UA126204C2 - Лікування нової підгрупи пацієнтів із dlbcl за допомогою обінутузумабу - Google Patents

Лікування нової підгрупи пацієнтів із dlbcl за допомогою обінутузумабу Download PDF

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Publication number
UA126204C2
UA126204C2 UAA202001356A UAA202001356A UA126204C2 UA 126204 C2 UA126204 C2 UA 126204C2 UA A202001356 A UAA202001356 A UA A202001356A UA A202001356 A UAA202001356 A UA A202001356A UA 126204 C2 UA126204 C2 UA 126204C2
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Ukraine
Prior art keywords
patient
antibody
patients
obinutuzumab
treatment
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UAA202001356A
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English (en)
Ukrainian (uk)
Inventor
Міккель Захле Оестергаард
Миккель Захле Оестергаард
Original Assignee
Ф. Хоффманн-Ля Рош Аг
Нанострінг Текнолоджіс, Інк.
Наностринг Текнолоджис, Инк.
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Application filed by Ф. Хоффманн-Ля Рош Аг, Нанострінг Текнолоджіс, Інк., Наностринг Текнолоджис, Инк. filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of UA126204C2 publication Critical patent/UA126204C2/uk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57426Specifically defined cancers leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
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    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00Oligonucleotides characterized by their use
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    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Genetics & Genomics (AREA)
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  • Epidemiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
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  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
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  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
UAA202001356A 2017-08-08 2018-08-08 Лікування нової підгрупи пацієнтів із dlbcl за допомогою обінутузумабу UA126204C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762542489P 2017-08-08 2017-08-08
PCT/EP2018/071462 WO2019030260A1 (en) 2017-08-08 2018-08-08 OBINUTUZUMAB TREATMENT OF A DLBCL PATIENT SUBGROUP

Publications (1)

Publication Number Publication Date
UA126204C2 true UA126204C2 (uk) 2022-08-31

Family

ID=63209389

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Application Number Title Priority Date Filing Date
UAA202001356A UA126204C2 (uk) 2017-08-08 2018-08-08 Лікування нової підгрупи пацієнтів із dlbcl за допомогою обінутузумабу

Country Status (20)

Country Link
US (2) US11597772B2 (OSRAM)
EP (1) EP3665196B1 (OSRAM)
JP (2) JP7418322B2 (OSRAM)
KR (1) KR102799421B1 (OSRAM)
CN (2) CN111032692A (OSRAM)
AU (1) AU2018314765C1 (OSRAM)
CA (1) CA3071618A1 (OSRAM)
CR (1) CR20200061A (OSRAM)
ES (1) ES2933256T3 (OSRAM)
IL (1) IL272418B2 (OSRAM)
MA (1) MA49830A (OSRAM)
MX (1) MX2020001493A (OSRAM)
MY (1) MY202382A (OSRAM)
PE (1) PE20200738A1 (OSRAM)
PL (1) PL3665196T3 (OSRAM)
SG (1) SG11202000985XA (OSRAM)
TW (1) TWI772488B (OSRAM)
UA (1) UA126204C2 (OSRAM)
WO (1) WO2019030260A1 (OSRAM)
ZA (1) ZA202000680B (OSRAM)

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* Cited by examiner, † Cited by third party
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JP7368856B2 (ja) 2017-07-25 2023-10-25 トゥルーバインディング,インコーポレイテッド Tim-3とそのリガンドとの相互作用の遮断によるがん治療
EP3665196B1 (en) * 2017-08-08 2022-10-19 F. Hoffmann-La Roche AG Obinutuzumab treatment of a dlbcl patient subgroup
EP3873942A4 (en) * 2018-10-29 2022-12-28 Tigatx, Inc. Compositions and methods comprising iga antibody constructs
CN116063505B (zh) 2019-01-30 2024-05-03 真和制药有限公司 抗gal3抗体及其用途
US12281166B2 (en) 2020-05-26 2025-04-22 Truebinding, Inc. Methods of treating inflammatory diseases by blocking Galectin-3

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EP1005870B1 (en) 1992-11-13 2009-01-21 Biogen Idec Inc. Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
ES2190087T3 (es) 1997-06-13 2003-07-16 Genentech Inc Formulacion estabilizada de un anticuerpo.
JP4653109B2 (ja) 2003-11-05 2011-03-16 ロシュ グリクアート アクチェンゲゼルシャフト 高められたFcレセプター結合親和性及びエフェクター機能をもつCD20抗体
GB0718684D0 (en) * 2007-09-24 2007-10-31 Roche Products Ltd Treatment method
US20130195843A1 (en) * 2010-06-23 2013-08-01 British Columbia Cancer Agency Branch Biomarkers for Non-Hodgkin Lymphomas and Uses Thereof
DE102013222576A1 (de) 2013-11-06 2015-05-07 BSH Bosch und Siemens Hausgeräte GmbH Haushaltsgerät
US10607717B2 (en) * 2013-11-06 2020-03-31 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method for subtyping lymphoma types by means of expression profiling
PL3066126T3 (pl) 2013-11-07 2019-08-30 F. Hoffmann-La Roche Ag Leczenie skojarzone z zastosowaniem niefukozylowanego przeciwciała anty-CD20 i inhibitora BTK
EP3122900A1 (en) * 2014-03-24 2017-02-01 F. Hoffmann-La Roche AG Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
EP3193932B1 (en) * 2014-09-15 2023-04-26 F. Hoffmann-La Roche AG Antibody formulations
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MX392539B (es) * 2015-06-08 2025-03-24 Debiopharm Int Sa Combinaciones de inmunoconjugado anti-cd37 y anticuerpo anti-cd20.
MX2017016651A (es) 2015-06-24 2018-05-14 Hoffmann La Roche Anticuerpos contra csf-1r humano para su uso en la induccion de linfocitosis en linfomas o leucemias.
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Publication number Publication date
WO2019030260A1 (en) 2019-02-14
KR102799421B1 (ko) 2025-04-30
JP2023179425A (ja) 2023-12-19
NZ761111A (en) 2024-05-31
AU2018314765A1 (en) 2020-01-30
IL272418B1 (en) 2024-05-01
MA49830A (fr) 2021-03-31
JP7418322B2 (ja) 2024-01-19
CR20200061A (es) 2020-05-23
PE20200738A1 (es) 2020-07-23
SG11202000985XA (en) 2020-02-27
US20230348611A1 (en) 2023-11-02
KR20200035441A (ko) 2020-04-03
MY202382A (en) 2024-04-24
JP2020530002A (ja) 2020-10-15
IL272418A (en) 2020-03-31
CN111032692A (zh) 2020-04-17
AU2018314765B2 (en) 2025-03-20
AU2018314765C1 (en) 2025-11-20
CA3071618A1 (en) 2019-02-14
TWI772488B (zh) 2022-08-01
CN119798437A (zh) 2025-04-11
EP3665196A1 (en) 2020-06-17
ES2933256T3 (es) 2023-02-03
TW202323297A (zh) 2023-06-16
MX2020001493A (es) 2020-03-24
PL3665196T3 (pl) 2023-01-23
TW201910353A (zh) 2019-03-16
IL272418B2 (en) 2024-09-01
US20200317800A1 (en) 2020-10-08
US11597772B2 (en) 2023-03-07
ZA202000680B (en) 2024-09-25
EP3665196B1 (en) 2022-10-19

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