CN108653414A - A kind of composition and preparation method thereof for treating burn and scald skin disease - Google Patents
A kind of composition and preparation method thereof for treating burn and scald skin disease Download PDFInfo
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- CN108653414A CN108653414A CN201810898096.6A CN201810898096A CN108653414A CN 108653414 A CN108653414 A CN 108653414A CN 201810898096 A CN201810898096 A CN 201810898096A CN 108653414 A CN108653414 A CN 108653414A
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- hydrochloric acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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Abstract
The invention belongs to technical field of pharmaceuticals, disclose a kind of composition and preparation method thereof for treating burn and scald skin disease, and the composition is grouped as by the group of following weight percent：Coptis extract：0.2% 0.9%；Hydrochloric acid 0.01% 0.09%；Dilute sulfuric acid 0.01% 0.09%；Alkali 0.01% 0.09%；Surplus is water；The mass fraction of solute is 25% 32% in the hydrochloric acid；The mass fraction of solute is 25% 35% in the dilute sulfuric acid.The preparation method includes step：A, coptis extract, dilute sulfuric acid, hydrochloric acid and water are uniformly mixed, obtain premixed liquid；B, alkali is added after mixing into premixed liquid, obtains lotion.The present invention has the characteristics of quickly detumescence, analgesic, promote skin own growth, infection risk small, will not cause superinfection.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, and in particular to a kind of composition that treating burn and scald skin disease and its preparation
Method.
Background technology
Skin participates in the functional activity of body as first of physiology defence line of human body and maximum organ, moment, maintains
The unity of opposites of body and natural environment, the abnormal conditions of body can also be reflected in skin surface.Skin has
The Physiological protection function of almost Perfect：Such as barrier action, sensation, adjust body temperature, absorption, secretion and Excretion
Deng in the health for safeguarding body, playing the role of highly important.The physiological function of skin is damaged, and causes skin disease.
However, for skin diseases such as some burns, scalds, in treatment, the swelling time needed is longer, and skin can not be certainly
Oneself growth reduction, the later stage still needs to do skin grafting, there are the danger of repeated infection, and existing prevents controlling for skin repeated infection
Treatment measure is relatively complicated, and is easy to be iteratively produced inflammation, and there are more serious repeated infection risks.
Invention content
In order to solve the above problem of the existing technology, present invention aims at provide a kind of to treat burn and scald skin disease
The composition and preparation method thereof of disease.
The technical solution adopted in the present invention is：
A kind of composition for treating burn and scald skin disease, is grouped as by the group of following weight percent：Coptis extract：
0.2%-0.9%；Hydrochloric acid 0.01%-0.09%；Dilute sulfuric acid 0.01%-0.09%；Alkali 0.01%-0.09%；Surplus is water；Institute
The mass fraction for stating solute in hydrochloric acid is 25%-32%；The mass fraction of solute is 25%-35% in the dilute sulfuric acid.
Further, a kind of composition for treating burn and scald skin disease, by the component of following weight percent
Composition：Coptis extract：0.3%-0.5%；Hydrochloric acid 0.01%-0.05%；Dilute sulfuric acid 0.01%-0.05%；Alkali 0.01%-
0.05%；Surplus is water；The mass fraction of solute is 28%-30% in the hydrochloric acid；The quality of solute point in the dilute sulfuric acid
Number is 30%-35%.
Further, a kind of composition for treating burn and scald skin disease, by the component of following weight percent
Composition：Coptis extract：0.4%；Hydrochloric acid：0.03%；Dilute sulfuric acid：0.04%；Alkali：0.03%；Surplus is water；In the hydrochloric acid
The mass fraction of solute is 30%；The mass fraction of solute is 30% in the dilute sulfuric acid.
Further, a kind of composition for treating burn and scald skin disease, by the component of following weight percent
Composition：It is grouped as by the group of following weight percent：Coptis extract：0.35%；Hydrochloric acid 0.02%；Dilute sulfuric acid 0.04%；Alkali
0.02%；Surplus is water；The mass fraction of solute is 30% in the hydrochloric acid；The mass fraction of solute is in the dilute sulfuric acid
30%.
Further, the alkali is analytically pure sodium hydroxide.
Further, the dosage form of the composition is external-use lotion.
A kind of preparation method of composition that treating burn and scald skin disease, including step：
A, coptis extract, dilute sulfuric acid, hydrochloric acid and water are uniformly mixed, obtain premixed liquid；
B, alkali is added after mixing into premixed liquid, obtains lotion.
Beneficial effects of the present invention are：A kind of composition that treating burn and scald skin disease of the present invention and its preparation side
Method has the characteristics of quickly detumescence, analgesic, promote skin own growth, infection risk small, will not cause superinfection；This hair
The bright coptis extract using has a broad antifungal spectrum, to play the role of preferably preventing superinfection to skin affected part, further through
Chlorion and hydrionic penetration, make sweat gland of skin keep penetrating state, and skin eupnea is kept to play
Effect；By generating cleaning action to wound with sodium ion, chlorion and sulfate ion (brine), to make the group of the present invention
It closes object to play the role of keeping skin permeation, antibacterial, promotion skin growth, finally plays quick swelling and pain relieving, promotes skin
The effect of own growth can play fast quick-recovery raw hide skin for shallow source property burn and scald, not stay the effect of scar.
Specific implementation mode
Technical scheme of the present invention is described in detail with reference to embodiments, it should be noted that be only below
The preferred embodiment of the present invention, for those of ordinary skill in the art, before not departing from the invention design
It puts, various modifications and improvements can be made, these should belong to protection scope of the present invention.With reference to specific implementation
Example does further explaination to the present invention.
One, drug forms
A kind of composition for treating burn and scald skin disease, is grouped as by the group of following weight percent by following weight hundred
The group of score is grouped as：Coptis extract：0.2%-0.9%；Hydrochloric acid 0.01%-0.09%；Dilute sulfuric acid 0.01%-0.09%；
Alkali 0.01%-0.09%；Surplus is water；The mass fraction of solute is 25%-32% in the hydrochloric acid；Solute in the dilute sulfuric acid
Mass fraction be 25%-35%.
In order to reach better effect, optimization composition is as follows：
A kind of composition for treating burn and scald skin disease, is grouped as by the group of following weight percent：The coptis
Extract：0.3%-0.5%；Hydrochloric acid 0.01%-0.05%；Dilute sulfuric acid 0.01%-0.05%；Alkali 0.01%-0.05%；Surplus
For water；The mass fraction of solute is 28%-30% in the hydrochloric acid；The mass fraction of solute is 30%- in the dilute sulfuric acid
35%.
In order to reach better effect, optimization composition is as follows：
A kind of composition for treating burn and scald skin disease, is grouped as by the group of following weight percent：Coptis extract：
0.4%；Hydrochloric acid：0.03%；Dilute sulfuric acid：0.04%；Alkali：0.03%；Surplus is water；The mass fraction of solute is in the hydrochloric acid
30%；The mass fraction of solute is 30% in the dilute sulfuric acid.
In order to reach better effect, optimization composition is as follows：
A kind of composition for treating burn and scald skin disease, is grouped as by the group of following weight percent：By following weight
The group of percentage is grouped as：Coptis extract：0.35%；Hydrochloric acid 0.02%；Dilute sulfuric acid 0.04%；Alkali 0.02%；Surplus is water；
The mass fraction of solute is 30% in the hydrochloric acid；The mass fraction of solute is 30% in the dilute sulfuric acid.
Further, the alkali is analytically pure sodium hydroxide.
Two, application method
The composition of the present invention may be used usual manner and lotion use be made.
Or method is prepared as follows, lotion use is made.
A kind of preparation method of composition that treating burn and scald skin disease, including step：
A, coptis extract, dilute sulfuric acid, hydrochloric acid and water are uniformly mixed, obtain premixed liquid；
B, alkali is added after mixing into premixed liquid, obtains lotion.
Three, major function
The composition of the present invention is suitable for burn and scald skin disease and other dermopathic skin convalescences use.
Four, embodiment
Embodiment 1
A kind of composition for treating burn and scald skin disease, is grouped as by the group of following weight percent：Coptis extract：
0.2%；Hydrochloric acid 0.01%；Dilute sulfuric acid 0.01%；Alkali 0.01%；Surplus is water；The mass fraction of solute is in the hydrochloric acid
25%；The mass fraction of solute is 25% in the dilute sulfuric acid.
The alkali is analytically pure sodium hydroxide.Lotion use is conventionally made.
Embodiment 2
A kind of composition for treating burn and scald skin disease, is grouped as by the group of following weight percent：Coptis extract：
0.9%；Hydrochloric acid 0.09%；Dilute sulfuric acid 0.09%；Alkali 0.09%；Surplus is water；The mass fraction of solute is in the hydrochloric acid
32%；The mass fraction of solute is 35% in the dilute sulfuric acid.
A kind of preparation method of composition that treating burn and scald skin disease, including step：
A, coptis extract, dilute sulfuric acid, hydrochloric acid and water are uniformly mixed, obtain premixed liquid；
B, alkali is added after mixing into premixed liquid, obtains lotion.
Embodiment 3
A kind of composition for treating burn and scald skin disease, is grouped as by the group of following weight percent：Coptis extract：
0.4%；Hydrochloric acid 0.3%；Dilute sulfuric acid 0.4%；Alkali 0.03%；Surplus is water；The mass fraction of solute is 26% in the hydrochloric acid；
The mass fraction of solute is 32% in the dilute sulfuric acid.
The alkali is analytically pure sodium hydroxide or potassium hydroxide.Lotion use is conventionally made.
Embodiment 4
A kind of composition for treating burn and scald skin disease, is grouped as by the group of following weight percent：Coptis extract：
0.3%；Hydrochloric acid 0.01%；Dilute sulfuric acid 0.01%；Alkali 0.01%；Surplus is water；The mass fraction of solute is in the hydrochloric acid
28%；The mass fraction of solute is 30% in the dilute sulfuric acid.
A kind of preparation method of composition that treating burn and scald skin disease, including step：
A, coptis extract, dilute sulfuric acid, hydrochloric acid and water are uniformly mixed, obtain premixed liquid；
B, alkali is added after mixing into premixed liquid, obtains lotion.
Embodiment 5
A kind of composition for treating burn and scald skin disease, is grouped as by the group of following weight percent：Coptis extract：
0.5%；Hydrochloric acid 0.05%；Dilute sulfuric acid 0.05%；Alkali 0.05%；Surplus is water；The mass fraction of solute is in the hydrochloric acid
30%；The mass fraction of solute is 35% in the dilute sulfuric acid.
The alkali is analytically pure sodium hydroxide or potassium hydroxide.Lotion use is conventionally made.
Embodiment 6
A kind of composition for treating burn and scald skin disease, is grouped as by the group of following weight percent：Coptis extract：
0.4%；Hydrochloric acid 0.03%；Dilute sulfuric acid 0.03%；Alkali 0.04%；Surplus is water；The mass fraction of solute is in the hydrochloric acid
29%；The mass fraction of solute is 33% in the dilute sulfuric acid.
A kind of preparation method of composition that treating burn and scald skin disease, including step：
A, coptis extract, dilute sulfuric acid, hydrochloric acid and water are uniformly mixed, obtain premixed liquid；
B, alkali is added after mixing into premixed liquid, obtains lotion.
Embodiment 7
A kind of composition for treating burn and scald skin disease, is grouped as by the group of following weight percent：Coptis extract：
0.4%；Hydrochloric acid：0.03%；Dilute sulfuric acid：0.04%；Alkali：0.03%；Surplus is water；The mass fraction of solute is in the hydrochloric acid
30%；The mass fraction of solute is 30% in the dilute sulfuric acid.
The alkali is analytically pure sodium hydroxide.Lotion use is conventionally made.
Embodiment 8
A kind of composition for treating burn and scald skin disease, is grouped as by the group of following weight percent：By following weight
The group of percentage is grouped as：Coptis extract：0.35%；Hydrochloric acid 0.02%；Dilute sulfuric acid 0.04%；Alkali 0.02%；Surplus is water；
The mass fraction of solute is 30% in the hydrochloric acid；The mass fraction of solute is 30% in the dilute sulfuric acid.
A kind of preparation method of composition that treating burn and scald skin disease, including step：
A, coptis extract, dilute sulfuric acid, hydrochloric acid and water are uniformly mixed, obtain premixed liquid；
B, alkali is added after mixing into premixed liquid, obtains lotion.
Above-mentioned specific implementation mode should not be understood the limitation of pairs of protection scope of the present invention, and protection scope of the present invention is answered
It is defined in claims when being subject to, and specification can be used for interpreting the claims.
Claims (7)
1. a kind of composition for treating burn and scald skin disease, it is characterised in that：It is grouped as by the group of following weight percent：It is yellow
Coptis extract：0.2%-0.9%；Hydrochloric acid 0.01%-0.09%；Dilute sulfuric acid 0.01%-0.09%；Alkali 0.01%-0.09%；It is remaining
Amount is water；The mass fraction of solute is 25%-32% in the hydrochloric acid；The mass fraction of solute is 25%- in the dilute sulfuric acid
35%.
2. a kind of composition for treating burn and scald skin disease according to claim 1, it is characterised in that：By following weight
The group of percentage is grouped as：Coptis extract：0.3%-0.5%；Hydrochloric acid 0.01%-0.05%；Dilute sulfuric acid 0.01%-
0.05%；Alkali 0.01%-0.05%；Surplus is water；The mass fraction of solute is 28%-30% in the hydrochloric acid；Dilute sulphur
The mass fraction of solute is 30%-35% in acid.
3. a kind of composition for treating burn and scald skin disease according to claim 1, it is characterised in that：By following weight
The group of percentage is grouped as：Coptis extract：0.4%；Hydrochloric acid：0.03%；Dilute sulfuric acid：0.04%；Alkali：0.03%；Surplus is
Water；The mass fraction of solute is 30% in the hydrochloric acid；The mass fraction of solute is 30% in the dilute sulfuric acid.
4. a kind of composition for treating burn and scald skin disease according to claim 1 or 2, which is characterized in that by as follows
The group of weight percent is grouped as：Coptis extract：0.35%；Hydrochloric acid 0.02%；Dilute sulfuric acid 0.04%；Alkali 0.02%；Surplus
For water；The mass fraction of solute is 30% in the hydrochloric acid；The mass fraction of solute is 30% in the dilute sulfuric acid.
5. a kind of composition for treating burn and scald skin disease according to claim 1-3 any one, it is characterised in that：
The alkali is analytically pure sodium hydroxide.
6. a kind of composition for treating burn and scald skin disease according to claim 1-3 any one, it is characterised in that：
The dosage form of the composition is external-use lotion.
7. a kind of preparation method of the composition of the treatment burn and scald skin disease described in claim 1-3 any one, special
Sign is：Including step：
A, coptis extract, dilute sulfuric acid, hydrochloric acid and water are uniformly mixed, obtain premixed liquid；
B, alkali is added after mixing into premixed liquid, obtains lotion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810898096.6A CN108653414A (en) | 2018-08-08 | 2018-08-08 | A kind of composition and preparation method thereof for treating burn and scald skin disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810898096.6A CN108653414A (en) | 2018-08-08 | 2018-08-08 | A kind of composition and preparation method thereof for treating burn and scald skin disease |
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| Publication Number | Publication Date |
|---|---|
| CN108653414A true CN108653414A (en) | 2018-10-16 |
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|---|---|---|---|
| CN201810898096.6A Pending CN108653414A (en) | 2018-08-08 | 2018-08-08 | A kind of composition and preparation method thereof for treating burn and scald skin disease |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322554A (en) * | 2001-05-17 | 2001-11-21 | 骆公久 | Cream for treating burns, scalds and sore ulcer and its preparation |
-
2018
- 2018-08-08 CN CN201810898096.6A patent/CN108653414A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322554A (en) * | 2001-05-17 | 2001-11-21 | 骆公久 | Cream for treating burns, scalds and sore ulcer and its preparation |
Non-Patent Citations (3)
| Title |
|---|
| 中华人民共和国卫生部医疗预防司: "《全国烧伤防治经验交流现场会议资料汇编》", 31 December 1958 * |
| 兰水中等: "《常见病单味中药新用》", 31 May 2013, 金盾出版社 * |
| 吴刚: "《压力焊作业》", 31 July 2011, 中国矿业大学出版社 * |
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Application publication date: 20181016 |