RU2283642C1 - Anti-cellulitis cream - Google Patents

Abstract

FIELD: cosmetic, in particular skin care agents.

SUBSTANCE: claimed cream contains cosmetis emulsion base, eftiderm, malavit, Eleuterococus extract, cedar oil, jojoba oil, citric, ascorbic and succinic acids, riboflavin (vitamin B2), retinal acetate (vitamin A), lipoic acid and lidase in specific ratio.

EFFECT: cream for cellulites prophylaxis and treatment with increased anti-inflammatory, resolving and reparative action; normalizing of lipid metabolism.

2 tbl

Description

The invention relates to cosmetics, namely to means for skin care, and mainly aimed at increasing anti-inflammatory, absorbable and reparative effects; elimination of edema, increased tone and elasticity; normalization of lipid metabolism and skin pH; prevention of the occurrence and elimination of cellulite.

Skin cosmetics are known which contain the active substance and various additives. So, body skin cream according to the patent of the Russian Federation No. 2146515, A 61 K 7/48, 2000, contains an active substance from a number of ethylidene diphosphonic acid derivatives, and as additives - mineral oil, vegetable oil, emulsion wax, monoglycerides, cosmetic stearin, lanolin anhydrous, triethanolamine, weak organic acid, vitamins, preservative, fragrance and water. However, such a skin cream is not intended to prevent the occurrence and elimination of cellulite, to eliminate edema, normalize lipid metabolism and skin pH.

Closest to patentable is a cream for the skin of the body and face, which is given the name "Malavtilin" (Patent for the invention of the Russian Federation No. 2189808, registered on 09.27.2002 - prototype). Malavtilin is produced by the company Medical Diagnostic Firm MEDIK, Yekaterinburg (License registration number PK10.V00256. Certificate of Conformity No.POCC.RU.PK10.A00256 No. 3620511 dated October 21, 1999).

The cream indicated as a prototype includes the basis of efthillin (wt.%: Eftederm - 40.00; petrolatum - 40.0; lanolin - 5.0; ethyl alcohol 95% - 5.0; eufillin - 0.5; water - 9, 5), extract of eleutherococcus, malavit, diphenhydramine, diclofenac, castor oil, glycerin, flavors, proteolytic enzyme - phytopain. The cream has anti-inflammatory, antiseptic and analgesic effects; prevents aging of the skin, reduces the number of wrinkles, heals minor injuries. However, the following are included in the composition of eptillin: ethyl alcohol, which has an irritating effect; lanolin and petroleum jelly, which quite often cause allergic reactions and skin irritation (for example, petrolatum). The cream is not intended to prevent the occurrence and elimination of cellulite, the normalization of lipid metabolism and skin pH.

The technical task is to improve the quality of the cream by eliminating ethyl alcohol, petroleum jelly and lanolin; increase of its anti-inflammatory, absorbable and reparative action, elimination of edema; increased tone and elasticity, normalization of lipid metabolism and skin pH; prevention of the occurrence and elimination of cellulite due to the introduction of additional ingredients into the cream, which, thanks to the transdermal activity of the eftederm, quickly penetrate into the deeper layers of the skin, while their effect is prolonged and enhanced several times.

In the present invention, a cosmetic base with an eftederm is used instead of a base - eptillin.

The technical result is achieved in that the anti-cellulite cream, including malavit, eleutherococcus extract, proteolytic enzymes and a base containing eftederm, water, aminophylline and castor oil, is characterized in that it additionally contains a cosmetic base, juniper oil, jojoba oil, lemon, ascorbic and succinic acid, riboflavin (vitamin B ₂ ), retinol acetate (vitamin A) and lipoic acid in the following ratio, wt.%:

malavit 0.10-2.00; eleutherococcus extract 0.05-0.30; juniper oil 0.05-0.30; jojoba oil 0.05-0.30; lemon acid 0.05-0.20; vitamin C 0.02-0.10; succinic acid 0.02-0.10; riboflavin (vitamin B ₂ ) 0.01-0.15; retinol acetate (vitamin A) 0.01-0.15; lipoic acid 0.01-0.05; lidase, PE 0.50-5.00 PE; cosmetic base with eftederm 98.00-92.00.

Eftiderm is a transdermal conductor of biologically active substances; it easily passes them into tissues. It is a non-steroidal anti-inflammatory agent, has an antioxidant and anti-edematous effect, increases cell viability, acts on enzymatic systems of biological membranes, which leads to an increase and prolongation of the cosmetic and therapeutic effect of all components of the composition. There is a decrease in the production of prostaglandins, histamine, bradykinin, the number of allergic and toxic complications; increased local immunity; skin metabolism normalizes. The cosmetic base contains 20% of the eftederm, it is at this concentration that all the properties of the eftederm are most pronounced.

Vegetable and castor oils are the oil phase of the cosmetic base. Cetylstearyl alcohol is a viscosity modifier. Romulgin is a co-emulsifier. Aminol is an emulsifier. Solbrol is a preservative. Eufillin - (FS 42-3212-95, changes 1, 2), has a vasodilating and decongestant effect.

Malavit has anti-inflammatory, antiseptic and analgesic effects. With its content of less than 0.1%, the effect is insignificant, and with the content of more than 2.0% the analgesic properties prevail and the anti-allergic effect of the cream sharply decreases.

Juniper oil is an adaptogen, has an antioxidant, anti-inflammatory and antiseptic effect, flavoring. With a content of less than 0.05%, its effect is negligible, and with a content of more than 0.30%, the cosmetic effect does not increase, but the smell sharply intensifies.

Jojoba oil is an adaptogen, it has anti-inflammatory, moisturizing, softening and nourishing effects, reduces the formation of wrinkles, improves the texture of the cream. With a content of less than 0.05%, its effect is negligible, and with a content of more than 0.30%, it practically does not increase (the difference in indicators is unreliable).

Eleutherococcus extract is an adaptogen, has antioxidant properties, normalizes the work of cellular structures and blood supply to the peripheral departments, including skin, has a tonic effect, increases metabolic processes. With its content of less than 0.05%, the effect is insignificant, and with the content of more than 0.30%, an increase in working capacity, physical activity, and blood pressure predominates.

Citric acid is involved in the respiratory chains of biological membranes, regulates metabolic processes. If its content in the cream is less than 0.05%, the effect is insignificant, and if it contains more than 0.20%, the effect practically does not increase (the difference in indicators is not significant).

Ascorbic acid stabilizes cell membranes, reduces the damaging effect of hypoxia (lack of oxygen) on cell structures, promotes the production of ATP, and also reduces the processes of conversion of pre-carcinogens to carcinogens, which prevents the development of cancer. When its content in the cream is less than 0.02%, the effect is negligible, and if it contains more than 0.1%, ascorbic acid does not dissolve and degrades the quality of the cream.

Succinic acid increases the rate of respiratory processes in tissues, due to which a large amount of ATP is formed in the body, the tone of all tissues, and the energy of the body increase. When the content of succinic acid in the cream is less than 0.02%, the effect is negligible, and when the content is more than 0.10%, the effect of the cream does not increase (the difference is not significant).

Riboflavin (vitamin B ₂ ) - after biotransformation into coenzyme forms (the process is significantly accelerated in the presence of the eftederm), riboflavin is involved in tissue respiration, normalizes the metabolism of fats, carbohydrates, porphyrins, amino acids, trace elements, enhances blood formation, increases reparative processes, including skin, increases the antimicrobial effect of drugs. With its content of less than 0.01%, the effect is negligible, and with the content of more than 0.15%, the effect is hardly enhanced (the difference is not significant).

Retinol acetate (vitamin A) is an adaptogen that affects the function of epithelial structures, increases the number of mitoses in epithelial cells and prevents the accumulation of keratogealine in them, stimulates epithelization and prevents excessive keratinization of the epithelium (hyperkeratosis), and prevents dry skin. Promote the synthesis of RNA and sulfated mucopolysaccharides, which play a significant role in the permeability of cell and subcellular membranes. When its content in the cream is less than 0.01%, the effect decreases sharply, when the content is more than 0.15%, the effect on hormonal metabolism is enhanced, and the desired effect does not increase (the difference is not significant).

Lipoic acid normalizes the function of liver cells, promotes the deposition of energy in the liver in the form of glycogen, thereby preventing the formation of adipose tissue and the formation of atherosclerosis. When its content in the cream is less than 0.01%, the effect is insignificant, and when the content is more than 0.05%, the effect of the cream is not enhanced (the difference is not significant).

Lidase (identical to phytopain) is a proteolytic enzyme that contains hyaluronidase. It has a resolving effect, quickly increases the permeability of tissues to biologically active substances. Improves the movement of fluids in interstitial spaces. With its content of less than 0.50 PE (per 100 g of cream), the effect is negligible, and with a content of more than 5.00 PE (per 100 g of cream), the membrane permeability sharply increases, and the desired effect does not intensify. Lidase helps to increase anti-inflammatory, absorbable and reparative effects; elimination of edema, increase tone, elasticity and pH, normalize lipid metabolism of the skin; prevention of the occurrence and elimination of cellulite.

The following ingredients are used to make the patented anti-cellulite cream:

- eftederm according to FS 42-3372-97,

- malavit - according to TU 9158.001.29731500-95 and SanPin 2.3.2.560-96,

- Eleutherococcus extract according to FS 42-2833-92,

- juniper oil - according to the current scientific and technical documentation,

- jojoba oil - according to the current NTD,

- citric acid according to GOST 908-79,

- ascorbic acid according to GF X Art. 6,

- succinic acid according to GOST 6341-75,

- riboflavin (vitamin B ₂ ) according to GF X, Art. 585,

- retinol acetate (vitamin A) according to GF X Art. 588,

- lipoic acid according to FS 42-1918-94,

- lidase according to TU 9291-003-49959837-99,

- cosmetic emulsion base according to GOST 29189-91.

To obtain a cream, 75% of the required amount of cosmetic emulsion base is loaded into a boiler with a stirrer.

Each dry ingredient that is part of the cream is weighed on the analytical balance in the right amount, rubbed into the smallest powder, sieved through a No. 36 sieve, then thoroughly rubbed with a cosmetic emulsion base in a ratio of at least 1:10 and introduced into the boiler, followed by stirring for 5 -7 minutes (each ingredient separately). In the resulting mass, alternately with constant stirring, add the liquid ingredients in the right amount, add the base to the right amount and mix thoroughly for 25-40 minutes until a homogeneous mass of white or white with a yellowish or greenish tint and a smell corresponding to the ingredients used is formed.

Composition compositions for comparative clinical trials are shown in tables 1, 2.

Table 1
Clinical trials of sensitive skin cream №№ Components Composition wt.% one 2 3 4-malavtilin one Eftiderm 20.00 10.00 2 Malavit 0.25 5.00 3 Eleutherococcus Extract 0.15 0.25 four Juniper oil 0.05 0.20 5 Jojoba oil 0.05 - 6 Lemon acid 0.10 - 7 Vitamin C 0.05 0.02 0.10 - 8 succinic acid 0.05 - 9 Riboflavin - Vitamin B ₂ 0.05 - 10 Retinol Acetate - Vit. BUT 0,03 - eleven Lipoic acid 0,025 0.01 0.05 - 12 Malavtilin components No 0.25 13 Emulsion base 79,195 79.24 79.12 84.30

Notes:

1. Previously, experimental studies on animals were carried out, as a result of which it was found that all the compositions listed in the table do not have acute and chronic toxicity, local irritant effects, do not cumulate, are not potential allergens.

2. In preliminary studies, optimal concentrations of all components of the cream were established except for ascorbic and lipoic acids.

3. The compositions 1, 2, 3 with different contents of ascorbic and lipoic acids were studied, which are shown in the table.

Comparative clinical studies were conducted on 40 female volunteers aged 18-50 years who were randomized into 4 groups equally.

All women showed signs of cellulite of 1-2 degrees with a primary lesion of the hips, buttocks, abdomen and shoulder girdle.

Women applied the cream, respectively, to the group on the lesion area, followed by massage for 3-5 minutes - 2 times a day for 60 consecutive days. All were trained in the method of massage, and they were also advised not to use other anti-cellulite drugs during the study period. The initial pH of the skin was 6.0-7.9.

Registration of indicators was carried out before using the cream, on the 7th, 14th, 21st, 30th, 37th, 45th and 60th days of its use. In the process of research, the pH of the skin was determined, the severity of cellulite, turgor and skin elasticity were visually and palpated. All studies were carried out according to generally accepted methods. The research results are presented in table 2.

As a result of studies, it was found that for all women of the 1st group with I degree of cellulite, turgor and elasticity significantly increased on day 7, edema decreased and skin graininess was 30-40%; on the 21st day, turgor and elasticity returned to normal, skin edema was not determined, in 4 out of 5 women cellulite was not determined, pH normalized; in one woman, the pH was 5.8 on day 30; slight signs of cellulitis were determined only in the proximal areas of the hands, which disappeared by day 37.

table 2
Research results Name of symptoms Symptoms 1 group 2 group 3 group 4 group Eliminated in = days % Eliminated in = days % Eliminated in = days % Eliminated in = days % I DEGREE OF CELLULITE Skin elasticity and turgor one hundred 21 150 21 140 21 140 45 130 Swelling of the skin one hundred 21 one hundred 21 one hundred 21 one hundred thirty one hundred Grain one hundred thirty 80 45 one hundred 37 60 60
- 37 one hundred 45 one hundred II DEGREE OF CELLULITE Skin elasticity and turgor one hundred 21 150 thirty 140 thirty 140 45 120 Swelling of the skin one hundred 21 one hundred 21 one hundred 21 one hundred thirty one hundred Grain one hundred 37 60 45 60 45 80 60 - 45 one hundred 60 one hundred 60 one hundred

Note: all manifestations of cellulite before the start of the study were taken as 100%.

Similar changes in women with II degree of cellulite occurred as follows: turgor and elasticity normalized, skin swelling disappeared on day 21; The “graininess” of the skin disappeared in 3 women from 5 on day 37, in the rest on day 45, by the 37th day the pH returned to normal (5.0-5.7).

For all women of the 2nd group with I degree of cellulite, turgor and elasticity normalized on the 21st day, skin edema disappeared, all women did not detect signs of cellulite on the 45th day, the pH was 5.0-5.8.

At the II degree of cellulite in women of the 2nd group, edema was not determined on day 21, normalization of turgor and skin elasticity occurred on day 30; “Granularity” in 3 out of 5 women disappeared on the 45th day, in the rest - on the 60th day, by the 45th day the pH returned to normal (5.3-5.9).

In all women of the 3rd group with I degree of cellulite, turgor and elasticity returned to normal on day 21, there was no swelling of the skin, 3 women did not detect signs of cellulite on day 37, and the rest on day 45; The pH of the skin was 5.2-5.8.

At the II degree of cellulite in women of the 3rd group, edema was not determined on day 21; turgor and skin elasticity normalized on day 30; “Granularity” in 4 out of 5 women disappeared on the 45th day, in one on the 60th day, the pH was normalized by the 60th day (5.3-5.9).

All women of 4 groups have a prototype, with I degree of cellulite, turgor and elasticity returned to normal on day 45, and there was no skin edema on day 30; skin pH was 5.8-7.2.

In the II degree of cellulitis in women of the 4th group, edema was not determined at day 30; turgor and skin elasticity normalized at day 45; skin pH by day 60 was 5.5-6.7. “Granularity” was determined in all women of the 4th group at all stages of the study.

So, the patentable cream (composition I), additionally containing jojoba oil, citric, ascorbic and succinic acids, riboflavin - vitamin B ₂ , retinol acetate - vitamin A, juniper oil, lipoic acid, lidase and a cosmetic base with eftederm, shows an anti-inflammatory effect more efficient than the prototype , absorbable and reparative action, eliminates swelling; increases tone, elasticity, normalizes lipid metabolism and skin pH; It is a means for preventing the occurrence and eliminates the effects of cellulite, and also improves the quality of the cream.

So, the local application of composition 1 (anti-cellulite cream) provided a good effect that occurred after 21-45 days of its use, which was manifested in the rapid disappearance of signs of cellulite, normalization of pH.

Thus, an anti-cellulite cream combining cosmetic and medicinal properties based on the use of non-deficient ingredients of natural and organic origin is proposed for patenting. This cream is given the name "Anti-cellulite cream."

Information sources

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3. Guidelines for assessing the allergenic properties of pharmacological agents. M .: Medicine, 1988, p. 19.

4. Rook A., Dauber R. Diseases of the hair and scalp. M .: Medicine, 1985, 528 S.

5. Guidelines for immunopharmacology. / Ed. Dale M.M., Foreman J.K. M .: Medicine, 1998, 332 S.

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Claims (1)

An anti-cellulite cream based on eftederm containing malavite, eleutherococcus extract, oils and additives, characterized in that it additionally contains a cosmetic base, with juniper oil, jojoba oil as oils and citric, ascorbic and succinic acids as additives, riboflavin (vitamin B ₂ ), retinol acetate (vitamin A), lipoic acid and lidase in the following ratio, wt.%: Eftiderm 10.00-25.00 Malavit 0.10-2.00 Eleutherococcus Extract 0.05-0.30 Juniper oil 0.05-0.30 Jojoba oil 0.05-0.30 Lemon acid 0.05-0.20 Vitamin C 0.02-0.10 succinic acid 0.02-0.10 Riboflavin (Vitamin B2) 0.01-0.15 Retinol Acetate (Vitamin A) 0.01-0.15 Lipoic acid 0.01-0.05 Lidase, PE 0.50-5.00 PE Cosmetic base Rest