CN104474289A - Traditional Chinese medicine eye drops for treating ocular inflammation and preparation method thereof - Google Patents
Traditional Chinese medicine eye drops for treating ocular inflammation and preparation method thereof Download PDFInfo
- Publication number
- CN104474289A CN104474289A CN201410692850.2A CN201410692850A CN104474289A CN 104474289 A CN104474289 A CN 104474289A CN 201410692850 A CN201410692850 A CN 201410692850A CN 104474289 A CN104474289 A CN 104474289A
- Authority
- CN
- China
- Prior art keywords
- parts
- traditional chinese
- chinese medicine
- eye drops
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Insects & Arthropods (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention belongs to the field of medicines and relates to traditional Chinese medicine eye drops for treating ocular inflammation and a preparation method thereof and in particular relates to traditional Chinese medicine eye drops for treating eye diseases, such as viral keratitis, viral conjunctivitis and acute and chronic conjunctivitis, and a preparation method thereof. The traditional Chinese medicine eye drops comprise the following medicine components in parts by weight: 20-30 parts of stem of noble dendrobium, 20-30 parts of climbing groundsel herb, 20-30 parts of indigowoad leaf, 20-30 parts of honey, 5-10 parts of coptis root, 3-5 parts of honeysuckle stem, 5-8 parts of herb of common stonecrop, 3-5 parts of barbary wolfberry fruit, 3-5 parts of thenardite, 10-20 parts of cassia seed, 20-30 parts of pale butterflybush flower, 10-20 parts of white chrysanthemum, 3-5 parts of pricklyash peel, 0.1-1 part of vitamin B1 and 0.1-1 part of vitamin B12. The traditional Chinese medicine eye drops have the advantages that the used traditional Chinese medicines meet the specifications of the China Pharmacopoeia and are safe and reliable; through compatibility of the medicines, the traditional Chinese medicine eye drops have the functions of resisting inflammation and allergy and nourishing peripheral trigeminal nerves of corneas, and have the characteristics of definite curative effects, high effect taking speed, high cure rate, no side effects, and the like.
Description
Technical field
The invention belongs to field of medicaments, relate to a kind of traditional Chinese medicine eye drops for the treatment of eye inflammation and preparation method thereof, be specifically related to a kind ofly treat traditional Chinese medicine eye drops of the ophthalmic diseasess such as viral keratitis, viral binding film is scorching, acute and chronic binding film is scorching and preparation method thereof.
Background technology
Viral keratitis, conjunctivitis are a kind of common ophthalmic diseasess, and caused by multiple virus, infectiousness is extremely strong, easy concurrent infection other diseases.Viral keratitis is the inflammation caused by viral pathogenesis original sense dye cornea.Cornea shallow-layer has abundant nervi trigeminus tip, therefore this disease often has obvious irritation, has photophobia, sheds tears, aches.This genus of cornea is transparent, once ill, then its transparency changes, and there is blurred vision in the normal main suit of patient.This disease is generally along nervi trigeminus morbidity, and diseased region is invaded comparatively dark, and it feels to go down, but because of the adjacent tissue of inflammatory stimulus keratopathy, therefore irritation is still more obvious.Viral keratitis, the course of disease herds length, more after and easily recur.Often can react with tunica uvea, even occur iridocyclitis, hypopyon, or secondary glaucoma, be one of comparatively common clinically diseases causing blindness.About there is symptom in viral conjunctivitis, comprise conjunctival congestion after the incubation period of 5 ~ 12 days, watery secretion, and on Ocular irritation and WA, palpebra inferior clings.There is symptom in normal eyes, and a usual lore starts.Many patients once contacted conjunctivitis person and/or suffered from respiratory tract infection person recently.Bulbar conjunctiva and palpebral conjunctiva hyperemia, there is conjunctival follicle in palpebral conjunctiva, preauricular lymph nodes enlargement and pain.Modal viral keratitis, conjunctivitis mainly contain herpes simplex, herpes zoster, epidemic keratitis and conjunctivitis etc. clinically.
Herpes simplex keratitis, be modal viral keratitis, its sickness rate is higher.Because it has easy recurrence, protracted course of disease, to clinical characters such as Drug therapy opposings, is main diseases causing blindness, has become current ophthalmologists and felt one of thorny oculopathy most.
Summary of the invention
According to above the deficiencies in the prior art, the invention provides a kind of traditional Chinese medicine eye drops for the treatment of eye inflammation and preparation method thereof, it is evident in efficacy, safe and reliable, have no side effect, there is wide potential applicability in clinical practice.
A kind of traditional Chinese medicine eye drops for the treatment of eye inflammation of the present invention, according to weight parts, comprise following ingredient: Herba Dendrobii 20 ~ 30 parts, Herba Hieracii Umbellati 20 ~ 30 parts, Folium Isatidis 20 ~ 30 parts, Mel 20 ~ 30 parts, Rhizoma Coptidis 5 ~ 10 parts, Caulis Lonicerae 3 ~ 5 parts, Herba hylotelephii erythrosticti 5 ~ 8 parts, Fructus Lycii 3 ~ 5 parts, Matrii Sulfas Exsiccatus 3 ~ 5 parts, Semen Cassiae 10 ~ 20 parts, Flos Buddlejae 20 ~ 30 parts, Flos Chrysanthemi 10 ~ 20 parts, 3 ~ 5 parts, Pericarpium Zanthoxyli, vitamin B
10.1 ~ 1 part and vitamin B
120.1 ~ 1 part.
Wherein, preferred version is as follows:
According to weight parts, comprise following ingredient: Herba Dendrobii 25 parts, Herba Hieracii Umbellati 25 parts, Folium Isatidis 25 parts, Mel 25 parts, Rhizoma Coptidis 8 parts, Caulis Lonicerae 3 parts, Herba hylotelephii erythrosticti 5 parts, Fructus Lycii 3 parts, Matrii Sulfas Exsiccatus 3 parts, Semen Cassiae 15 parts, Flos Buddlejae 25 parts, Flos Chrysanthemi 10 parts, 3 parts, Pericarpium Zanthoxyli, vitamin B
11 part and vitamin B
121 part.
The preparation method of the traditional Chinese medicine eye drops for the treatment of eye inflammation of the present invention, during preparation, carry out according to following steps:
(1) first Herba Dendrobii, Herba Hieracii Umbellati, Folium Isatidis, Rhizoma Coptidis, Caulis Lonicerae, Herba hylotelephii erythrosticti, Fructus Lycii, Matrii Sulfas Exsiccatus, Semen Cassiae, Flos Buddlejae, Flos Chrysanthemi, Pericarpium Zanthoxyli are added water 5000 milliliters, slow fire boils 1 hour, gets filtrate;
(2) residue adds water 5000 milliliters again, and slow fire gets filtrate after boiling 1 hour, twice filtrate is merged;
(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, place after 24 hours with filter paper filtering;
(4) after filtrate being waved most or recovery ethanol, vitaminize B
1, vitamin B
12powder and Mel, stir evenly adding distil water to 1000 ~ 5000 milliliter again and obtain medicinal liquid;
(5) adjust medicinal liquid and be equivalent to the osmotic pressure that mass fraction is the sodium chloride of 0.8 ~ 1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%;
(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.
During use, every day 3 ~ 5 times, each 1 ~ 2.
Pharmacology analysis:
Herba Dendrobii: be Chinese medicine, derives from the orchid family Herba Dendrobii, belongs to the stem of Dendrobium various plants, cold nature.Effect reinforcing stomach reg fluid, clearing away heat and nourishing YIN, cure mainly consumption of body fluid caused by febrile disease, that xerostomia excessive thirst, after being ill deficiency-heat, the moon hinder order be dark.Containing multiple alkaloid, polysaccharide, aminoacid and starch etc. in stem of Dendrobium, there is certain antipyretic effect; Can gastric secretion be promoted, aid digestion; Have and strengthen metabolism, the anti-ageing effect of waiting for a long time.The traditional Chinese medical science is thought, the vital essence of the vital organs of the human body is all by blood vessels are noted in eyes, and liver " is had one's ideas straightened out in order ", and it is whether in close relations that the physiological and pathological of eyes and the moon essence of liver fill Sheng.The moon essence of liver fills Sheng, then eye is fair bright and eagle-eyed, and rotate flexibly, full of vigor, people also seems hale and hearty; If cloudy insufficiency of essence, eye is fine will be intense darkness without light, or two are dry and astringent, or blurring of vision, or nyctalopia etc.Radix Stephaniae Tetrandrae has the function of YIN nourishing nourishing the liver, therefore is used as the good merchantable brand of eye-protecting by ancient Chinese medicine doctor.
Herba Hieracii Umbellati: heat-clearing and toxic substances removing; Improving acuity of vision and removing nebula; Killing parasites for relieving itching.Main flow sense; Upper respiratory tract infection; Pneumonia; Acute tonsillitis; Rib adenitis; Acute enteritis; Bacillary dysentery; Icterohepatitis; Gallbladder exudative dermatitis is scorching; Acute urinary tract infection; Conjunctival congestion and swelling pain cataracta; Carbuncle furuncle poison; Erysipelas; Eczema; Dry exudative dermatitis skin ulcer; Trichomonal vaginitis; Burn and scald.
Folium Isatidis: enter liver, the heart, stomach warp.Heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spit blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Certain inhibitory action is had to staphylococcus aureus, alpha streptococcus, meningococcus, streptococcus pneumoniae, micrococcus catarrhalis, Bacillus typhi, escherichia coli, hemophilus influenza, diphtheria corynebacterium and dysentery bacterium; Folium Isatidis also has inhibitory action to encephalitis b virus, mumps virus, influenza virus etc.In addition Folium Isatidis kills leptospiral effect.
Mel: containing a kind of antimicrobial, can prevent antibacterial from growing in vivo.In addition, Mel can also produce hydrogen peroxide, and this can contain that bacteria infection is at your body internal diffusion enzyme.Prove after deliberation, Mel contains multivitamin and the abundant and bioactive substance of uniqueness makes it have the several functions such as antibacterial, antiinflammatory, antioxidation, elimination free radical, immunomodulating, antitumor, promotion tissue regeneration, medical treatment, health-care effect is widely had to human body, and the pathogenic factors of immunity and inflammatory factor and xerophthalmia is closely related, now become the focus of research at present.
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.
Caulis Lonicerae: sweet, cold.Attach to the lung and stomach meridians.Heat-clearing and toxic substances removing, dispelling wind dredging collateral.Cure mainly epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, redness and swelling of joints burning pain.
Herba hylotelephii erythrosticti: expelling wind and removing dampness, promoting blood circulation to remove blood stasis, hemostasis and pain-relieving.For laryngitis, urticaria, spits blood, infantile erysipelas, mastitis; Furuncle carbuncle is controlled in external, traumatic injury, clavus, burn and scald, venom, herpes zoster, tinea pedis.
Fructus Lycii: cure mainly nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Containing 14 seed amino acids in Fructus Lycii, and containing special dietary compositions such as betanin, beautiful another name for Sichuan Province flavin, physalins, make it have outstanding health-care effect.Fructus Lycii contains the required nutrient substance of abundant carotene, multivitamin and the healthy eye such as calcium, ferrum, therefore has the merit of improving eyesight, is commonly called as " bright eye ".What ancient Chinese medicine doctor treatment deficiency of liver-blood, deficiency of kidney-YIN caused looks thing duskization and nyctalopia, usually uses Fructus Lycii.Famous prescription " QIJU DIHUANG WAN " is just key agents with Fructus Lycii.
Matrii Sulfas Exsiccatus: there is purging heat to relax the bowels; Hard masses softening and resolving; Heat-clearing and toxic substances removing; Lung heat clearing expelling summer-heat; Effect of removing food stagnancy stomach function regulating.Primary treatment excess-heat stagnates; Constipation; Conjunctival congestion and swelling pain; Pharyngeal swelling aphtha; Swollen ulcer drug.
Semen Cassiae: the function of tool clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.Removing heat from the liver is longer than by raw Semen Cassiae, and intestine moistening is dry.For conjunctival congestion and swelling pain, constipation.
Flos Buddlejae: sweet, is slightly cold.Return Liver Channel.Clearing away heat-fire, nourishing the liver to improve visual acuity, nebula removing.For conjunctival congestion and swelling pain, many tear photophobia, the raw nebula film of order, hepatasthenia dim eyesight, blurring of vision.
Flos Chrysanthemi: loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.
Pericarpium Zanthoxyli: acrid in the mouth, warm in nature.Return spleen, stomach, kidney channel.Warming middle-JIAO to relieve pain, killing parasites for relieving itching.For coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation; External: eczema, pudendal pruritus.
Vitamin B
1: in the crust being mainly present in seed and plumule, as in Testa oryzae and wheat bran, content is very abundant, in yeast, content is also extremely abundant.In lean meat, Chinese cabbage and Herba Apii graveolentis, content is also abundanter.Vitamin B used at present
1all products of chemosynthesis.In vivo, vitamin B
1participate in catabolism of carbohydrate with co-enzyme form, have the effect of neuroprotective system; Can also enterogastric peristalsis be promoted, increase appetite.Vitamin B
1be one of optic nerve and perineural source of nutrition, can ophthalmoplegia be improved, nystagmus and asthenopia.
Vitamin B
12: the peripheral nerve of energy nutrition cornea, strengthens the resistance against diseases of cornea peripheral nerve, promotes the rehabilitation of the state of an illness.
The invention has the advantages that used medicine meets Pharmacopoeia of People's Republic of China regulation, safety of medicine is reliable.All medicine phases and have antiinflammatory antiallergic, the trifacial effect of nutrition cornea tip, have that determined curative effect, instant effect, cure rate are high, the feature such as have no side effect.
Outcome measure:
1 clinical data
The routine herpes simplex keratitis patient of 1.1 physical data treatment group 80 is responsible for observing treatment (totally 96 eyes) by special messenger in outpatient service, wherein man 52 example, female 28 example; 5 ~ 73 years old age; The course of disease 2 ~ 26 days, average 16.3 ± 6.36 days, 96 eye middle-shallow layer herpes simplex keratitises, 62 eyes, Deep Stromal herpetic Keratitis 34 eyes.
1.2 Syndrome Differentiation of Traditional Chinese Medicine
1.2.1 shallow-layer herpes simplex keratitis (attacking type outside wind heat) patient have headache, shed tears, generate heat, the symptom such as aversion to wind, red tongue, yellow and thin fur, floating and rapid pulse.Pathological changes is only confined to epithelium or 1/3 hypothallus before involving cornea.
1.2.2 Deep Stromal herpetic Keratitis (in liver-fire vehement type) patient has symptom, red tongue, yellow and greasy fur, slippery and rapid pulse or the stringy and rapid pulse such as feeling of fullness in the head, conjunctival congestion, the vexed discomfort of rib.Pathological changes reaches cornea 1/2 hypothallus or descemet's membrane and endodermis deeply, comprises ground pattern corneal ulcer, disciform keratitis and cornea uveitis.
1.2.3 convalescent period herpes simplex keratitis (lack of lung-YIN type) patient have order puckery, look the symptoms such as the mixed dark companion of thing is weak, night sweat, red tongue, few tongue thready and rapid pulse.In the pathological changes later stage, state of an illness trend is stable, and corneal infiltration is clearly better Restoration stage.
2 Therapeutic Method
Every day 3 ~ 5 times, each 1 ~ 2.20 days courses for the treatment of, treat two courses for the treatment of.
2.1.6 1. criterion of therapeutical effect cures: shallow-layer herpes simplex keratitis is ulcer healing, and focal zone fluorescence rope is painted transfers feminine gender to; Deep Stromal herpetic Keratitis and convalescent period herpes simplex keratitis except above-mentioned standard, in slit lamp tangent plane, hypothallus infiltrates, edema disappears, do not thicken, descemet's membrane gauffer and aqueous flare disappear and 2. take a turn for the better: shallow-layer herpes simplex keratitis is the healing of ulcer part, focus reduces, residual a little fluorescein colored spots.Deep layer and convalescent period herpes simplex keratitis except above-mentioned standard, in slit lamp tangent plane, hypothallus infiltrates, edema alleviates, and corneal thickness is close to normal 3. invalid: the state of an illness is without change or increase the weight of.
3 therapeutic outcomes.
The treatment of three groups of cases was all 1 course for the treatment of with 20 days, statistical result after two courses for the treatment of.Treatment group total effective rate is 98.75%; Refer to following table.
Model case is introduced
Song, female, 53 years old, eyes are red, bitterly, shed tears, aversion to wind 3 days.Check right vision 0.3, left vision 0.2, find that cornea of both eyes temporo side has shallow-layer branch sample to infiltrate, fluorescent staining is painted, red tongue, yellow and thin fur, floating and rapid pulse, belongs to outside wind heat and attacks type.Through eye drops in treatment of the present invention recovery from illness in 28 days.
Jiang, female, 62 years old, left eye was red, bitterly, shed tears, aversion to wind, to keep in dark place 5 days, companion's eyelid Mild edema.Check right vision 1.0, left vision 0.06, find that cornea of left eye central authorities have deep layer ground pattern to infiltrate, fluorescent staining is painted, red tongue, yellow and greasy fur, slippery and rapid pulse, belongs to vehement type in liver-fire.Within 18 days, be clearly better through eye drops in treatment of the present invention.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1:
A kind of traditional Chinese medicine eye drops for the treatment of eye inflammation, according to weight parts, comprise following ingredient: Herba Dendrobii 25 parts, Herba Hieracii Umbellati 25 parts, Folium Isatidis 25 parts, Mel 25 parts, Rhizoma Coptidis 8 parts, Caulis Lonicerae 3 parts, Herba hylotelephii erythrosticti 5 parts, Fructus Lycii 3 parts, Matrii Sulfas Exsiccatus 3 parts, Semen Cassiae 15 parts, Flos Buddlejae 25 parts, Flos Chrysanthemi 10 parts, 3 parts, Pericarpium Zanthoxyli, vitamin B
11 part and vitamin B
121 part.
Embodiment 2:
Embodiment 1 is prepared according to following steps:
(1) first Herba Dendrobii, Herba Hieracii Umbellati, Folium Isatidis, Rhizoma Coptidis, Caulis Lonicerae, Herba hylotelephii erythrosticti, Fructus Lycii, Matrii Sulfas Exsiccatus, Semen Cassiae, Flos Buddlejae, Flos Chrysanthemi, Pericarpium Zanthoxyli are added water 5000 milliliters, slow fire boils 1 hour, gets filtrate;
(2) residue adds water 5000 milliliters again, and slow fire gets filtrate after boiling 1 hour, twice filtrate is merged;
(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, place after 24 hours with filter paper filtering;
(4) after filtrate being waved most or recovery ethanol, vitaminize B
1, vitamin B
12powder and Mel, stir evenly adding distil water to 1000 ~ 5000 milliliter again and obtain medicinal liquid;
(5) adjust medicinal liquid and be equivalent to the osmotic pressure that mass fraction is the sodium chloride of 0.8 ~ 1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%;
(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.
Claims (3)
1. treat the traditional Chinese medicine eye drops of eye inflammation for one kind, it is characterized in that according to weight parts, comprise following ingredient: Herba Dendrobii 20 ~ 30 parts, Herba Hieracii Umbellati 20 ~ 30 parts, Folium Isatidis 20 ~ 30 parts, Mel 20 ~ 30 parts, Rhizoma Coptidis 5 ~ 10 parts, Caulis Lonicerae 3 ~ 5 parts, Herba hylotelephii erythrosticti 5 ~ 8 parts, Fructus Lycii 3 ~ 5 parts, Matrii Sulfas Exsiccatus 3 ~ 5 parts, Semen Cassiae 10 ~ 20 parts, Flos Buddlejae 20 ~ 30 parts, Flos Chrysanthemi 10 ~ 20 parts, 3 ~ 5 parts, Pericarpium Zanthoxyli, vitamin B
10.1 ~ 1 part and vitamin B
120.1 ~ 1 part.
2. the traditional Chinese medicine eye drops for the treatment of eye inflammation according to claim 1, it is characterized in that according to weight parts, comprise following ingredient: Herba Dendrobii 25 parts, Herba Hieracii Umbellati 25 parts, Folium Isatidis 25 parts, Mel 25 parts, Rhizoma Coptidis 8 parts, Caulis Lonicerae 3 parts, Herba hylotelephii erythrosticti 5 parts, Fructus Lycii 3 parts, Matrii Sulfas Exsiccatus 3 parts, Semen Cassiae 15 parts, Flos Buddlejae 25 parts, Flos Chrysanthemi 10 parts, 3 parts, Pericarpium Zanthoxyli, vitamin B
11 part and vitamin B
121 part.
3. a preparation method for the traditional Chinese medicine eye drops for the treatment of eye inflammation according to claim 1, when it is characterized in that preparation, carry out according to following steps:
(1) first Herba Dendrobii, Herba Hieracii Umbellati, Folium Isatidis, Rhizoma Coptidis, Caulis Lonicerae, Herba hylotelephii erythrosticti, Fructus Lycii, Matrii Sulfas Exsiccatus, Semen Cassiae, Flos Buddlejae, Flos Chrysanthemi, Pericarpium Zanthoxyli are added water 5000 milliliters, slow fire boils 1 hour, gets filtrate;
(2) residue adds water 5000 milliliters again, and slow fire gets filtrate after boiling 1 hour, twice filtrate is merged;
(3) above-mentioned filtrate is concentrated into 125 milliliters, adds the ethanol mixing that 375 milliliters of mass fractions are 95% after cooling, place after 24 hours with filter paper filtering;
(4) after filtrate being waved most or recovery ethanol, vitaminize B
1, vitamin B
12powder and Mel, stir evenly adding distil water to 1000 ~ 5000 milliliter again and obtain medicinal liquid;
(5) adjust medicinal liquid and be equivalent to the osmotic pressure that mass fraction is the sodium chloride of 0.8 ~ 1.2%, adding preservative agent cyanogen Mercury difluoride. in medicinal liquid, wherein, the volume ratio of cyanogen Mercury difluoride. and medicinal liquid is 1:1500, then adjusts pH value to 7.0 with the sodium hydroxide that mass fraction is 10%;
(6) last medicinal liquid is through filter paper filtering, seals, autoclave sterilization, subpackage 8 mls/branch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410692850.2A CN104474289A (en) | 2014-11-25 | 2014-11-25 | Traditional Chinese medicine eye drops for treating ocular inflammation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410692850.2A CN104474289A (en) | 2014-11-25 | 2014-11-25 | Traditional Chinese medicine eye drops for treating ocular inflammation and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104474289A true CN104474289A (en) | 2015-04-01 |
Family
ID=52748990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410692850.2A Pending CN104474289A (en) | 2014-11-25 | 2014-11-25 | Traditional Chinese medicine eye drops for treating ocular inflammation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104474289A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106362015A (en) * | 2016-08-31 | 2017-02-01 | 贵州苗侗古方民族医药开发有限公司 | Eye drop for treating conjunctivitis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638432A (en) * | 2013-11-27 | 2014-03-19 | 许伟 | Traditional Chinese medicine eye drop |
-
2014
- 2014-11-25 CN CN201410692850.2A patent/CN104474289A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638432A (en) * | 2013-11-27 | 2014-03-19 | 许伟 | Traditional Chinese medicine eye drop |
Non-Patent Citations (1)
| Title |
|---|
| 叶丽南: "单纯疱疹性角膜炎", 《广西卫生》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106362015A (en) * | 2016-08-31 | 2017-02-01 | 贵州苗侗古方民族医药开发有限公司 | Eye drop for treating conjunctivitis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104288609A (en) | Traditional Chinese medicine composition curing stomach fire flaming gingivitis and preparation method for traditional Chinese medicine composition | |
| CN104606615A (en) | Traditional Chinese medicine eyedrop for treating ocular inflammation and preparation method thereof | |
| CN104117005A (en) | Traditional Chinese medicine preparation for treating heat stroke and preparation method thereof | |
| CN104587043A (en) | Traditional Chinese medicine eye drops for treating ocular inflammation and preparation method thereof | |
| CN105560891A (en) | Traditional Chinese medicine eye drops containing borneol and preparation method thereof | |
| CN105125630A (en) | Eye drops and preparation method thereof | |
| CN104027651A (en) | Eye drops for treating eye diseases | |
| CN104367832A (en) | Compound dendrobe eye drops for treating xerophthalmia and preparation method thereof | |
| CN103520643B (en) | A kind of Chinese medicine preparation being used for the treatment of diabetic cataract and preparation method thereof | |
| CN104474289A (en) | Traditional Chinese medicine eye drops for treating ocular inflammation and preparation method thereof | |
| CN103877424B (en) | A kind of Chinese medicine liquid medicine and preparation method for the treatment of trachoma | |
| CN105726984A (en) | Traditional Chinese medicine eye drops for treating eye inflammation and preparation method thereof | |
| CN105056078A (en) | Traditional Chinese medicine composition for treating stomach fire exuberance, toothache and ozostomia | |
| CN104523981A (en) | Traditional Chinese medicine preparation for treating optic neuritis and preparation method | |
| CN104587076A (en) | Traditional Chinese medicine lotion for treating conjunctivitis | |
| CN105726983A (en) | Compound dendrobium eye drops for treating xerophthalmia and preparation method thereof | |
| CN104147411A (en) | Traditional Chinese medicine preparation for treating primary glaucoma | |
| CN104623040A (en) | Nursing composition with wound sterilization and inflammation diminishment effects and preparation method thereof | |
| CN102940753A (en) | Pills for treating glaucoma and preparation method | |
| CN104474439A (en) | Traditional Chinese medicine eye drops for treating ocular inflammation and preparation method thereof | |
| CN105727132A (en) | Traditional Chinese medicine eye drops for treating eye inflammation and preparation method thereof | |
| CN105748938A (en) | Traditional Chinese medicinal eye drop for treating ocular inflammations, and preparation method thereof | |
| CN102755549A (en) | Drug for curing cataract and preparation method thereof | |
| CN104288225A (en) | Traditional Chinese medicine eye drop for treating ocular inflammation and preparation method thereof | |
| CN104288306A (en) | Traditional Chinese medicine eye drop for treating ocular diseases and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150401 |