The plate was burned with a metal plate having a width of 2 cm. After 2 hours, the experimental group was applied to the burn site at an interval of 0.025 g / cm ² in the burned area for 8 days for 5 days, and a control group was treated with only disinfection using potadidine. In the cardiac group, the percentage of image area with respect to the number of days was determined with respect to the initial image area, and the image survival rate (%) was measured (see Table 1).

Change in Image Retention Rate (%) Over Time Elapsed days Control Experimental group One 95.3 ± 0.6 80.1 ± 0.8 2 86.4 ± 0.4 55.3 ± 0.4 3 79.8 ± 0.7 32.1 ± 0.3 4 71.2 ± 0.3 10.6 ± 0.4 5 60.8 ± 1.2 2.8 ± 0.6

As shown in Table 1, it was found that the burn residual rate of the experimental group was rapidly decreased, and the blister remained for about 3.5 days in the control group, but in the experimental group, the blister remaining time was only 20 hours, so that the blisters were removed. It was found that the composition for burn treatment of the present invention is excellent.

Example 2-2 : Effect of the composition for burn treatment (II)

Residual burn rate (%) was measured in the same manner as in Example 2-1, except that a commercially available burn treatment agent (petrolatum) was applied to the burn site (see Table 2).

Change in Image Retention Rate (%) Over Time Elapsed days Control Experimental group One 90.3 ± 0.2 80.1 ± 0.8 2 76.4 ± 0.9 55.3 ± 0.4 3 59.8 ± 0.6 32.1 ± 0.3 4 31.2 ± 0.7 10.6 ± 0.4 5 20.8 ± 0.2 2.8 ± 0.6

As shown in Table 2, it was found that the burn residual rate of the experimental group using the burn treatment composition of the present invention was reduced more rapidly than the control using a commercially available burn treatment agent, and the blisters in the control group were about 1.5 days. Although remaining in the experimental group, the remaining time of the blister was only 20 hours, it was found that the composition for burn treatment of the present invention is excellent in terms of removing the blister.

Example 2-3 : Effect of Burn Treatment Composition (III)

Remaining burn rate (%) in the same manner as in Example 2-1, except that the blisters of the control group were artificially removed, the burned area was disinfected, and then a commercially available burn treatment agent (petrolatum) was applied to the burned area. ) Was measured (see Table 3).

Change in Image Retention Rate (%) Over Time Elapsed days Control Experimental group One 85.3 ± 0.2 80.1 ± 0.8 2 66.4 ± 0.9 55.3 ± 0.4 3 42.8 ± 0.6 32.1 ± 0.3 4 19.2 ± 0.7 10.6 ± 0.4 5 8.8 ± 0.2 2.8 ± 0.6

As shown in Table 3, it was found that the burn residual rate of the experimental group using the burn treatment composition of the present invention was reduced more rapidly than the control group using the commercially available burn treatment agent by removing the blisters. There is no blister due to the removal, but in order to suppress the occurrence of the disease caused by the infection of the external infectious bacteria to the removed site, additional antibiotics were to be treated, it was found that the experimental group treated with only the burn treatment composition is better.

Example 3 Evaluation of Skin Toxicity of Wound Care Compositions

In order to examine the side effects of the wound healing composition of the present invention, male rabbits were subjected to skin toxicity evaluation using a closed patch method.

8 weeks old (2 kg body weight) healthy male rabbit (New Zealand White Rabbit, Animal Breeding Center) was bred under the conditions of the breeding room, and the back skin of the experimental animal was depilated using an animal chipper, Example 1 The burn treatment composition prepared in the above was applied to the patch paper (3M paper) in the amount of 5g / cm ² , and then patched on the hair removal site and wrapped in the back of the male rabbit with a pressure bandage so that the patch does not fall. Subsequently, after 48 hours, the patch was removed and the patch was visually observed. As a result, it was found that no side effects such as erythema or edema occurred in the hair removal site of any experimental animal. It was safe.

As described and demonstrated in detail above, the present invention provides a composition for the treatment of burns containing bamboo extract as an active ingredient and a pharmaceutically acceptable carrier. The burn treatment composition of the present invention contains a bamboo extract as an active ingredient, and includes a pharmaceutically acceptable carrier. When using the composition for the treatment of burns of the present invention, it is possible to omit or simplify the step of removing poisonous and blisters, and thus it may be widely used for quick and easy treatment of burns.

Claims (6)

Burn composition comprising a bamboo extract as an active ingredient, comprising a pharmaceutically acceptable carrier. The method of claim 1, Adding a mixture of aloe extract, cucumber extract or electric extract Characterized in that it comprises Burn treatment composition. The method of claim 2, The mixing ratio of bamboo extract, cucumber extract and aloe extract is 90: 5: 5 To 70:15:15 (w / w / w) Burn treatment composition. The method of claim 1, Characterized in that it further comprises a normal dose of known antibiotics. Burn treatment composition. The method of claim 1, Pharmaceutically acceptable carriers include binders, disintegrants, diluents, glidants, Stabilizer, preservative or flavoring Burn treatment composition. The method of claim 1, Of tablets, porous membranes, powders, gels, ointments, creams or solutions Characterized in that the formulation Burn treatment composition.