UA127918C2 - СПОСІБ ДІАГНОСТИКИ ТА МОНІТОРИНГУ ЛЕГКОГО ТРАВМАТИЧНОГО ПОШКОДЖЕННЯ ГОЛОВНОГО МОЗКУ (mTBI) ЗА ДОПОМОГОЮ БІОМАРКЕРА мікроРНК miR-502 - Google Patents
СПОСІБ ДІАГНОСТИКИ ТА МОНІТОРИНГУ ЛЕГКОГО ТРАВМАТИЧНОГО ПОШКОДЖЕННЯ ГОЛОВНОГО МОЗКУ (mTBI) ЗА ДОПОМОГОЮ БІОМАРКЕРА мікроРНК miR-502 Download PDFInfo
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1603967.9A GB201603967D0 (en) | 2016-03-08 | 2016-03-08 | Biomarkers of traumatic brain injury |
| PCT/GB2017/050231 WO2017153710A1 (en) | 2016-03-08 | 2017-01-30 | Biomarkers of traumatic brain injury |
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Families Citing this family (19)
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| EP3122905B1 (en) | 2014-03-27 | 2020-09-09 | Yale University | Circulating micrornas as biomarkers for endometriosis |
| GB201603967D0 (en) | 2016-03-08 | 2016-04-20 | Univ Birmingham | Biomarkers of traumatic brain injury |
| MX2019002425A (es) * | 2016-08-30 | 2019-08-16 | Univ Yale | Micro ácidos ribonucleicos como biomarcadores para la endometriosis. |
| WO2018175941A1 (en) * | 2017-03-23 | 2018-09-27 | Quadrant Biosciences Inc. | Analysis and prediction of traumatic brain injury and concusion symptoms |
| US11739323B2 (en) * | 2017-06-08 | 2023-08-29 | Temple University-Of The Commonwealth System Of Higher Education | Micro-RNAs as biomarkers for subconcussive and concussive injury and therapeutic applications |
| EP3803416A4 (en) * | 2018-05-31 | 2022-05-18 | Amydis, Inc. | COMPOSITIONS AND METHODS FOR DETECTING BRAIN TRAUMA |
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| US11315660B2 (en) | 2018-10-31 | 2022-04-26 | Dot Laboratories, Inc. | Method of detecting and treating endometriosis in a female subject |
| PE20220877A1 (es) * | 2019-02-14 | 2022-05-27 | Marker Diagnostics Uk Ltd | Biomarcadores salivales de lesion cerebral |
| KR102184840B1 (ko) * | 2019-05-20 | 2020-11-30 | 이화여자대학교 산학협력단 | 외상 후 스트레스 장애 진단 또는 예측용 바이오마커 및 그의 용도 |
| US11965879B2 (en) * | 2019-08-23 | 2024-04-23 | Mcmaster University | Method for diagnosing and assessing endometriosis |
| KR102272915B1 (ko) | 2019-09-27 | 2021-07-06 | 주식회사 이지다이아텍 | 새로운 외상성 뇌손상 및 감염병 poct 진단시스템 |
| CN110684835A (zh) * | 2019-10-12 | 2020-01-14 | 山东大学齐鲁医院 | miR-21在诊治蛛网膜下腔出血中的应用 |
| CN111419866A (zh) * | 2020-03-02 | 2020-07-17 | 南通大学 | miR-29a-3p在制备治疗周围神经损伤药物中的应用 |
| US12157918B2 (en) * | 2020-09-04 | 2024-12-03 | University Of Kentucky Research Foundation | Clinical assessment of cerebral vasospasm risk following aneurysmal subarachnoid hemorrhage |
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| CN116219019A (zh) * | 2023-03-02 | 2023-06-06 | 圣湘生物科技股份有限公司 | 一种用于结直肠癌诊断的microRNA标志物组合物及检测试剂、检测试剂盒 |
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Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH31414A (en) | 1994-02-24 | 1998-10-29 | Boehringer Ingelheim Int | Method of diagnosing cancer precancerous state, orsusceptibility to other forms of diseases by anal ysis of irf-1 specific rna in biopsy samples. |
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| CN101424640B (zh) | 2007-11-02 | 2012-07-25 | 江苏命码生物科技有限公司 | 血清中微小核糖核酸的检测方法和用于检测的试剂盒、生物芯片及其制作和应用方法 |
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| EP2336353A1 (en) | 2009-12-17 | 2011-06-22 | febit holding GmbH | miRNA fingerprints in the diagnosis of diseases |
| HUE040281T2 (hu) * | 2009-09-14 | 2019-03-28 | Banyan Biomarkers Inc | Autoantitest markerek traumás agysérülés diagnózisára |
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| CN103237901B (zh) * | 2010-03-01 | 2016-08-03 | 卡里斯生命科学瑞士控股有限责任公司 | 用于治疗诊断的生物标志物 |
| WO2013159091A2 (en) * | 2012-04-20 | 2013-10-24 | Aptamir Therapeutics, Inc. | Mirna modulators of thermogenesis |
| US20150203916A1 (en) | 2012-06-27 | 2015-07-23 | Music Foundation For Research Development | Plasma analytes predict diagnosis and prognosis of thoracic aortic aneurysm |
| GB201223243D0 (en) * | 2012-12-21 | 2013-02-06 | King S College London | Detection method |
| EP3418430B1 (en) | 2013-03-15 | 2023-03-29 | The Trustees of the University of Pennsylvania | Blood biomarkers that predict persistent cognitive dysfunction after concussion |
| US9890428B2 (en) * | 2013-05-14 | 2018-02-13 | Ohio State Innovation Foundation | MiRNA biomarkers for radiation biodosimetry |
| US9434945B2 (en) * | 2013-08-02 | 2016-09-06 | University Of Maryland, Baltimore | Use of miR-23a-3p and/or miR-27a-3p mimics as therapeutic agents for inhibition of neuronal apoptosis following brain injury |
| CN103667445A (zh) * | 2013-10-16 | 2014-03-26 | 石磊 | 一种脑梗塞早期诊断标志物及其应用 |
| WO2015073972A1 (en) * | 2013-11-18 | 2015-05-21 | Diamir, Llc | METHODS OF USING mIRNAs FROM BODILY FLUIDS FOR DETECTION AND MONITORING OF PARKINSON'S DISEASE (PD) |
| WO2015128192A1 (en) * | 2014-02-26 | 2015-09-03 | Koninklijke Philips N.V. | Light reflectance based detection |
| WO2015134551A1 (en) * | 2014-03-03 | 2015-09-11 | Banyan Biomarkers, Inc. | Micro rna markers for diagnosis of a neurological condition |
| US9605315B2 (en) * | 2014-03-26 | 2017-03-28 | The University Of Montana | Detection of traumatic brain injury |
| WO2015153864A2 (en) | 2014-04-02 | 2015-10-08 | Hopkins Patricia T | Methods for treating inflammatory conditions |
| WO2015164431A2 (en) * | 2014-04-22 | 2015-10-29 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods, processes, devices and kits for the measurement of post traumatic stress disorder microrna markers |
| WO2015196191A1 (en) * | 2014-06-20 | 2015-12-23 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Microrna biomarkers for traumatic brain injury and methods of use thereof |
| ES2558262B2 (es) | 2014-08-01 | 2016-07-14 | Universidad Católica De Valencia "San Vicente Mártir" | Método de diagnóstico de fibromialgia basado en microRNAs |
| CN104293791B (zh) * | 2014-10-22 | 2018-01-12 | 首都医科大学附属北京友谊医院 | miR‑200b在制备Rac‑1蛋白表达抑制剂中的新用途 |
| CA2993989A1 (en) * | 2015-07-29 | 2017-02-02 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Microrna biomarkers for traumatic brain injury and methods of use thereof |
| WO2017044650A1 (en) | 2015-09-08 | 2017-03-16 | The Translational Genomics Research Institute | Biomarkers and methods of diagnosing and prognosing mild traumatic brain injuries |
| GB201603967D0 (en) | 2016-03-08 | 2016-04-20 | Univ Birmingham | Biomarkers of traumatic brain injury |
| WO2018175941A1 (en) | 2017-03-23 | 2018-09-27 | Quadrant Biosciences Inc. | Analysis and prediction of traumatic brain injury and concusion symptoms |
| WO2018175422A1 (en) | 2017-03-23 | 2018-09-27 | Quadrant Biosciences Inc. | Method for diagnosing or monitoring conditions characterized by abnormal temporal variations method of normalizing epigenetic data to compensate for temporal variations |
| PE20220877A1 (es) | 2019-02-14 | 2022-05-27 | Marker Diagnostics Uk Ltd | Biomarcadores salivales de lesion cerebral |
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