JP7111619B2 - 外傷性脳傷害のバイオマーカー - Google Patents

外傷性脳傷害のバイオマーカー Download PDF

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JP7111619B2
JP7111619B2 JP2018546868A JP2018546868A JP7111619B2 JP 7111619 B2 JP7111619 B2 JP 7111619B2 JP 2018546868 A JP2018546868 A JP 2018546868A JP 2018546868 A JP2018546868 A JP 2018546868A JP 7111619 B2 JP7111619 B2 JP 7111619B2
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mirna
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JP2019509044A5 (enExample
JP2019509044A (ja
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ベリ，アントニオ
ピエトロ，バレンティナ ディ
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University of Birmingham
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Priority to JP2023220147A priority patent/JP7654769B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2018546868A 2016-03-08 2017-01-30 外傷性脳傷害のバイオマーカー Active JP7111619B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2022116002A JP7413455B2 (ja) 2016-03-08 2022-07-21 外傷性脳傷害のバイオマーカー
JP2023220147A JP7654769B2 (ja) 2016-03-08 2023-12-27 外傷性脳傷害のバイオマーカー
JP2025044721A JP2025098112A (ja) 2016-03-08 2025-03-19 外傷性脳傷害のバイオマーカー

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1603967.9 2016-03-08
GBGB1603967.9A GB201603967D0 (en) 2016-03-08 2016-03-08 Biomarkers of traumatic brain injury
PCT/GB2017/050231 WO2017153710A1 (en) 2016-03-08 2017-01-30 Biomarkers of traumatic brain injury

Related Child Applications (1)

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JP2022116002A Division JP7413455B2 (ja) 2016-03-08 2022-07-21 外傷性脳傷害のバイオマーカー

Publications (3)

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JP2019509044A JP2019509044A (ja) 2019-04-04
JP2019509044A5 JP2019509044A5 (enExample) 2020-03-05
JP7111619B2 true JP7111619B2 (ja) 2022-08-02

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JP2018546868A Active JP7111619B2 (ja) 2016-03-08 2017-01-30 外傷性脳傷害のバイオマーカー
JP2019539924A Active JP7132224B2 (ja) 2016-03-08 2017-12-22 外傷性脳傷害のバイオマーカー
JP2022116002A Active JP7413455B2 (ja) 2016-03-08 2022-07-21 外傷性脳傷害のバイオマーカー
JP2023220147A Active JP7654769B2 (ja) 2016-03-08 2023-12-27 外傷性脳傷害のバイオマーカー
JP2025044721A Pending JP2025098112A (ja) 2016-03-08 2025-03-19 外傷性脳傷害のバイオマーカー

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JP2019539924A Active JP7132224B2 (ja) 2016-03-08 2017-12-22 外傷性脳傷害のバイオマーカー
JP2022116002A Active JP7413455B2 (ja) 2016-03-08 2022-07-21 外傷性脳傷害のバイオマーカー
JP2023220147A Active JP7654769B2 (ja) 2016-03-08 2023-12-27 外傷性脳傷害のバイオマーカー
JP2025044721A Pending JP2025098112A (ja) 2016-03-08 2025-03-19 外傷性脳傷害のバイオマーカー

Country Status (14)

Country Link
US (5) US20190085395A1 (enExample)
EP (7) EP3426796B1 (enExample)
JP (5) JP7111619B2 (enExample)
KR (4) KR20240167935A (enExample)
CN (4) CN116004796A (enExample)
AU (3) AU2017231845B2 (enExample)
CA (2) CA3015150A1 (enExample)
ES (4) ES2967073T3 (enExample)
GB (1) GB201603967D0 (enExample)
NZ (1) NZ782016A (enExample)
PL (2) PL3712277T3 (enExample)
UA (1) UA127918C2 (enExample)
WO (2) WO2017153710A1 (enExample)
ZA (1) ZA201805982B (enExample)

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GB201603967D0 (en) 2016-03-08 2016-04-20 Univ Birmingham Biomarkers of traumatic brain injury
MX2019002425A (es) * 2016-08-30 2019-08-16 Univ Yale Micro ácidos ribonucleicos como biomarcadores para la endometriosis.
WO2018175941A1 (en) * 2017-03-23 2018-09-27 Quadrant Biosciences Inc. Analysis and prediction of traumatic brain injury and concusion symptoms
US11739323B2 (en) * 2017-06-08 2023-08-29 Temple University-Of The Commonwealth System Of Higher Education Micro-RNAs as biomarkers for subconcussive and concussive injury and therapeutic applications
EP3803416A4 (en) * 2018-05-31 2022-05-18 Amydis, Inc. COMPOSITIONS AND METHODS FOR DETECTING BRAIN TRAUMA
SG10201807529VA (en) * 2018-09-03 2020-04-29 Nec Asia Pacific Pte Ltd Systems and methods for predicting recovery of a patient
US11315660B2 (en) 2018-10-31 2022-04-26 Dot Laboratories, Inc. Method of detecting and treating endometriosis in a female subject
PE20220877A1 (es) * 2019-02-14 2022-05-27 Marker Diagnostics Uk Ltd Biomarcadores salivales de lesion cerebral
KR102184840B1 (ko) * 2019-05-20 2020-11-30 이화여자대학교 산학협력단 외상 후 스트레스 장애 진단 또는 예측용 바이오마커 및 그의 용도
US11965879B2 (en) * 2019-08-23 2024-04-23 Mcmaster University Method for diagnosing and assessing endometriosis
KR102272915B1 (ko) 2019-09-27 2021-07-06 주식회사 이지다이아텍 새로운 외상성 뇌손상 및 감염병 poct 진단시스템
CN110684835A (zh) * 2019-10-12 2020-01-14 山东大学齐鲁医院 miR-21在诊治蛛网膜下腔出血中的应用
CN111419866A (zh) * 2020-03-02 2020-07-17 南通大学 miR-29a-3p在制备治疗周围神经损伤药物中的应用
US12157918B2 (en) * 2020-09-04 2024-12-03 University Of Kentucky Research Foundation Clinical assessment of cerebral vasospasm risk following aneurysmal subarachnoid hemorrhage
IL307369A (en) 2021-04-02 2023-11-01 Marker Holdings Ag Biomarkers of muscle and skeletal injury
CN116219019A (zh) * 2023-03-02 2023-06-06 圣湘生物科技股份有限公司 一种用于结直肠癌诊断的microRNA标志物组合物及检测试剂、检测试剂盒
WO2024242411A1 (ko) 2023-05-19 2024-11-28 주식회사 이지다이아텍 자동 항체 커플링 및 이를 확인하는 장치
WO2025039033A1 (en) * 2023-08-21 2025-02-27 Glia Diagnostics Pty Ltd Methods and reagents for diagnosis and/or prognosis of traumatic brain injury

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KR102729795B1 (ko) 2024-11-14
GB201603967D0 (en) 2016-04-20
EP3574117B1 (en) 2023-08-16
HK1258615A1 (zh) 2019-11-15
JP2024041804A (ja) 2024-03-27
EP3712280B1 (en) 2023-08-09
EP4257705C0 (en) 2025-04-23
EP3712280B8 (en) 2023-09-13
ZA201805982B (en) 2022-01-26
CN109415769A (zh) 2019-03-01
JP7132224B2 (ja) 2022-09-06
CN110291210A (zh) 2019-09-27
WO2018138468A1 (en) 2018-08-02
CA3015150A1 (en) 2017-09-14
AU2023282212B2 (en) 2025-10-16
UA127918C2 (uk) 2024-02-14
AU2017231845B2 (en) 2023-09-28
EP4582559A2 (en) 2025-07-09
EP4403649A3 (en) 2024-10-30
CN118441040A (zh) 2024-08-06
NZ782016A (en) 2025-07-25
EP3426796B1 (en) 2023-09-06
KR20180118670A (ko) 2018-10-31
EP4582559A3 (en) 2025-10-08
EP3574117A1 (en) 2019-12-04
CN110291210B (zh) 2024-05-28
KR102618993B1 (ko) 2023-12-28
JP2025098112A (ja) 2025-07-01
RU2018135107A (ru) 2020-04-08
RU2018135107A3 (enExample) 2020-12-14
ES2967073T3 (es) 2024-04-25
JP2020511953A (ja) 2020-04-23
AU2017231845A1 (en) 2018-09-13
US20200385808A1 (en) 2020-12-10
US12467095B2 (en) 2025-11-11
ES3032995T3 (en) 2025-07-29
EP3712280A1 (en) 2020-09-23
US20180127828A1 (en) 2018-05-10
BR112018067882A2 (pt) 2019-02-05
WO2017153710A1 (en) 2017-09-14
US11414705B2 (en) 2022-08-16
AU2023282212A1 (en) 2024-01-04
KR20240011189A (ko) 2024-01-25
PL3712277T3 (pl) 2025-02-10
ES2965297T3 (es) 2024-04-12
KR20240167935A (ko) 2024-11-28
ES2987237T3 (es) 2024-11-14
EP3712277B1 (en) 2024-06-12
CN109415769B (zh) 2022-09-30
EP3712277C0 (en) 2024-06-12
JP2019509044A (ja) 2019-04-04
JP2022163063A (ja) 2022-10-25
US20230295726A1 (en) 2023-09-21
US10563262B2 (en) 2020-02-18
AU2025263788A1 (en) 2025-11-27
US20190085395A1 (en) 2019-03-21
US20230313300A1 (en) 2023-10-05
PL4257705T3 (pl) 2025-08-18
CA3050996A1 (en) 2018-08-02
NZ745808A (en) 2024-09-27
EP3712277A1 (en) 2020-09-23
EP4403649A2 (en) 2024-07-24
EP4257705A3 (en) 2024-01-17
JP7413455B2 (ja) 2024-01-15
KR20190111967A (ko) 2019-10-02
EP3426796A1 (en) 2019-01-16
JP7654769B2 (ja) 2025-04-01
CN116004796A (zh) 2023-04-25
EP4257705A2 (en) 2023-10-11
EP4257705B1 (en) 2025-04-23

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