MX2017000520A - Derivados de azaspiro(4.5)decano sustituido. - Google Patents
Derivados de azaspiro(4.5)decano sustituido.Info
- Publication number
- MX2017000520A MX2017000520A MX2017000520A MX2017000520A MX2017000520A MX 2017000520 A MX2017000520 A MX 2017000520A MX 2017000520 A MX2017000520 A MX 2017000520A MX 2017000520 A MX2017000520 A MX 2017000520A MX 2017000520 A MX2017000520 A MX 2017000520A
- Authority
- MX
- Mexico
- Prior art keywords
- decane derivatives
- substituted azaspiro
- substituted
- compounds
- preparation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- C07D209/96—Spiro-condensed ring systems
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract
La invención se relación con derivados de ciclohexano espirocíclico sustituidos que tienen una afinidad para el receptor del opioide µ y/o el receptor de ORL1, los procesos para la preparación de los mismos, los medicamentos que contienen estos compuestos y el uso de estos compuestos para la preparación de medicamentos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14002439 | 2014-07-15 | ||
PCT/EP2015/001445 WO2016008582A1 (en) | 2014-07-15 | 2015-07-14 | Substituted azaspiro(4.5)decane derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017000520A true MX2017000520A (es) | 2017-05-01 |
Family
ID=51211484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017000520A MX2017000520A (es) | 2014-07-15 | 2015-07-14 | Derivados de azaspiro(4.5)decano sustituido. |
Country Status (20)
Country | Link |
---|---|
US (1) | US10214520B2 (es) |
EP (1) | EP3169666B1 (es) |
JP (1) | JP6509321B2 (es) |
CN (1) | CN106660954A (es) |
AU (1) | AU2015291467B2 (es) |
BR (1) | BR112017000762A2 (es) |
CA (1) | CA2955071A1 (es) |
CY (1) | CY1120812T1 (es) |
DK (1) | DK3169666T3 (es) |
EA (1) | EA201790185A1 (es) |
ES (1) | ES2686326T3 (es) |
HR (1) | HRP20181112T1 (es) |
HU (1) | HUE040133T2 (es) |
LT (1) | LT3169666T (es) |
MX (1) | MX2017000520A (es) |
PL (1) | PL3169666T3 (es) |
PT (1) | PT3169666T (es) |
RS (1) | RS57732B1 (es) |
SI (1) | SI3169666T1 (es) |
WO (1) | WO2016008582A1 (es) |
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---|---|---|---|---|
WO2019152688A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CN111548343B (zh) * | 2018-06-01 | 2021-06-01 | 杭州阿诺生物医药科技有限公司 | 一种高活性csf1r抑制剂化合物的制备方法 |
CN111848423B (zh) * | 2019-04-30 | 2022-10-14 | 尚科生物医药(上海)有限公司 | 3-氧代环丁基氨基甲酸叔丁酯的制备方法 |
CN112679405B (zh) * | 2019-10-17 | 2023-12-15 | 南京富润凯德生物医药有限公司 | 一种(s)-7-氧杂-2-氮杂螺[4.5]癸烷衍生物的制备方法 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3928182A1 (de) | 1989-08-25 | 1991-02-28 | Goedecke Ag | Verfahren zur herstellung von gabapentin |
DE19608653A1 (de) | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
CA2309175A1 (en) | 1997-11-04 | 1999-05-14 | Pfizer Products Inc. | Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors |
HUP9902374A3 (en) | 1999-07-15 | 2002-11-28 | Sanofi Aventis | Process for producing spiro[(4-cyclohexanone)-[3h]indol-2'[1'h]-on derivatives and intermediates |
DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
CN1266112C (zh) | 2001-04-24 | 2006-07-26 | 麻省理工学院 | 铜-催化的碳-杂原子键和碳-碳键的形成 |
DE10252667A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE10360793A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE102004039382A1 (de) | 2004-08-13 | 2006-02-23 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
US8003792B2 (en) | 2004-09-13 | 2011-08-23 | Merck Sharp & Dohme Corp. | Bicyclic anilide spirolactam CGRP receptor antagonists |
JP2008513476A (ja) | 2004-09-17 | 2008-05-01 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | c−Kit癌原遺伝子阻害剤としての(スピロシクリルアミド)アミノチオフェン化合物 |
DE102005016460A1 (de) | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
DE102005038141A1 (de) * | 2005-08-12 | 2007-02-15 | Grünenthal GmbH | Substituierte 8-(3-Aminopropyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-on-Derivate |
TW200800999A (en) | 2005-09-06 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
AR057579A1 (es) | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
KR20080087817A (ko) | 2005-12-14 | 2008-10-01 | 브리스톨-마이어스 스큅 컴퍼니 | 인자 xia 억제제로서 아릴프로피온아미드,아릴아크릴아미드, 아릴프로핀아미드 또는 아릴메틸우레아유사체 |
DE102005061428A1 (de) | 2005-12-22 | 2007-08-16 | Grünenthal GmbH | Substituierte Cyclohexylmethyl-Derivate |
WO2007127763A2 (en) | 2006-04-25 | 2007-11-08 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
DE102006019597A1 (de) | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
DE102006033109A1 (de) | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
DE602007007497D1 (de) | 2006-09-18 | 2010-08-12 | Hoffmann La Roche | Octahydropyrroloä3,4-cüpyrrolderivate und ihre verwendung als antivirale mittel |
CN101541806A (zh) | 2006-09-22 | 2009-09-23 | 詹森药业有限公司 | 用作血管升压素拮抗剂的螺环苯并氮杂 |
DE102007009319A1 (de) | 2007-02-22 | 2008-08-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE102007009235A1 (de) * | 2007-02-22 | 2008-09-18 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
GB0707934D0 (en) | 2007-04-24 | 2007-05-30 | Glaxo Group Ltd | Chemical compounds |
US8450522B2 (en) | 2008-03-06 | 2013-05-28 | Amgen Inc. | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders |
MX2010010337A (es) | 2008-03-27 | 2010-10-07 | Gruenenthal Gmbh | Derivados de espiro(5.5)undecano. |
DK2260042T3 (da) | 2008-03-27 | 2011-10-31 | Gruenenthal Gmbh | Substituerede spirocykliske cyklohexan-derivater |
JP2012506883A (ja) * | 2008-10-29 | 2012-03-22 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 置換されたスピロアミン |
TW201038572A (en) * | 2009-03-25 | 2010-11-01 | Gruenenthal Gmbh | Substituted spiro-amide compounds |
ES2462290T3 (es) * | 2009-06-08 | 2014-05-22 | Grünenthal GmbH | Bencimidazoles, benzotiazoles y benzoxazoles sustituidos |
CN107266345B (zh) | 2011-10-20 | 2021-08-17 | 奥瑞泽恩基因组学股份有限公司 | 作为lsd1抑制剂的(杂)芳基环丙胺化合物 |
TW201607923A (zh) * | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環(4.5)癸烷衍生物 |
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- 2015-07-14 AU AU2015291467A patent/AU2015291467B2/en not_active Ceased
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- 2015-07-14 ES ES15738274T patent/ES2686326T3/es active Active
- 2015-07-14 HU HUE15738274A patent/HUE040133T2/hu unknown
- 2015-07-14 EA EA201790185A patent/EA201790185A1/ru unknown
- 2015-07-14 US US15/326,138 patent/US10214520B2/en not_active Expired - Fee Related
- 2015-07-14 SI SI201530319T patent/SI3169666T1/en unknown
- 2015-07-14 EP EP15738274.8A patent/EP3169666B1/en active Active
- 2015-07-14 RS RS20181037A patent/RS57732B1/sr unknown
- 2015-07-14 CA CA2955071A patent/CA2955071A1/en not_active Abandoned
- 2015-07-14 PL PL15738274T patent/PL3169666T3/pl unknown
- 2015-07-14 JP JP2017502138A patent/JP6509321B2/ja not_active Expired - Fee Related
- 2015-07-14 PT PT15738274T patent/PT3169666T/pt unknown
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- 2015-07-14 DK DK15738274.8T patent/DK3169666T3/en active
- 2015-07-14 CN CN201580038275.7A patent/CN106660954A/zh active Pending
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AU2015291467A1 (en) | 2017-03-09 |
CN106660954A (zh) | 2017-05-10 |
SI3169666T1 (en) | 2018-08-31 |
WO2016008582A8 (en) | 2016-03-24 |
ES2686326T3 (es) | 2018-10-17 |
JP2017520601A (ja) | 2017-07-27 |
CA2955071A1 (en) | 2016-01-21 |
PT3169666T (pt) | 2018-10-19 |
JP6509321B2 (ja) | 2019-05-08 |
US10214520B2 (en) | 2019-02-26 |
HRP20181112T1 (hr) | 2018-09-21 |
AU2015291467B2 (en) | 2019-01-24 |
DK3169666T3 (en) | 2018-07-30 |
CY1120812T1 (el) | 2019-12-11 |
LT3169666T (lt) | 2018-08-10 |
RS57732B1 (sr) | 2018-12-31 |
EP3169666B1 (en) | 2018-06-06 |
HUE040133T2 (hu) | 2019-02-28 |
EA201790185A1 (ru) | 2017-07-31 |
WO2016008582A1 (en) | 2016-01-21 |
PL3169666T3 (pl) | 2019-03-29 |
US20170210734A1 (en) | 2017-07-27 |
EP3169666A1 (en) | 2017-05-24 |
BR112017000762A2 (pt) | 2017-11-21 |
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