RU2405535C1 - Foot care cream-gel - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention belongs to cosmetic industry, notably to foot care cream gel making; abovementioned cream gel contains cosmetic base with eftiderm, ethereal oil of juniper, furacilin, ethereal oil of mint, propylenglycolic marigold extract, raisin-seed oil, jojoba oil, wheat germ oil, propilenglycolic aloe vera extract, bisabolol, propilenglycolic kalanchoe extract, propilenglycolic horse chestnut seed extract, propilenglycolic chamomile extract, citric acid, ethereal oil of sage, zinc and copper ions, vitamin B₂.

EFFECT: product intensifies cosmetic effects, notably, antifungal, anti-inflammatory, reparative, and deodorising, due to quick penetration in tissues.

2 tbl

Description

The invention relates to pharmacy and cosmetics, in particular to foot skin care products, and is mainly aimed at preventing the occurrence and elimination of cracks, dryness and peeling of the skin, fungal diseases, smell and sweating of the feet, increasing elasticity and turgor of the skin, normalizing blood supply to the feet .

Skin cosmetics are known which contain active substances and various additives. So, the cream for the skin of the body and face Malavtilin (Patent for the invention of the Russian Federation No. 2189808, registered on September 27, 2002) contains efthillin (in the composition of 40% eftederm), eleutherococcus extract, malavit, diphenhydramine, diclofenac and other components, has anti-inflammatory, antiseptic and analgesic action; prevents skin aging, heals minor injuries. However, it is not specifically designed for foot skin care.

Closest to patentable is foot cream (RF patent No. 2284180, publ. September 27, 2006), which contains a cosmetic base with eftederm, malavit, tincture (extract) of calendula, nitrofungin, juniper oil, eucalyptus and peppermint, tocopherol acetate (vitamin E ), retinol acetate (vitamin A), furatsilin and lidase.

The disadvantages of the prototype include the fact that its composition contains an insignificant amount of macro- and microelements, nutrients and components that contribute to the healing of cracks, elimination of dryness and peeling, fungal diseases, smell and sweating of the feet, to increase elasticity and turgor, normalize blood circulation and skin pH.

Anti-fungal, anti-inflammatory, reparative and deodorizing effects are not sufficiently expressed. In addition, it is necessary to simplify the method of applying the cream, because Before starting the use of foot cream, it is recommended to conduct a 20-minute hot foot bath with laundry soap, followed by treating the plantar surface of the feet with a foot grater or pumice stone. In the following days, daily foot wash with cool water at night.

The technical task is to increase the antifungal, anti-inflammatory, reparative and deodorizing effects, increase the content of nutrients, macro- and microelements by introducing new ingredients into the cream gel for feet, which, due to the transdermal activity of the eftederm, quickly penetrate into the tissues, prolonging and enhancing the effect compositions several times, as well as simplifying the method of applying the cream.

The technical result is achieved in that a foot gel cream, including a cosmetic base with eftederm, tincture of calendula, juniper essential oil, furatsilin, peppermint essential oil, characterized in that calendula propylene glycol extract is used as a tincture of calendula, and it additionally contains grape seed oil , jojoba oil, wheat germ oil, aloe propylene glycol extract, bisabolol, Kalanchoe propylene glycol extract, horse chestnut propylene glycol extract, propylene glycol extra kt chamomile, citric acid, essential oil of sage, zinc and copper ions, vitamin B _2, with the following component ratio, wt.%:

- grape seed oil 0.40-0.60 - jojoba oil 0.40-0.60 - wheat germ oil 0.40-0.60 - propylene glycol aloe vera extract 0.40-0.60 - bisabolol 0.20-0.40 - propylene glycol extract of Kalanchoe 0.10-0.20 - Calendula propylene glycol extract 0.10-0.20 - propylene glycol horse chestnut extract 0.10-0.20 - propylene glycol chamomile extract 0.10-0.20 Juniper essential oil 0.05-0.15 - lemon acid 0.04-0.06 - sage essential oil 0.02-0.04 - furatsilin 0.02-0.04 - zinc ions 0.01-0.02 - copper ions 0.01-0.02 - peppermint essential oil 0.001-0.002 - vitamin B ₂ 0,0002-0,0006 - cosmetic base with eftederm 97.60-96.00

The use of cream gel for feet: apply 2 times a day to clean skin of the feet for 2 weeks.

The following ingredients are used to make foot gel cream

Grape seed oil is an adaptogen, has a cytoprotective, antioxidant, anti-inflammatory, exfoliating and regenerating effect, promotes rejuvenation, improves skin elasticity, supports lipid balance and normalizes skin hydro-balance. It is suitable for any type of skin, significantly improves the tone and structure of the skin, which becomes much softer and smoother; regulates the normal activity of the sebaceous glands, prevents excessive fat and sweat, pore enlargement. Strengthens the walls of blood vessels, increases the tone of veins, reduces seizures. Prevents the development of varicose veins.

Grape seed oil has the highest linoleic acid content (up to 76%) among all known oils and products, which controls skin moisture and its ability to regenerate and restructure. Grape seed oil has a high (up to 135 mg%) content of vitamin E. Contains vitamins C and B, macro- and microelements: sodium, potassium, calcium, magnesium, phosphorus, iron; sugars, sucrose, glycosides, organic acids (malic, tartaric, oxalic, salicylic), lycetin, vanillin, choline, betaine and other substances necessary for humans, including amino acids.

Grape seed oil quickly normalizes exfoliation of keratinized cells, it is used to care for problem skin, with streptoderma, dermatitis, and with skin tightening and overdrying. It promotes the rapid healing of cracks, abrasions, cuts, burns. Gives the skin a healthy and beautiful appearance.

When its content in this composition is less than 0.40%, the effect is noticeably reduced, and when the content is more than 0.60%, the effect is practically not enhanced, but during storage the colloidal and temperature instability of the cream gel is revealed.

Jojoba oil is an adaptogen, has a pronounced anti-inflammatory effect, softens, nourishes and moisturizes the skin, normalizes hydrobalance, and eliminates wrinkles. It contains a high concentration of vitamins, microelements, unsaturated fatty acids identical to skin lipids, which makes the cream structure especially soft and suitable for any skin.

When its content in this composition is less than 0.40%, the effect is noticeably reduced, and when the content is more than 0.60%, the effect is practically not enhanced, but during storage the colloidal and temperature instability of the cream gel is revealed.

Wheat germ oil is an adaptogen that has a softening and restorative effect. Favorably affects the metabolism. Contains a complex of amino acids and vitamins. The lipid regulator, a pronounced moisturizing effect, a source of vitamin E. Normalizes fluid balance, heals damage and eliminates the feeling of "tightening the skin." It is especially effective for sensitive, problematic and dry skin.

When its content in this composition is less than 0.40%, the effect is noticeably reduced, and when the content is more than 0.60%, the effect is almost not observed, but colloidal and temperature instability of the cream-gel is revealed during storage, in addition, the smell is significantly enhanced.

Propylene glycol (PG) aloe vera extract is an adaptogen that reduces itching, skin irritation, the appearance of pustules and spots, resolves scar elements, improves the appearance of the skin. It has anti-inflammatory, wound healing, antimicrobial and absorbable effects. Increases immunity. Contains enzymes, vitamins, volatile, resins, essential oils.

When its content in this composition is less than 0.40%, the effect is markedly reduced, and when the content is more than 0.60%, the absorbable effect intensifies, which can worsen the condition of the skin.

Bisabolol is an adaptogen, antiseptic, has antimicrobial, antifungal and reparative effects.

When its content is less than 0.20%, the effect is noticeably reduced, and when its content is more than 0.40%, it practically does not increase (the difference between the indicators is unreliable).

Propylene glycol (PG) Kalanchoe extract is an adaptogen, it has antioxidant, anti-inflammatory, wound healing and antimicrobial effects, it contributes to the rapid elimination of purulent rashes, purification of purulent wounds and ulcers from necrosis, their rapid epithelization, as well as normalization of metabolism, increases immunity. Slows down skin aging. It contains polysaccharides, enzymes, organic acids, mineral salts (trace elements), vitamins and flavonoids.

When its content is less than 0.10%, the effect is noticeably reduced, and when its content is more than 0.20%, it practically does not increase (the difference in indicators is not significant).

Propylene glycol (PG) marigold extract is an adaptogen that has antioxidant, anti-inflammatory, decongestant, antispasmodic, wound healing, antimicrobial and bactericidal effects, helps to normalize metabolism, increases immunity. Slows down aging, normalizes skin hydro-balance. Promotes the normalization of cardiovascular activity. It contains a large amount of carotenoids (provitamin "A"), carbohydrates, resins, glycosides, organic acids, vitamin "C", mucous and bitter substances.

When its content is less than 0.10%, the effect is noticeably reduced, and when its content is more than 0.20%, it practically does not increase (the difference in indicators is not significant).

Propylene glycol (PG) horse chestnut extract is an adaptogen. It contains flavonoids, vitamins of groups B, C and K. It stabilizes the walls of blood vessels, increases the tone of veins, reduces blood clotting and blood clotting, and reduces spasm of peripheral vessels. Tones up smooth muscles of veins.

With its content of less than 0.10%, the effect is markedly reduced, and with the content of more than 0.25%, the muscle tone of the venous vessels increases significantly.

Propylene glycol (PG) chamomile extract is an adaptogen that has antioxidant, anti-inflammatory, anticonvulsant, antispasmodic, sedative, analgesic, wound healing and antimicrobial effects. Helps normalize metabolism, boosts immunity. Slows down the aging process, especially the skin. Contains carotenoids (provitamin "A"), essential oils, carbohydrates, resins, glycosides, ascorbic, nicotinic and other acids, mucous and bitter substances.

With its content of less than 0.10%, the effect is markedly reduced, and with the content of more than 0.20%, it practically does not increase (the difference between the indicators is not significant).

Juniper essential oil - an adaptogen, has antioxidant, anti-inflammatory, antiseptic and antifungal effects.

When the content in this composition is less than 0.05%, its antiseptic and antifungal effect decreases sharply, and when the content is more than 0.15%, the effect practically does not increase (the difference is not significant), but the smell of the composition intensifies sharply.

Citric acid is a general strengthening and decongestant. Normalizes metabolism, tissue respiration, reduces the formation of fat deposits, improves immunity. Reduces the damaging effect of hypoxia (lack of oxygen); increases the speed of respiratory processes, due to which a large amount of ATP (energy) is formed. Increases tissue tone, normalizes metabolic processes at the cellular level.

With a content of less than 0.03%, its effect is negligible, and with a content of more than 0.10%, keratolytic processes intensify, which can lead to a slowdown in the healing of cracks.

Sage essential oil is an adaptogen that has a pronounced anti-inflammatory, antiseptic, antimicrobial, hemostatic, astringent, wound healing and deodorizing effect. It slows down the aging process, strengthens the nervous system, improves metabolism. It gives a good effect in the treatment of long-term non-healing wounds and ulcers, diseases of blood vessels and skin. Salvia antibiotic is isolated from sage oil, which is a mixture of organic acids and causes extremely rapid death of bacteria. For example, 5 minutes after rinsing, hemolytic streptococcus and staphylococcus disappear from the oral cavity and pharynx. Salven inhibits the growth of pathogens of dysentery, coli bacteria, Staphylococcus aureus, as well as some other pathogenic microorganisms, and increases immunity.

Contains fatty and essential oils, D-camphor and other terpenoids; alkaloids, flavonoids, tannins, etc.

With a content of less than 0.02%, its effect is less pronounced, and with a content of more than 0.04%, the smell of the composition is sharply enhanced.

Furacilin is a broad-acting antiseptic.

When its content in the cream is less than 0.01%, the effect is insignificant, and when the content is more than 0.05%, the effect practically does not increase (the difference is not significant), but the likelihood of toxic reactions appears.

Zinc ions ZnSO ₂ (zinc sulfate 26.7% solution) - has antiseptic, disinfectant, anti-inflammatory and astringent effects.

When their content is less than 0.01%, the effect is noticeably reduced, and when the content is more than 0.02%, it practically does not increase (the difference in indicators is unreliable).

Copper ions CuSO ₂ (copper sulfate 23.5% solution) - has antiseptic, disinfectant, anti-inflammatory and astringent effects.

When their content is less than 0.005%, the anti-inflammatory effect is reduced, and when the content is more than 0.02%, the cream gel is stained blue.

Peppermint essential oil (essential) is an adaptogen. It has a general strengthening, calming, analgesic, antimicrobial, anti-inflammatory, wound healing, antispasmodic, deodorizing and hemostatic effect. Helps to normalize metabolism, improves immunity, softens the skin, eliminates dryness, odors and sweating. It contains a large amount of essential oils, flavonoids, vitamins, carotene, organic acids, trace elements, tannins and other substances.

With its content of less than 0.001%, the effect is insignificant, and with the content of more than 0.002%, the smell of cream gel intensifies sharply.

Vitamin B ₂ , riboflavin is involved in tissue respiration, normalizes the metabolism of fats, carbohydrates, porphyrins, amino acids, trace elements, enhances hematopoiesis, increases reparative processes, including skin, dramatically increases the antimicrobial effect, especially with coccal infection, antiseptics.

When its content is less than 0.0001%, the effect is negligible, and when the content is more than 0.0004%, an undesirable coloring of the composition in bright yellow occurs.

Cosmetic base with eftederm contains: eftederm, oil phase components, viscosity modifiers, coemulsifiers, aminophylline, diclofenac, preservatives, emulsifiers and water.

Eftiderm is a transdermal conductor of biologically active substances; it easily passes them into tissues and blood. In addition, it is a non-steroidal anti-inflammatory drug (NSAID), has a pronounced antioxidant and anti-edematous effect, increases cell viability, affects the enzymatic systems of biological membranes, which leads to an increase and prolongation of the cosmetic and therapeutic effect of all components of the composition. As a result of the combined action of the complex of ingredients on all tissues, there is a decrease in the production of prostaglandins, histamine, bradykinin, increased resistance, local immunity, the possibility of allergic and toxic complications is reduced, metabolic processes are normalized, blood supply to all skin structures is improved, itching, peeling and dryness of the skin disappear.

When the content in the cream gel of eftederm is less than 15%, the effect is reduced, and when the content is more than 25%, the effect is practically not increased (the difference is not significant).

The following ingredients are used to make the patentable foot gel cream:

- grape seed oil - according to SEZ No. 54.NS.06.914.P.002970.04.06 until 04/27/2010 (Henry Lamotte);

- jojoba oil, refined - according to SEZ 77.01.12.915.P.30279.12.4 "Respharma";

- wheat germ oil, refined - according to SEZ No. 54.NS.06. 914.P.002970.04.06 until 04/27/2010 (Henry Lamotte);

- GHG aloe vera extract - according to SEZ 77.01.12.915. P.066578.08.07 until 08.28.2012;

- bisabolol - according to SEZ 77.01.12.915. P. 047175.11.05 to 01.12.2010;

- GH Kalanchoe extract - according to SEZ No. 77.99.40.915. D.003249.04.08 from 04/08/2013;

- PG marigold extract - according to SEZ No. 77.99.40.915. D.003249.04.08 until 04/08/2013;

- GHG horse chestnut extract - according to SEZ 77.01.12.915. P. 20626.09.4 to 01.10.2009;

- PG chamomile extract - according to SEZ on 01/01/12.915. P. 20626.09.4 to 10/01/2009;

- juniper essential oil - according to SEZ 78.01.05.915. P.002485.05.04 dated 05.21.2009 / Duellberg Konzentra;

- citric acid - according to 78.01.009.U.000216.05.08 / unlimited;

- sage essential oil - according to SEZ 78.01.05.915. P.002485.05.04 to 05.21.09;

- furatsilin according to GF X, Art.295;

- zinc ions (zinc sulfate 26.7% solution) - according to GF X, Article 737;

- copper ions (copper sulfate 23.5% solution) - according to GF X, Art. 191;

- peppermint essential oil - according to the State Fund X, Art. 488, SEZ 8.01.05.915. P.002485.05.04 to 05.21.2009 / Duellberg Konzenta;

- vitamin B ₂ riboflavin - according to the Global Fund XI, issue 2, Art. 47, FS 42-2954-93;

- cosmetic base with eftederm - according to GOST 29189-91

- Eftiderm - according to FSP 42-0361-3723-02.

Getting cream gel for the feet

To obtain a cream-gel for feet, 75% of the required amount of cosmetic base with eftederm is loaded into a cauldron with a stirrer. Each liquid ingredient that is part of the cream-gel is weighed on an analytical balance in the right amount, separately added to the boiler, followed by stirring for 5-7 minutes. Citric acid, furatsilin and vitamin B ₂ , previously weighed in the right amount, are added alternately with constant stirring to the resulting mass, the remainder of the base is added and mixed thoroughly for 25-40 minutes until a homogeneous mass of white or white with a yellowish or brownish tint and the smell corresponding to the ingredients used. After receiving the OCC analysis that meets the requirements of the NTD, the resulting reactive mass is transferred to the packaging.

Foot cream gel compositions for comparative clinical trials are shown in Table 1.

Table 1 The composition of the compositions of the gel cream for the feet in clinical trials Components Composition wt.% one 2 3 4 foot cream Grape seed oil 0.50 - Jojoba oil 0.50 - Wheat germ oil 0.50 - PG Kalanchoe Extract 0.15 - PG marigold extract 0.15 Tincture 0.25 PG horse chestnut extract 0.15 - PG chamomile extract 0.15 Juniper essential oil 0.10 0.10 Lemon acid 0.05 - Furatsilin 0,03 0.02 Zinc ions 0.015 - Copper ions 0.015 - Peppermint essential oil 0.0015 0.0015 Vitamin B ₂ 0,0004 Other prototype 2.2800 additives PG aloe vera extract 0.30 0.50 0.70 Bisabolol 0.10 0.30 0.40 Sage essential oil 0.01 0,03 0.05 Cosmetic base 97,0781 96.8581 96.9175 97.3485 including eftederm 20.00 20.00 20.00 20.00 Note 1. Previously, experimental studies on animals were carried out, as a result of which it was found that all the compositions listed in the table do not have acute and chronic toxicity, local irritant effects, do not cumulate, are not potential allergens. 2. In preliminary studies, the optimal concentrations of all the ingredients of the compositions were established except for PG extract of aloe vera, bisabolol and sage essential oil. 3. The compositions 1, 2, 3 were studied with different contents of PG of aloe vera extract, bisabolol and sage essential oil, which are shown in the table.

CLINICAL RESEARCHES

Comparative clinical studies were carried out on 40 male and female volunteers aged 35-60 years, randomized into 4 groups in 4 groups.

The study was dominated by dry skin of the feet (92.5%), cracks in the heel area (75%), peeling of the skin (100%), areas of hyperkeratosis (87.5%), periodic itching (100%), unpleasant odor from the feet (82.5%), the pH averaged 7.3.

Visual inspection was carried out before using the gel cream for the feet, on the 3rd, 7th and 14th day of its use; determination of skin pH on the back of the foot was carried out before using cream-gel and on day 14.

Upon examination, the condition of the skin was assessed: its type, turgor, cracks, peeling, hyperkeratosis, itching, unpleasant odor and sweating feet; clarified anamnesis, complaints, performed bacterioscopy of scrapings from the plantar surface and interdigital spaces of the feet. All studies were carried out according to generally accepted methods.

Patients applied the composition corresponding to the group 2 times a day on clean skin of the feet for 2 weeks.

RESULTS OF CLINICAL STUDIES

As a result of the studies (see table 2), it was found that for all persons included in group 1, itching, unpleasant odor and sweating of the feet disappeared on the 3-5th day of applying the gel cream for the feet, peeling disappeared by the 5-7th day and dry skin; cracks epithelized by 7-8 days; by 12-14 days, the elasticity and turgor of the skin returned to normal. On day 14, the symptoms of hyperkeratosis disappeared in 9 people, and the pH was 5.7.

table 2 Research results Name of symptoms % 1 group 2 group 3 group 4 group Improved through days on % days on % days on % days on % Skin elasticity and turgor one hundred 12-14 one hundred 9-10 one hundred 9-10 one hundred 12-14 80 Dry skin one hundred 5-7 one hundred 3-5 one hundred 3-5 one hundred 5-7 one hundred Skin peeling one hundred 5-7 one hundred 3-5 one hundred 3-5 one hundred 10-12 one hundred Cracks one hundred 7-8 one hundred 5-7 one hundred 7-10 one hundred 7-14 one hundred Hyperkeratosis one hundred fourteen 90 10-12 one hundred 9-12 one hundred fourteen 70 Itching one hundred 3-5 one hundred 2-3 one hundred 2-3 one hundred 3-5 one hundred Bad smell and sweating feet one hundred 3-5 one hundred 2-3 one hundred 2-3 one hundred 3-5 one hundred skin pH (average) 7.3 fourteen 5.7 fourteen 5.5 fourteen 5,6 fourteen 5.9 Note: all the studied parameters before the study are taken as 100%, the pH is average.

In group 2, the effect was significantly higher: on day 2-3 of applying the cream gel, itching, unpleasant odor and sweating of the feet disappeared, peeling and dryness of the skin disappeared by day 3-5, cracks epithelized by day 5-7; by 9-10 days, the elasticity and turgor of the skin returned to normal, by 10-12 days, the symptoms of hyperkeratosis disappeared. On day 14, the pH was 5.5.

The results of group 3, practically coincided with the results of group 2, only epithelialization of cracks occurred 3 days later. On day 14, the pH was 5.6. In addition, the GH content of aloe vera extract, bisabolol and sage essential oil in cream gel 3 was higher than in the 2nd by 40, 33.3 and 66.6%, respectively.

In group 4 (prototype), the results were close to those obtained in group 1, only peeling of the skin disappeared 5 days later, and epithelialization of cracks occurred with a lag of 4 days. In addition, the increase in skin elasticity was significantly lower than in patients of group 1. On day 14, the pH was 5.9.

Based on the foregoing, it is obvious that the best results were obtained in patients of group 2, and therefore composition 2 is submitted for patenting.

So, patentable cream gel for feet, including a cosmetic base with eftederm, tincture of calendula, juniper essential oil, furatsilin, peppermint essential oil, characterized in that calendula propylene glycol extract is used as a tincture of calendula, additionally contains grape seed oil, jojoba oil, wheat germ oil, aloe vera propylene glycol extract, bisabolol, ca-lanchoe propylene glycol extract, horse chestnut propylene glycol, camomile propylene glycol extract, citric acid y, sage essential oil, zinc and copper ions, vitamin B ₂ , more effective than the prototype, exhibits antifungal, anti-inflammatory, reparative and deodorizing effects; contains a greater amount of nutrients, macro and micro elements due to the introduction of new ingredients into the cream gel for feet, which, due to the transdermal activity of the eftederm, quickly penetrate into tissues, prolonging and enhancing the effect of the composition several times; and also simplified the method of applying cream gel for the feet.

Thus, “Cream gel for feet” is proposed for patenting, combining cosmetic and medicinal properties, based on the use of non-deficient ingredients of natural and organic origin.

The proposed cream meets the criteria of novelty, effectiveness, non-obviousness and industrial applicability, in connection with which, a patent for an invention is proposed for legal protection.

Claims (1)

Foot gel cream, including a cosmetic base with eftederm, calendula extract, juniper essential oil, furatsilin, peppermint essential oil, characterized in that calendula propylene glycol extract is used as a calendula extract, and it also contains grape seed oil, jojoba oil, wheat germ oil, aloe vera propylene glycol extract, bisabolol, Kalanchoe propylene glycol extract, horse chestnut propylene glycol extract, chamomile propylene glycol extract, citric acid, sage essential oil, zinc and copper ions, vitamin B ₂ , in the following ratio, wt.%:
Grape seed oil 0.40-0.60 Jojoba oil 0.40-0.60 Wheat germ oil 0.40-0.60 Aloe Vera Propylene Glycol Extract 0.40-0.60 Bisabolol 0.20-0.40 Propylene glycol Kalanchoe extract 0.10-0.20 Calendula Propylene Glycol Extract 0.10-0.20 Horse Chestnut Propylene Glycol Extract 0.10-0.20 Propylene glycol chamomile extract 0.10-0.20 Juniper essential oil 0.05-0.15 Lemon acid 0.04-0.06 Sage essential oil 0.02-0.04 Furatsilin 0.02-0.04 Zinc ions 0.01-0.02 Copper ions 0.01-0.02 Peppermint essential oil 0.001-0.002 Vitamin B ₂ 0,0002-0,0006 Cosmetic base with eftederm 97.60-96.00