UA41365C2 - Похідні азоліламіну та фунгіцидний засіб на їх основі - Google Patents
Похідні азоліламіну та фунгіцидний засіб на їх основіInfo
- Publication number
- UA41365C2 UA41365C2 UA95125159A UA95125159A UA41365C2 UA 41365 C2 UA41365 C2 UA 41365C2 UA 95125159 A UA95125159 A UA 95125159A UA 95125159 A UA95125159 A UA 95125159A UA 41365 C2 UA41365 C2 UA 41365C2
- Authority
- UA
- Ukraine
- Prior art keywords
- group
- atom
- azolylamine
- derivatives
- substituents
- Prior art date
Links
- QLSWIGRIBOSFMV-UHFFFAOYSA-N 1h-pyrrol-2-amine Chemical class NC1=CC=CN1 QLSWIGRIBOSFMV-UHFFFAOYSA-N 0.000 title abstract 3
- 239000000417 fungicide Substances 0.000 title abstract 2
- 125000004429 atom Chemical group 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 208000024386 fungal infectious disease Diseases 0.000 abstract 1
- 238000010413 gardening Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polymerization Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13293193 | 1993-05-10 | ||
| PCT/JP1994/000737 WO1994026734A1 (fr) | 1993-05-10 | 1994-05-02 | Derive d'azolylamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA41365C2 true UA41365C2 (uk) | 2001-09-17 |
Family
ID=15092851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA95125159A UA41365C2 (uk) | 1993-05-10 | 1994-05-02 | Похідні азоліламіну та фунгіцидний засіб на їх основі |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US5620994A (Direct) |
| EP (1) | EP0698606B1 (Direct) |
| KR (1) | KR100339166B1 (Direct) |
| CN (1) | CN1046278C (Direct) |
| AT (1) | ATE161257T1 (Direct) |
| AU (1) | AU685116B2 (Direct) |
| CA (1) | CA2162463C (Direct) |
| DE (1) | DE69407409T2 (Direct) |
| DK (1) | DK0698606T3 (Direct) |
| ES (1) | ES2110749T3 (Direct) |
| GR (1) | GR3025715T3 (Direct) |
| HU (1) | HU225416B1 (Direct) |
| TW (1) | TW325473B (Direct) |
| UA (1) | UA41365C2 (Direct) |
| WO (1) | WO1994026734A1 (Direct) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0698606T3 (da) * | 1993-05-10 | 1998-08-24 | Kaken Pharma Co Ltd | Azolylaminderivat |
| CA2233617A1 (en) * | 1995-09-28 | 1997-04-03 | Kaken Pharmaceutical Co., Ltd. | Process for the preparation of 4-methylenepiperidine |
| ATE434667T1 (de) | 1999-07-28 | 2009-07-15 | Kaken Pharma Co Ltd | Verfahren zum nachweis pathogener mikroorganismen und antimikrobieller mittel, verfahren zum nachweis der arzneimittelwirkung antimikrobieller mittel und antimikrobielle mittel |
| US20100080869A1 (en) * | 2004-05-25 | 2010-04-01 | Watson James B | Live Bacteria product |
| US20090162419A1 (en) * | 2004-05-25 | 2009-06-25 | Watson James B | Live bacteria product |
| US20090162481A1 (en) * | 2004-05-25 | 2009-06-25 | Watson James B | Live bacteria product |
| US7625927B2 (en) * | 2006-02-27 | 2009-12-01 | Alcon Research, Ltd. | Method of treating glaucoma |
| ES2350806T3 (es) | 2006-12-28 | 2011-01-27 | Kaken Pharmaceutical Co., Ltd. | Composición de gel para el tratamiento de micosis. |
| US20090175810A1 (en) | 2008-01-03 | 2009-07-09 | Gareth Winckle | Compositions and methods for treating diseases of the nail |
| US8039494B1 (en) | 2010-07-08 | 2011-10-18 | Dow Pharmaceutical Sciences, Inc. | Compositions and methods for treating diseases of the nail |
| CN106045970B (zh) * | 2010-08-31 | 2019-11-08 | 科研制药株式会社 | 1-三唑-2-丁醇衍生物的制造方法 |
| CN110433291B (zh) | 2013-10-03 | 2023-04-28 | 博世健康爱尔兰有限公司 | 稳定的艾菲康唑组合物 |
| CA3052643A1 (en) | 2013-11-22 | 2015-05-28 | Bausch Health Ireland Limited | Anti-infective methods, compositions, and devices |
| CN104292214B (zh) * | 2014-09-24 | 2017-04-05 | 南京华威医药科技开发有限公司 | 艾氟康唑及其中间体的合成方法 |
| CN104327047B (zh) * | 2014-10-17 | 2016-04-06 | 苏州明锐医药科技有限公司 | 艾菲康唑的制备方法 |
| US9617241B2 (en) | 2014-11-23 | 2017-04-11 | Mapi Pharma Ltd. | Intermediate compounds and process for the preparation of efinaconazole |
| US20180002310A1 (en) * | 2015-01-20 | 2018-01-04 | Perrigo Api Ltd. | Crystalline forms of efinaconazole |
| ITUB20150417A1 (it) | 2015-05-08 | 2016-11-08 | Dipharma Francis Srl | Procedimento per la preparazione di composti piperidinici |
| EP3294723A1 (en) | 2015-05-12 | 2018-03-21 | Lupin Limited | Process for the preparation of efinaconazole |
| EP3112360A1 (en) * | 2015-06-29 | 2017-01-04 | Dipharma Francis S.r.l. | Process for the preparation of efinaconazole |
| CN106565672A (zh) * | 2015-10-08 | 2017-04-19 | 中美华世通生物医药科技（武汉）有限公司 | 制备艾氟康唑的方法 |
| US20170129874A1 (en) * | 2015-11-10 | 2017-05-11 | Virupaksha Organics Limited | Novel improved process for preparing a triazole antifungal agent |
| CN106810534A (zh) * | 2015-11-30 | 2017-06-09 | 中美华世通生物医药科技（武汉）有限公司 | 艾氟康唑晶型及其制备方法 |
| CN106928186A (zh) * | 2015-12-29 | 2017-07-07 | 中美华世通生物医药科技（武汉）有限公司 | 化合物及其制备方法和用途 |
| ITUB20159795A1 (it) * | 2015-12-30 | 2017-06-30 | Procos Spa | Processo per la sintesi di efinaconazolo |
| ITUA20162545A1 (it) | 2016-04-13 | 2017-10-13 | Laboratorio Chimico Int S P A | Procedimento per la preparazione di intermedi utili nella sintesi di farmaci |
| WO2018115319A2 (en) | 2016-12-23 | 2018-06-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases |
| IT201700048270A1 (it) | 2017-05-04 | 2018-11-04 | Seegpharm Sa | Procedimento per la preparazione di un derivato azolico. |
| IL270691B (en) * | 2017-05-19 | 2022-07-01 | Kaken Pharma Co Ltd | Production and purification methods for efinconazole |
| SG11201911637QA (en) | 2017-08-10 | 2020-01-30 | Sumitomo Chemical Co | Process for producing epoxy alcohol compound |
| EP3885341A4 (en) * | 2018-12-29 | 2022-08-10 | Viwit Pharmaceutical Co., Ltd. | METHOD FOR THE PREPARATION OF EFINACONAZOLE |
| KR102181155B1 (ko) | 2019-09-26 | 2020-11-20 | 대봉엘에스 주식회사 | 이온성 액체를 매개로 한 에피나코나졸의 신규 제조방법 |
| JP2021054781A (ja) | 2019-09-26 | 2021-04-08 | デボン エルエス，リミテッド | 共結晶形エフィナコナゾール、及びその製造方法 |
| KR102301743B1 (ko) | 2020-12-29 | 2021-09-13 | 대봉엘에스 주식회사 | 에피나코나졸 경구용 조성물 |
| CN118994102A (zh) * | 2024-08-27 | 2024-11-22 | 张小宇 | 艾氟康唑衍生物及其抗真菌活性 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU187399B (en) * | 1980-12-24 | 1985-12-28 | Sumitomo Chemical Co | Process for preparing imidazolyl-propanol derivatives |
| US4507484A (en) * | 1982-07-24 | 1985-03-26 | Pfizer Inc. | Triazole antifungal agents |
| GB8412750D0 (en) * | 1984-05-18 | 1984-06-27 | Ici Plc | Heterocyclic compounds |
| DK0698606T3 (da) * | 1993-05-10 | 1998-08-24 | Kaken Pharma Co Ltd | Azolylaminderivat |
-
1994
- 1994-05-02 DK DK94914585T patent/DK0698606T3/da active
- 1994-05-02 ES ES94914585T patent/ES2110749T3/es not_active Expired - Lifetime
- 1994-05-02 CA CA002162463A patent/CA2162463C/en not_active Expired - Lifetime
- 1994-05-02 UA UA95125159A patent/UA41365C2/uk unknown
- 1994-05-02 CN CN94192041A patent/CN1046278C/zh not_active Expired - Lifetime
- 1994-05-02 EP EP94914585A patent/EP0698606B1/en not_active Expired - Lifetime
- 1994-05-02 DE DE69407409T patent/DE69407409T2/de not_active Expired - Lifetime
- 1994-05-02 KR KR1019950704971A patent/KR100339166B1/ko not_active Expired - Lifetime
- 1994-05-02 HU HU9503217A patent/HU225416B1/hu unknown
- 1994-05-02 AU AU66896/94A patent/AU685116B2/en not_active Expired
- 1994-05-02 AT AT94914585T patent/ATE161257T1/de active
- 1994-05-02 WO PCT/JP1994/000737 patent/WO1994026734A1/ja not_active Ceased
- 1994-05-11 TW TW083104253A patent/TW325473B/zh not_active IP Right Cessation
-
1995
- 1995-11-07 US US08/532,800 patent/US5620994A/en not_active Expired - Lifetime
-
1997
- 1997-01-09 US US08/781,204 patent/US5716969A/en not_active Expired - Lifetime
- 1997-11-10 US US08/966,527 patent/US5962476A/en not_active Expired - Lifetime
- 1997-12-18 GR GR970403105T patent/GR3025715T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0698606A4 (Direct) | 1996-04-10 |
| ES2110749T3 (es) | 1998-02-16 |
| US5620994A (en) | 1997-04-15 |
| CA2162463C (en) | 2006-01-03 |
| HU225416B1 (en) | 2006-11-28 |
| GR3025715T3 (en) | 1998-03-31 |
| HUT75031A (en) | 1997-03-28 |
| TW325473B (en) | 1998-01-21 |
| EP0698606A1 (en) | 1996-02-28 |
| ATE161257T1 (de) | 1998-01-15 |
| US5962476A (en) | 1999-10-05 |
| CN1122598A (zh) | 1996-05-15 |
| KR100339166B1 (ko) | 2004-04-30 |
| AU685116B2 (en) | 1998-01-15 |
| DE69407409D1 (de) | 1998-01-29 |
| AU6689694A (en) | 1994-12-12 |
| DK0698606T3 (da) | 1998-08-24 |
| CA2162463A1 (en) | 1994-11-24 |
| HU9503217D0 (en) | 1996-01-29 |
| WO1994026734A1 (fr) | 1994-11-24 |
| US5716969A (en) | 1998-02-10 |
| EP0698606B1 (en) | 1997-12-17 |
| DE69407409T2 (de) | 1998-04-09 |
| CN1046278C (zh) | 1999-11-10 |
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