UA41287C2 - Алкоголяти металів для отримання похідних таксану - Google Patents

Алкоголяти металів для отримання похідних таксану

Info

Publication number
UA41287C2
UA41287C2 UA94005359A UA94005359A UA41287C2 UA 41287 C2 UA41287 C2 UA 41287C2 UA 94005359 A UA94005359 A UA 94005359A UA 94005359 A UA94005359 A UA 94005359A UA 41287 C2 UA41287 C2 UA 41287C2
Authority
UA
Ukraine
Prior art keywords
taxane derivatives
metal alcoholates
group
oxoprotective
hydrogen
Prior art date
Application number
UA94005359A
Other languages
English (en)
Russian (ru)
Inventor
Роберт А. Холтон
Original Assignee
Флоріда Стейт Юніверсіті
Юниверсити Флорида Стейт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Флоріда Стейт Юніверсіті, Юниверсити Флорида Стейт filed Critical Флоріда Стейт Юніверсіті
Publication of UA41287C2 publication Critical patent/UA41287C2/uk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/003Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Saccharide Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Compositions Of Oxide Ceramics (AREA)

Abstract

Запропоновоні алкоголяти металів загальної формули (I) де Т1 - водень або оксизахисна група, Z - ОТ2 - або -ОСОСН3 - група, де Т2 - водень або оксизахисна група, М - метал, Ac - ацетил, Ph - фенил, для отримання похідних таксану.
UA94005359A 1991-09-23 1992-09-22 Алкоголяти металів для отримання похідних таксану UA41287C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76380591A 1991-09-23 1991-09-23
US07/862,778 US5229526A (en) 1991-09-23 1992-04-03 Metal alkoxides
PCT/US1992/007952 WO1993006094A1 (en) 1991-09-23 1992-09-22 Metal alkoxides

Publications (1)

Publication Number Publication Date
UA41287C2 true UA41287C2 (uk) 2001-09-17

Family

ID=27117339

Family Applications (1)

Application Number Title Priority Date Filing Date
UA94005359A UA41287C2 (uk) 1991-09-23 1992-09-22 Алкоголяти металів для отримання похідних таксану

Country Status (24)

Country Link
US (1) US5229526A (uk)
EP (1) EP0605638B1 (uk)
JP (1) JP3320416B2 (uk)
CN (1) CN1058714C (uk)
AT (1) ATE184004T1 (uk)
AU (1) AU643911B2 (uk)
CA (1) CA2098568C (uk)
CZ (1) CZ289299B6 (uk)
DE (1) DE69229916T2 (uk)
DK (1) DK0605638T3 (uk)
ES (1) ES2137951T3 (uk)
FI (1) FI109796B (uk)
HU (1) HU225914B1 (uk)
IL (1) IL103192A (uk)
MX (1) MX9205370A (uk)
MY (1) MY128481A (uk)
NO (1) NO305120B1 (uk)
NZ (1) NZ244458A (uk)
PH (1) PH30213A (uk)
PT (1) PT100884B (uk)
RU (1) RU2098413C1 (uk)
TW (1) TW368502B (uk)
UA (1) UA41287C2 (uk)
WO (1) WO1993006094A1 (uk)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6005138A (en) 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6521660B2 (en) 1991-09-23 2003-02-18 Florida State University 3′-alkyl substituted taxanes and pharmaceutical compositions containing them
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US6011056A (en) 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
ZA926828B (en) * 1991-09-23 1993-03-15 Univ Florida State Novel alkoxy substituted taxanes and pharmaceutical compositions containing them.
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US7074945B2 (en) * 1991-09-23 2006-07-11 Florida State University Metal alkoxide taxane derivatives
US5284864A (en) 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6335362B1 (en) * 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
US5614549A (en) * 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
FR2697752B1 (fr) * 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
FR2698363B1 (fr) * 1992-11-23 1994-12-30 Rhone Poulenc Rorer Sa Nouveaux dérivés du taxane, leur préparation et les compositions qui les contiennent.
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5646176A (en) * 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
AU682173B2 (en) * 1993-01-15 1997-09-25 Florida State University Process for the preparation of 10-desacetoxybaccatin III
ZA94128B (en) * 1993-02-01 1994-08-19 Univ New York State Res Found Process for the preparation of taxane derivatives and betalactam intermediates therefor
US6187916B1 (en) * 1993-02-01 2001-02-13 Research Foundation Of State University Of New York Process for the preparation of taxane derivatives and β-lactam intermediates therefor
US6593482B2 (en) 1993-02-01 2003-07-15 Aventis Pharma S.A. Methods for preparing new taxoids and pharmaceutical compositions containing them
WO1994020485A1 (en) * 1993-03-05 1994-09-15 Florida State University Process for the preparation of 9-desoxotaxanes
US6710191B2 (en) 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
US5547981A (en) * 1993-03-09 1996-08-20 Enzon, Inc. Taxol-7-carbazates
TW467896B (en) * 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
PT690712E (pt) * 1993-03-22 2002-05-31 Univ Florida State Taxanos possuindo uma cadeia lateral substituida com piridilo
FR2703049B1 (fr) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.
DE69434190T2 (de) * 1993-03-22 2005-05-25 Florida State University, Tallahassee Pharmazeutische Zusammenstellungen enthaltende eine furyl oder thienyl substituierte Seitenkette
IT1261667B (it) * 1993-05-20 1996-05-29 Tassano ad attivita' antitumorale.
DE69435002T2 (de) * 1993-07-19 2008-03-20 Angiotech Pharmaceuticals, Inc., Vancouver Anti-angiogene Mittel enthaltend Taxol und einen nicht biodegradierbaren Träger und deren Verwendung
US5405972A (en) * 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
AU8052194A (en) * 1993-10-20 1995-05-08 Enzon, Inc. 2'- and/or 7- substituted taxoids
US6441026B1 (en) 1993-11-08 2002-08-27 Aventis Pharma S.A. Antitumor compositions containing taxane derivatives
FR2718137B1 (fr) * 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Procédé de préparation de trialcoylsilyl-7 baccatine III.
FR2722191B1 (fr) * 1994-07-08 1996-08-23 Rhone Poulenc Rorer Sa Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle
US6201140B1 (en) 1994-07-28 2001-03-13 Bristol-Myers Squibb Company 7-0-ethers of taxane derivatives
US6500858B2 (en) 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6100411A (en) * 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6458976B1 (en) 1994-10-28 2002-10-01 The Research Foundation Of State University Of New York Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods
AU4133096A (en) * 1994-10-28 1996-05-23 Research Foundation Of The State University Of New York, The Taxoid derivatives, their preparation and their use as antitumor agents
US5847170A (en) * 1995-03-27 1998-12-08 Rhone-Poulenc Rorer, S.A. Taxoids, their preparation and pharmaceutical compositions containing them
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US5760251A (en) * 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
JP2001524067A (ja) * 1995-09-13 2001-11-27 フロリダ・ステイト・ユニバーシティ 放射線感作性タキサン類およびその医薬製剤
US5654448A (en) * 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
US5854278A (en) * 1995-12-13 1998-12-29 Xechem International, Inc. Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents
US6177456B1 (en) 1995-10-02 2001-01-23 Xechem International, Inc. Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
US5840748A (en) * 1995-10-02 1998-11-24 Xechem International, Inc. Dihalocephalomannine and methods of use therefor
US5807888A (en) * 1995-12-13 1998-09-15 Xechem International, Inc. Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
EP0927175A4 (en) * 1996-05-06 2002-05-22 Univ Florida State 1-DEOXYBACCATIN III, 1-DEOXYTAXOL AND 1-DEOXYTAXOL ANALOG AND METHOD FOR THE PRODUCTION THEREOF
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
US5750736A (en) * 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US5750737A (en) * 1996-09-25 1998-05-12 Sisti; Nicholas J. Method for paclitaxel synthesis
US5973170A (en) * 1996-09-25 1999-10-26 Napro Biotherapuetics, Inc. C-7 metal alkoxides of baccatin III
US5912264A (en) * 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
US5914411A (en) * 1998-01-21 1999-06-22 Napro Biotherapeutics, Inc. Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
PT1082316E (pt) 1998-05-01 2004-11-30 Napro Biotherapeutics Inc Processos e intermediarios uteis para a sintese de paclitaxel a partir de c-7,c-10-di-cbz-bacatina iii
US6066749A (en) * 1998-05-01 2000-05-23 Napro Biotherapeutics, Inc. Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis
US6048990A (en) * 1998-05-01 2000-04-11 Napro Biotherapeutics, Inc. Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position
US6025516A (en) * 1998-10-14 2000-02-15 Chiragene, Inc. Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes
US6136999A (en) * 1999-06-21 2000-10-24 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-n-acyl (2R,3S)-3-phenylisoserine substituted phenyl activated esters and method for production thereof
US6143902A (en) * 1999-06-21 2000-11-07 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-N-acyl (2R,3S)-3-phenylisoserine N-imido activated esters and method for production thereof
HK1049787B (en) 1999-10-01 2014-07-25 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6548293B1 (en) * 1999-10-18 2003-04-15 Fsu Research Foundation, Inc. Enzymatic process for the resolution of enantiomeric mixtures of β-lactams
US7063977B2 (en) * 2001-08-21 2006-06-20 Bristol-Myers Squibb Company Enzymatic resolution of t-butyl taxane derivatives
PL368945A1 (en) * 2001-11-30 2005-04-04 Bristol-Myers Squibb Company Paclitaxel solvates
US6703599B1 (en) * 2002-01-30 2004-03-09 Microsoft Corporation Proximity sensor with adaptive threshold
WO2004033442A2 (en) * 2002-10-09 2004-04-22 Chatham Biotec Ltd. Novel taxanes and methods related to use and preparation thereof
US7030253B2 (en) * 2003-08-07 2006-04-18 Bristol-Myers Squibb Company Process for preparing 4-alkyl- or 4-aryl-oxycarbonyl paclitaxel analogs and novel intermediates
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
US20050272807A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
US20050288520A1 (en) * 2004-06-25 2005-12-29 Phytogen Life Sciences Inc. One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
JP2006302679A (ja) * 2005-04-21 2006-11-02 Seiko Epson Corp 導電膜の形成方法、及び電子機器の製造方法
WO2006116532A2 (en) * 2005-04-28 2006-11-02 University Of Massachusetts Lowell Synthesis of oligo/poly(catechins) and methods of use
US7662980B2 (en) * 2006-10-20 2010-02-16 Scinopharm Singapore Pte Ltd. Crystalline forms of docetaxel and process for preparation thereof
CN101289432B (zh) * 2007-04-20 2010-12-15 上海天伟生物制药有限公司 异丝氨酸酯衍生物及其制备方法
EP2285792A2 (en) * 2008-05-07 2011-02-23 Ivax Research, Llc Processes for preparation of taxanes and intermediates thereof
KR101096282B1 (ko) 2009-04-24 2011-12-20 주식회사 삼양제넥스 탁산 유도체를 제조하는 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone

Also Published As

Publication number Publication date
WO1993006094A1 (en) 1993-04-01
HU9400831D0 (en) 1994-06-28
NZ244458A (en) 1994-06-27
RU2098413C1 (ru) 1997-12-10
EP0605638B1 (en) 1999-09-01
AU2688892A (en) 1993-04-27
CA2098568A1 (en) 1993-03-24
PT100884A (pt) 1993-11-30
CZ289299B6 (cs) 2001-12-12
HU225914B1 (en) 2007-12-28
CZ66294A3 (en) 1994-12-15
FI941323L (fi) 1994-03-22
EP0605638A1 (en) 1994-07-13
US5229526A (en) 1993-07-20
ATE184004T1 (de) 1999-09-15
JPH07502982A (ja) 1995-03-30
FI109796B (fi) 2002-10-15
PT100884B (pt) 1999-07-30
DE69229916T2 (de) 2000-02-17
DK0605638T3 (da) 2000-02-28
EP0605638A4 (en) 1994-08-24
NO941020L (no) 1994-05-20
CN1058714C (zh) 2000-11-22
CN1075718A (zh) 1993-09-01
CA2098568C (en) 1997-06-03
PH30213A (en) 1997-02-05
IL103192A0 (en) 1993-02-21
NO305120B1 (no) 1999-04-06
FI941323A0 (fi) 1994-03-22
NO941020D0 (no) 1994-03-22
AU643911B2 (en) 1993-11-25
DE69229916D1 (de) 1999-10-07
IL103192A (en) 1997-06-10
MX9205370A (es) 1993-03-31
HUT66398A (en) 1994-11-28
MY128481A (en) 2007-02-28
ES2137951T3 (es) 2000-01-01
JP3320416B2 (ja) 2002-09-03
TW368502B (en) 1999-09-01

Similar Documents

Publication Publication Date Title
UA41287C2 (uk) Алкоголяти металів для отримання похідних таксану
MY102705A (en) Proline derivaties and related compounds.
DE69016463D1 (de) Handfreie hardwaretastatur.
EP0528858A4 (en) Inhibitors of dipeptidyl-aminopeptidase type iv
FI910857A0 (fi) Foerfarande foer framstaellning av oxetanoner.
ES2176776T3 (es) Ligandos del neuropeptido-y.
TR200800474T2 (tr) Florfenikole aracı maddelerin hazırlanmasına ilişkin işlem.
DK0515544T3 (da) Steroidsulfataseinhibitorer
TR200002921T2 (tr) Yarı-Sentetik ekteinasidinler
TR200002865T2 (tr) Organik bileşikler.
DE3162004D1 (en) Metal chelates of 1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones
MY105344A (en) New sulphonyl compounds
GEP19970781B (en) Uracil derivatives
CA2037975A1 (en) 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors
TR199800243T1 (xx) Prolil endopeptidaz inhibit�rleri.
NO981393D0 (no) Guanidinoproteasehemmere
ES2020953B3 (es) Complejos de tetrahidro-3,4-furanodiamina-n-n'platino.
MX9700179A (es) Derivados de triazol y su utilizacion.
BG38637A3 (en) Method for preparing 2- exo- hydroxy- 7- oxabicyclo [2, 2, 1] heptanes
JPS52118405A (en) Novel polyamines
BG35031A3 (bg) Метод за получаване на 1,1,2-трифенилпропанови (пропенови) производни
BG33436A3 (en) Method for obtaining of 4- dezacetyl- vinblastine- 3- spiro- 5"- oxazolidin- 2", 4"- dion
MX9801792A (es) Inhibidores cicloantihelminticos.
JPS5424856A (en) 1-(3 or 4-methyl-3-cyclohexenyl)-2-methyl-1-penten-3-ol
BR9407232A (pt) Compostos de tiocarbamoíla