RU2190389C1 - Ointment for treating inflammatory and posttraumatic diseases of locomotor apparatus and peripheral nervous system - Google Patents

Abstract

FIELD: medicine, particularly, pharmaceutical industry for production of ointment designed for treatment of inflammatory and posttraumatic diseases of locomotor apparatus and PERIPHERAL nervous system. SUBSTANCE: ointment contains the following components, mas.%: pine tree or spruce oleoresin, 5.0-15.0; beeswax, 5.0-15.0; propolis, 1.0-3.0; mumiyo, 0.1-0.3; fir oil, 1.0-4.0; sea buckthorn oil, 1.0-5.0; vegetable oil, the balance. EFFECT: broadened range of healing effect and field of application. 2 cl, 9 ex

Description

 The invention relates to medicine, in particular to pharmacology, and can be used to obtain therapeutic ointments with a wide range of anti-inflammatory effects for the treatment of purulent-inflammatory processes of the skin, as well as inflammatory and post-traumatic diseases of the musculoskeletal system and peripheral nervous system.

 Known ointment "Benin" for the treatment of purulent and infected wounds of various etiologies, including fir oil, propolis, conifers, spermaceti and penguin fat with a mass ratio of components 3 - 7: 0.5 - 1.5: 0.5 - 1.5 : 1.5 - 2.5: 7-15, respectively (RF patent 2058776, class A 61 K 9/06, publ. 04/27/96).

 A disadvantage of the known ointment is the presence in the formulation of the last spermaceti and penguin fat, the availability and raw materials of which are limited.

 Known anti-inflammatory ointment "Pihtoin" containing, wt.%: 19.0 - 21.0 pine resin; 16.8 - 17.5 beeswax; 10.5 - 12.0 chalk; industrial oil - the rest (RF patent 2097056, class A 61 K 35/78, 9/06, publ. 11/27/97).

 A disadvantage of the known ointment is the limited area of use (veterinary medicine), due to the fact that the ointment contains industrial oil as a fat base.

 Known ointment for the treatment of purulent skin diseases and osteomyelitis, containing, weight. %: animal fat - 40, tar - 5, resin gum (fir) - 12, gruel of onion - 20, wax - 3, propolis - 10, purified sulfur - 5, copper sulfate - 2.48, baby soap - 2, 48, chicken intestinal mucus - 0.04 (RF patent 2135158, class A 61 K 9/06, publ. 27.08.99).

 The disadvantages of the known ointments are a narrow range of therapeutic effects and the content of inaccessible components.

 The closest to the claimed ointment - the prototype, is the ointment "Zvar" for the treatment of purulent and infected wounds of various etiologies, containing the following components, wt. %: coniferous resin (resin of pine or spruce) - 7.0 - 8.0; beeswax - 6.7 - 7.3; butter - 6.5 - 7.5; vegetable oil - 6.5 - 7.5; interior fat (pork or beef or goose or sheep) - 19.0 - 22.0; propolis - 0.5 - 1.0; onion turnip - the rest (RF patent N 2139708, class A 61 K 9/06, publ. 20.10.99).

 A disadvantage of the known ointment is an insufficient range of therapeutic effects and the presence of inaccessible components in the formulation.

 The aim of the invention is the expansion of the therapeutic effect of the ointment and its scope.

 An additional goal is to expand the range of therapeutic ointments while ensuring the availability of the starting components.

This goal is achieved by the proposed ointment formulation containing the following components, wt.%:
Zhivitsa pine and / or spruce - 5.0 - 15.0
Beeswax - 5.0 - 15.0
Propolis - 1.0 - 3.0
Mummy - 0.1 - 0.3
Fir oil - 1.0 - 4.0
Sea buckthorn oil - 1.0 - 5.0
Vegetable Oil - Else
The proposed ointment is used for long non-healing wounds, trophic ulcers, bedsores; for the treatment of clean and infected wounds and purulent-inflammatory diseases of the skin and subcutaneous tissue (furunculosis, pyoderma, etc.); in inflammatory and post-traumatic diseases of the musculoskeletal system and peripheral nervous system (arthritis, arthralgia, osteoarthritis, osteochondrosis, myositis, myalgia, neuralgia, damage to the ligamentous apparatus, bruises, closed fractures).

 The proposed ointment is prepared as follows.

 Previously, the mummy is dissolved in warm water, in a ratio of 1:10. After complete dissolution of the mummy, the solution is fixed with 96:% alcohol in a ratio of 1: 1. The addition of alcohol is necessary for subsequent mixing with the oily components of the ointment. Then, coniferous resin, wax, fir, sea buckthorn and vegetable oil are loaded into a container in a water bath in accordance with the recipe, options, and calculated weight. The resulting mass is heated in a water bath and mixed until complete mutual dissolution of the incorporated components. Then, in a container in a water bath with a prepared hot solution of the components of the ointment, an alcohol solution of propolis is poured with constant stirring, then a water-alcohol solution of mummy. After mixing to a homogeneous consistency, the resulting mass is poured in a hot state into wide-necked bottles, jars of the required volume with the appropriate label.

 Ointment at room temperature is a homogeneous mass of yellow-orange color with a pleasant smell of coniferous resin. In contact with the skin of the body and when rubbing, the ointment is well absorbed into the skin.

 Contraindication to use is individual intolerance to the components of the ointment.

 The use of ointment: the ointment is applied in a thin layer on a gauze napkin folded in two layers and applied to the wound, then a napkin with ointment is strengthened with a bandage or plaster. Change the dressing with ointment 1-2 times a day. The inventive ointment is used to treat shallow wounds with a good outflow of wound exudate. For the treatment of inflammatory diseases of the musculoskeletal system - a small amount of ointment is carefully rubbed into the skin of the painful area.

 The determining significant difference of the claimed ointment from the prototype is that it additionally contains mummy, fir oil and sea buckthorn oil in an experimentally selected, optimal amount, which, together with the known components: coniferous resin, propolis, beeswax and vegetable oil, allows you to expand the range of therapeutic effects and the scope of the ointment, namely, in addition to treating purulent and infected wounds of various etiologies (prototype ointment), use the ointment for the treatment of inflammatory and post-traumatic diseases timetotal musculoskeletal system and peripheral nervous system.

 Separate components of the ointment or their groups are found in well-known therapeutic ointments, however, only this combination of components, taken in an experimentally selected, optimal amount, provides a qualitatively new therapeutic effect. Other ratios of the components taken do not allow achieving the necessary therapeutic effect in a short time.

 Achieving this goal is also due to the fact that the proposed ointment has a multifaceted effect: antiseptic, necrolytic, anti-inflammatory and wound healing, thanks to the natural components that make up the ointment, which have a wide spectrum of biologically active action.

 Propolis is a vital product of bees that collect resinous secretions of plants, trees, buds and, together with wax, disinfect the hive insides, frames, cracks, crevices, etc. with these plant resins. Propolis has a bactericidal, antiviral, fungicidal, anti-inflammatory, biostimulating, anti-allergic, analgesic, dermatological effect.

 Mummy - is known among many peoples of the world since ancient times as a unique natural stimulant.

In the middle mountains of Siberia, the mummy is a product of the activity of the high-altitude vole of the Senostavka Alticola strelzowi, which live in colonies, large families at altitudes of up to 3 km and form perennial deposits of their excrement. In winter, field voles feed on harvested haystacks consisting of dozens of high-mountain medicinal herbs. The aqueous extract of caked excrement, evaporated in different ways at a temperature of 50-70 ^o C to a solid state, is a mummy, ready to eat. Thus, the mummy is a combination of biologically active substances, vitamins, amino acids, macro- and microelements in the form of easily digestible organometallic complexes. Mummy with external or internal use has a beneficial effect on all life processes in the body.

 Coniferous resin (resin) is obtained by counting ripe stands. The large-tonnage production of pine resin in many forestries of Siberia has been established. Rosin and gum turpentine are produced from gum. The healing properties of resin of pine, spruce, fir and cedar have long been known and are widely used by traditional healers. The resin resin of conifers is evolutionarily adapted to suppress infection in wound surfaces.

 Fir oil as a product of the processing of fir paws, i.e. needles and ground fir branches, contains about 40 biologically active compounds in a naturally evolutionary balanced ratio, which provides a stable response to almost any microbial infection. It has a tonic, antimicrobial, antiviral, tonic effect. The oil is effective for suppuration, diathesis, psoriasis, diaper rash, boils, herpes, pain in the joints of the arms and legs, fractures, bruises, polyarthritis, osteochondrosis, radiculitis, varicose veins.

 Sea buckthorn oil is obtained from a mixture of fruits and leaves. It contains up to 40 carotenoids, tocopherols, oleic, linoleic, palmitic, stearic acids, vitamins C, A, P, E, K. It has an epithelizing effect, stimulates the healing of skin and mucous membrane lesions (radiation, burns, ulcers). It has analgesic, antiseptic, antioxidant, capillary-strengthening properties.

 A search in the patent and scientific and technical literature did not reveal known therapeutic ointments containing a combination of the above components in the proposed quantitative ratio, which allows us to conclude that the claimed technical solution meets the criteria of "novelty" and "inventive step".

 The invention is illustrated by the following examples of specific performance.

 Example 1. Preparation of ointment.

 A container with a volume of 1.5 - 2 liters is placed in a water bath and 50 g of pine resin, 50 g of wax, 10 ml of fir oil, 10 ml of sea buckthorn oil and 870 ml of sunflower oil are successively loaded. The resulting mass is heated in a water bath and stirred until the components are completely dissolved. Then load 10 ml of propolis (10% alcohol solution) and 20 ml of an aqueous-alcoholic solution of mummy (1 g of dry mummy. After stirring to a homogeneous mass, the ointment obtained is poured into a prepared container in a hot state. The ointment is stored in a glass dish in a dark , cool place up to 5 years, without loss of initial activity.

 Example 2

The inventive ointment is prepared analogously to example 1 with the following content of components, wt.%:
Zhivitsa ate - 5.0
Beeswax - 10.0
Propolis - 2.0
Mummy - 0.2
Fir Oil - 2.0
Sea buckthorn oil - 2.0
Corn oil - 78.8
Example 3

The inventive ointment is prepared analogously to example 1, with the following content of components, wt.%:
Zhivitsa pine - 15.0
Beeswax - 15.0
Propolis - 3.0
Mummy - 0.3
Fir Oil - 4.0
Sea buckthorn oil - 5.0
Olive Oil - 57.7
Example 4

 Patient V., 12 years old, diagnosis: pyoderma. The lesions are concentrated on the hands of both hands, neck and lower face.

 The proposed ointment was applied to the lesions of the skin daily 2 times a day. After 6 days, the epithelization of the affected areas of the skin began.

 Example 5

 Patient K., 32, complained of a long non-healing wound. Objectively: skin hyperemia, edema, infiltration with purulent compartments. Appointed: lubrication of the wound with the claimed ointment 2 times a day (morning and evening), and then at night applying a wipe with ointment to the wound. On the 3rd day, hyperemia and edema subsided, the wound cleansed of pus, infiltration decreased. On the 5th day, epithelization began, and on the 7th day, the wound healed.

 Example 6

 Patient M., 28 years old, complained of severe pain, burning after a burn with boiling water of the left hand. At the burn site, skin hyperemia, swelling, and a small number of vesicles were observed. A bandage with the claimed ointment was applied to the burn site, replaced 2 times a day. On the 2nd day, the pain sensations decreased, on the 3rd day, the bubbles subsided, the area of the burn lesion decreased in size; on the 6th day, the affected area began to be released from the crusts, under which the skin was pale pink. The treatment is completed on the 8th day.

Example 7 (osteochondrosis)
Patient M., 45 years old, complained of exacerbation of osteochondrosis. The treatment was carried out using massage of the spine followed by rubbing of the claimed ointment. After 5 sessions, the patient stopped pain, normal sleep was restored.

Example 8 (arthritis, arthrosis)
Patient 3., 67 years old, complained of exacerbation of chronic arthritis. The inventive ointment was rubbed 2 times a day in painful areas of the skin, which were then covered with a warm bandage. The duration of treatment was 10 days. On the 5th day of applying the ointment, the pain syndrome decreased, the volume of active movements in the joints of the arms and legs increased, the patient's mood improved.

Example 9 (damage to the joint, ligaments)
Patient K, 67 years old, diagnosis: front drawer of the right knee, trauma 30 years ago, joint deformation, pain when walking. The ointment was rubbed into the steamed knee (after a hot bath), regularly, in the evening. After the first procedure, severe pain stopped. Regular procedures relieved pain. In the future, after severe fatigue and the resumption of pain, the repetition of the procedure, even just rubbing the ointment with massage, stopped the pain and restored a relatively healthy state.

Using the proposed ointment will allow, in comparison with the prototype:
- increase therapeutic efficacy and expand the range of therapeutic effects of ointments;
- expand the scope of the ointment.

Claims (1)

1. An ointment for the treatment of inflammatory and post-traumatic diseases of the musculoskeletal system and peripheral nervous system, containing resin of pine or spruce, beeswax, propolis and vegetable oil, characterized in that it additionally contains mummy, fir oil and sea buckthorn oil in the following ratio of components , wt.%:
Zhivitsa pine or spruce - 5.0-15.0
Beeswax - 5.0-15.0
Propolis - 1.0-3.0
Mummy - 0.1-0.3
Fir oil - 1.0-4.0
Sea buckthorn oil - 1.0-5.0
Vegetable Oil - Else
2. Ointment according to claim 1, characterized in that as a vegetable oil it contains sunflower, or corn, or olive oil.