CN1137711C - Cream for treating burns, scalds and sore ulcer and its preparation - Google Patents
Cream for treating burns, scalds and sore ulcer and its preparation Download PDFInfo
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- CN1137711C CN1137711C CNB011136286A CN01113628A CN1137711C CN 1137711 C CN1137711 C CN 1137711C CN B011136286 A CNB011136286 A CN B011136286A CN 01113628 A CN01113628 A CN 01113628A CN 1137711 C CN1137711 C CN 1137711C
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Abstract
The present invention relates to cream for treating burn, scale and sore ulcer. The cream of the present invention is prepared from raw materials benne oil, calcium lime, lanolin, tween 80, coptis, borneol and nipagin methyl or nipagin ethyl by weight. The present invention aims at the pathological states of the burn, the scald and the sore ulcer of skin mucosa, and adopts medicine and addition agents with the advantages of good analgesic effect, good anti-infection effect, wound surface nourishing and moistening function, fast transdermal absorption and histotrophic nutrition substance supply. The cream has high pertinency on the burn, the scald and the sore ulcer, and has the advantages of high bioavailability and rapid curative effect taking. In the treatment process, people feel comfortable on wound surfaces, the restoration is fast, the healing effect is good, and the surface is smooth and flat after healed. The present invention also relates to a preparation method for the cream.
Description
The present invention relates to a kind of medicine for the treatment of burns, scalds and sore ulcer, specifically is the treatment burns, scalds and sore ulcer emulsifiable paste of primary raw material preparation with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Skin is the organ of human body maximum, is the barrier of resisting extraneous invasion and attack, and therefore the chance that is hurt is maximum, especially can not heal for a long time for burn and scald and sore ulcer surface, brings very big misery to patient.At present, aspect the treatment burn and scald, in the medicine commonly used, as moist expose burn ointment, Radix Arnebiae (Radix Lithospermi) burn cream, its weak point is that analgesic effect is poor, and Transdermal absorption is bad, and inconvenient operation is unfavorable for the reparation of organizing.The another one patent No. is 93103501.5 Chinese invention patent, its prescription contains following Chinese herbal medicine: Radix Arnebiae (Radix Lithospermi), Rhizoma Coptidis, Radix Angelicae Sinensis, Borneolum Syntheticum, lanoline, Oleum Sesami, yellow fat, Radix Sanguisorbae, Cortex Phellodendri, Radix Et Rhizoma Rhei, Fructus Gardeniae, the problem of its existence is, prescription is complicated, Transdermal absorption is bad, bioavailability is not high, and the treatment healing time is long.
The object of the present invention is to provide a kind of with strong pointsly to burn and scald, sore ulcer surface, prescription is simple, bioavailability height, the emulsifiable paste of the treatment burns, scalds and sore ulcer that curative effect is fast.
Another object of the present invention is to provide the preparation method of the emulsifiable paste of this treatment burns, scalds and sore ulcer.
Purpose of the present invention is achieved through the following technical solutions, the present invention is directed to burn and scald and injure the pathological state of mucocutaneous wound infections wound surface, achieve with reference to modern pharmacological research, selection has medicine and the additives that analgesic effect is good, anti-infectious function is strong, wound surface is moist, Transdermal absorption is fast, the histotrophic nutrition material can be provided, with strong points to burn and scald, sore ulcer surface, the bioavailability height, curative effect is fast.
The emulsifiable paste of treatment burns, scalds and sore ulcer of the present invention, make by following materials of weight proportions:
Oleum Sesami 50-150, quicklime 25-150 lanoline 8-40,
Tween 80 3-10, Rhizoma Coptidis 10-50, Borneolum Syntheticum 3-30,
Ethyl hydroxybenzoate 0.5-1.5.
The emulsifiable paste of treatment burns, scalds and sore ulcer of the present invention, can also make by following materials of weight proportions:
Oleum Sesami 50-150, quicklime 25-150, lanoline 8-40,
Tween 80 3-10, Rhizoma Coptidis 10-50, Borneolum Syntheticum 3-30,
Ethyl hydroxybenzoate 0.5-1.5,
Radix Arnebiae (Radix Lithospermi) 10-60, Radix Sanguisorbae 10-60.
Pharmaceutical dosage form of the present invention is a water-in-oil emulsion.
The emulsifiable paste of treatment burns, scalds and sore ulcer of the present invention, the ethyl hydroxybenzoate in its composition of raw materials can also substitute with Methyl p-hydroxybenzoate.
The emulsifiable paste of treatment burns, scalds and sore ulcer of the present invention, its preparation method is:
1, get adult quicklime, adding distil water stirs, and the leaching supernatant is regulated its pH value with dilute hydrochloric acid and is 8-12, and is standby,
2, get Oleum Sesami slow fire to boiling, add the Rhizoma Coptidis of smashing to pieces and extracted 10 minutes 130-150 degree centigrade of control temperature with 150-170 degree centigrade, filter, treat that temperature adds lanoline to 80-110 degree centigrade and stirs evenly, treat that temperature adds the Borneolum Syntheticum fine powder to 60-80 degree centigrade and stirs to whole dissolvings, filter, standby
3, lime water slowly adds in the above-mentioned standby oil phase, and the limit edged stirs fast, until whole emulsifyings, adds Tween 80, ethyl hydroxybenzoate powder, stirs 1 minute, gets product.
The emulsifiable paste of treatment burns, scalds and sore ulcer of the present invention, when adding Radix Arnebiae (Radix Lithospermi), Radix Sanguisorbae, its preparation method is:
1, adult quicklime, adding distil water stirs, and the leaching supernatant is regulated its pH value with dilute hydrochloric acid and is 8-12, and is standby,
2, take by weighing Oleum Sesami slow fire to boiling, adding Radix Sanguisorbae, the Rhizoma Coptidis smashed to pieces extracted 10 minutes with 150-170 degree centigrade, 130-150 degree centigrade of control Wen Zhidu, add Radix Arnebiae (Radix Lithospermi) and extracted 5 minutes, filter, treat that temperature adds lanoline to 80-110 degree centigrade and stirs evenly, treat that temperature adds the Borneolum Syntheticum fine powder to 60-80 degree centigrade and stirs to whole dissolvings, filter, standby
3, lime water slowly adds in the above-mentioned standby oil phase, and the limit edged stirs fast, until whole emulsifyings, adds Tween 80, ethyl hydroxybenzoate powder, stirs 1 minute, gets product.
Characteristics of the present invention are, contain tissue repair growth desired nutritional active component, and its main active has: oleic acid, linoleic acid long-chain glyceride, sterol, sesamin, sesamol, vitamin E, berberine, shikonin, shikonin, dextro Borneolum Syntheticum etc.
Another characteristics of the present invention are, finished product is a non-Newtonian fluid, water-in-oil emulsion, and stretchability is good, and is easy to use, is beneficial to preservation.The quicklime property and flavor of peppery and warm, the energy removing dampness and killing parasites, the hemostasis analgesic therapy, meat is disliked in erosion.The draft warp is dredged and is claimed its " the hot wind heat poison that can loose, and energy etching off evil meat, and tissue regeneration promoting flesh, blood sees that Calx then ends "; The medical center bun will claim its " suffering can be loose and can be manageed it, and hardship can be fallen can be hard, and puckery can the receipts can be ended "; Japan hanako materia medica claims its " granulation promoting is put on flesh, stopped blooding, ".In traditional prescription, how to be used as medicine with powder, and be to be used as medicine with infusion among the we, fatty acid in its calcium ion and the Oleum Sesami generates the bivalence soap at oil-water interfaces, under the combined effect of emulsifying agent, form the suitable water-in-oil emulsion of denseness, select lime water for use, go its shape to get its property, undertaking the double effects of polar support and treatment.
The present invention shows through clinical use result for many years, the following advantage of tool,
1, raw material of the present invention is the kind that Chinese medicine voluminous dictionary Chinese Pharmacopoeia records, and is safe and reliable, extensively be easy to get, and the few height of imitating of amount, price is low, not limited by geography and climate.
2, the present invention is a non-Newtonian fluid, has rheological characteristic, thixotropy, and denseness reduces during use, and stretchability is good, and is easy to operate, and denseness increases when leaving standstill, and is beneficial to preservation; Big with the wound tissue contact surface, the bioavailability height, pain relieving is only oozed, and antiinflammatory, detumescence effect are remarkable, and clinical none example take place to infect and anaphylaxis.
3, the present invention has good adsorption, and easy and wound surface polymerization forms the protection mantle, resists environmental stimuli, and control organizes serosity to ooze out, and shows the good moisture preserving effect, safeguards the local organization growing environment, provides the prescribing adequate nutrition support for tissue simultaneously; Free free gap between the Emulsion spherolite helps the reparation and the growth of skin tissue cell.
4, transdermal enhancing effect of the present invention is strong, and linoleic acid, lanoline are similar to the skin physiology activity, promotes medicine to penetrate Intradermal on the one hand, improves the bioavailability of medicine, penetrates excretory lipoids of skin and slough on the one hand, has quickened their hydrolysis.Since the adsorption at interface, the lipoids after hydrolysis, and slough is replaced by medicine, transfers to the surface with liquefaction from the wound surface deep layer gradually and comes up.
5, the present invention writes out a prescription concisely, and chemical property is soft, and medicine is imitated height less.Oleum Sesami not only had been principal agent but also as non-polar support; Lime water is existing removes the rotten and lets fresh grow, the hemostatic effect, is again polar support; The Borneolum Syntheticum pain relieving of both having dispelled the heat is again a penetration enhancer; Lanoline be emulsifying agent be again penetration enhancer.So effect of the present invention is rapid, can alleviate not the tip nerve irritability of intense stimulus to external world rapidly, remove the blood capillary spasm, adjustment is because of pain and the histone degeneration disorderly stacking states of tissue fibers due to stimulating, thereby alleviate local organization tension force, improve blood circulation, set up microcirculation.
6, the present invention have cooling blood and relieving pain, detoxifcation, only ooze, the effect of antipruritic, removing the necrotic tissue and promoting granulation, in the therapeutic process, wound surface is comfortable, repairs and heal soon, the no cicatrix afterwards that heals, smooth in appearance is smooth.
The present invention is used for various burn and scald, skin wounds and ulcers, decubital ulcer, skin ulcer scabies, dermatomycosis and mucosal erosion, and escherichia coli are had killing action.Usage: about local coating 1 millimeters thick, when large tracts of land was used, available dressing was protected a little to secondary in one day one.Heavy metal free class material of the present invention has no side effect.Avoid with other preparation and use simultaneously.In addition, the present invention contains the quinones composition, occurs change color during use and belongs to normal phenomenon, does not influence therapeutic effect.
Use the emulsifiable paste of burns, scalds and sore ulcer of the present invention, clinical cure burn and scald 383 examples, depth of burn I degree 48 examples wherein, medication is all cured for 1-2 time; Depth of burn II degree 245 examples were cured in general 7-8 days, wound surface cleaning, smooth surface; With III degree burns victims 81 examples, 15-20 days wound healings have an even surface, the no cicatrix in healing back.Clinical cure wound infections 66 examples, healing is fast, wound surface cleaning, smooth surface.
Embodiment one, and the emulsifiable paste of treatment burns, scalds and sore ulcer of the present invention is made by following materials of weight proportions:
Oleum Sesami 50, quicklime 25, lanoline 8,
Tween 80 3, Rhizoma Coptidis 10, Borneolum Syntheticum 3,
Ethyl hydroxybenzoate 0.5.
Pharmaceutical dosage form of the present invention is a water-in-oil emulsion.
Embodiment two, and the emulsifiable paste of treatment burns, scalds and sore ulcer of the present invention is the water-in-oil emulsion of being made by following materials of weight proportions:
Oleum Sesami 150, quicklime 150, lanoline 40,
Tween 80 10, Rhizoma Coptidis 50, Borneolum Syntheticum 30,
Methyl p-hydroxybenzoate 1.5.
Embodiment three, the emulsifiable paste of treatment burns, scalds and sore ulcer of the present invention, and the water-in-oil emulsion that can also make by following materials of weight proportions:
Oleum Sesami 100, quicklime 100, lanoline 25,
Tween 80 6, Rhizoma Coptidis 30, Borneolum Syntheticum 15,
Methyl p-hydroxybenzoate 1,
Embodiment four, the emulsifiable paste of treatment burns, scalds and sore ulcer of the present invention, and the water-in-oil emulsion that can also make by following materials of weight proportions:
Oleum Sesami 100, quicklime 100, lanoline 25,
Tween 80 6, Rhizoma Coptidis 30, Borneolum Syntheticum 15,
Ethyl hydroxybenzoate 1,
Radix Arnebiae (Radix Lithospermi) 35, Radix Sanguisorbae 35.
Embodiment five, the emulsifiable paste of treatment burns, scalds and sore ulcer of the present invention, and the water-in-oil emulsion that can also make by following materials of weight proportions:
Oleum Sesami 50, quicklime 25, lanoline 8,
Tween 80 3, Rhizoma Coptidis 10, Borneolum Syntheticum 3,
Ethyl hydroxybenzoate 0.5,
Radix Arnebiae (Radix Lithospermi) 10, Radix Sanguisorbae 10.
Embodiment six, the emulsifiable paste of treatment burns, scalds and sore ulcer of the present invention, and the water-in-oil emulsion that can also make by following materials of weight proportions:
Oleum Sesami 150, quicklime 150, lanoline 40,
Tween 80 10, Rhizoma Coptidis 50, Borneolum Syntheticum 30,
Methyl p-hydroxybenzoate 1.5,
Radix Arnebiae (Radix Lithospermi) 60, Radix Sanguisorbae 60.
Embodiment seven, the emulsifiable paste of treatment burns, scalds and sore ulcer of the present invention, and its preparation method is:
(1) take by weighing adult quicklime, adding distil water stirs, and the leaching supernatant is regulated its pH value with dilute hydrochloric acid and is 8-12, and is standby,
(2) take by weighing Oleum Sesami slow fire to boiling, add the Rhizoma Coptidis of smashing to pieces and extracted 10 minutes 130-150 degree centigrade of control temperature with 150-170 degree centigrade, filter, treat that temperature adds lanoline to 80-110 degree centigrade and stirs evenly, treat that temperature adds the Borneolum Syntheticum fine powder to 60-80 degree centigrade and stirs to whole dissolvings, filter, standby
(3) lime water is slowly added in the above-mentioned standby oil phase, the limit edged stirs fast, until whole emulsifyings, adds Tween 80, ethyl hydroxybenzoate powder, stirs 1 minute, gets product.
Embodiment eight, the emulsifiable paste of treatment burns, scalds and sore ulcer of the present invention, and when adding Radix Arnebiae (Radix Lithospermi), Radix Sanguisorbae, its preparation method is:
(1), get adult quicklime, adding distil water stirs, the leaching supernatant is regulated its pH value with dilute hydrochloric acid and is 8-12, and is standby,
(2), take by weighing Oleum Sesami slow fire to boiling, adding Radix Sanguisorbae, the Rhizoma Coptidis smashed to pieces extracted 10 minutes with 150-170 degree centigrade, 130-150 degree centigrade of control Wen Zhidu, add Radix Arnebiae (Radix Lithospermi) and extracted 5 minutes, filter, treat that temperature adds lanoline to 80-110 degree centigrade and stirs evenly, treat that temperature adds the Borneolum Syntheticum fine powder to 60-80 degree centigrade and stirs to whole dissolvings, filter, standby
(3), lime water is slowly added in the above-mentioned standby oil phase, the limit edged stirs fast, until whole emulsifyings, adds Tween 80, ethyl hydroxybenzoate powder, stirs 1 minute, gets product.
Claims (5)
1. emulsifiable paste for the treatment of burns, scalds and sore ulcer is characterized in that it is the water-in-oil emulsion of being made by following materials of weight proportions:
Oleum Sesami 50-150, quicklime 25-150, lanoline 8-40,
Tween 80 3-10, Rhizoma Coptidis 10-50, Borneolum Syntheticum 3-30,
Ethyl hydroxybenzoate 0.5-1.5.
2. the emulsifiable paste of treatment burns, scalds and sore ulcer according to claim 1 is characterized in that it is the water-in-oil emulsion of being made by following materials of weight proportions:
Oleum Sesami 50-150, quicklime 25-150, lanoline 8-40,
Tween 80 3-10, Rhizoma Coptidis 10-50, Borneolum Syntheticum 3-30,
Ethyl hydroxybenzoate 0.5-1.5,
Radix Arnebiae (Radix Lithospermi) 10-60, Radix Sanguisorbae 10-60.
3. the emulsifiable paste of treatment burns, scalds and sore ulcer according to claim 1 and 2 is characterized in that: the ethyl hydroxybenzoate in the raw material can also substitute with Methyl p-hydroxybenzoate.
4. the preparation method of the emulsifiable paste of the described treatment burns, scalds and sore ulcer of claim 1 is characterized in that:
(1) take by weighing adult quicklime, adding distil water stirs, and the leaching supernatant is regulated its pH value with dilute hydrochloric acid and is 8-12, and is standby,
(2) take by weighing Oleum Sesami slow fire to boiling, add the Rhizoma Coptidis of smashing to pieces and extracted 10 minutes 130-150 degree centigrade of control temperature with 150-170 degree centigrade, filter, treat that temperature adds lanoline to 80-110 degree centigrade and stirs evenly, treat that temperature adds the Borneolum Syntheticum fine powder to 60-80 degree centigrade and stirs to whole dissolvings, filter, standby
(3) lime water is slowly added in the above-mentioned standby oil phase, the limit edged stirs fast, until whole emulsifyings, adds Tween 80, ethyl hydroxybenzoate powder, stirs 1 minute, gets product.
5. the preparation method of the emulsifiable paste of the described treatment burns, scalds and sore ulcer of claim 2 is characterized in that:
(1) take by weighing adult quicklime, adding distil water stirs, and the leaching supernatant is regulated its pH value with dilute hydrochloric acid and is 8-12, and is standby,
(2) take by weighing Oleum Sesami slow fire to boiling, adding Radix Sanguisorbae, the Rhizoma Coptidis smashed to pieces extracted 10 minutes with 150-170 degree centigrade, 130-150 degree centigrade of control Wen Zhidu, add Radix Arnebiae (Radix Lithospermi) and extracted 5 minutes, filter, treat that temperature adds lanoline to 80-110 degree centigrade and stirs evenly, treat that temperature adds the Borneolum Syntheticum fine powder to 60-80 degree centigrade and stirs to whole dissolvings, filter, standby
(3) lime water is slowly added in the above-mentioned standby oil phase, the limit edged stirs fast, until whole emulsifyings, adds Tween 80, ethyl hydroxybenzoate powder, stirs 1 minute, gets product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011136286A CN1137711C (en) | 2001-05-17 | 2001-05-17 | Cream for treating burns, scalds and sore ulcer and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011136286A CN1137711C (en) | 2001-05-17 | 2001-05-17 | Cream for treating burns, scalds and sore ulcer and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1322554A CN1322554A (en) | 2001-11-21 |
| CN1137711C true CN1137711C (en) | 2004-02-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB011136286A Expired - Fee Related CN1137711C (en) | 2001-05-17 | 2001-05-17 | Cream for treating burns, scalds and sore ulcer and its preparation |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101028365B (en) * | 2007-03-27 | 2010-11-10 | 杨学栋 | Medicine for treating burn and ambustion and its production |
| CN102247414A (en) * | 2010-05-18 | 2011-11-23 | 徐腾飞 | Medicament for treating scald and preparation method thereof |
| CN102846991B (en) * | 2012-09-18 | 2014-06-11 | 刘海英 | Ointment for treating burn or scald |
| CN102973691A (en) * | 2012-12-24 | 2013-03-20 | 中国人民解放军第一〇一医院 | Compound violaxanthin cream and preparation method thereof |
| CN103083420A (en) * | 2013-01-21 | 2013-05-08 | 长春中医药大学 | Traditional Chinese medicine composition for treating bedsore and preparation method thereof |
| CN104721444B (en) * | 2015-03-26 | 2018-11-09 | 梁毅 | A kind of Chinese medicine composition and preparation method thereof for treating burn |
| CN107485636A (en) * | 2017-07-19 | 2017-12-19 | 广东名辰堂健康产业股份有限公司 | Chinese herbal medicine burn oil and its production method |
| CN108653414A (en) * | 2018-08-08 | 2018-10-16 | 易贵鹏 | A kind of composition and preparation method thereof for treating burn and scald skin disease |
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2001
- 2001-05-17 CN CNB011136286A patent/CN1137711C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1322554A (en) | 2001-11-21 |
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