RU2816954C2 - Intimate hygiene product - Google Patents

Abstract

FIELD: cosmetic industry.

SUBSTANCE: invention relates to intimate hygiene products. The intimate hygiene product contains D-panthenol, inulin, lactic acid and preservatives in the following ratio of components (in terms of the main substance): D-panthenol — 0.1–5.0%; inulin — 0.1–10.0%; lactic acid — 0.2–5.0%; food preservative sodium benzoate — 0.5–0.7%; booster — antioxidant hydroxyacetophenone with a content of 0.3–0.5% (in terms of the main substance); a mixture of phenylpropanol and o-cymen-5-ol (and) decylene glycol with a content of not more than 0.4% (in terms of the main substance).

EFFECT: invention provides an intimate hygiene product that provides skin care.

1 cl, 1 tbl, 3 ex

Description

Field of technology to which the invention relates

The invention relates to the cosmetic industry, in particular to intimate hygiene products.

State of the art

Washing is one of the basic requirements for cleaning the body in terms of removing dirt and maintaining hygiene.

Daily use of personal care product compositions containing certain active agents is known to cause irritation and dryness of the skin, especially in sensitive/private areas of the body. This circumstance limits the frequency of use of these personal care products and often requires the use of corrective skin moisturizers.

Poor hygiene can contribute to odor, lead to infections and cause health problems. Additionally, maintaining microbial balance is key to overall health.

Known products for intimate hygiene of women are described earlier in patents: RU 2149640, 05.27.2000; RU 2008337, 02/28/1994; US 6844303, 01/18/2005; RU 2201207, 03/27/2003. The disadvantages of these products include their insufficient protective function in relation to pathogenic microflora, the adverse effects on the body of synthetic components introduced into the formulations (dyes, plasticizers, superfatting additives, synthetic surfactants and other synthetic components). In addition, the disadvantages of known agents also include a high pH value.

Thus, the “Detergent for intimate hygiene of women” is known (Patent No. RU 2243762, Application: 2003133474/15, November 19, 2003, Patent holder: Open Joint Stock Company “Moscow Pharmaceutical Factory” (RU)). The invention relates to the field of cosmetology and concerns hygiene products for women intended for cleansing and washing the skin and mucous membranes of the intimate area. The detergent for intimate hygiene of women is made in the form of a gel and contains disodium sulfosuccinate, cocoglycoside, glycerin, hydroxyethylcellulose, Lamesoft, whey, lactic acid, germaben, fragrance and water, the components are taken in a certain quantitative content.

This product contains germaben - a paraben that disrupts the endocrine system and very often causes allergic reactions. Acid whey plays two roles in the composition, being both a humectant and a regulator of the concentration of hydrogen ions (pH), and together with lactic acid creates a buffer system, steadily maintaining the pH of the gel at a level of pH values of at least 4, while the pH value of the proposed product may be 3.5.

The use of products with a high pH value is not recommended by the Royal College of Obstetricians and Gynecologists (RCOG) and most doctors, as such products can cause dry skin or other skin problems. When using such products, irritation and redness may occur, especially for people with dry and sensitive skin.

Despite the fact that the claimed invention also provides for the presence of lactic acid in the composition, it does not contain parabens harmful to the skin, the pH level is lower, and there is also a healing effect.

The invention “Intimate cosmetics product for women “Women’s Magic” (Patent No. RU 2240778, Application: 2003128679/15, 09/26/2003, Patentee Open Joint Stock Company “Moscow Pharmaceutical Factory” (RU), like the claimed invention, helps prevent microcracks and their healing.This product is made in the form of a gel and contains propylene glycol, glyceryl polymethacrylate, hydroxypropylcellulose, allantoin, methylparaben, propylparaben and water at a certain content of components.

However, the composition contains parabens, which are harmful to sensitive genital skin. In addition, the finished product has a pH of 5.0-6.5.

Thus, the disadvantages of known intimate hygiene products in general include their insufficient protective function, the adverse effects of synthetic components on the body, and a high pH value.

The essence of the invention

The claimed invention is carried out in order to solve the above problem, and, therefore, the technical objective of the present invention is to create a product for intimate hygiene that provides skin care, including dry and sensitive skin, as well as the mucous membrane of the intimate area of women and her external genitalia organs.

The technical result of the claimed invention is to expand the range of intimate hygiene products.

The proposed product allows you to solve the problem of daily care, as well as gentle and effective cleansing of sensitive skin, including the mucous membrane of the intimate area of women, without disturbing the pH. Helps restore the epidermal barrier. Does not cause irritation when used. Restores the natural balance of saprophytic microflora.

The technical result is achieved by the fact that the intimate hygiene product contains specially selected active substances and preservatives, and the pH of the finished product is in the range of 3.5-5.5.

The proposed product simultaneously cleanses and moisturizes the skin, has a mild antimicrobial effect and maintains microbial balance. The goals are achieved at the optimal pH value for the skin. The proposed product does not have a destructive effect on the natural microflora of the skin and promotes the formation of a balanced microflora on human skin.

The composition of the proposed product includes D-panthenol, inulin, lactic acid and preservatives. The use of these particular components is determined by the benefits of these substances for sensitive skin.

In the proposed product, the specified substances are used in the following percentages, in terms of the main substance:

No. Ingredient % input ACTIVE INGREDIENTS 1 D-panthenol (pantothenic acid derivative R-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide) 0.1-5.0% 2 inulin (polymer of D-fructose (C ₆ H ₁₀ O ₅ ) _n -) 0.1 - 10.0% 3 lactic acid (2-hydroxypropanoic acid, CH3CH(OH)COOH) (including sodium salt, lactate) 0.2 - 5.0% POSSIBLE PRESERVATIVES 1 food preservative sodium benzoate (Sodium Benzoate) 0.5 - 0.7% 2 food preservative sodium benzoate (Sodium Benzoate) with booster - antioxidant hydroxyacetophenon (Hydroxyacetophenon) 0.3 - 0.5% 3 mixture of Phenylpropanol (and) o-Cymen-5-Ol (and) Decylene Glycol no more than 0.4% 4 a mixture of Phenylpropanol (and) o-Cymen-5-Ol (and) Decylene Glycol in combination with the antioxidant booster hydroxyacetophenone 0.3 - 0.5%

Thus, a product for intimate hygiene is proposed, characterized in that D-panthenol, inulin, lactic acid are present as active ingredients, and preservatives are also used in the following ratio of components (in terms of the main substance):

1. D-panthenol - 0.1-5.0%;

2. inulin - 0.1 - 10.0%;

3. lactic acid - 0.2 - 5.0%.

The following may be present as preservatives:

1. food preservative sodium benzoate - 0.5 - 0.7%

2. food preservative sodium benzoate with booster - antioxidant hydroxyacetophenone - 0.3 - 0.5%

3. mixture of Phenylpropanol (and) o-cymen-5-ol (and) decylene glycol - no more than 0.4%

4. a mixture of phenylpropanol (and) o-cymen-5-ol (and) decylene glycol in combination with the antioxidant booster hydroxyacetophenone - 0.3 - 0.5%

The proposed product can be sold as liquid soap, gel, mousse, cream-gel, shampoo, bathing foam, emulsion, liquid lotion, skin cleansing tonic or composition for impregnating wet wipes.

D-panthenol is the active form of vitamin B5 (pantothenic acid) and is used in cosmetics and medicines in a concentration of 0.5 - 5.0% to accelerate the regeneration of irritated skin and effectively moisturize it. The scientific literature provides the results of clinical and laboratory studies of various products containing D-panthenol (dexpanthenol) (see Puchkova T.V. Encyclopedia of ingredients for cosmetics and perfumes / 2nd edition. - M: School of Cosmetic Chemists, 2015. 408 C .).

A review of the results of 70 years of use of dexpathenol in topical cosmetics and medicines highlights its widespread use in two main areas: 1. skin hydration and restoration of the epidermal barrier (% input 2.5 and 5.0); 2. Healing of damaged skin, including wounds (% input 5.0) (see Proksch E. et al. Topical use of dexpanthenol: a 70th anniversary article //Journal of Dermatological Treatment. - 2017. - Vol. 28. - No. 8. - pp. 766-773).

Dexpanthenol in concentrations of 2 to 5% (in a water-in-oil emulsion) stimulates the regeneration of damaged skin (see Ebner F. et al. Topical use of dexpanthenol in skin disorders //American journal of clinical dermatology. -2002. - T. 3. - No. 6. - P. 427-433).

Dexpanthenol in two lipophilic formulations (input percentages 1.0, 2.5 and 6.0) was applied to the skin twice daily for 7 days. The measurement results showed a significant effect of these agents on the synthesis of epidermal lipids (see Gehring W., Gloor M. Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration // Arzneimittelforschung. - 2000. - T. 50. - No. 07 . - pp. 659-663).

In a double-blind, randomized, placebo-controlled study of the moisturizing effects of dexpanthenol (input percentage 0.5, 1.0 and 5%) on 40 volunteers, the 1.0% and 5.0% formulas showed a significant reduction in TransEpidermal Water Loss (TEWL) after 15 and 30 days of use compared to control group (see Camargo Jr F. B. et al. Skin moisturizing effects of panthenol-based formulations // Journal of cosmetic science. - 2011. - T. 62. - No. 4. - P. 361).

The practice recommendations, based on a meta-analysis of 7 reviews, 19 randomized clinical trials and 15 international guidelines, emphasize that topical application of dexpanthenol products at concentrations of 2.5% to 5.0% shows a significant protective effect against skin irritation (see Lichterfeld A . et al. Evidence-based skin care // Journal of Wound, Ostomy and Continence Nursing. - 2015. - T. 42. - No. 5. - P. 501-524).

The guide for cosmetic product developers points out the moisturizing effect of dexpanthenol not only on the skin, but also on the hair. For example, applying a 2% aqueous solution of dexpanthenol to the hair increases the diameter of the hair by 10% (see S. Barel A. O., Paye M., Maibach H. I. (ed.). Handbook of cosmetic science and technology. - CRC press, 2014).

Moreover, the moisturizing effect on hair of products containing dexpanthenol in low concentrations (0.1%, 0.3%, 0.5%) has been confirmed (see A. Kretz, Vitamins in cosmetics, Olaj Szappan Kozmetika, 50(3), 94-96 (2001 )).

The prebiotic inulin maintains the natural balance of skin microbiota, as it is a selective nutrient medium for saprophytic microflora and does not support the growth of pathogenic microorganisms.

On the one hand, inulin and its derivatives are used in the production of cosmetics as an emulsion stabilizer (see Tripodo G., Mandracchia D. Inulin as a multifaceted (active) substance and its chemical functionalization: from plant extraction to applications in pharmacy, cosmetics and food //European Journal of Pharmaceutics and Biopharmaceutics. - 2019. - T. 141. - P. 21-36).

For oil-in-water systems, the injection percentage is typically between 0.2% and 1.0%. For the preparation of nanoemulsions, it is recommended to use at least 8.0% by weight of the oil phase used (see Nizioł-Łukaszewska Z. et al. Inulin as an effectiveness and safe ingredient in cosmetics // Polish Journal of Chemical Technology. - 2019. - T. 21. - No. 1. - P. 44-49).

On the other hand, a more important property of inulin as a fructooligosaccharide seems to be its protective antimicrobial effect on the skin and mucous membranes, maintaining a healthy microbiota. The prebiotic properties of this ingredient depend on the composition of different brands of raw materials, with the recommended percentage of input varying from 1.0% to 5.0% (see Sangeetha P. T., Ramesh M. N., Prapulla S. G. Recent trends in the microbial production, analysis and application of fructooligosaccharides //Trends in food science & technology. - 2005. - T. 16. - No. 10. - P. 442-457).

The antioxidant effect of inulin is also important. Thus, it was shown that the addition of inulin from two sources of origin (chicory root and artichoke) to the “bathing gel” formula in concentrations of 1.0, 2.5, 5.0, 7.5 and 10% demonstrates the appearance of antioxidant properties and also leads to a significant reduction in the irritating effect of the product (see Nizioł-Łukaszewska Z. et al. Inulin as an effectiveness and safe ingredient in cosmetics // Polish Journal of Chemical Technology. - 2019. - T. 21. - No. 1. - P. 44-49).

According to the manufacturer of the active ingredient PolyFructol Plus (INCI (EU-Declaration / PCPC-Declaration) Inulin (and) Glycerin (and) Phenoxyethanol (and) Lecithin (and) Xanthan Gum (and) Aqua/Water), moisturizing, increasing elasticity and firmness skin, as well as a decrease in TEWL is observed at levels of active use in concentrations from 0.1% to 5.0%.

Inulin has unique properties to regulate skin balance, restore the natural balance and ratio of microflora on the surface of human skin. It also has film-forming properties, forming a light film with a pleasant feel on the surface of the skin. In intimate hygiene products, inulin allows for a natural balance of beneficial microflora and delicate care for a girl’s sensitive skin.

The lactic acid contained in the product is a natural acidifier and moisturizer, as it is part of the skin's Natural Moisturizing Factor. In concentrations of 0.2% - 5.0% in cosmetics, it helps maintain the physiological pH level of the skin and mucous membranes, which does not inhibit the growth of saprophytic microflora and inhibits the growth of pathogenic microorganisms.

Clinical trial protocols for cosmetics containing lactic acid, as well as its sodium and potassium salts, were described back in the 1970s. Since these substances are part of Natural Moisturizing Factor (NMF), numerous studies have confirmed their moisturizing effect (see Draelos Z. D. (ed.). Cosmetic dermatology: products and procedures. - John Wiley & Sons, 2015).

Although lactic acid is described as a humectant in most cosmetic formulation guidelines, it (like most AHAs) rather modulates keratinization and improves the quality of the stratum corneum (at concentrations ranging from 5 to 10%) (see Barel A.O., Paye M. , Maibach H. I. (ed.). Handbook of cosmetic science and technology. - CRC press, 2014).

But it has been shown that when more than 5% is injected, it can cause a burning and tingling sensation. It is more rational to use it or its salts (sodium lactate) in a concentration of 3-5% to obtain a moisturizing effect (see Baran R., Maibach H. I. (ed.). Textbook of cosmetic dermatology. - CRC Press, 2017).

In addition to its moisturizing effect, lactic acid is widely used in the production of cosmetics to maintain optimal pH levels.

The pH-regulating effect is especially important in intimate hygiene products for women. Normally, the vagina and external genitalia are populated by saprophytic microbiota, consisting of 90% lactobacilli that produce lactic acid. With dysbiosis of the intimate zone, the pH of the environment increases (> 4.5), which leads to an imbalance in the composition of the microbiota (see Bahamondes M. V. et al. Use of a lactic acid plus lactoserum intimate liquid soap for external hygiene in the prevention of bacterial vaginosis recurrence after metronidazole oral treatment //Revista da Associação Médica Brasileira (English Edition). - 2011. - T. 57. - No. 4. - P. 408-413).

Additional acidification using products containing lactic acid (0.2-0.5%), with a pH of 3.5-4.0, both with topical application (cream) and intravaginal application (gel), leads to pronounced antimicrobial, antiviral and immunomodulatory effects (see. Andersch B. et al. Treatment of bacterial vaginosis with an acid cream: a comparison between the effect of lactate-gel and metronidazole // Gynecologic and obstetric investigation. - 1986. - T. 21. - No. 1. - P. 19 -25, Andersch B. et al. Bacterial vaginosis and the effect of intermittent prophylactic treatment with an acid lactate gel // Gynecologic and obstetric investigation. - 1990. - T. 30. - No. 2. - P. 114-119) .

The proposed product uses safe, non-synthetic food preservatives. The percentage of preservatives added is regulated, on the one hand, by the Technical Regulations TR CU 009/2011 “On the safety of perfumes and cosmetics”, and, on the other, by the documentation of the companies producing these ingredients and may vary depending on the type of emulsion and the purpose of the cosmetic product.

Embodiments of the invention

The proposed product can be sold as a cream-gel. In this case, the composition includes:

1. Sorbitol 70% food grade or pharmacopoeial - 5.00%;

2. Pharmacopoeial glycerin - 3.00%;

3. Emulsion wax - 2.00%;

4. Vegetable oil (sunflower or olive) - 1.50%;

5. Caprylic/capric triglycerides - 1.50%;

6. Glyceryl stearate - 1.00%;

7. Dimethicone - 1.00%;

8. Cetearyl alcohol - 1.00%;

9. D-panthenol - 1.00%;

10. Inulin (and) alpha-oligosaccharides - 1.00%;

11. PEG-7-glyceryl cocoate Cetiol HE - 0.50%;

12. Edible lactic acid 80% - 0.40%;

13. Fragrance - as much as needed;

14. PEG-40-castor oil hydrogenate - 0.30%;

15. Hydroxyacetophenone - 0.30%;

16. Allantoin - 0.10%;

17. Carbomer or other multifunctional polymer - 0.35%;

18. Sodium hydroxide - as needed;

19. Phenylpropanol (and) o-Cymen-5-ol (and) decylene glycol - 0.30%;

20. Vitamin E-acetate - 0.10%;

21. Drinking water - Up to 100.00%

The cream-gel can be sold as a leave-in product. For a leave-in product, a safe and environmentally friendly antimicrobial agent is used as a preservative system at a concentration of 0.3%, at which it does not inhibit beneficial lactobacilli on the skin of the intimate area and external mucosa, as well as hydroxyacetophenone at a concentration of 0.3% as a booster and antioxidant.

The proposed product can be sold as a mousse. In this case, the composition includes:

1. Fatty alcohol sulfoethoxylate 70% - 6.00%;

2. Alkylamidopropyl betaine - 4.50%;

3. Disodium laureth-3-sulfosuccinate - 3.00%;

4. Coconut oil fatty acid diethanolamide - 1.50%;

5. Inulin (and) Alpha-glucan oligosaccharide - 1.00%;

6. Glyceret-2-cocoate - 1.00%;

7. Food grade or pharmacopoeial glycerin - 1.00%;

8. Laureth-7-citrate - 1.00%;

9. Fragrance - as much as needed;

10. Lactic acid 80% food grade - 0.25%;

11. D-panthenol - 1.00%;

12. Disodium EDTA - 0.10%;

13. Hydroxyacetophenone - 0.30%;

14. Sodium benzoate - 0.5%;

15. Plant extract propylene glycol - 0.5%;

16. Edible citric acid - as much as needed;

17. Drinking water - Up to 100.00%.

This rinse-off intimate hygiene product uses a safe (food grade) preservative at a concentration of 0.5% combined with a booster of hydroxyacetophenone at an optimal concentration of 0.3%.

The proposed product can be sold in the form of a gel.

1. Sulfoethoxylate of fatty alcohols 70% - 5.00%;

2. Lauryl glucoside - 4.60%;

3. Alkylamidopropyl betaine - 3.50%;

4. Coconut oil fatty acid diethanolamide - 1.90%;

5. Inulin (and) Alpha-glucan oligosaccharide - 1.00%;

6. Glycol distearate (and) Coconut oil fatty acid monoethanolamide (and) Sodium laureth sulfate (and) Laureth-10 - 0.80%;

7. Sodium chloride - Up to 1.00%;

8. Glycereth-2-cocoate - 0.50%;

9. Laureth-11 carboxylate laureth-10 - 1.00%;

10. PEG/PPG-120/10 Trimethylpropane Trioleate (and) Laureth-2 - 0.50%;

11. Laureth-7-citrate - 1.00%;

12. Fragrance - as much as needed;

13. Lactic acid 80% food grade - 0.25%;

14. D-panthenol - 1.00%;

15. Disodium EDTA - 0.10%;

16. Almond oil PEG-8 - esters - 0.30%;

17. Plant extract propylene glycol - 0.50%;

18. Hydroxyacetophenone - 0.30%;

19. Phenylpropanol (and) o-cymen-5-ol (and) decylene glycol - 0.30%;

20. Alpha bisabolol - 0.01%;

21. Drinking water - Up to 100.00%.

For this rinse-off product, a safe and environmentally friendly antimicrobial agent at a concentration of 0.3% is used as a preservative system, at which it does not inhibit beneficial lactobacilli on the skin of the intimate area and external mucosa, as well as hydroxyacetophenone at a concentration of 0.3% as a booster and antioxidant .

According to clinical, toxicological, microbiological and physicochemical tests, it has been established that these products do not have a general toxic or irritating sensitizing effect. They carefully care for delicate skin.

Claims (1)

An intimate hygiene product, characterized in that it contains D-panthenol, inulin, lactic acid and preservatives in the following ratio of components (in terms of the main substance): D-panthenol - 0.1-5.0%; inulin - 0.1-10.0%; lactic acid - 0.2-5.0%; food preservative sodium benzoate - 0.5-0.7%; booster - antioxidant hydroxyacetophenone with a content of 0.3-0.5% (in terms of the main substance); a mixture of phenylpropanol and o-cymen-5-ol (and) decylene glycol with a content of not more than 0.4% (in terms of the main substance).