UA122348C2 - Нові гетероциклічні антиестрогени - Google Patents
Нові гетероциклічні антиестрогениInfo
- Publication number
- UA122348C2 UA122348C2 UAA201805396A UAA201805396A UA122348C2 UA 122348 C2 UA122348 C2 UA 122348C2 UA A201805396 A UAA201805396 A UA A201805396A UA A201805396 A UAA201805396 A UA A201805396A UA 122348 C2 UA122348 C2 UA 122348C2
- Authority
- UA
- Ukraine
- Prior art keywords
- antiestrogens
- novel heterocyclic
- heterocyclic
- novel
- degraders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
У даному винаході представлені нові гетероциклічні сполуки як протиракові засоби, зокрема антагоністи/супресори рецептора естрогену (ER), і спосіб їх одержання. WO 2017/072792 PCT/IN2016/050364 4
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN4058MU2015 | 2015-10-27 | ||
| PCT/IN2016/050364 WO2017072792A1 (en) | 2015-10-27 | 2016-10-26 | Novel heterocyclic antiestrogens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA122348C2 true UA122348C2 (uk) | 2020-10-26 |
Family
ID=58629986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201805396A UA122348C2 (uk) | 2015-10-27 | 2016-10-26 | Нові гетероциклічні антиестрогени |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US10865199B2 (uk) |
| EP (2) | EP4043438A1 (uk) |
| JP (2) | JP6855475B2 (uk) |
| KR (1) | KR20180088375A (uk) |
| CN (1) | CN108699021B (uk) |
| AU (1) | AU2016347679B2 (uk) |
| BR (1) | BR112018008375B1 (uk) |
| CA (1) | CA3001958A1 (uk) |
| DK (1) | DK3368519T3 (uk) |
| EA (1) | EA034131B1 (uk) |
| ES (1) | ES2916223T3 (uk) |
| HR (1) | HRP20220640T1 (uk) |
| HU (1) | HUE059386T2 (uk) |
| IL (2) | IL283559B (uk) |
| LT (1) | LT3368519T (uk) |
| MX (1) | MX2018005305A (uk) |
| PH (1) | PH12018500829A1 (uk) |
| PL (1) | PL3368519T3 (uk) |
| PT (1) | PT3368519T (uk) |
| RS (1) | RS63217B1 (uk) |
| SA (1) | SA518391423B1 (uk) |
| SG (2) | SG11201803119XA (uk) |
| SI (1) | SI3368519T1 (uk) |
| UA (1) | UA122348C2 (uk) |
| WO (1) | WO2017072792A1 (uk) |
| ZA (1) | ZA201802615B (uk) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201803119XA (en) * | 2015-10-27 | 2018-05-30 | Sun Pharma Advanced Res Co Ltd | Novel heterocyclic antiestrogens |
| NZ743651A (en) | 2015-12-09 | 2023-07-28 | Univ Illinois | Benzothiophene-based selective estrogen receptor downregulators |
| WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
| EP3565558B1 (en) | 2017-01-06 | 2023-12-06 | G1 Therapeutics, Inc. | Combination therapy with a serd compound and a cdk4/6 inhibitor for the treatment of cancer |
| US10208011B2 (en) | 2017-02-10 | 2019-02-19 | G1 Therapeutics, Inc. | Benzothiophene estrogen receptor modulators |
| BR112022001285A2 (pt) | 2019-07-22 | 2022-03-22 | Sun Pharma Advanced Res Co Ltd | Degradador seletivo do receptor de estrogênio |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5395842A (en) | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| DE69023906T2 (de) | 1990-08-09 | 1996-04-11 | Council Scient Ind Res | Benzopyrane und Verfahren zu deren Herstellung. |
| US6060503A (en) | 1991-12-02 | 2000-05-09 | Endorecherche, Inc. | Benzopyran-containing compounds and method for their use |
| US5407947A (en) | 1993-11-05 | 1995-04-18 | Eli Lilly And Company | Methods for inhibiting bone loss using pyrolidine and piperidine substituted benzopyrans |
| US5389646A (en) | 1993-12-30 | 1995-02-14 | Zymogenetics, Inc. | Methods for treatment and prevention of bone loss using 2,3-benzopyrans |
| US5916916A (en) * | 1996-10-10 | 1999-06-29 | Eli Lilly And Company | 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods |
| WO1999002512A1 (en) | 1997-07-09 | 1999-01-21 | Novo Nordisk A/S | Dl-2,3-diaryl-2h-1-benzopyrans |
| DE10013782A1 (de) * | 2000-03-15 | 2001-10-18 | Schering Ag | 4-Fluoralkyl-2H-benzopyrane mit antiestrogener Wirksamkeit, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, die diese enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln |
| WO2004091488A2 (en) * | 2003-04-14 | 2004-10-28 | Merck & Co., Inc. | Estrogen receptor modulators |
| CA2595477A1 (en) * | 2005-01-21 | 2006-07-27 | Janssen Pharmaceutica N.V. | Novel heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors |
| US20100317635A1 (en) * | 2009-06-16 | 2010-12-16 | Endorecherche, Inc. | Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators |
| EA022551B1 (ru) | 2010-06-10 | 2016-01-29 | Серагон Фармасьютикалс, Инк. | Модуляторы рецепторов эстрогена и их применение |
| JP2015500346A (ja) | 2011-12-14 | 2015-01-05 | セラゴン ファーマシューティカルズ，インク． | エストロゲン受容体モジュレーターおよびその使用 |
| KR20140103335A (ko) | 2011-12-16 | 2014-08-26 | 올레마 파마슈티컬스 인코포레이티드 | 신규한 벤조피란 화합물, 조성물 및 이의 용도 |
| WO2014205136A1 (en) | 2013-06-19 | 2014-12-24 | Seragon Pharmaceuticals, Inc. | Azetidine estrogen receptor modulators and uses thereof |
| SG11201509508YA (en) | 2013-06-19 | 2015-12-30 | Seragon Pharmaceuticals Inc | Estrogen receptor modulator and uses thereof |
| WO2014203132A1 (en) | 2013-06-19 | 2014-12-24 | Olema Pharmaceuticals, Inc. | Substituted benzopyran compounds, compositions and uses thereof |
| JP2017538727A (ja) | 2014-12-18 | 2017-12-28 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 癌の治療に有用な２，３−ジフェニルクロメンの誘導体 |
| CN107531722B (zh) | 2015-05-26 | 2020-07-17 | 豪夫迈·罗氏有限公司 | 杂环雌激素受体调节剂及其用途 |
| SG11201803119XA (en) * | 2015-10-27 | 2018-05-30 | Sun Pharma Advanced Res Co Ltd | Novel heterocyclic antiestrogens |
-
2016
- 2016-10-26 SG SG11201803119XA patent/SG11201803119XA/en unknown
- 2016-10-26 BR BR112018008375-5A patent/BR112018008375B1/pt active IP Right Grant
- 2016-10-26 EP EP22164031.1A patent/EP4043438A1/en active Pending
- 2016-10-26 PL PL16859220T patent/PL3368519T3/pl unknown
- 2016-10-26 US US15/770,824 patent/US10865199B2/en active Active
- 2016-10-26 DK DK16859220.2T patent/DK3368519T3/da active
- 2016-10-26 CN CN201680072702.8A patent/CN108699021B/zh active Active
- 2016-10-26 MX MX2018005305A patent/MX2018005305A/es unknown
- 2016-10-26 ES ES16859220T patent/ES2916223T3/es active Active
- 2016-10-26 PT PT168592202T patent/PT3368519T/pt unknown
- 2016-10-26 EP EP16859220.2A patent/EP3368519B1/en active Active
- 2016-10-26 CA CA3001958A patent/CA3001958A1/en active Pending
- 2016-10-26 HR HRP20220640TT patent/HRP20220640T1/hr unknown
- 2016-10-26 SI SI201631534T patent/SI3368519T1/sl unknown
- 2016-10-26 WO PCT/IN2016/050364 patent/WO2017072792A1/en active Application Filing
- 2016-10-26 IL IL283559A patent/IL283559B/en unknown
- 2016-10-26 LT LTEPPCT/IN2016/050364T patent/LT3368519T/lt unknown
- 2016-10-26 SG SG10201913001SA patent/SG10201913001SA/en unknown
- 2016-10-26 UA UAA201805396A patent/UA122348C2/uk unknown
- 2016-10-26 KR KR1020187012256A patent/KR20180088375A/ko not_active Application Discontinuation
- 2016-10-26 AU AU2016347679A patent/AU2016347679B2/en active Active
- 2016-10-26 EA EA201890981A patent/EA034131B1/ru unknown
- 2016-10-26 JP JP2018521529A patent/JP6855475B2/ja active Active
- 2016-10-26 RS RS20220454A patent/RS63217B1/sr unknown
- 2016-10-26 HU HUE16859220A patent/HUE059386T2/hu unknown
-
2018
- 2018-04-18 PH PH12018500829A patent/PH12018500829A1/en unknown
- 2018-04-19 ZA ZA2018/02615A patent/ZA201802615B/en unknown
- 2018-04-24 SA SA518391423A patent/SA518391423B1/ar unknown
- 2018-04-26 IL IL258949A patent/IL258949B/en active IP Right Grant
-
2020
- 2020-10-28 US US17/082,488 patent/US11465990B2/en active Active
-
2021
- 2021-03-17 JP JP2021043019A patent/JP7052111B2/ja active Active
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