RU2308962C1 - Agent for treatment and prophylaxis of locomotor system diseases - Google Patents

Abstract

FIELD: medicine, chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to creature of agents used in prophylaxis and treatment of diseases and pathological states associated with the locomotor system. Agent represents the complex preparation including the composition № 1 and № 2. The composition № 1 on hydrophobic base comprises the following active substances: phytocomponents of peppermint, common wormwood, mountain arnica, grape seeds, matricary, pine cones, pot-marigold, bur-marigold, sea-buckthorn oil, red pepper oil, red palm oil, mixture of essential oils of peppermint, lavender and clove in the ratio 1:1:1, bee venom, menthol, synthetic camphor and the following accessory substances: form-forming thickening agent - bee wax; preserving agent - propylparaben; emolents - cetiol CC, DC 345 and vaseline oil; antioxidant - kovi-ox. The composition № 2 on hydrophilic base comprises the following active substances: aqueous extracts of lilac flowers, mountain arnica, walnut peel; propocyanides of grape berries, propolis alcoholic extract, Kova-B-trox, and accessory substances: gel-forming agent - natrosol 250; moistening agents - propylene glycol and urea; chelating agent - disodium-EDTU; emolent - PLN phospholipids; preserving agents - methylparaben and caton CG; pH regulating component - triethanolamine and deionized water. Proposed agent possesses the expressed and prolonged curative effect that allows its using both for prophylaxis and treatment of different diseases and damages of structures in locomotor system and for improving skin state and adjacent tissues. Agent shows high therapeutic activity, namely its rapid and deep penetration into tissues, heating and relaxing effect, improving circulation in tissues and enlargement of blood vessels. Agent shows analgesic, anti-inflammatory, anti-edematous effect, accelerates reparative processes and improves tissue trophism. Agent shows the complex directivity on all mechanisms in base of diseases and pathological states of the locomotor system and their clinical symptoms and possesses the broad spectrum of pharmacological effect and both recovers the damaged functions of organ and shows the systemic effect on all body.

EFFECT: valuable medicinal properties of agent.

2 tbl

Description

The invention relates to the field of cosmetology and medicine, namely to means for the prevention and treatment of diseases and pathological conditions of the musculoskeletal system, and can also be used as a means to improve the condition of the skin.

In modern conditions of high speeds, increasing flows of information, rapidly changing living conditions, the human body is exposed to ever greater stresses that it does not have time to adapt to: stresses, physical inactivity, electromagnetic radiation (mobile telephone, computers, industrial and household noise, etc.) . As a result of these processes, an early depletion of the immune system and other body systems occurs. aging. The musculoskeletal system, which is in a state of increased stress, is particularly affected. There is a need to create new products for the skin, muscles and joints with a universal effect that can solve for the patient at the same time a wide range of problems that arise, and independently, without visiting a doctor.

It is known that many diseases of the musculoskeletal system (osteochondrosis, arthrosis, arthritis, arthrosoarthritis, dorsalgia) pass over time into a chronic and irreversible stage, often leading to severe deviations and the need for surgical intervention due to untimely medical attention and the absence of preventive measures.

Currently, the problem of recovery of the body after heavy physical exertion, treatment of diseases of the musculoskeletal system and musculo-ligamentous apparatus remains very relevant.

There are a large number of means intended for the prevention and treatment of diseases of the skin, muscles, joints and improve their condition on an alcohol, balsamic and gel-forming basis, which include biologically active substances of natural origin. Each of them, depending on the tasks to be solved, has its own composition and spectrum of action.

Known, for example, the transdermal balm "Miralgin" (Products of the Mirra company, Directory, M., 1998, v.1, p.41), which includes grape seed oil, eikanol, essential oil of clary sage, eucalyptus, cloves , cypress, mint, tea tree, phytoextracts arteca, licorice, carotene. The balm is intended for the treatment of the musculoskeletal system.

Its disadvantage is the short duration of the analgesic effect.

The Mentoclar warming gel is also known (Dribpohod Yu.Yu. Handbook for a cosmetologist, St. Petersburg: All, 2001, p. 466-477), the hydrophilic base of which contains mixtures of essential oils of eucalyptus, turpentine, peppermint, thyme, cedar, camphor menthol.

However, the gel has a narrow spectrum of action. Allergic reactions to turpentine essential oil may occur. The penetrating and warming effect and, consequently, the therapeutic result are insufficient.

Also known is a balsamic topical product with antimicrobial, anti-inflammatory and analgesic effects, called “Taiga Balm” (RU 2088214, class IPC: A61K 9/06; A61K 9/31, 1997), which is a transparent green gel with a strong balsamic odor. The gel contains monoterpenoids, salicylic acid, camphor, excipients (benzyl alcohol, copper sulfate pentahydrate) and a gelling base.

The disadvantages of the known funds include its toxicity and the ability to cause allergic reactions, as well as the use of synthetic components that have a specific action that is not harmful to the body, which limits the spectrum of its use. The gel also has a short shelf life - not more than 12 months.

A cosmetic product with a warming effect is known (Shigolakova massage cream-balm “Idas B”, RU 2163481 class. IPC: А61К 7/48, 2003), which contains essential fir oil, wax, oil extracts of plant materials: frankincense root, peony , calamus, thyme; propolis; Cedar oil; clarified butter; formic alcohol; sunflower oil. The tool has an antiseptic effect, anti-inflammatory and analgesic effect, improves blood circulation in the tissues.

However, the product has low organoleptic properties. It can be stored at best for 4 months, since the shelf life of cedar and butter does not exceed 6 months due to strong oxidation. In addition, the use of only the oil (hydrophobic) fraction of medicinal plants does not provide a sufficiently pronounced therapeutic effect.

As the closest analogue, “Pain Relief Gel for Joints P.C. 28” (http://www.justcosmetics.ru/vivasan/get.htm), intended for the treatment of diseases of the musculoskeletal and nervous systems, was adopted. It contains extracts of fragrant martinia, birch, mussel, arnica, red algae, essential oils of mint, lemon, thyme, lavender, sweet orange, polysaccharide as active components. The gel has anti-inflammatory, anti-stress, tonic effect and is used for arthritis, arthrosis, neuralgia, radiculitis, sports injuries of soft tissues, myositis.

However, the known tool has several disadvantages. There is no effect of speed, which is an important factor in the elimination of acute pain arising from injuries, in particular sports, dorsalgia, arthritis, arthrosis. In addition, the gel has limited functionality for muscle and joint pain of a non-infectious nature, since it does not have a regenerating and prolonged effect. Short shelf life - 6 months - reduce its consumer properties.

The objective of the invention is to provide a tool for the treatment and prevention of diseases of the musculoskeletal system, which does not have toxic and side effects, has wide functional capabilities, a more pronounced and quick therapeutic and prophylactic effect while improving consumer properties.

The essence of the invention lies in the fact that the tool for the treatment and prevention of diseases of the musculoskeletal system is characterized by the fact that it is a complex preparation, including complex No. 1 on a hydrophobic basis, containing active substances: peppermint peppermint, bitter wormwood, mountain arnica, seeds grapes, pharmacy chamomile, pine cones, marigold, string, sea buckthorn oil, bitter pepper oil, red palm oil, a mixture of essential oils of peppermint, lavender and cloves in a ratio of 1: 1: 1, bee venom, menthol, ca synthetic Mphora and auxiliary substances: shaping thickener - beeswax, preservative - propyl paraben, emollients - cetiol SS, DS 345 and liquid paraffin, antioxidant - Coveyx in the following ratio of components, wt.%

peppermint gorofit 0.5-1.5 wormwood wormwood 0.5-1.5 Arofnik mountain horophyte 0.5-1.5 Gorofit grape seed 0.5-1.5 gorofit chamomile pharmacy 0.5-1.5 pineapple cones 0.5-1.5 gorofit calendula 0.5-1.5 horofit series 0.5-1.5 sea buckthorn oil 1.0-5.0 bitter pepper oil 0.5-1.5 red palm oil 3.0-5.0 peppermint essential oil 1.0-5.0 lavender essential oil 1.0-5.0 clove essential oil 1.0-5.0 bee venom 0.001-0.006 menthol 1.0-6.0 synthetic camphor 1.9-2.6 beeswax 1.0-25.0 propyl paraben 0.005-0.04 Cetiol SS 5.0-10.0 DS 345 0.5-6.0 Covey Oaks 0.03-0.08 Vaseline oil up to 100%

and complex No. 2 on a hydrophilic basis, containing active substances: aqueous extracts of lilac, mountain arnica flowers, walnut peels, grape fruit procyanides, alcohol extract of propolis, Cova-B-trox and excipients: gelling agent - natrosol 250, moisturizers - propylene glycol and urea, complexing agent - disodium EDTU. emollient - phospholipids PLN, preservatives - methyl paraben and CG caton, pH-adjusting component - triethanolamine and deionized water in the following ratio of components. wt.%

water extract of lilac flowers 1.0-10.0 water extract of mountain arnica 1.0-10.0 walnut peel water extract 1.0-10.0 grape fruit procyanides 0.05-1.0 propolis alcohol extract 1.0-10.0 Cova-In-Trox 1.0-5.0 Natrosol 250 0.5-1.5 Propylene glycol 1.0-10.0 Urea 1.0-5.0 disodium EDTU 0.01-0.1 phospholipids PLN 1.0-10.0 Triethanolamine 0.05-0.2 Methylparaben 0.01-0.1 Cato CG 0.05-0.09 deionized water up to 100%

the ratio of complex No. 1 and complex No. 2 is 1: 1.

Using the invention allows to obtain the following technical result.

The proposed tool has a pronounced and prolonged therapeutic effect, which allows it to be used both for the prevention and treatment of various diseases and damage to the structures of the musculoskeletal system, and for improving the condition of the skin and underlying tissues.

The tool has a high therapeutic activity, which is expressed in its rapid and deep penetration into the tissues, warming and relaxing effect, improving blood circulation in the tissues and the expansion of blood vessels. It has an analgesic, anti-inflammatory, decongestant effect, accelerates reparative processes, improves trophic tissue. When using it, there is a significant improvement in the short term of the state of muscles, joints, skin, reduction or elimination of edema, soreness in problem areas of the body, restoration of joint mobility. The condition of the connective tissue improves.

A distinctive feature of the proposed therapeutic and prophylactic agent is its ability not only to easily penetrate through the skin, but also to accelerate bioenergetic processes in places of damage.

Its use helps to improve metabolic processes, reduce free radicals. However, it does not have a toxic effect and does not cause allergic reactions and side effects.

The effect obtained remains for a long time at a higher quality level, the state of which, after the application of the gel is not reduced to the initial one.

The use of the product has a general strengthening, healing and rejuvenating effect on the whole organism, increases its protective forces and adaptive capabilities, and replenishes the composition of microelements. Incidence decreases, including influenza and acute respiratory infections. The state of the cardiovascular and nervous systems, the activity of the cerebral cortex improves. The psycho-emotional state of a person and the quality of life in general are improving.

The tool has wide functionality. It can be used in cosmetology, in hygienic and therapeutic purposes, in particular for skin and underlying tissue care, restoration and strengthening in case of disorders such as atrophy, thinning, decrease in the density of connective tissue fibers, due to improved metabolic processes, strengthening blood vessels, normalization of the thickness of the epidermis, regeneration of the skin and connective tissues. It can be effectively used for resorption of collagen scars.

In sports medicine, the tool can be used as a massage to reduce pain during injuries, eliminate edema, bruises, damage to the musculo-ligamentous apparatus, restore joint mobility, restore athletes' performance after heavy physical exertion.

In the field of medicine it can be used for the prevention and treatment of arthrosis, arthritis, osteochondrosis, dorsalgia, arthrosoarthritis, myositis. Moreover, it exhibits an anti-inflammatory, decongestant, analgesic effect, and a quick restoration of the function of the damaged joint occurs.

It is possible to use the drug in the complex treatment of bronchitis, tracheobronchitis, pneumonia, pleurisy caused by any infectious agent, the etiological characteristic of which is not caused by cancer.

With osteochondrosis, the therapeutic effect of the drug is manifested in the removal of pain, muscle relaxation, restoration of mobility in the affected segments. The innervation of the extremities involved in the pathological process is normalized. With myositis, neuralgia, the use of the drug contributes to the persistent removal of the pain syndrome, normalization of muscle tissue tone, restoration of mobility of the involved part of the body.

Perhaps the effective use of the remedy for chronic fatigue syndrome, asthenic conditions, neuroses of various origins and other psychological diseases in combination therapy. The use of the drug is also shown for neuralgia, in particular the trigeminal nerve, neuritis, for various pathologies of the neurological profile in general therapeutic and neurological practice - with hypertonicity, hypotension, etc.

In addition to these therapeutic properties, the proposed tool has higher chemical and technological properties and consumer qualities. Compared with gels of this type, it has longer shelf life and shelf life. Its properties are maintained stably for at least 2 years, which is of no small importance for consumers and trading organizations.

The technical result is achieved due to the fact that the claimed tool has a comprehensive focus on all the mechanisms that underlie violations in diseases and pathological conditions of the musculoskeletal system and their clinical manifestations, has a wide range of pharmacological effects and not only restores all impaired organ functions, but and has a systemic effect on the whole organism as a whole, having a self-regulating nature.

The high effectiveness of the composition is primarily due to the wide range of pharmacological effects due to the unique selection of biologically active components in complex No. 1 and complex No. 2.

The therapeutic properties of complex No. 1 on a hydrophobic basis are due to its constituent components, primarily horophytes. Horophytes - the name of plant extracts produced by the NRC ER GORO company, Rostov-on-Don, obtained by supercritical extraction with carbon dioxide at a temperature of over 100 degrees C and a pressure of about 500 atm in the form of oil extracts (TU 9154-001 -51585120-01). This allows you to selectively isolate hydrophobic substances such as tocopherols, triglycerides, polyunsaturated fatty acids, ubiquinone, steroids, flavanoids, essential oils, avoiding the presence of a number of substances, including free fatty acids, which ensures oxidative stability of the system and preserves the properties of the released substances . All supercritical carbon dioxide extracts are strong antioxidants. The absence of organic solvents that adversely affect the skin is also a positive point.

Peppermint horophyte, which is part of complex No. 1, has a wide spectrum of pharmacological action due to the presence of a complex of biologically active compounds in it: essential oil, including menthol and other terpenoid compounds, a fatty oil consisting of triglycerides and fat-soluble vitamins. It has a light local anesthetic and antiseptic effect, has antimicrobial, soothing, spasmolytic properties. Due to the local irritating effect on the peripheral neuroreceptors of the skin and mucous membranes, it enhances capillary circulation, which provides optimal conditions for transporting leukocytes, hemoglobin, therapeutic substances and decay products, toxins, and microbes to the affected organ or body area.

Wormwood gorophyte contains essential oil and fat-soluble vitamins. Capillin has an active antibacterial effect. Absintin glycoside has an anti-inflammatory effect and helps stabilize non-specific immune responses. The terpinoid compounds contained in the plant have a pronounced anti-inflammatory effect and stimulate phagocytic activity. Bitterness increases the excitability and reaction of neurorespersters. Wormwood essential oil has a pacing and stimulating central nervous system effect. Provitamin A stimulates the activity of skin cells and connective tissue, strengthens it, eliminating sagging skin and increasing its turgor, improves the immunological status of the body.

Horophyte of chamomile pharmacy was introduced into the complex No. 1 as an anti-inflammatory, antiseptic, sedative and relaxing agent. Chamazulene, which is part of chamomile essential oil, has an anti-allergic effect. The hydrophobic fraction of chamomile has antispastic, soothing, analgesic properties. It accelerates the processes of epithelial regeneration, delays the development of tissue inflammation, relieves spasm of blood vessels and muscles.

The use of pine cones in the composition of the horophyte complex is due to its pronounced general strengthening and healing properties. Pine kidney extract contains antiviral and antimicrobial agents. The composition of the needles includes ascorbic acid, tannins and anthocyanins, alkaloids, terpenes, and others. Pine cones contain tarry and tannins, essential oils, vitamins, and pinicrin (bitterness). Penetrating deeply into the skin, pine extract has a warming, relaxing effect, irritates skin receptors, and improves the exertion of internal organs. It has antiviral and antimicrobial effects. It has a therapeutic effect in various diseases of the musculoskeletal system: sciatica, neuralgia, myositis, arthritis, arthrosis and other inflammatory diseases.

The main properties of calendula are anti-inflammatory, bactericidal, antispasmodic, wound healing. The antiviral activity of calendula preparations was established when applied topically (suppresses the activity of the herpes virus). Calendula horophyte has a wide spectrum of pharmacological action, primarily due to the rich content of biologically active compounds such as carotenoids and flavonoids in the plant’s flowers. Calendula extract accelerates tissue regeneration processes, accelerates growth and improves the quality of granulations, contributes to faster epithelization and the formation of a more tender scar. In combination with chamomile, these properties are enhanced and prolonged, providing a pronounced anti-inflammatory effect on the skin, muscles and joints.

Gorofit grape seed (seed) is introduced into the formulation as a general strengthening, metabolism enhancing agent, as well as a source of polyunsaturated fatty acids, indispensable for maintaining the structure of the skin.

Horophyte of mountain arnica contains resinous substances, essential oil, carotenoids, alkaloids and other compounds that determine the biological activity and spectrum of application in medicine. Arnica horophyte has an anti-inflammatory and absorbable effect on the skin and underlying tissues, relieves swelling, reduces redness and blueness of the skin with bruises, bruises, bruises, sprains. Along with tonic, it has a sedative effect, relieves muscle tension, and soothes inflammation. Effective with pustular skin lesions, light burns, frostbite.

Gorofit series contains essential oil, bitter substances, carotene. flavonoids, trace elements, including manganese, with which the antimicrobial properties of the series are associated. Improves trophic tissue, strengthens the walls of blood vessels.

Sea buckthorn oil is formulated as a valuable biologically active ingredient. It contains a significant amount of vitamins: tocopherol (vitamin E), B ₁ , B ₂ , B ₆ , P, K, carotenoids (provitamin A), trace elements, fatty acids (oleic, linoleic, linolenic), coumarins, flavonoids, essential oils.

Essential fatty acids - linolenic and linoleic - take an active part in fat metabolism, enhance lipolytic activity, the regenerative ability of the epidermis, improve the condition of connective tissue, increase the fat content in it, strengthen the walls of blood vessels, make them more elastic, improve blood and lymph circulation, prevent and cure dermatoses. Carotenoids stimulate the activity of skin cells, eliminate its sagging, favorably affect the immunological status of the body. Sea buckthorn oil has a regenerative ability, accelerates epithelization and stimulates the growth of granulations, protects biological membranes from the damaging effects of chemical agents. Tocopherols, being a natural anti-inflammatory agent and at the same time an antioxidant, participate in protein biosynthesis, cell proliferation, cellular and tissue respiration, increase and restore the body’s working capacity. They regulate the metabolism of proteins, fats, carbohydrates, increase skin resistance to the development of age-related changes. Sea buckthorn oil has a multifaceted effect: softens the skin, nourishes it and the underlying tissue, restores its condition, strengthens connective tissue, and increases the body's resistance. Its main properties: antiseptic, antispasmodic, bactericidal, hypotensive. healing. It has a pronounced anti-inflammatory activity. Promotes rapid recovery of forces, provides energy relaxation.

Red palm oil, which is part of the complex, contains provitamin A, (carotenoids) vitamin E, (tocopherols, tocotrienols), coenzyme Q 10 is a powerful antioxidant. Used for skin diseases. Strengthens the immune system, prevents the formation of blood clots, slows down the aging process.

Bitter pepper oil is used as an irritant and distracting agent for radiculitis, myositis, lumbar and myalgia, and rheumatic joint pain. The alkoloid-like amidcapsancin, which is part of the fruit, has an irritating effect.

The complex No. 1 introduced a mixture of essential oils of peppermint, lavender and cloves in a ratio of 1: 1: 1.

Peppermint essential oil helps with inflammatory skin diseases, eliminates nervous agitation. Relieves fatigue. It creates the effect of cooling and freshness.

Lavender essential oil has an anti-inflammatory effect on the skin, promotes the regeneration of skin cells and reduces the possibility of scar formation. It has an antispasmodic effect, stimulates the lymphatic system and thus promotes the removal of toxins from the body resulting from metabolism, frees the body from toxins.

Clove essential oil is an antiseptic. It has an analgesic effect with neuralgia, arthritis, rheumatism. Strengthens the immune system. Effectively with inflammation of the skin, helps to relax after physical overwork, relieves muscle cramps, eliminates mental fatigue, slows down the aging process.

Bee venom helps with inflammatory skin diseases, eliminates nervous agitation.

The composition of bee venom includes the MSD peptide (peptide-401), which can increase capillary permeability, irritate the central nervous system and has an anti-inflammatory effect. Adolapine causes anti-inflammatory, analgesic and antioxidant effects. Hyaluronidase catalyzes the breakdown of hyaluronic acid - the main component of connective tissue, facilitating the penetration of bee venom and other active components through the skin.

Menthol has a calming, analgesic, antiseptic effect. It has anti-inflammatory and locally irritating effects, reflexively causes the expansion of coronary vessels, increases the permeability of skin capillaries. When rubbed into the skin, it causes irritation of the nerve endings, accompanied by a feeling of cold, a slight burning sensation and tingling sensation. Used as a pain reliever.

Camphor is one of the main representatives of analeptic drugs. Under the influence of camphor, peripheral blood vessels narrow. There are indications that it inhibits platelet aggregation, and therefore can be recommended for use to improve microcirculation. It is used for rheumatism and arthritis. The absence of significant differences between the action of natural and synthetic camphor has been established.

The excipients introduced into the complex No. 1 - beeswax, liquid paraffin, cetiol SS, DS 345, propyl paraben, cove-ox, were carefully selected by the authors taking into account its hydrophobic nature according to the principle of compatibility, interaction and optimization of the properties of the whole composition.

Beeswax was formulated as a formative thickener. Of all beekeeping products, it has the least reactivity. Being a polyhydric alcohol, it forms a nonionic compound with gorophytes, which gives the composition the form of a gel-like substance. Beeswax is a complex combination of more than three hundred substances. It has absorbent, bactericidal, anti-inflammatory, wound healing properties.

As emollients (softeners), a complex of substances with different spreadability is used - vaseline oil, Cetiol SS and DS 345.

Petroleum jelly is a transparent, heavy, odorless emollient with a low flow rate, and is used with light and / or medium emollients to ensure optimal glide.

Cetiol SS is a transparent, colorless, almost odorless light emollient with low polarity and molecular weight, with a high spreadability. Has good skin compatibility. Its use is especially advisable in cosmetics for the skin.

DS 345-cyclomethicone is a light silicone emollient.

Propylparaben is a fat-soluble preservative selected from their paraben sodium salts.

Covey-oks (COVI-OX) - a product of natural origin, which is a mixture of tocopherols in the form of a clear brown-red viscous oil, introduced into the composition as a natural antioxidant.

All components of complex No. 1 are certified for cosmetic use.

The formulation of complex No. 1 is designed in such a way that active and auxiliary substances of hydrophobic nature are introduced into it, carefully selected in quantitative and qualitative composition, which together enhance the therapeutic properties of the therapeutic and prophylactic agent, potentiate and prolong the action of the active components, thereby determining its uniqueness and effectiveness.

Thus, complex No. 1, due to the special combination and properties of its constituent components and the synergy of their action, has a therapeutic and prophylactic effect: bacteriostatic and fungicidal properties, exhibiting antiviral activity when applied topically. It has anti-inflammatory, sedative, decongestant, anti-allergic, analgesic, regenerative effects. Stimulates cell activity and metabolism. It also has an antioxidant effect, blocking free radicals of exogenous and endogenous origin. It has a general strengthening, healing and rejuvenating effect. Due to the plant components included in the hydrophobic fractions, the tone of peripheral skin neuroreceptors, capillary circulation and lymph circulation are normalized, providing optimal conditions for transporting leukocytes, hemoglobin, trace elements and removal of decay products, toxins and microbes from it. This leads to tone correction and strengthening of the walls of blood vessels, helps relieve swelling, prevent blood clots, and resolve bruises. Relieves spasm of blood vessels and muscles (muscle tension and muscle cramps). Helps to relax after exercise. Relieves skin irritation and softens it. It has analgesic, relaxing effect. Improves the immunological status of the body. Stimulates factors of nonspecific resistance, slowing down the aging process of tissues. The overall tone and performance of the body is restored.

The therapeutic properties of complex No. 2, which is hydrophilic in nature, are determined by its constituent components: aqueous extracts of lilac flowers, mountain arnica, walnut peels, alcohol extract of propolis, grape fruit procyanides (LCW, France), complex extract from brown algae and chicory polysaccharides with a high content of magnesium ions, Cova В Trox (Cova В Trox LCW, France).

The aqueous extract of lilac flowers has an antimicrobial, anti-inflammatory, analgesic and sedative effect, has a bactericidal effect (inhibits gram-positive bacteria due to farnesol, which is part of the lilac flowers), relieves inflammation in the affected areas both on the skin surface and in the connective tissue. It acts on the skin neuroreceptors, providing an analgesic effect.

Water extract of mountain arnica is introduced into the composition as a means of having a calming, protective, regenerating effect.

The aqueous extract of the walnut peel contains vitamins C, B ₃ , PP, quinones (cyclic diketones - compounds contained in natural pigments), salts of iodine, iron and phosphorus. It has bactericidal, anti-inflammatory, restorative, astringent, epithelizing properties. It normalizes the permeability of the walls of blood vessels, increases the body's reactivity to infections, and participates in the redox processes of the body. The diamine, organic acids, iron, phosphorus which are a part contribute to improvement of a metabolism. Due to ascorbic acid (as part of vitamin C), the permeability of the walls of blood vessels is normalized, and the body's reactivity to infections increases. Vitamin PP - nicotinic acid - is actively involved in redox processes, carbohydrate metabolism; contributes to the normalization of capillary permeability, thus simplifying the process of penetration of biologically active substances into the lower layers of the skin, subcutaneous fat, muscle.

Propolis consists of a mixture of resins, waxes of essential oils, flavones, flavonoids and phytoncides. It is a painkiller anti-inflammatory and disinfectant. The main components of propolis are flavanoids. Flavanoids are most active in combination with ascorbic acid, reducing the fragility of blood vessels.

Procyanides of grape fruit are substances isolated from grape fruit that have a strong antioxidant property and are soluble in water. They have a tonic, antioxidant, anti-inflammatory, anti-allergic, anti-edematous effect. They contribute to the strengthening of metabolic processes, improve the adsorption of vitamins, stabilize cell membranes, reduce the permeability of capillaries, and also block the action of free radicals, inhibit the aging process of the skin. They are an effective component in the complex treatment of inflammatory joint diseases - arthrosis, arthritis, etc.

Cova-B-Trox (Cova-B-Trox) is a complex extract of polysaccharides and alginates of red and brown algae, chicory and magnesium salts, provides relaxation of muscle fibers and activates the synthesis of substances of the dermal matrix.

All components of complex No. 2 are certified for cosmetic use.

Excipients, carefully selected by the authors, taking into account its hydrophilic nature according to the principle of compatibility, interaction and optimization of the properties of the whole composition, were introduced into complex No. 2.

Natrosol-250 is a gelling base.

Propylene glycol is a moisturizer that retains moisture in the upper layers of the epidermis.

Urea is a moisturizer, which is a component of a natural moisturizing factor, retaining moisture in the stratum corneum of the epidermis.

Methylparaben is a water-soluble preservative selected from paraben salts.

Cato CG is a preservative.

Disodium EDTU (ethylenediaminetetraacetic acid) was formulated as a complexing agent. It is a mixture of ethylenediaminetetraacetic acid, it is a chelating agent that enhances antimicrobial activity.

Triethanolamine was introduced into the complex No. 2 as a component that regulates the pH of the medium.

Phospholipid PLN obtained from soy is used as a natural emollient (softener) and to maintain the structure of the epidermal layer.

Phospholipids have a unique natural structure, representing amphipathic molecules with hydrophobic and hydrophilic ends, due to which when a hydrophobic and hydrophilic complex is applied to the skin, a viscous network of lipid layers is formed that additionally stabilize the emulsion without disturbing the structure of the lipid plates of the stratum corneum of the epidermis (unlike unstructured oils). At the same time, the stability and biological activity of the components of both hydrophobic and hydrophilic compositions, including unstable active substances, are maintained. The impaired metabolism and the protective function of the skin and underlying tissues are restored. Phospholipids control the gradual release of active components, thus ensuring their prolonged action.

The formulation of complex No. 2 is designed in such a way that all its constituent components are hydrophilic in nature. Along with water-soluble extracts of biologically active substances, the complex includes procyanidins of grape fruits, which have maximum antioxidant and antimutagenic activity, improve the absorption of vitamin C and provide capillaroprotective functions.

An optimally selected composition, including active and auxiliary substances of a hydrophilic nature, contributes to a more effective manifestation of the therapeutic properties of all active ingredients.

Complex No. 2, due to the components contained in it and the synergy of their action, has therapeutic and prophylactic properties: anti-inflammatory, soothing, reparative, regenerating, antioxidant, analgesic bactericidal, anti-allergic and decongestant.

Due to the active components of the hydrophilic base, cell membranes are stabilized, capillary permeability is normalized, oxidation-reduction processes are stabilized, lipid and carbohydrate metabolism is improved, and the general level of metabolism is regulated.

Separate components are involved in the formation of phospholipids, which strengthens cell membranes and helps to remove toxic metabolic products from them.

The composition of the active components relieves skin hyperemia during bruising, bruising, bruises and sprains, promotes the penetration of natural active substances into the deeper layers of the skin, subcutaneous fat, muscles, joints, and replenishes the deficiency of trace elements and vitamins in the body, increasing overall resistance to infections.

In combination, these properties are enhanced, providing a pronounced prolonged effect on the skin, muscles and joints.

The claimed technical result is achieved using two complexes: hydrophobic - No. 1 and hydrophilic - No. 2, which are part of the product, with a ratio of 1: 1, which provides a comprehensive therapeutic and preventive effect on all the functions of the musculoskeletal system.

For the first time, a tool has been developed, which is a composition of two complexes, one of which has a hydrophobic base, and the second is hydrophilic. All components included in complex No. 1 are hydrophobic, and the components of complex No. 2 are hydrophilic. The complexes are stored in separate containers in order to ensure primarily their oxidative stability and activity. Some of the substances of even the same plant with a hydrophobic composition cannot be mixed with hydrophilic, since this leads to a violation of the spatial separation of the media in different parts of the plant, as a result of which they lose their activity. For example, it is impossible to maintain the activity of ascorbic acid in the walnut extract when it comes in contact with sea buckthorn oil, since copper ions contained in sea buckthorn oil destroy ascorbic acid, therefore, preservation of properties and consumer qualities is possible only if stored separately, the shelf life of which increases to 2 or more years.

The high effectiveness of the drug is also due to the synergistic action of its constituent components, which, when two complexes interact, simultaneously produce original bi-directional biological potentiated and prolonged effects, which allows for a pronounced therapeutic effect at their low concentrations. So, due to flavonoids, contained in large quantities in complex No. 1, and water-soluble polysaccharides of complex No. 2, good absorption and deep penetration of the components of the gel into the tissue occurs, and its activity increases. In combination with ascorbic acid of complex No. 2, flavonoids reduce the fragility of blood vessels, including capillaries. Phospholipids of PLN, having both a hydrophobic and hydrophilic nature, provide a prolonged action of the entire composition, gradually releasing the active components of the hydrophobic and hydrophilic components, which interact effectively.

The tool provides a simultaneous complex effect on all parts of the pathological processes underlying the violation of the function and condition of the skin and musculoskeletal system, as well as on the mechanisms of restoration of affected structures, including self-regulation processes.

Using the tool allows you to achieve rapid stabilization and elimination of inflammatory and degenerative processes, preventing their transition to a chronic form and recurrence. Improved or restored impaired functions of the musculoskeletal system, skin condition due to improved microcirculation, rapid delivery and deep penetration into the inflammatory and / or pathological focus of biologically active substances and prolonged therapeutic effect. The effect of the effect is manifested in an increase in the number of functioning capillaries and acceleration of capillary blood flow against the background of heating and relaxation of the exposure area, including skin and muscles. This leads not only to an improvement in blood supply to a given part of the body surface, causing the growth of new cells, but also to an acceleration of blood flow in other parts of the body and organs, having a positive effect on hemodynamics. The pathological focus is also eliminated by improving the drainage function of the skin, stimulating detoxification, reparative and degenerative processes, increasing the resistance of the skin and underlying tissues against the background of an increase in the immunological status of the whole organism.

The tool has a pronounced strengthening and restorative effect on the condition and function of connective tissue, which, as you know, is the support of the whole organism. With its inflammatory and degenerative diseases, its structure changes, the transport function is disrupted: the delivery of nutrients, oxygen, the removal of metabolic products. Destructive processes develop that adversely affect the body. Their manifestation is diverse: violation of innervation and pain syndrome with osteochondrosis, impaired joint mobility with arthritis, arthrosis. Violation of the venous outflow is accompanied by swelling and pain of the lower extremities, ischemic tissue. When using the product, regenerative and reparative processes in the connective tissue, accelerated cell formation, and then the accumulation of collagen in the skin, muscles, ligaments, cartilage, increased lipid biosynthesis, improved transport function, support and protective functions are restored. Perhaps a complete restoration of joint mobility and, in general, the function of the musculoskeletal system. When using an agent for the treatment of spinal diseases, the restoration of impulse conduction from nerve endings was noted, as a result of which the innervation of tissues and internal organs improves.

The tool is offered in the most effective form - the gel form. The gelling agents that make up the complexes form a stable viscous substance in the product, non-toxic. In addition, the gel-forming base is able to penetrate quickly and deeply into tissues, providing favorable conditions for obtaining a quick, prolonged and pronounced therapeutic effect. In the proposed tool, including two compositions, all components are selected in a strictly balanced ratio. The exclusion of one of them or a change in their ratio in each of the compositions leads to a decrease or disappearance of the claimed effects. None of the substances included in the tool, alone in itself does not have the entire breadth of the spectrum and duration of action. When changing the amount of one of the components in one of the complexes (No. 1 or No. 2), correction of all components in both compositions is required. The complex interaction of trace elements, vitamins and other biologically active substances at the same time of both complexes No. 1 and No. 2 allows to obtain a technical result, including not only mutual potentiation, increase of biological value, absorption and impact on tissues, but also to show new, unobvious effects.

An agent for the treatment and prevention of diseases of the musculoskeletal system, which is a complex preparation, including complex No. 1 and complex No. 2, is prepared as follows.

For the preparation of complex No. 1, all the necessary components are prepared in prescription amounts in accordance with the consumption norms.

As a shaping thickener, beeswax or a substance similar in properties to it is used.

Preservative - propylparaben is selected from sodium salts of parabens or similar substances according to their properties.

As emollients, liquid paraffin, cetiol-SS and DS 345 or substances similar in their properties are used.

As an antioxidant, Covey-ox is used.

The following are used as biologically active substances: horophytes - oil extracts obtained by the method of supercritical extraction: peppermint, wormwood, mountain arnica, grape seed (seeds), pharmacy chamomile, pine cones, calendula, succession; sea buckthorn oil; bitter pepper oil, red palm oil, a mixture of essential oils of mint, lavender and cloves in a ratio of 1: 1: 1, as well as bee venom, menthol and camphor.

Emollients are placed in homogenizer No. 1: liquid paraffin and DS 345, peppermint horophytes, bitter wormwood, mountain arnica, grape seeds. pharmacy chamomile, pine cones, marigold, string, bitter pepper oil, bee venom and antioxidant Covey-oks. The resulting mixture is stirred using a frame mixer at a temperature of 25 ° C for 20 minutes until a homogeneous mass is formed.

In parallel, in a homogenizer No. 2, a mixture of essential oils of peppermint, lavender and cloves in a ratio of 1: 1: 1 and the active substance menthol are placed, mixed with a frame stirrer at a temperature of 25 ° C for 20 minutes until a homogeneous mass is formed.

At the same time, cetiol SS emollient, biologically active substances: palm oil, sea buckthorn oil, as well as camphor, preservative - propyl paraben and shaping thickener - beeswax are placed in homogenizer No. 3. Heated to 40 ° C and stirred to a homogeneous mass for 20 minutes using a frame mixer.

Then the contents of homogenizers No. 1 and No. 2 are pumped into the homogenizer No. 3. The resulting mixture is homogenized for 5 minutes at a temperature of 30 ° C.

The finished product is checked for microbiological purity and compliance with TU 9158-004-08628011-00 and packaged in vacuum dispensers.

The finished product is a homogeneous jelly-like mass of orange-brown color with the smell of menthol. The viscosity of the mixture is 2000-5000 cP.

For the preparation of complex No. 2, all the necessary components are prepared in prescription quantities in accordance with the consumption norms.

As a gelling agent, natrosol 250 or gelling agents similar in properties are used.

Propylene glycol and urea, or substances similar in properties to them, are used as humidifiers.

As a complexing agent, disodium EDTU (ethylenediaminetetraacetic acid) or chemicals similar in properties are used.

As an emollient (softener), phospholipids of PLN or similar substances are used.

As preservatives, methyl paraben and Catone CG or similar preservatives are used.

As a pH adjusting component, triethanolamine or a pH regulator similar in properties is used.

As biologically active substances, water extracts of the flowers of lilac, mountain arnica, walnut peel, alcohol extract of propolis, procyanidins of grape fruit are used.

Deionized water is poured into homogenizer No. 4 until the upper tier of the mixer is coated, then procyanidins of grape fruit are introduced and mixed with a frame mixer at 25 ° C until completely dissolved.

At the same time, a humidifier — propylene glycol, Kova-in trox — is placed in homogenizer No. 5 and mixed with a frame mixer for 10 minutes at 25 ° C until a homogeneous mass is formed.

In parallel, homogenizer No. 6 is injected with a preservative - CG Caton, mountain arnica extract, alcohol extract of propolis and mixed at 25 ° C until a homogeneous mass is formed. Then, the contents of homogenizers No. 4 and No. 5 are pumped into the same homogenizer and the mixture is mixed using a frame mixer at a temperature of 25 ° C until gel formation. Then, aqueous extracts of lilac flowers and walnut peels are added to the resulting gel with constant stirring.

Deionized water is poured into homogenizer No. 7 until the upper tier of the mixer is coated, then a humidifier - urea, a complexing agent - disodium EDTU, a preservative - methyl paraben are introduced, heated to 60 ° C and a gel-forming agent - natrosol 250 is added with stirring with a frame stirrer until a gel-like mass is obtained. The resulting gel is cooled to 30 ° C and, upon homogenization, emulsions - phospholipid PLN are added, the pH regulator is triethanolamine. Then, the contents of homogenizer No. 6 are pumped into the homogenizer No. 7 with constant stirring.

The finished product is checked for microbiological purity and compliance with TU 64-19-162-92. Then packaged in vacuum dispensers.

The resulting gel is a homogeneous jelly-like mass of orange-brown color with a viscosity of 600-700 cP with the smell of propolis and walnut essential oils.

Vacuum dispensers with complex No. 1 and vacuum dispensers with complex No. 2 contain an equal amount of these products and are stored at 25 ° C. Shelf life 2 years.

Examples of obtaining funds for the treatment and prevention of diseases of the musculoskeletal system are presented in table 1.

Table 1 Complex number Components The value of the content of components, wt.% Examples one 2 3 Complex number 1 Peppermint Horophyte 0.5 1,5 0.8 Gorofit wormwood 1,5 0.5 0.6 Horofit arnica mountain 0.5 1,5 0.7 Gorofit grape seed 0.5 1,5 0.6 Gorofit chamomile pharmacy 1,5 0.5 0.77 Pine cones gorofit 0.5 1,5 0.95 Horophyte calendula 0.5 1,5 085 Horophyte series 1,5 0.5 0.78 Sea buckthorn oil 1,0 5,0 3.0 Bitter pepper oil 0.5 1,5 0.67 Palm oil 3.0 5,0 4.0 Peppermint essential oil 1,0 5,0 3,5 Lavender essential oil 1,0 5,0 3,5 Clove essential oil 1,0 5.0 3,5 Bee venom 0.001 0.003 0.006 Menthol 1,0 3.0 6.0 Camphor synthetic 2.0 2.6 4.0 Beeswax 16,0 1,0 25.0 Propylparaben 0.005 0.1 0.04 Cetiol CG 6.3 5,0 10.0 DS 345 0.5 6.0 1,0 Covey Oaks 0,03 0.08 0.05 Vaseline oil up to 100 up to 100 up to 100 Complex number 2 Water extract of lilac flowers 1,0 4.0 10.0 Water extract of mountain arnica 1,0 10.0 5,0 Walnut Peel Water Extract 10.0 1,0 5.5 Grape Procyanides 0.05 1,0 0.12 Propolis Alcohol Extract 1,0 10.0 6.0 Cova-In-Trox 1,0 2.6 5,0 Natrosol 250 0.8 0.5 1,5 Triethanolamine 0.05 0.2 0.1 Propylene glycol 1,0 5,0 10.0 Urea 3.0 1,0 5,0 Disodium EDTU 0.01 0.1 0.05 Phospholipids PLN 5,0 1,0 10.0 Methylparaben 0.01 0.05 0.1 Cato CG 0.06 0.05 0.09 Deionized water up to 100 up to 100 up to 100

The proposed tool is used as follows.

In the area of the lesion or the painful part of the body, a small amount of gel of composition No. 1 and composition No. 2 in a ratio of 1: 1 is simultaneously applied to the skin surface and rubbed by gentle massaging movements until completely absorbed. In sports injuries, the drug is used twice a day for 5-10 days until recovery. In case of joint diseases - arthritis, arthrosis - the product is applied to the joint projection area, capturing 1-3 cm of the painless area, 1-2 times a day for 3-7 days until the pain symptoms are completely relieved and the joint mobility is restored to normal. In osteochondrosis, the course of treatment is 10 days to a state of significant improvement or recovery. For preventive purposes - if the patient has a history of diseases of the musculoskeletal system, with increased physical exertion, and also with the aim of quickly removing the inflammatory process to prevent its transition to a chronic form - the drug is used 1-2 times a day for 3-5 days.

The proposed tool was tested on 15 volunteers at the Sports base MVVKU.

A pilot study of the drug was carried out for 28 days. Athletes with a training level of at least 2nd category and professional athletes participated as subjects. Each subject underwent a course of treatment from 2 to 12 days.

Analysis of the results of a pilot study of the proposed tool for the treatment and prevention of diseases of the musculoskeletal system showed its high efficiency. Only in a single case did the subject experience an allergic reaction. The test results are shown in table 2.

Thus, the proposed tool for the treatment and prevention of diseases of the musculoskeletal system can be widely used in the field of medicine and cosmetology.

table 2 No. (p / p) Initials Age Sports Status Disease, type of injury Therapeutic effect Terms of use Achieved therapeutic result The stability of the therapeutic effect one. M.M. 45 International Master of Sports (MSMK), World Champion in Cross-Country. In sports for 30 years. Radiculitis of the lumbosacral spine, myositis of the muscles of the thoracic region Reduction of pain, restoration of mobility in the lumbosacral region on the 2nd day For 3 days, 1 time per day Significant improvement 4 months no relapse 2. L.V. 37 MSMK, in sports for 23 years. Sports direction: 800m running Sciatic Neuralgia Reduced pain, improved functional mobility, a marked improvement in overall well-being on the 3rd day of use For 3 days, 2 times a day Significant improvement Remission for 6 months of follow-up 3. HER. 37 MSMK, Sports: marathon Sciatic Neuralgia Reduced pain, improved functional mobility, a marked improvement in overall well-being on the 3rd day of use For 3 days, 2 times a day Significant improvement No complaints during 6 months of observation four. D.N. 19 Spot Master (MC), Russian Champion 400m. In sports for 6 years. Femoral muscle injury Improving microcirculation, reducing the area of edema, restoring muscle normotonicity on the 3rd day after application Treatment for 3 days, 1 time per day Recovery There are no complications within 6 months 5. M.N 33 MS, Champion of Russia in marathon. In sports 16 years. Radiculitis of the lumbosacral spine, sciatic nerve neuralgia Reduced pain, a marked improvement in mobility on the 5th day of use Course treatment for 7 days, 1 time per day Recovery No relapse within 6 months 6. A.S. 17 Candidate for Master of Sports (CCM), 4 years in sport. Sports direction: 800m running Femoral muscle injury Improving microcirculation, reducing the area of edema, restoration of muscle normotonicity on the 3rd day of use Treatment for 3 days, 1 time per day Recovery No complaints within 6 months 7. Yu. V. 17 CCM, Sports: Sprint 200 m. Ankle pain Reduced swelling, improved joint mobility, reduced pain for 3 days of use Course treatment for 10 days, 1 time per day Significant improvement No deterioration was observed within 6 months 8. YES. 19 CCM, Champion of Russia in cross-country, in sports for 6 years. Achilles tendon injury Reduced swelling, improved joint mobility, reduced pain for 3 days of use For 3 days, 2 times a day Significant improvement No complaints during 6 months of observation 9. E.A. 27 MS, in sports for 10 years. Sports Direction: Stayer Muscle pain after training. Removing pain, restoring normotonus the day after the start of use Within 2 days, with the appearance of pain, after 2 weeks, repeated use within 2 days Significant improvement No complaints within 3 months of observation 10. A.V. 25 MSMK, in sports for 10 years. Sports direction: marathon. Muscle pain after training. Removing pain, restoring normotonus the day after the start of use Within 3 days, after 3 weeks, repeated use within 2 days Significant improvement No complaints within 3 months of observation eleven. R.I. 25 MS, in sports for 10 years. Sports direction: marathon. Muscle pain after training. Pain relief the day after application, complete recovery on the 7th day Course treatment for 7 days, 1 time per day Significant improvement No complaints within 3 months of observation 12. E.F. 17 2 category, Sports direction: styer. Pain syndrome of the knee joint. Removing pain, improving joint mobility Application for 3 days, 1 time per day Recovery No complaints during 6 months of observation 13. S.I. 26 Honored Master of Sports, World Champion in Pole Vault Radiculitis of the lumbosacral spine, Achilles tendon injury Refused further use of the gel Single use Negative effect and allergic reaction - fourteen. O.A. eighteen 2 category, in sport 4 years. Sports direction: 800 m Pain in the calf muscles Removing pain, reducing swelling on the 2nd day of use Application for 3 days, 1 time per day Full recovery No complaints during 6 months of observation fifteen. G.B. eighteen MS, Champion of Russia, in sports for 6 years. Knee pain Removal of pain. reduction of puffiness on the 3rd day of use For 3 days, 1 time per day Noticeable improvement No complaints during 6 months of observation

Claims (1)

Means for the treatment and prevention of diseases of the musculoskeletal system, characterized in that it is a complex preparation, including hydrophobic composition No. 1, containing gorophytes of peppermint, wormwood, mountain arnica, grape seeds, pharmacy chamomile, pine cones, calendula , series, sea buckthorn oil, bitter pepper oil, red palm oil, peppermint, lavender and clove essential oils, bee venom, menthol, synthetic camphor, beeswax, propyl paraben, cetiol SS and DS 345, Coveyx and VAZ olein oil in the following ratio of components, wt.%: Peppermint Horophyte 0.5-1.5 Gorofit wormwood 0.5-1.5 Horofit arnica mountain 0.5-1.5 Gorofit grape seed 0.5-1.5 Gorofit chamomile pharmacy 0.5-1.5 Pine cones gorofit 0.5-1.5 Horophyte calendula 0.5-1.5 Horophyte series 0.5-1.5 Sea buckthorn oil 1.0-5.0 Bitter pepper oil 0.5-1.5 Red palm oil 3.0-5.0 Peppermint essential oil 1.0-5.0 Lavender essential oil 1.0-5.0 Clove essential oil 1.0-5.0 Bee venom 0.001-0.006 Menthol 1.0-6.0 Camphor synthetic 1.9-2.6 Beeswax 1.0-25.0 Propylparaben 0.005-0.04 Cetiol SS 5.0-10.0 Cetiol DS 345 0.5-6.0 Covey Oaks 0.03-0.08 Vaseline oil rest and composition No. 2 on a hydrophilic basis, containing aqueous extracts of lilac, mountain arnica flowers, walnut peels, grape fruit procyanides, alcohol extract of propolis, Cova-B-trox, natrosol 250, propylene glycol, urea, disodium EDTU, PLN phospholipids, methyl paraben, CG caton, triethanolamine and deionized water in the following ratio, wt.%: Water extract of lilac flowers 1.0-10.0 Water extract of mountain arnica 1.0-10.0 Walnut Peel Water Extract 1.0-10.0 Grape Procyanides 0.05-1.0 Propolis Alcohol Extract 1.0-10.0 Cova-In-Trox 1.0-5.0 Natrosol 250 0.5-1.5 Propylene glycol 1.0-10.0 Urea 1.0-5.0 Disodium EDTU 0.01-0.1 Phospholipids PLN 1.0-10.0 Triethanolamine 0.05-0.2 Methylparaben 0.01-0.1 Cato CG 0.05-0.09 Deionized water rest the ratio of composition No. 1 and composition No. 2 is 1: 1.