RU2325175C2 - Ointment for burns, dermatoses treatment and wound healing - Google Patents

Abstract

FIELD: medicine; pharmacology.

SUBSTANCE: ointment for burns, dermatoses treatment and wound healing contains turpentine, beeswax, sea-buckthorn oil, cow's butter, pig's fat and biologically active substance selected from: aloe extract, plantain extract, beggars-ticks extract, rosehip extract, St. John's wort oil, linseed oil, calendula oil, bur oil, camomile oil, or propolis.

EFFECT: stimulating effect on regenerative processes in connective tissues and epithelium.

19 ex

Description

The invention relates to pharmaceuticals and relates to an ointment for external use with biostimulating properties for the treatment of burns, skin diseases and wound healing, which can also be used in cosmetology.

Known ointment "Benin" for the treatment of purulent and infected wounds of various etiologies, including fir oil, propolis, conifers, spermaceti and penguin fat with a mass ratio of components 3-7: 0.5-1.5: 0.5-1.5 : 1.5-2.5: 7-15, respectively (RF patent No. 2058776, IPC 6 A61K 9/06, publ. 04/27/96).

A disadvantage of the known ointment is the presence in the formulation of the known ointment of spermaceti and penguin fat, the availability and raw materials of which are limited.

Known ointment "Zvar" for the treatment of purulent and infected wounds of various etiologies, containing the following components, wt.%: Coniferous resin (resin of pine or spruce) - 7.0-8.0; beeswax - 6.7-7.3; butter - 6.5-7.5; vegetable oil - 6.5-7.5; interior fat (pork, or beef, or goose, or sheep) - 19.0-22.0; propolis - 0.5-1.0; onion turnip - the rest (RF patent N 2139708, IPC 6 АКК 9/06, publ. 20.10.99).

A disadvantage of the known ointment is an insufficient spectrum of therapeutic action and the presence of inaccessible components in the formulation.

The closest technical solution to the proposed solution is an ointment for the treatment of inflammatory and post-traumatic diseases of the musculoskeletal system and peripheral nervous system, containing resin of pine or spruce, beeswax, propolis and vegetable oil, mummy, fir oil and sea buckthorn oil in the following ratio of components, wt.%: resin of pine or spruce - 5.0-15.0; beeswax - 5.0-15.0; propolis - 1.0-3.0; mummy - 0.1-0.3; fir oil - 1.0-4.0; sea buckthorn oil - 1.0-5.0; vegetable oil - the rest (RF Patent No. 2190389, IPC 7 A61K 9/06, publ. 10.10.2002).

A disadvantage of the known ointment is an insufficient range of therapeutic effects due to the low content of active components in the ointment. The known composition does not allow to maintain the high quality of the ointment for a long time, and is also inconvenient to use due to poor fixation and uneven distribution on the skin surface.

The technical problem to which the invention is directed is the creation of a domestic drug in the form of an ointment with pronounced anti-inflammatory, antiviral and regenerative effects with good fixation and uniform distribution on the skin surface, convenient to use with a pronounced prolonged action.

The technical task is solved in that the ointment for the treatment of burns, skin diseases and wound healing, containing gum, beeswax, sea buckthorn oil, according to the invention further includes a fat base containing cow oil and pork fat in the following ratio, wt.%:

Sap 5.0-15.0 Beeswax 5.0-10.0 Cow butter 10.0-20.0 Sea buckthorn oil 5.0-10.0 Pork fat Rest

The ointment additionally includes a biologically active substance in an amount of 3.0-5.0 wt.%, Selected from the group: aloe extract, plantain extract, propolis, succession extract, rosehip extract, hypericum oil, linseed oil, calendula oil, burdock oil, oil daisies.

The given quantitative intervals of the ratio of the components that make up the ointment were determined experimentally, are optimal and provide maximum effectiveness of the ointment. Deviation from the proposed ratio of the components is impractical, since the therapeutic effect is reduced.

So, the content of beeswax should be in the range of 5-10 wt.%. An increase in its content in excess of 10 wt.% And a decrease in less than 5 wt.% Leads to a deterioration in the plasticity of the ointment, which is manifested in the inconvenience of using the ointment.

An increase in the content of cow oil over 20 wt.% Leads to an ointment of liquid consistency spreading over the surface of the skin, which prevents the creation of a maximum concentration of ointment at the location of the burn or wounds, and a decrease in the amount of cow oil less than 10 wt.% Leads to thickening of the ointment worsens the uniformity of its application to the affected area of the body.

A decrease in the amount of sea buckthorn oil below 5.0 wt.% Leads to a decrease in the effectiveness of this component in the composition of the ointment, and an increase in the amount of sea buckthorn oil more than 10 wt.% Leads to an ointment of liquid consistency spreading over the skin surface, which also leads to inconvenience of use ointments.

An increase in the amount of resin in the composition of the ointment more than 15 wt.% Causes a local irritant effect and leads to pain, and a decrease in the amount of less than 5.0 wt.% Reduces the effectiveness of the ointment.

The use of the aforementioned extracts and oils of biologically active substances of aloe in concentrations of less than 3.0% does not have sufficient antibacterial activity, and when using concentrations greater than 5.0%, ointment separation may occur.

Achieving this goal is also due to the fact that the proposed ointment has a multifaceted effect: antiseptic, necrolytic, anti-inflammatory and wound healing due to the natural components that make up the ointment, which have a wide spectrum of biologically active action.

The technical result, which is achieved by using the totality of the claimed essential features, is to increase the effectiveness of treatment. reducing the time of treatment of the skin surface due to the therapeutic effect of the components of the ointment, good fixation on the surface and prolonged action, as well as the convenience and hygiene of the proposed ointment.

The components of the ointment each individually have a therapeutic effect on the skin.

Pork fat has a calming and moisturizing effect, in addition, pork fat has long been used as a remedy for burns.

Cow butter also has similar properties, but in a more fluid consistency. Cow butter has a high immunobiological and bactericidal property, it is rich in micro and macro elements. Cow butter in its composition contains vital organic acids, and also contains a large amount of fat-soluble vitamins A, E, B1, B2, B6, C. The inclusion of up to 20% of cow's oil in the ointment components (20.0 g per 100.0 g ointments) gives the ointment a finely divided state, due to which it is easily absorbed by the skin.

Beeswax helps to heal wounds and cracks, nourishes and strengthens the skin. Chemical wax is close to fats. The wax contains free alcohols and fatty acids, as well as a large amount of vitamin A. The presence of carotene and vitamin A in wax makes it useful in the treatment of many skin diseases, delays the growth of a number of pathogens, and has an antibiotic effect. In the ointment, beeswax facilitates the formation of an emulsion and increases its stability, and due to its nature improves its absorption property.

Zhivitsa is a biologically active substance that enhances the regenerative processes of connective tissues and skin. Coniferous resin (resin) is obtained by counting ripe stands. The healing properties of resin of pine, spruce, fir and cedar have long been known and are widely used in medicine. The resin resin of conifers is evolutionarily adapted to suppress infection in wound surfaces.

Sea buckthorn oil is the richest source of vitamin A, and also has a high content of vitamin E. Sea buckthorn oil has an epithelizing effect, promotes healing of wounds, cracks in the arms and legs, resorption of scars, is used for thermal and chemical burns, frostbite and radiation damage to the skin, as well as for the treatment of various skin diseases: eczema, dermatitis, psoriasis. It also has analgesic, antiseptic, antioxidant, capillary-strengthening properties.

Aloe has a softening, moisturizing and preventive anti-inflammatory effect. The effect of aloe is enhanced by the content of vitamin E, which has an antioxidant effect, aloe gives the ointment a significant anti-inflammatory effect, it also has a bactericidal effect. Aloe promotes wound healing, is used for burns, frostbite and radiation damage to the skin, is used to treat dermatitis, ulcers, acne, abscesses and abscesses.

St. John's wort is primarily known as a medicinal plant, because it contains hypercytin, flavonoids, hyperoside, rutin, quartzetine, essential oil, tarry substances, carotene; rich in vitamins C, PP, tannins. St. John's wort oil has bactericidal properties, an antiseptic effect on infected wounds, a pronounced astringent and antimicrobial effect, promotes tissue regeneration, soothes irritated skin.

Calendula contains bitter substances, mucus (2.5%), organic acids, essential oil, beta-carotene, vitamin C, flavonoids, bioflavonoids, saponins, tannins, resins (over 3%), inulin. Calendula oil has anti-inflammatory, antiseptic, wound healing, disinfectant, analgesic effects and is used to treat wounds, bruises, purulent inflammations, to protect against the formation of disfiguring scars during wound healing, skin rashes, lichens, and swelling caused by frostbite.

Flaxseed oil is obtained by hot pressing from crushed seeds. The exceptional value of this oil lies in the high content of unsaturated fatty acids (linolenic, linoleic, oleic), which are more in it than in any of the known vegetable oils. The oil obtained by cold pressing at t = 40-45 ° C is a "living" product and retains all useful biologically active substances, vitamins and phospholipids. Flaxseed oil helps to heal wounds and cracks, is used for burns and radiation damage to the skin, soothes irritated skin. It promotes faster regeneration of affected tissues.

Plantain has a hemostatic, anti-inflammatory and bactericidal effect, which are due to polysaccharides (mucus, pectins), carotenes and vitamin U. The inclusion of plantain extract in the ointment accelerates the healing of wounds and cracks, soothes irritated skin.

Propolis is a product of the vital activity of bees. Propolis has a bactericidal, antiviral, fungicidal, anti-inflammatory, biostimulating, anti-allergic, analgesic, dermatological effect. Amino acids, organic acids, antibiotic and tannins, balms, essential oils, carbohydrates, mineral salts, vitamins, trace elements and other components that make up propolis determine its diverse pharmacological properties. It exhibits antimicrobial activity against more than 100 types of bacteria, fungi and viruses, positively affects the immunological reactivity of a person (Sinyakov AF, Bee first-aid kit. M.: Physical education and sports, 1995, p.100-101, 104-145) Propolis promotes wound healing, is used for burns and frostbite, soothes irritated skin, and is used in folk medicine to treat eczema, furunculosis, psoriasis, and erysipelas.

Burdock oils are easily absorbed into the skin and contribute to the rapid penetration of vitamins A and E into the skin, and have wound healing properties.

Chamomile contains essential oils, as well as flavonoids and coumarin. Chamomile essential oil has disinfecting and anti-inflammatory properties due to the presence of chamazulene in it, helps to heal cracks in the arms and legs, helps with burns and frostbite, and reduces the skin allergic reaction.

The sequence contains essential oil, flavonoids, cinnamic acid derivatives, tannins with a high content of polyphenol fractions, polysaccharides, carotenoids and coumarins, chalcones. The combination in a series of flavonoids and water-soluble polysaccharides helps to improve the absorption of the plant complex of the series and increase its activity. A series of flavonoid compounds (flavones and chalcones) have a bacteriostatic and insecticidal property. The antimicrobial and anti-inflammatory properties of the extract of the series are associated with tannins, which are composed of the simplest in structure polyphenols with pronounced antimicrobial properties. The pronounced antimicrobial properties of the series are associated, in addition, with a high content of manganese. The series promotes wound healing, soothes irritated skin, reduces skin allergic reactions, and is used in folk medicine to treat eczema, skin and acne, furunculosis, psoriasis and dermatitis.

Rosehip extract have a variety of pharmacological activity, mainly due to ascorbic acid, which has reducing properties and promotes tissue regeneration. Rosehip helps to heal wounds, absorb scars, soothe irritated skin, and is used to treat eczema, dermatitis, psoriasis and ulcers.

In the proposed ointment, the fat base, for example, softens the focus of inflammation, sea buckthorn oil gives a therapeutic effect, gum promotes accelerated healing.

Despite the fact that the individual components of the ointment or their combination are found in well-known therapeutic ointments for this purpose, the claimed combination of ingredients and their ratio in the composition of the ointment were not found. The inventive combination of components, taken in experimentally selected, optimal amount, provides the claimed therapeutic effect. Other ratios of the components taken do not allow achieving the necessary therapeutic effect in a short time.

The invention is illustrated by the following examples of specific performance.

Example 1. Preparation of ointment

Heated to a liquid state and filtered pork fat (650 g), cow oil (150 g) and beeswax (100 g) are mixed and pine gum is added (50 g). The resulting mixture is thoroughly mixed and heated to 120-130 ° C. Then the mixture is cooled to 70 ° C and mixed with sea buckthorn oil (50 ml). After mixing to a homogeneous mass, the resulting ointment is poured in a hot state into the prepared container. The ointment is a uniform, thick, viscous mass with a pleasant smell. The ointment is non-toxic. The melting point of the obtained ointment is 50 ° C. The ointment is stored in a dark, cool place at a storage temperature of 0-15 ° C, protecting from direct sunlight. Shelf life - 1 year without loss of initial activity.

Example 2

The inventive ointment is prepared analogously to example 1 with the following content of components, wt.%: Gum - 10.0%; beeswax - 5.0%; cow oil - 15.0%; sea buckthorn oil - 5.0%; aloe extract - 3.0%; pork fat - 62%.

Example 3

The inventive ointment is prepared analogously to example 1 with the following content of components, wt.%: Gum - 10.0%; beeswax - 5.0%; cow oil - 15.0%; sea buckthorn oil - 5.0%; plantain extract - 3.0%; pork fat - 62%.

Example 4

The inventive ointment is prepared analogously to example 1 with the following content of components, wt.%: Gum - 10.0%; beeswax - 5.0%; cow oil - 15.0%; sea buckthorn oil - 5.0%; succession extract - 3.0%; pork fat - 62%.

Example 5

The inventive ointment is prepared analogously to example 1 with the following content of components, wt.%: Gum - 13.0%; beeswax - 10.0%; cow oil - 15.0%; sea buckthorn oil - 8.0%; propolis - 5.0%; pork fat - 49%.

Example 6

The inventive ointment is prepared analogously to example 1 with the following content of components, wt.%: Gum - 5.0%; beeswax - 8.0%; cow oil - 15.0%; sea buckthorn oil - 6.0%; rosehip extract - 4.0%; pork fat - 62%.

Example 7

The inventive ointment is prepared analogously to example 1 with the following content of components, wt.%: Gum - 10.0%; beeswax - 5.0%; cow oil - 15.0%; sea buckthorn oil - 7.0%; St. John's wort oil - 3.0%; pork fat - 60%.

Example 8

The inventive ointment is prepared analogously to example 1 with the following content of components, wt.%: Gum - 10.0%; beeswax - 5.0%; cow oil - 15.0%; sea buckthorn oil - 7.0%; marigold oil - 3.0%; pork fat - 60%.

Example 9

The inventive ointment is prepared analogously to example 1 with the following content of components, wt.%: Gum - 12.0%; beeswax - 10.0%; cow oil - 10.0%; sea buckthorn oil - 10.0%; linseed oil - 3.0%; pork fat - 55.0%.

Example 10

The inventive ointment is prepared analogously to example 1 with the following content of components, wt.%: Gum - 15.0%; beeswax - 10.0%; cow oil - 10.0%; sea buckthorn oil - 5.0%; burdock oil - 3.0%; pork fat - 57.0%.

Example 11

The inventive ointment is prepared analogously to example 1 with the following content of components, wt.%: Gum - 10.0%; beeswax - 7.0%; cow oil - 20.0%; sea buckthorn oil - 10.0%; chamomile oil - 3.0%; pork fat - 50.0%.

The ointment is applied to the skin or to sterile gauze wipes in the form of compresses, depending on the degree of damage. When applied to an open wound or burn, the claimed ointment allows you to remove the dressing without damaging the fragile epithelium, while changing the dressings is carried out until the epithelization is completed.

With radiation burns and lesions, the ointment is applied externally in the form of ointment dressings 1-2 times a day at a dose of 2-5 g with a course of treatment of 10-20 days.

With thermal burns and lesions, the ointment is applied externally in the form of ointment dressings 1-2 times a day at a dose of 10-50 g (depending on the area of the lesion) with a course of treatment of 7-21 days.

With eczema, atopic dermatitis, keratoderma, ichthyosis, the claimed ointment is applied to the affected areas of the skin 2-3 times a day with a thin layer, rubbing it with the fingertips, with light circular movements.

With dry skin, deep and painful cracks in the hands and feet, the claimed ointment is used 3-4 times a day.

Contraindication to use is individual intolerance (allergy).

Example 12

Patient V. - 23 years. Handled with a thermal burn of 3 degrees in size about 15 cm in diameter. For treatment, an ointment prepared according to Example 2 was prescribed. An ointment dressing was applied 3 times a day to the burn site. Inflammation stopped on the third day of applying the ointment. On the seventh day of treatment, a smooth pink skin was formed at the burn site. Complete healing occurred after a 20-day treatment. At the burn site, scars and screeds were not observed.

Example 13

Patient I. - 35 years old. I was treated for psoriasis for one year with various medications, including ointments: ichthyol, sulfur-tar, salicylic, but no lasting positive effect was observed. An ointment prepared according to Example 5 was prescribed for treatment. After 35 days, papules with a diameter of up to 2 cm completely disappeared, "plaques" in their place also resolved, the skin turned pinkish, the itching disappeared. No allergies were observed.

Example 14

Patient L. - 10 years. Diagnosis: pyoderma. The lesions are localized on the hands, neck and lower face. For treatment, an ointment prepared according to Example 11 was prescribed. The inventive ointment was applied to foci of skin lesions daily 2 times a day. After 6 days, epithelization of the affected areas of the skin began.

Example 15

Patient S. - 32 g. He complained of a long non-healing wound; skin hyperemia with edema and infiltration with purulent compartments was observed. For treatment, an ointment prepared according to Example 7 was prescribed. The inventive ointment was applied to the wound 2 times a day and applied at night in the form of an ointment dressing. On the fourth day, hyperemia and edema subsided, the wound cleansed of pus, and infiltration decreased. On the fifth day, epithelization began and by the ninth day the wound healed.

Example 16

Patient T. - 40 years old. She complained of cracks in the heels of her legs. For treatment, an ointment prepared according to Example 9 was prescribed. The ointment was applied 4 times a day. After two or three days, the cracks healed, the skin on the heels of the legs cleansed and became softer.

Example 17

Patient S., 19 years old. Diagnosis: folliculitis of the chin, left half of the face and neck. There is an increase in temperature. There are pustules ranging in size from 2 to 5 mm in diameter with a pink-red inflammatory rim; slight pain. For treatment, an ointment prepared according to Example 3 was prescribed. The ointment was applied to the affected areas of the skin 2-3 times a day. On the 3rd day, the contents of the abscesses dried into a brown crust, after tearing off of which there was slight pigmentation and peeling. By the fifth day, the manifestations of folliculitis are completely stopped. It was recommended to continue the lubrication procedure with a frequency of 1-2 times a day. On the 8th-9th day, the manifestations of folliculitis and associated symptoms are completely eliminated. The patient's condition is satisfactory.

Example. eighteen.

Patient L., 41 years old. Received complaints of itching and skin rashes. Diagnosis: allergic dermatitis. For treatment, an ointment prepared according to Example 8 was prescribed. The ointment was applied to the affected areas of the skin 2 times a day. Already on the 5th day, significant improvements in the condition of the skin were observed: itching decreased, the affected areas noticeably turned pale. The duration of treatment was 14 days. When examining the patient on the 14th day of treatment, it was noted that the condition improved significantly, skin itching did not bother, and skin elasticity was restored.

Example 19

Patient D. 28 years. He complained of burning, itching, rashes and pustules on the skin of the hands, suffers from eczema for six months. For treatment, an ointment prepared according to Example 8 was prescribed. The ointment was rubbed with a thin layer in the area adjacent to the affected skin, 2 times a day. On the 3rd day, itching, burning, and the number of pustules decreased, especially around the affected area, which also decreased. On the 6th day, abscesses, itching and burning were practically absent. Further, the infiltration stopped, the area of the affected area decreased, and the ointment was rubbed into the areas that left the affected area. In previously affected areas, especially on the periphery, brown crusts began to be torn off, after which slight pigmentation remained. On day 14, treatment was completed. The patient's condition is satisfactory.

The claimed ointment was treated in almost all cases with a positive result; accelerated wound healing was observed without complications and side effects. Using the proposed ointment showed a stimulating effect of the ointment on the regenerative processes of connective tissue and epithelium, which indicates the biostimulating effect of the ointment and is confirmed by a reduction in the healing time of wounds with good fixation and uniform distribution on the skin surface and ease of use.

Claims (1)

An ointment for the treatment of burns, skin diseases and wound healing, containing gum, beeswax, sea buckthorn oil, characterized in that it additionally contains cow oil and pork fat, as well as plant-derived substances selected from the group: aloe extract, plantain extract, extract series, rosehip extract, St. John's wort oil, marigold oil, chamomile oil, linseed oil, burdock oil or propolis in the following ratio, wt.%: sap 5.0-15.0 beeswax 5.0-10.0 cow butter 10.0-20.0 sea buckthorn oil 5.0-10.0 plant matter origin or propolis 3.0-5.0 pork fat rest