MX2011008254A - Composition for the cellular regeneration of topic application for treating different skin disorders. - Google Patents

Abstract

The present invention is related to compositions used for treating skin disorders and more particularly being referred to a composition for the cellular regeneration of topic application for treating different skin disorders, which is characterised in that it comprises a safe and effective amount of lard, a safe and effective amount of turpentine, a safe and effective amount of virgin bees wax and a safe and effective amount of lemon juice (citrus limonium).

Description

COMPOSITION FOR CELLULAR REGENERATION OF TOPICAL APPLICATION FOR THE TREATMENT OF VARIOUS AFFECTATIONS OF THE SKIN FIELD OF THE INVENTION The present invention is related to the compositions used for the treatment of disorders and skin affectations and more specifically it is referred to a composition for the cellular regeneration of topical application for the treatment of various affectations of the skin.

BACKGROUND OF THE INVENTION There are multiple disorders of the skin such as sores, ulcers derived from diseases such as diabetes, acne, pimples, pimples, cloth, stretch marks, scars, etc. caused by multiple factors, and for this a wide variety of products have been developed tending to solve these disorders and offer solutions; however, they are mostly products that have few and long-term results.

Over the years, a variety of compositions and methods of topical and systemic treatments have been developed to cure such skin affectations, many of which are of prolonged time, which increases the risk of secondary reactions. Many of these compositions produce serious side effects, and in some cases once the treatment is finished it is possible that the affectations resurface.

In the market for example, there are products such as "bell ointment" used to lighten the skin, moisturize the skin, avoid wrinkles and dry lips, freckle removal, skin cleansing, protection against environmental factors, etc. said ointment is composed mainly of: white petrolatum, mineral oil, zinc oxide, capryl methyl methicone, vitamin A palmitate, tocopheryl acetate, fragrance, allantoin.

The bell ointment is very oily and it should not be used during the day because it stains the skin and can even burn it; if used frequently, there is hypersensitivity to the components of the formula.

It is also known the cream called "cicatricure®" that was developed to combat scars, wrinkles, cellulite and spots on the face, which has different compositions and presentations in cream or gel; but this product is considered within the so-called miracle products, and for example, the formula of Cicatricure® Anti-stretch mark body cream contains, among other active ingredients, Asian Centella and Vitamin E that maintains and promotes the elasticity of the tissues.

This ointment can cause irritation of the skin and skin rash, in some patients it does not work and in others its evolution is very slow, it can generate acne and there is a persistence of the formula.

Also known is vitacillin® which is used in insect bites, minor burns, scrapes, dry skin, diaper rash burns caused by excessive sun exposure and some minor skin infections, such as pimples and pimples. Its formula includes per 100 g: Neomycin sulfate equivalent to 0.350 g of neomycin base, Retinol (Vitamin A Palmitate) 100,000 U.I., excipient cbp 100 g.

Vitacillin can cause burns if applied and exposed to sunlight; It should not be applied to wounds and there is hypersensitivity to the components.

The ointment known as "Furacin®" is also known, which for every 100 g contains 0.2 g of Nitrofurazone and 100 g of Excipient c.b.p. when its presentation is in cream and when it is in solution per 100 ml of solution contains 0.2g of Nitrofurazone and 100 ml of Vehicle c.b.p. The ointment is a water-soluble topical bactericide which is indicated in the prevention of bacterial infections, in burns, wounds, lacerations, abrasions, skin ulcers, since the great positive and negative bacteria are sensitive to FURACIN, there is little resistance to this product and minimal probability of cross-resistance with other antibiotics As it is a bactericide, it should not be applied during pregnancy or during lactation, crazy hypersensitivity or eczema and contact dermatitis; that is, far from helping the skin tends to generate affectations.

A product known commercially as "nikson®" is also known, which is a medicine indicated as an aid in the treatment of hemorrhoids with active ingredients of natural origin. The main ingredients that make up its formula are 20 mg of standardized extract of Ruscus aculeatus root, (Ruscus) equivalent to 2 mg of ruscogenin Lactobacillus sporomogens 8.3 mg (Equivalent to 50 million CFU), 40 mg of ascorbic acid (vitamin C) and excipient cbp It is indicated for the treatment of hemorrhoids, relieves symptoms like itching pain when evacuating inflammation and burning; for the treatment of chronic venous insufficiency; It strengthens the intestinal flora so it contributes to an improvement and maintenance of digestion.

It is also formulated for the treatment of gastrointestinal motility disorders as an adjuvant in states of slow lactase antiflatuse deficiency; as a coadjuvant in the treatment of diarrhea and restorer of the normal microbial flora.

It regulates the harmful microbial flora that produces abdominal inflammation, gas and digestive problems, which reduces abdominal distension.

It has an unspecific immunostimulant action due to the increase in synthesis in I g A. It improves the digestion product of imbalances of the normal intestinal flora. Antihemorrhoid. Phleboconstrictor and anti-inflammatory effect that relieves hemorrhoids.

This product has many effects from hypersensitivity to the components, mild gastric discomfort such as nausea, vomiting, diarrhea, gastritis, peptic ulcer and esophagitis.

Also known is a product called "Quadriderm®" which is composed of 0.0643 g of betamethasone dipropionate, equivalent to 50 mg of betamethasone; 1.0 g Clotrimazole; Gentamicin sulfate equivalent to 0.100 g of gentamicin base and Excipient, c.b.p. 100.0 g.

This cream is indicated for the relief of inflammatory manifestations of dermatoses that respond to corticosteroid therapy, complicated by a secondary infection caused by organisms sensitive to the components of this dermatological preparation or when the possibility of such infection is suspected. Clotrimazole has been shown to be effective in the treatment of tinea tinea, tinea cruris and ringworm due to Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum and Microsporum canis; candidiasis caused by Candida albicans and tinea versicolor due to Malassezia fúrfur (Pityrosporon orbiculare). Bacteria susceptible to the action of gentamicin include sensitive strains of Streptococci (group A beta haemolytic, alpha haemolytic), Staphylococcus aureus (positive coagulase, negative coagulase and some strains that produce penicillinase) and gram-negative bacteria Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris and Klebsiella pneumoniae. The cream combines the anti-inflammatory, antipruritic and sustained vasoconstrictor effect of betamethasone dipropionate with the broad-spectrum antifungal action of clotrimazole and the antibiotic effect of gentamicin. Clotrimazole appears to act on the cell membrane of fungi, causing loss of cellular content. Gentamicin provides a highly effective topical treatment for primary and secondary bacterial infections of the skin.

There is hypersensitivity to the components, it should not be used in tuberculous lesions of the skin, nor viral lesions such as herpes, varicella; it should not be used during the vaccination period and should not be used near the eyes; neither should be used during pregnancy and / or lactation or in minors.

In the state of the art, the following documents were also located; in Mexico it was found the patent MX 215613 of Carlos Gabriel Linares et al., filed on November 24, 1992 and granted on August 6, 2003, which protects compositions to regulate wrinkles of the skin and / or atrophy of the skin. skin, which comprises treating the skin with a safe and effective amount of salicylic acid and / or an additional active component, which is characterized as comprising a safe and effective amount of salicylic acid; a sunscreen agent; and a pharmaceutically acceptable vehicle.

Other patent documents were found that disclose the use of salicylic acid in combination with other components, which generate complex formulations, whose mixtures must be controlled and which considerably increase the production costs and the final product.

It was also found the patent application MX / a / 2007/007304 filed on June 15, 2007, which seeks the protection of a cellular regenerating oil that is a compound with anti-inflammatory, healing, antibacterial, lubricating and regenerating effects, demonstrating its effectiveness to deflate, restructure, and prevent the proliferation of pathogens at the level of the dermis, epidermis, and smooth muscle; It has been used in humans in recent postsurgical wounds, 1st, 2nd and 3rd degree burns, decubitus ulcers, diabetic feet, open varicose ulcers, contusions and hemorrhoids, deflating and calming discomfort, accelerating the fibrinization process, without leaving trace of the lesions, since once the tissue is restructured it is pigmented with the same skin color of the patient, and can be used according to the lesion or pathology as a solution in spray or ointment.

The present invention is directed to a composition for the cellular regeneration of topical application. In this situation, the topical composition was developed for the treatment of various affectations of the skin, which is a simple but effective composition for these purposes.

OBJECTIVES OF THE INVENTION The main objective of the present invention is to make available a composition for deep and superficial cell regeneration of topical application that allows to treat various affectations of the skin such as eliminating varicose and diabetic ulcers, healing fistulas, deflating blood vessels, generating the hair follicle, healing hemorrhoids , clear the skin, remove cloth, acne, pimples and pimples, eliminate cellulite, stretch marks, and fade scars, treat and heal burns without leaving scar marks, eliminate rashes, treat fungal and bacterial affectations, eliminate dermatitis, gangrene, treat wounds infected, abscesses, among other affectations.

Another objective of the invention is to make available said composition for cell regeneration of topical application for the treatment of various affectations of the skin, which also acts in a fast and effective way, eliminating the problem in the short term.

Another objective of the invention is to make available said composition for cell regeneration of topical application for the treatment of various affectations of the skin, which also allows the protection of the skin against free radicals, avoiding dryness and maintaining the natural moisture of the skin .

Another objective of the invention is to make available said composition for cell regeneration of topical application for the treatment of various affectations of the skin, which can also be elaborated in a simple and practical way.

Another objective of the invention is to make available said composition for cell regeneration of topical application for the treatment of various skin affectations, which also avoids affectations by action of the solar rays on the skin once applied.

Another objective of the invention is to make available said composition for cell regeneration topical application for the treatment of various skin affectations, which also does not produce side effects.

And all those qualities and objectives that will become apparent when making a general and detailed description of the present invention supported by the illustrated modalities.

DESCRIPTION OF THE INVENTION The composition for cell regeneration topical application for the treatment of various skin affectations, is applied directly on the affected region which means that it is based on suitable components for direct use on the affected skin and is designed for deep cell regeneration and superficial topical application that allows to treat various skin affectations such as eliminating varicose and diabetic ulcers, heal fistulas, deflate blood vessels, generate the hair follicle, heal hemorrhoids, clear the skin, remove cloth, acne, pimples and pimples, eliminate cellulite, stretch marks, and fade scars, treat and heal burns without leaving scar marks, eliminate rashes , treat affectations by fungi and bacteria, eliminate dermatitis, gangrene, treat infected wounds, abscesses, among other affections.

In order to obtain the final composition, it was necessary to carry out several effectiveness studies of several compositions until it reached the composition that provides the best results; according to the following examples: Example 1 A mixture of an amount of turpentine with virgin wax was made and applied to patients with problems of acne, cloth and varicose and diabetic ulcers; after a time of approximately 15 days two applications per day in the affected areas, satisfactory results were not obtained.

Example 2 A mixture of an amount of turpentine with virgin wax, copal and some oils like virgin olive oil was made and applied to the same patients with problems of acne, cloth and varicose and diabetic ulcers; After a period of approximately 15 days with two applications per day in the affected areas, satisfactory results were not obtained.

Example 3 After a while and after studying the healing effects of various ingredients, a mixture of a quantity of pig's broth with turpentine and lemon was made and applied to patients with skin affectations in different areas; After a time of approximately 5 days with two to three applications per day in the affected areas, no results were seen so this composition was discarded.

Example 4 Tests were carried out applying a composition that included an extract of pine tree bark, turpentine, lemon juice, pork fat and virgin olive oil, to some patients with skin disorders for different reasons for a period of approximately 15 days. and it was found that they did not have good healing and its curative effect was not adequate.

Example 5 Tests were carried out applying a composition that included an extract of pine tree bark, turpentine, lemon juice, pork fat and virgin olive oil, copal gum and an extract of cedar bark, to some patients with disorders of the skin for different reasons for a period of approximately 15 days and it was found that they had a better response to healing and a slight improvement in skin conditions.

Example 6 After a while and after studying and testing the healing effects of various ingredients, a mixture of a quantity of pig gum, turpentine, copal gum, virgin wax (beeswax) and lemon juice was made and applied to patients with different skin affectations and in different areas; after a time of approximately 5 days with two to three applications per day in the affected areas, remarkable improvements were seen.

This composition gave very satisfactory healing results in a period of 15 days.

The composition was used in patients with different skin affectations and in all cases excellent results were obtained. Thus, for example, it was used in patients with alopecia and it was observed that it was able to regenerate the hair follicle and hair growth was observed in the patient in a period of 3 to 4 weeks.

Thus, the topical composition of the present invention is an acceptable composition for the treatment of cutaneous disorders already described and consists essentially of a safe and effective amount of pork fat, a safe and effective amount of turpentine, a safe and effective amount of virgin wax (beeswax), a safe and effective amount of copal gum (Bursera cuneata) and a safe and effective amount of lemon juice (Citrus limonium).

The composition in one of its preferred embodiments further includes a safe and effective amount of an extract of arnica (Arnica montana L_) and a safe and effective amount of a drago blood extract. { Crotón lechleri) that is a plant of the family of Euphorbiaceae, of division of the Angiosperms, of the dicotyledonous class and of the order geraniales, of the Croton genus.

The composition further comprises in another of the embodiments, a safe and effective amount of cuaresmeño chile extract. { Capsicum annunm), a safe and effective amount of garlic extract (Allium sativum) and a safe and effective amount of onion extract (Allium cepa L_).

The composition for cell regeneration of topical application for the treatment of various skin affectations, quantitatively comprises the following amounts, for each kilogram of pork fat 25 Og of virgin wax, 250 g of turpentine, 250 g must be used. of copal gum and 20 ml of lemon juice. You can formulate compositions with other quantities, always keeping this proportion.

The pork fat is obtained from the inside of the skin of a pig, which is subjected to heating to melt it and leave it ready for use; pig's daub allows to reconstitute the skin.

Turpentine is the liquid obtained from the steam distillation of the oily resin that is extracted by the resination of several species of conifers and several species of terebentacean trees; it is an almost colorless liquid with a characteristic odor. Currently, it is obtained in large quantities as a byproduct of cellulose production (raw material for papermaking) in industries that use coniferous raw materials. It can be used as a disinfectant.

Virgin wax is an emulsifying agent and is used as an ingredient in various cleansing and moisturizing creams, it is obtained from honeycombs.

Copal gum is a vegetable resin of the tree of the genus Bursera that is obtained by making incisions in the stems of trees, and that is diluted with turpentine. It is an exciting topic in old and indolent ulcers, can be used to treat burns, bleeding, fevers, stomach pain, to prepare dental products such as toothpastes.

Lemon juice contains high amounts of vitamin C and has some healing functions to treat colds, to disinfect, stimulates liver function, is antiseptic, is diuretic, can be used for the treatment of rheumatism, cure scurvy, internal bleeding of intestines and hemorrhoids, among other benefits offered.

Arnica extract (Arnica montana L_J is used as an effective element in cases of bruises, contusions and dislocations, rheumatic pains, and inflammation of the skin, prevents the appearance of bruises because it increases the blood flow where it is applied.

The drago blood extract (Croton lechieri) seals the wounds in the skin, stop the infection and accelerate the healing by the alkaloid taspina content, and as an antiviral, by the content of the SP-303 principle, an oligomeric proanthocyanidin with antiviral action . It is also analgesic and desinflammatory is special for the treatment of ulcers.

The properties of garlic (Allium sativum) are based mainly on the large amount of sulfur it contains, it also has calcium, phosphorus, iron, sodium, potassium, vitamins A, B, C and Nicotinamide; It is a scrubber of toxic substances, makes blood more fluid, inhibits the growth and development of bacteria, regulates blood pressure, promotes healing, etc.

Onion (Allium cepa L.) in addition to many other functions for its intake, in the case of external application it acts as a bactericide, antibiotic, anti-inflammatory, eliminates acne, eliminates itchy skin, among other qualities.

In the case of the cuaresmeño chile (Capsicu annunm). capsaicin is found in its seeds and veins, and according to some research carried out at the University of Texas (United States), this substance has shown optimistic results in treatments against pain in problems such as herpes, rheumatism and arthritis; It has healing properties to treat hemorrhoids and high blood pressure, in addition to having anticoagulant properties.

Although the ingredients separately have some curative function, the fact of mixing the components as described and in the indicated amounts, generates the composition of the present invention, which offers potentiated results and offers synergistic effects for the treatment of the various skin affectations.

The composition in its preferred modality once tested in different groups of individuals with different affectations for an average time of 15 days with two to three topical applications in the affected areas per day, excellent results were obtained and it was possible to test it in different affectations.

According to the above, the composition as described is able to cure and regenerate the cells in individuals with skin affectations such as varicose and diabetic ulcers, can heal fistulas, desinflamar blood vessels, generate the hair follicle, heal hemorrhoids, clarify the skin, remove cloth, acne, pimples and pimples, eliminate cellulite, stretch marks, and fade scars, with this composition you can treat and heal burns without leaving scar marks, you can eliminate rashes, fungal and bacterial infections are treated, can eliminate dermatitis, gangrene, can treat infected wounds, abscesses, among other affectations.

The process for obtaining the composition for cell regeneration of topical application for the treatment of various skin affectations comprises the following steps: a) Heat in a deep bowl 1 kg of pork fat on high heat until completely melted; b) Add 250 g of virgin wax; 250 g of turpentine, 250 g of copal gum; c) Let boil for an average time of 10 minutes; d) Allow to cool for an estimated time of 5 minutes; e) Add 20 ml of lemon juice and let it cool for a period of one hour; f) Strain with sterilized strainer and empty in sterilized bottles.

With the composition as described, a group of 10 children aged 7 months to 5 years who had problems with sweat dermatitis, diaper dermatitis, rash and other skin diseases was treated. These children were given 1 to 2 applications each day of a safe and effective amount of the composition of the present invention, for 2 weeks, obtaining favorable results, visibly improving the skin of infants even in chafing.

A group of 5 patients aged 15 to 25 years with acne, athlete's foot, onychomycosis, pharynx, wounds infected by carelessness, were applied topical composition in the form of ointment at night, and daily Next, the affected area was washed with soap and water to be applied again at night, during a period of 15 days, at the end of which surprising results were observed, since acne decreased favorably, athlete's foot problems were eliminated, the onychomycosis, the praline nose healed and the wounds closed satisfactorily without leaving healing mark.

In a group of 5 elderly patients with keloid scars derived from surgery or wound, varicose and diabetic ulcers, fistulas and skin blemishes, the composition of the present invention was applied twice a day in a 15-day period. days resulting in an almost perfect healing, without noticeable marks.

A group of 5 people aged 8 to 15 years with burns problems of first, second and third degree were applied the ointment with the composition of the present invention twice a day for 15 days, obtaining favorable results where it was seen that pain, burning and inflammation were removed and healing was markedly improved, in addition to avoiding infections in the affected area by regenerating the skin satisfactorily.

In a group of 5 female patients aged 30 to 50 years with problems of varicose veins, hemorrhoids, stretch marks, keloid scars, skin spots on the face and hands, a patient with an abscess by injection and fistulas, the ointment was applied to the composition of the invention twice a day for 15 days and at night it was only applied on the face as an ointment, washing the next day with soap and water, obtaining very favorable results and eliminating the affectations of the skin.

The invention has been described sufficiently so that a person with average skill in the art can reproduce and obtain the results mentioned in the present invention. However, any person skilled in the art who is competent in the present invention may be able to make modifications not described in the present application, however, if for the application of these modifications in a certain structure or in the manufacturing process thereof, the subject matter claimed in the following claims is required, said structures should be understood within the scope of the invention.

Claims (6)

R E I V I N D I C A C I O N S Having sufficiently described the invention, the content of the following claim clauses is claimed as property.

1. - A composition for cell regeneration topical application for the treatment of various skin affectations, characterized by comprising a safe and effective amount of pork fat, a safe and effective amount of turpentine, a safe and effective amount of copal gum (Bursera cuneata), a safe and effective amount of virgin wax (beeswax) and a safe and effective amount of lemon juice (Citrus limonium).

2. - The composition for cell regeneration topical application for the treatment of various skin affectations, according to claim 1, characterized in that it also comprises a safe and effective amount of an extract of arnica (Arnica montana L_) and a safe amount and effective of a drago blood extract. { Crotón lechleri),

3. - The composition for cell regeneration of topical application for the treatment of various skin affectations, according to claim 1 or 2, characterized in that it also comprises a safe and effective amount of cuaresmeño chile extract (Capsicum annunm), an amount safe and effective garlic extract (Allium sativum) and a safe and effective amount of onion extract (Allium cepa L_).

4. - The composition for cell regeneration topical application for the treatment of various skin affectations, according to claim 1, characterized in that quantitatively comprises for each 1 kg of pork fat, 250 g of virgin wax, 250 g of turpentine , 250 g. of copal gum and 20 ml of lemon juice.

5. - The use of a composition for deep and superficial cell regeneration, topical application, according to claims 1 to 4, to eliminate varicose and diabetic ulcers, heal fistulas, deflate blood vessels, generate the hair follicle, heal hemorrhoids, clarify skin, remove cloth, acne, pimples and pimples, eliminate cellulite, stretch marks, and fade scars, treat and heal burns without leaving scar marks, eliminate rashes, treat fungal and bacterial affectations, eliminate dermatitis, gangrene, treat infected wounds, abscesses, among other affectations.

6. - A process for obtaining the composition for cell regeneration topical application for the treatment of various skin affectations, according to claims 1 to 4, characterized by comprising the following steps: a) Heat in a deep container 1 Kg pork fat on high heat until melted completely; b) Add 250 g of virgin wax; 250 g of turpentine, 250 g of copal gum; c) Let boil for an average time of 10 minutes; d) Allow to cool for an estimated time of 5 minutes; e) Add 20 ml of lemon juice and let it cool for a period of one hour; f) Strain with sterilized strainer and empty in sterilized bottles. SUMMARY The present invention is related to the compositions used for the treatment of disorders and skin affectations and more specifically it is referred to a composition for the cellular regeneration of topical application for the treatment of various affectations of the skin; characterized by understanding to understand a safe and effective amount of pork paste, a safe and effective amount of turpentine, a safe and effective amount of copal gum. { Bursera cuneata), a safe and effective amount of virgin wax (beeswax) and a safe and effective amount of lemon juice (Citrus limonium).