UA124755C2 - Поліморфні форми тримебутину малеату і спосіб застосування - Google Patents
Поліморфні форми тримебутину малеату і спосіб застосування Download PDFInfo
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- UA124755C2 UA124755C2 UAA202003442A UAA202003442A UA124755C2 UA 124755 C2 UA124755 C2 UA 124755C2 UA A202003442 A UAA202003442 A UA A202003442A UA A202003442 A UAA202003442 A UA A202003442A UA 124755 C2 UA124755 C2 UA 124755C2
- Authority
- UA
- Ukraine
- Prior art keywords
- polymorphic form
- maleate
- trimebutin
- trimebutin maleate
- gastrointestinal tract
- Prior art date
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-M valerate Chemical class CCCCC([O-])=O NQPDZGIKBAWPEJ-UHFFFAOYSA-M 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/18—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2017140269A RU2706166C2 (ru) | 2017-11-20 | 2017-11-20 | Новые полиморфные формы тримебутина малеата, способ получения и применения |
| PCT/RU2018/000729 WO2019098883A1 (ru) | 2017-11-20 | 2018-11-08 | Полиморфные формы тримебутина малеата и способ применения |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA124755C2 true UA124755C2 (uk) | 2021-11-10 |
Family
ID=66540370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA202003442A UA124755C2 (uk) | 2017-11-20 | 2018-11-08 | Поліморфні форми тримебутину малеату і спосіб застосування |
Country Status (7)
| Country | Link |
|---|---|
| KR (1) | KR102509190B1 (pt) |
| CN (1) | CN111432811B (pt) |
| BR (1) | BR112020010135A2 (pt) |
| EA (1) | EA202091237A1 (pt) |
| RU (1) | RU2706166C2 (pt) |
| UA (1) | UA124755C2 (pt) |
| WO (1) | WO2019098883A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2752086C1 (ru) * | 2020-04-27 | 2021-07-22 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Новое соединение [2-(диметиламино)-2-фенилбутил]-3,4,5-триметоксибензоата 4-метил-2н-хромен-2-он-7-илсульфат и его применение |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2131804B1 (pt) * | 1971-03-12 | 1974-03-22 | Jouveinal Sa | |
| FR2752162B1 (fr) * | 1996-08-07 | 1998-11-06 | Jouveinal Lab | Comprime de maleate de trimebutine pellicule |
| CN102188389B (zh) * | 2010-03-18 | 2014-04-02 | 杭州赛利药物研究所有限公司 | 马来酸曲美布汀干混悬剂及其制备方法 |
| KR101220829B1 (ko) * | 2010-07-16 | 2013-01-10 | 안국약품 주식회사 | 트리메부틴 함유 서방성 정제 |
| EP2481403A1 (en) * | 2011-02-01 | 2012-08-01 | Deva Holding Anonim Sirketi | Pharmaceutical combination of otilonium and trimebutine |
| JP2015511589A (ja) * | 2012-03-12 | 2015-04-20 | ギケア・ファーマ・インク | 新規なスルホネートベースのトリメブチン塩 |
-
2017
- 2017-11-20 RU RU2017140269A patent/RU2706166C2/ru active
-
2018
- 2018-11-08 UA UAA202003442A patent/UA124755C2/uk unknown
- 2018-11-08 WO PCT/RU2018/000729 patent/WO2019098883A1/ru active Application Filing
- 2018-11-08 KR KR1020207016962A patent/KR102509190B1/ko active IP Right Grant
- 2018-11-08 CN CN201880074646.0A patent/CN111432811B/zh active Active
- 2018-11-08 BR BR112020010135-4A patent/BR112020010135A2/pt unknown
- 2018-11-08 EA EA202091237A patent/EA202091237A1/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA202091237A1 (ru) | 2020-08-17 |
| CN111432811A (zh) | 2020-07-17 |
| RU2017140269A (ru) | 2019-05-20 |
| BR112020010135A2 (pt) | 2021-03-23 |
| KR102509190B1 (ko) | 2023-03-14 |
| CN111432811B (zh) | 2023-06-23 |
| KR20200110308A (ko) | 2020-09-23 |
| WO2019098883A1 (ru) | 2019-05-23 |
| RU2017140269A3 (pt) | 2019-05-20 |
| RU2706166C2 (ru) | 2019-11-14 |
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