KR20100111061A - Composition for wound healing - Google Patents

Abstract

PURPOSE: A composition for wound healing is provided to promote scar without skin irritation and to regenerate skin tissue. CONSTITUTION: A pharmaceutical composition for wound healing contains 8-10 weight parts of potassium chloride, 40-60 weight parts of potassium carbonate, 1-2 weight parts of magnesium chloride, 1-2 weight parts of calcium lactate, 3-7 weight parts of sodium citrate, 15-30 weight parts of white sugar and 2-5 weight parts of purified glucose in 100 weight parts of purified water. The pharmaceutical composition also contains pharmaceutically acceptable excipient or carrier. The pharmaceutical composition is used in the form of gel, paste, ointment frost, powder, emulsion or aerosol.

Description

Composition for wound healing {Composition for wound healing}

The present invention relates to a novel wound treatment composition. More specifically, the present invention relates to a pharmaceutical composition for treating wounds excellent in wound healing effects on skin tissue.

In addition to direct wounds such as cuts and cuts, the skin may cause various types of damage such as heat burns, eczema due to various physical and chemical stimuli, or stretch marks due to an increase in corticosteroids. Among them, in the case of damage due to wounds or burns, treatment is generally performed to prevent infection of bacteria due to wounds using an ointment containing antibiotics in general.

In general, "wounds" that occur on the skin can be characterized as open wounds and closed wounds. Open wounds are surface wounds and nails that have peeled off the top layer of the skin resulting from lacerations, abrasions or often rough surfaces such as knives or razors, which are rough and irregular wounds caused by cuts, squeezing or squeezing by a sharp, sharp material. It can be classified into many different types, including a cut from a skin-sticking substance such as a needle. Closed wounds are also divided into fewer categories but are as dangerous as open wounds. In other words, closed wounds include bruises or bruises caused by blunt trauma that damage the underlying tissue of the skin, hematoma caused by blood vessels staying under the skin, and squeezing damage caused by a strong or excessive force applied for a long time. .

In addition, one of the major damages to the skin is burns. Burns are damage to the body skin caused by contact with heat, chemicals, electricity, or radiation. Burns are called vapor thermal burns, which are divided into 1 degree and 3 degree burns, depending on the area and depth of skin damage. In first-degree burns, the skin's outer layer, called the epidermis, becomes red, sensitive to contact, and often swollen. Although no treatment is usually needed, ointment can help relieve pain. Second-degree burns are characterized by variable destruction of the epidermis and blister formation, and can expose nerve endings. In more serious cases, a doctor should be consulted and care should be taken to prevent infection. The treatment for second-degree burns is a topical treatment that uses a compound such as silver nitrate to create a soft skin, lower the risk of infection, and relieve pain. In third degree burns, the entire skin layer and underlying connective tissue are destroyed. In more serious cases, the underlying bone is burnt. The surface area of the burned area is more important than the depth of the burn. Shock must be prevented or neutralized and blood transfusion may be needed to replace lost fluids. In the case of such third degree burns, antibiotics and other drugs should be administered to prevent or treat various bacterial invasion. Morphine can also be used to relieve pain. Further long-term treatment methods may include transplantation of natural or artificial skin grafts.

On the other hand, the treatment of the burned skin may use a therapeutic agent or other synthetic medicines composed of ingredients extracted from natural materials such as plants, but conventional medicines are generally ineffective and take a long time even if they are treated. In addition, there is a risk of secondary infection of harmful bacteria during the treatment process, and treatment should be done by separately putting painkillers or anti-inflammatory drugs to prevent the occurrence of inflammation in order to soothe severe pain accompanied by burns. In addition to the enormous cost of treatment, there was a problem requiring a long treatment period.

Therefore, the inventors of the present invention are developing a wound treatment which is inexpensive and has excellent therapeutic effect on skin wounds and has little pain, so that patients can use it, while potassium chloride, potassium carbonate, magnesium chloride, calcium lactate, sodium citrate, and white sugar The composition comprising purified glucose and water can promote the healing of the wound with little irritation to the damaged skin and help the damaged area regenerate in its original form with a normal touch to form scars and granule tissue. The present invention has been completed by discovering that there is an effect that can suppress.

Accordingly, an object of the present invention is to provide a pharmaceutical composition for treating wounds comprising potassium chloride, potassium carbonate, magnesium chloride, calcium lactate, sodium citrate, white sugar, refined glucose and water.

In order to achieve the above object of the present invention, the present invention provides a pharmaceutical composition for treating wounds comprising potassium chloride, potassium carbonate, magnesium chloride, calcium lactate, sodium citrate, white sugar, refined glucose and water.

Wound healing compositions comprising potassium chloride, potassium carbonate, magnesium chloride, calcium lactate, sodium citrate, white sugar, refined glucose and water according to the present invention can promote the treatment of wounds with little irritation to the damaged skin, It helps to restore the damaged area to its original appearance with normal touch and to suppress the formation of scars and granule tissues. Itching and itching caused by the regeneration process of the skin it is also effective to alleviate the itching caused by the disease.

The present invention provides a pharmaceutical composition for treating wounds comprising potassium chloride, potassium carbonate, magnesium chloride, calcium lactate, sodium citrate, white sugar, refined glucose, and water. More preferably, 8 to 10 parts by weight of potassium chloride, 40 to 60 parts by weight of potassium carbonate, 1 to 2 parts by weight of magnesium chloride, 1 to 2 parts by weight of calcium lactate, and citric acid to 100 parts by weight of purified water heated to 50 to 60 ° C. It provides a pharmaceutical composition for wound treatment, comprising 3 to 7 parts by weight of sodium, 15 to 30 parts by weight of white sugar and 2 to 5 parts by weight of refined glucose.

In one embodiment of the present invention, based on 1 liter of purified water heated to 50 ~ 60 ℃ potassium chloride 80 ~ 100g, potassium carbonate 400 ~ 600g, magnesium chloride 10 ~ 20g, sodium citrate 30 ~ 70g, calcium lactate 10 ~ 20g, 150 per white A pharmaceutical composition for wound treatment was prepared by adding, dissolving, and ionizing ˜300 g and 20-50 g of purified glucose.

The water for preparing a pharmaceutical composition for treating wounds according to the present invention can be purified according to methods known in the art to remove the raw water from the intake source to remove protists and foreign substances present in the water. Preferably, it may be carried out through filtration, and more preferably, it may be performed using an activated carbon filtration tank or an ultra-precision filtration device. Thereafter, the composition of the present invention may be prepared by dissolving mineral substances in purified water from which foreign substances have been removed through filtration, and preferably, the purified water may be heated to be used. The reason for using heated purified water in the manufacture of a pharmaceutical composition for treating wounds according to the present invention is that when cold purified water is used, mineral components may remain as precipitates without being completely dissolved, and thus the heating is mixed. It is preferable to heat the purified water to the extent that mineral components do not precipitate, and more preferably to a temperature of 50 ℃ to 60 ℃.

Therefore, the pharmaceutical composition for treating wounds of the present invention prepared by the above method contains mineral components of potassium, sodium, magnesium and calcium that are ionized in water and exhibit alkalinity.

In particular, potassium in the mineral component used in the present invention is a major cation of intracellular fluids and is involved in the osmotic pressure and water balance control together with sodium, the main cation of extracellular fluids, and plays an essential role in maintaining the balance between acid and alkali. However, deficiency of potassium can lead to histolysis, diarrhea and vomiting, whereas excess potassium in the body can cause hypothyroidism. Therefore, the composition of the present invention preferably contains 80 to 100 g of potassium chloride with respect to 1000 ml of purified water so that there are no side effects in the body, and preferably contains 400 to 600 g of potassium carbonate.

Sodium, together with potassium, functions to regulate osmotic pressure, plays an important role in cell mass exchange, and is involved in maintaining normal muscle irritation and excitability. Therefore, lack of sodium may cause anorexia, indigestion, muscle atrophy, intestinal gas accumulation, etc., and excessive sodium may cause fatigue, nervousness, seizures, headaches and gum disease. Therefore, it is preferable that the composition of this invention contains 30-70 g of sodium citrate with respect to 1000 ml of purified water.

Calcium plays the most important role in maintaining the skeletal system in the body, and is involved in muscle contraction and relaxation, enzyme activation and regulation of immunity and hormone secretion. In case of calcium deficiency, it causes inferior growth, depression, insomnia and various pains, and excessive calcium causes loss of appetite, weight loss and constipation. On the other hand, since such calcium reacts violently with water, it cannot generally be used for the preparation of alkaline solutions. However, in the present invention, an appropriate amount of calcium can be added to make an alkaline solution in a short time with other mineral components. Therefore, in view of such a point, it is preferable that the composition of this invention contains 10-20 g of calcium lactates with respect to 1000 ml of purified water.

Magnesium is the most important component of cellular metabolism, plays an important role in enzyme activity and constitutes the skeleton and teeth. Lack of magnesium causes nerve hypersensitivity, convulsions, seizures and atherosclerosis, and lack of magnesium causes coma, vomiting and anorexia. In addition, magnesium reacts with water in water to form hydroxide ions as the magnesium is oxidized, and water is alkaline due to the hydroxide ions formed, and at the same time, it has a reducing power by the hydrogen molecules formed. Therefore, when such magnesium is included in the composition of the present invention in too large a quantity, the ability to make alkalinity is rapidly lowered because it is easily oxidized to magnesium oxide in water to form an oxide film on the surface of magnesium, whereas when included in too small There is a problem that the effect of alkalizing the solution is insignificant. In view of such a point, the composition of the present invention preferably contains 10 to 20 g of magnesium chloride with respect to 1000 ml of purified water.

Furthermore, glucose and white sugar serve to stabilize the solution by preventing the ionized mineral components from recombining. Therefore, it is preferable that the composition of this invention contains 150-300 g of white sugar with respect to 1000 ml of purified water, and 20-50 g of refined glucose is preferable.

The wound treatment composition according to the present invention has an effect of quickly treating and recovering a wound occurring on the skin. In addition, it can promote the healing of the wound with little irritation to the damaged skin, and has the effect of suppressing the formation of scars and granulated tissue by helping the damaged area to be regenerated with a normal touch.

In addition, the wound treatment composition according to the present invention has an excellent bactericidal effect on the wound site, the pain that can be felt by the patient during sterilization, for example, the degree of soreness has an effect that occurs only very short time. Furthermore, there is an effect that can reduce the itching caused by itching and skin diseases during the wound treatment process.

As used herein, "wound" refers to physical rupture of continuity or integrity of tissue structure, and "wound healing" refers to restoration of tissue integrity. This may mean partial or complete restoration of tissue integrity, and thus wound healing refers to the promotion, improvement, progression, acceleration or progression of one or more steps or processes involved in the wound healing process.

In addition, the wound may be any internal wound or external wound, in particular a skin wound, in which the external structural integrity of the skin is maintained, such as, for example, a bruise or internal ulcer, so that the tissue may be internal or external body tissue. In one example, the tissue is skin (eg, human skin) and the wound may be a skin wound such as a dermal or epidermal wound.

Types of wounds to which the composition for treating wounds of the present invention may be applied include, but are not limited to, cuts and cuts, surgical incisions or wounds, punctures, grazes, scratches, compression wounds, abrasions ), Frictional wounds (e.g. diaper rash, friction blisters), pressure sores (e.g. pressure sores or ulcers), thermal wounds (directly or burns from cold and heat and electrical sources through conduction, convection or radiation) , Chemical wounds (e.g. acid or alkali burns) or pathogenic infections (e.g. viral, bacterial or fungal infections), including open or intact boils, skin rashes, scratches and acne, ulcers, chronic wounds (diabetic-related wounds, Such as lower leg and foot ulcers, venous leg ulcers and pressure sores), skin grafts / transplant donors and recipient sites, immune response abnormalities such as psoriasis and eczema, stomach or intestinal ulcers, oral ulcers Oral wounds, damaged cartilage or bone, and may include a cut wound and corneal lesions.

The pharmaceutical composition according to the present invention may further include other conventional agents having wound healing functions such as anti-inflammatory agents, antimicrobials, analgesics, alleviators or astringents, apart from the above-mentioned effective ingredients. Those skilled in the art will be readily able to practice the invention. In addition, moisturizers, skin protectants and preservatives may be further added.

Excipients or carriers included in the pharmaceutical composition for treating wounds according to the present invention include those commonly used in gels, pastes, ointments, frosts, powders, emulsions or aerosol formulations. The composition ratio of the carrier and other additives as described above is determined according to the dissolution rate and properties of the effective drug.

In addition, the pharmaceutical composition for wound treatment according to the present invention may be used in addition to cosmetics, washing lotions or sunscreens.

The dosage of the pharmaceutical composition according to the present invention is a conventional external preparation, preferably applied in the morning and evening in an appropriate amount depending on the affected area once to several times a day.

The preferred dosage of the composition of the present invention varies depending on the condition and the weight of the patient, the degree of disease, the type of drug, the route of administration and the period of time, but can be appropriately selected by those skilled in the art. However, for the desired effect, the composition of the present invention is preferably administered at 0.0001 to 100 mg / kg, preferably at 0.001 to 10 mg / kg. Administration may be administered once a day or may be divided several times. The dosage does not limit the scope of the invention in any aspect.

Hereinafter, the present invention will be described in detail by way of examples. However, these examples are intended to illustrate the present invention in more detail, and the scope of the present invention is not limited to these examples.

<Examples 1 to 3>

Preparation of a wound healing composition according to the present invention

To prepare a composition for wound treatment according to the invention in the composition ratio as shown in Table 1. First, 1000 ml of purified water was kept at 50 to 60 ° C., and then potassium chloride, potassium carbonate, magnesium chloride, sodium citrate, calcium lactate, white sugar and refined glucose were added in turn according to the following composition ratio, and gradually stirred to dissolve. After stabilization, the composition of the present invention was prepared by filtering with a membrane filter having a pore diameter of 0.2 μm to obtain a clear pale off-white liquid mixture in which impurities were removed.

Components and Contents of the Composition for Wound Care According to the Present Invention ingredient Example 1 Example 2 Example 3 Purified water 1000 ml 1000 ml 1000 ml Potassium chloride 100 g 100 g 80 g Potassium carbonate 600 g 540 g 400 g Magnesium chloride 20g 15 g 20g Sodium citrate 50 g 70 g 30 g Calcium lactate 20g 10g 20g White sugar 150 g 180 g 300 g Refined Glucose 30 g 20g 50 g

<Example 1>

Preparation of Paste Formulations Using Compositions of the Invention

The composition of the present invention prepared in Example 1 was prepared by the conventional formulation method for preparing a wound composition for wound healing.

<Example 2>

Preparation of the ointment using the composition of the present invention

The pharmaceutical composition for wound treatment in the form of an ointment was prepared by the conventional formulation method of the composition of the present invention prepared in Example 2.

Experimental Example 1

Burn treatment effect of the composition for wound healing of the present invention

The inventors carried out the following experiments on the effect of the composition of the present invention to treat recall. That is, healthy New Zealand White Rabbits (Animal Breeding Center) of 2 weeks old (2 kg body weight) were fed with unlimited feed (drinking feed) and water (drinking water) under breeding conditions. Subsequently, 2 × 2cm wide skin located 5% horizontally from the inferior border of scapular of the experimental animal skin was designated as an image processing site, and the designated area was disinfected, The plate was burned with a metal plate having a width of 2 cm. After 2 hours, the experimental group and the control group was treated only by disinfection treatment using the potadidine applied to the wound treatment composition prepared in Example 2 in an amount of 0.025 g / cm ² to the burned area at 8 hour intervals for 5 days. In the control group and the test group, the ratio of the image area to the initial image area was determined to determine the image residual rate (%), and the results are shown in Table 2 below.

Change in Image Retention Ratio (%) with Time Elapsed days Control Experimental group One 90.3 ± 0.6 82.1 ± 0.8 2 84.4 ± 0.4 57.3 ± 0.4 3 80.8 ± 0.4 30.1 ± 0.3 4 67.2 ± 0.3 11.6 ± 0.4 5 60.8 ± 1.2 2.8 ± 0.6

As a result, as shown in Table 2, it can be seen that the image survival rate of the experimental group is rapidly reduced, the blister remained for about 3.5 days in the control group, but in the experimental group because the remaining time of the blister in the experimental group was only 20 hours In terms of removal of the wound composition of the present invention was found to be excellent.

So far I looked at the center of the preferred embodiment for the present invention. Those skilled in the art will appreciate that the present invention can be implemented in a modified form without departing from the essential features of the present invention. Therefore, the disclosed embodiments should be considered in an illustrative rather than a restrictive sense. The scope of the present invention is shown in the claims rather than the foregoing description, and all differences within the scope will be construed as being included in the present invention.

Claims (4)

A pharmaceutical composition for treating wounds, comprising potassium chloride, potassium carbonate, magnesium chloride, calcium lactate, sodium citrate, white sugar, refined glucose, and water. According to claim 1, 8 to 10 parts by weight of potassium chloride, 40 to 60 parts by weight of potassium carbonate, 1 to 2 parts by weight of magnesium chloride, 1 to 2 parts by weight of calcium lactate, based on 100 parts by weight of purified water heated to 50 to 60 ° C, Sodium citrate, 3 to 7 parts by weight, per white sugar 15 to 30 parts by weight and tablets for the pharmaceutical composition for wound treatment comprising 2 to 5 parts by weight of glucose. The pharmaceutical composition for treating wounds, according to claim 1, wherein the pharmaceutical composition for treating wounds comprises a pharmaceutically acceptable excipient or carrier. A pharmaceutical composition for treating wounds according to any one of claims 1 to 3, wherein the pharmaceutical composition for wound treatment is an agent selected from the group consisting of gels, pastes, ointment frosts, powders, emulsions and aerosols. Composition.