CN101322717A - Medicament composition for preventing and treating eye diseases - Google Patents
Medicament composition for preventing and treating eye diseases Download PDFInfo
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- CN101322717A CN101322717A CNA2008101408154A CN200810140815A CN101322717A CN 101322717 A CN101322717 A CN 101322717A CN A2008101408154 A CNA2008101408154 A CN A2008101408154A CN 200810140815 A CN200810140815 A CN 200810140815A CN 101322717 A CN101322717 A CN 101322717A
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- baicalin
- regulator
- pharmaceutical composition
- borneolum syntheticum
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Abstract
The invention provides a pharmaceutical composition for preventing and treating eye diseases, which is characterized in that the pharmaceutical composition takes baicalin and borneol as the pharmaceutical components, and uses osmo-regulator and pH regulator as the adjuvants. The weight ratios are as follows: 20-80g of baicalin, 0.1-10g of borneol, 0-4.2g of osmo-regulator and 0-2.5g of thickener. The pharmaceutical composition has the efficacies of resisting bacteria, relieving inflammation, expelling pathogenic wind, reducing fever, detoxifying and eliminating nebula, and can be used for anti-infective therapy in ophthalmology, essentially for treating conjunctivitis, keratitis, trachoma, stye and the like, and can improve tired eyesight, improve eyesight and eliminate cataract.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of pharmaceutical composition of preventing and treating disease of eye.
Background technology
The common ophthalmic diseases of China is distributed in all ages of teenager to person in middle and old age, mainly contains this five big class oculopathy of myopia, trachoma, conjunctivitis (pink eye disease) and glaucoma and cataract.In the existing treatment ophthalmic diseases, in the Western medicine eye drop, the Western medicine eye drop with antibiotic, antiviral drugs is more, and the ubiquity drug toxicity is big, subject range is narrow, life-time service easily produces drug resistance, defectives such as recurrence easily.And the Chinese medicine eye drop is evident in efficacy in the clinical practice of long-term treatment ophthalmic diseases, and no obvious toxic-side effects is having special advantages aspect the treatment ophthalmic diseases.
Summary of the invention
The objective of the invention is the Chinese medicine eye drop that a kind of instant effect, short treating period, stable performance is provided, has no side effect for the patient---be a kind of pharmaceutical composition of preventing and treating disease of eye, for clinical and patient provide a kind of new selection.
Purpose of the present invention can realize by following technique measures:
Medical composite for eye of the present invention is with baicalin, and Borneolum Syntheticum is an ingredient, is equipped with osmotic pressure regulator, pH value regulator, and its weight ratio is baicalin 20-80g, Borneolum Syntheticum 0.1-10g, osmotic pressure regulator 0-4.2g, thickening agent 0-2.5g.
Furtherly, the raw material of medical composite for eye of the present invention and weight consist of: baicalin 30-60g, Borneolum Syntheticum 0.2-6g, osmotic pressure regulator 0-4.2g, thickening agent 0-2.5g.
Preparation of drug combination method of the present invention can adopt following step to realize: get baicalin 20-80g by weight, add 2-3 and doubly measure (weight ratio) water for injection, stir evenly, regulate pH value 8.0-9.0 with sodium hydroxide solution (content 20%), make dissolving, and overanxious; Get Borneolum Syntheticum 0.1-10g, use the 1.0-10ml dissolve with ethanol, slowly add in the above-mentioned filtrate, add eye drop additives such as osmotic pressure regulator, thickening agent again, fully stir, regulate pH value to 5.5-8.0 with the pH value regulator, adjust volume to 1000ml with solvent at last, microporous filter membrane filters, packing, promptly.
The present invention utilizes that baicalin is antibiotic, antiviral, antiinflammatory, antipyretic pharmacological action, mix have the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain, the Borneolum Syntheticum of merit of nebula of dispelling that makes eye bright, the guide drugs composition easily arrives focus, play prove effective rapidly, the effect of reinforced effects.
Baicalin (Baicalin) is a kind of flavone compound that extraction separation comes out from scutellariae,radix, has significant biological activity, mainly show the following aspects: 1. antiinflammatory antiallergic action: baicalin is shunk by guinea-pig isolated trachea anaphylaxis and the whole animal allergic asthma has mitigation, and with ephedrine synergism is arranged.2. antibiotic: baicalin is one of Radix Scutellariae antimicrobial component, contains the clinical trachoma that is used for the treatment of of collyrium of 3% this product, and medicament benemicin is similar preferably to treatment trachoma for curative effect.3. diuresis: baicalin has diuresis to rabbit.4. function of gallbladder promoting: baicalin can increase dog, lapin bile excretion.5. analgesic: when abdominal cavity or intravenous administration, baicalin all can be analgesic to the rabbit of vaccine or yeast pyrogenicity.6. blood pressure lowering: dog, cat and rabbit all can cause blood pressure lowering when intravenous injection or intramuscular injection or filling stomach.7. calm: baicalin suppresses the spontaneous activity of mice.Other: the strychnine that baicalin can the reduce mice rate of being poisoned to death, 10 μ g just can improve the about 2-5 of its LD50 doubly.Baicalin can reduce the level of T-CHOL, free cholesterol and the triglyceride of experimental rat liver.
Borneolum Syntheticum is the processed goods of Dipterocarpaceae plant Borneolum Syntheticum, and its composition contains dextro Borneolum Syntheticum humulene, beta-elemene, caryophyllene etc.Acrid in the mouth, cold in nature, tool have one's ideas straightened out refreshment, clearing away heat to alleviate pain effect have logical all keys, a stagnated fire of loosing, effects such as detumescence removing nebula." Newly Revised Canon of Materia Medica ": " main trusted subordinate's pathogen, rheumatism is gathered, and deafness makes eye bright, and goes conjunctival congestion skin nebula." Compendium of Material Medica: " treat that sore throat, headache, nose are flat, toothache, typhoid fever protrusion of the tongue, children's's pox fall into.Logical all keys, the stagnated fire of loosing.”
The Borneolum Syntheticum topical application has than microstimulation sensory nerve, and certain pain relieving and gentle antisepsis are arranged.Higher concentration (0.5%) has inhibitory action to staphylococcus, streptococcus, the two ball mattresses of pneumonia, escherichia coli and the pathogenic dermatophytes of part etc.Mainly (1) is used for conjunctival congestion and swelling pain, the sore throat aphtha.This product bitter cold has the merit of clearing away heat to alleviate pain, detumescence, is department of eye medicine commonly used.The treatment conjunctival congestion and swelling pain, list is promptly imitated with eye dripping.(2) be used for skin infection and swell and ache, do not hold back after bursting.This product also has heat-clearing and toxic substances removing, erosion prevention and muscle growing effect.Stirred to be dissolved in this product modern age and dripped ear in the walnut oil, treated acute and chronic suppurative otitis media, better curative effect was arranged.In addition, this product has certain curative effect with controlling angina pectoris and toothache.
The invention provides and contain baicalin and Borneolum Syntheticum topical ophthalmic pharmaceutical composition.Particularly can effectively treat eye inflammation, have the effect of anti-inflammation, wind dispelling heat clearing away, detoxifcation nebula removing as eye drop.This medicine is to develop summing up on the basis of clinical experience for many years, and still being difficult baicalin and Borneolum Syntheticum at present is that raw material is united the relevant report of using the treatment ocular disease.The present invention also provides the preparation method of this medical composite for eye.
The present invention has the effect of anti-inflammation, wind dispelling heat clearing away, detoxifcation nebula removing.Can be used for the treatment of ophthalmology anti-infective, be mainly used in conjunctivitis, keratitis, trachoma, hordeolum etc., but the while alleviating asthenopia, and the nebula of dispelling makes eye bright.
The specific embodiment
The present invention is further described below with reference to embodiment, but this should be interpreted as that scope of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1:
Get baicalin 30g by weight, add 2 times of amounts (weight ratio) water for injection, stir evenly, regulate pH value 8.0, make dissolving with sodium hydroxide solution (content 20%), and overanxious; Get Borneolum Syntheticum 0.15g by weight, use the 1.0ml dissolve with ethanol, slowly add in the above-mentioned filtrate, add osmotic pressure regulator sodium chloride 4.2g, thickening agent hyaluronate sodium 1.0g again, fully stir, regulate pH value to 6.0 with the pH value regulator, add the injection water at last and adjust volume to 1000ml, microporous filter membrane filters, packing, promptly.
Embodiment 2:
Get baicalin 20g by weight, add 2 times of amounts (weight ratio) water for injection, stir evenly, regulate pH value 9.0, make dissolving with sodium hydroxide solution (content 20%), and overanxious; Get Borneolum Syntheticum 0.2g by weight, use the 1.5ml dissolve with ethanol, slowly add in the above-mentioned filtrate, fully stir, regulate pH value to 6.0 with the pH value regulator, add the injection water at last and adjust volume to 1000ml, microporous filter membrane filters, packing, promptly.
Embodiment 3:
Get baicalin 25g by weight, add 3 times of amounts (weight ratio) water for injection, stir evenly, regulate pH value 8.4, make dissolving with sodium hydroxide solution (20%), and overanxious; Get Borneolum Syntheticum 0.5g by weight, use the 5ml dissolve with ethanol, slowly add in the above-mentioned filtrate, add osmotic pressure regulator glucose 4.0g, thickening agent hyaluronate sodium 1.5g again, fully stir, regulate pH value to 5.5 with the pH value regulator, add the injection water at last and adjust volume to 1000ml, microporous filter membrane filters, packing, promptly.
Embodiment 4:
Get baicalin 30g by weight, add 2 times of amounts (weight ratio) water for injection, stir evenly, regulate pH value 9.0, make dissolving with sodium hydroxide solution (20%), and overanxious; Get Borneolum Syntheticum 0.45g by weight, use the 5ml dissolve with ethanol, slowly add in the above-mentioned filtrate, add osmotic pressure regulator boric acid 4.1g, thickening agent hyaluronate sodium 0.8g again, fully stir, regulate pH value to 6.5 with the pH value regulator, add the injection water at last and adjust volume to 1000ml, microporous filter membrane filters, packing, promptly.
Embodiment 5:
Get baicalin 60g by weight, add 2 times of amounts (weight ratio) water for injection, stir evenly, regulate pH value 9.0, make dissolving with sodium hydroxide solution (20%), and overanxious; Get Borneolum Syntheticum 0.15g by weight, use the 2ml dissolve with ethanol, slowly add in the above-mentioned filtrate, fully stir, regulate pH value to 6.8 with the pH value regulator, add the injection water at last and adjust volume to 1000ml, microporous filter membrane filters, packing, promptly.
Claims (2)
1. prevent and treat the disease of eye pharmaceutical composition for one kind, it is characterized in that: described pharmaceutical composition is with baicalin, Borneolum Syntheticum is an ingredient, is equipped with osmotic pressure regulator, pH value regulator, and its weight ratio is baicalin 20-80g, Borneolum Syntheticum 0.1-10g, osmotic pressure regulator 0-4.2g, thickening agent 0-2.5g.
2. pharmaceutical composition according to claim 1 is characterized in that: contained drug composition and weight ratio are: baicalin 30-60g, Borneolum Syntheticum 0.2-6g, osmotic pressure regulator 0-4.2g, thickening agent 0-2.5g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101408154A CN101322717A (en) | 2008-07-28 | 2008-07-28 | Medicament composition for preventing and treating eye diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101408154A CN101322717A (en) | 2008-07-28 | 2008-07-28 | Medicament composition for preventing and treating eye diseases |
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| Publication Number | Publication Date |
|---|---|
| CN101322717A true CN101322717A (en) | 2008-12-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101408154A Pending CN101322717A (en) | 2008-07-28 | 2008-07-28 | Medicament composition for preventing and treating eye diseases |
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| CN (1) | CN101322717A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104888051A (en) * | 2015-06-30 | 2015-09-09 | 青岛海之星生物科技有限公司 | Honeyed pills for treating spleen deficiency and dampness heat type hordeolum and preparation method therefor |
| CN105796784A (en) * | 2016-06-03 | 2016-07-27 | 陈瑞 | Eye drops for curing trachoma |
| CN115105520A (en) * | 2022-07-15 | 2022-09-27 | 中国科学技术大学 | Application of baicalin in preparation of medicine for treating amblyopia |
-
2008
- 2008-07-28 CN CNA2008101408154A patent/CN101322717A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104888051A (en) * | 2015-06-30 | 2015-09-09 | 青岛海之星生物科技有限公司 | Honeyed pills for treating spleen deficiency and dampness heat type hordeolum and preparation method therefor |
| CN105796784A (en) * | 2016-06-03 | 2016-07-27 | 陈瑞 | Eye drops for curing trachoma |
| CN115105520A (en) * | 2022-07-15 | 2022-09-27 | 中国科学技术大学 | Application of baicalin in preparation of medicine for treating amblyopia |
| CN115105520B (en) * | 2022-07-15 | 2023-10-20 | 中国科学技术大学 | Application of baicalin in preparation of medicine for treating amblyopia |
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| PB01 | Publication | ||
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Open date: 20081217 |