UA118120C2 - Макроциклічні похідні піридину - Google Patents
Макроциклічні похідні піридинуInfo
- Publication number
- UA118120C2 UA118120C2 UAA201611003A UAA201611003A UA118120C2 UA 118120 C2 UA118120 C2 UA 118120C2 UA A201611003 A UAA201611003 A UA A201611003A UA A201611003 A UAA201611003 A UA A201611003A UA 118120 C2 UA118120 C2 UA 118120C2
- Authority
- UA
- Ukraine
- Prior art keywords
- compounds
- macrocylic
- pyridine derivatives
- inhibitory activity
- present
- Prior art date
Links
- 150000003222 pyridines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 101000605630 Homo sapiens Phosphatidylinositol 3-kinase catalytic subunit type 3 Proteins 0.000 abstract 1
- 102100038329 Phosphatidylinositol 3-kinase catalytic subunit type 3 Human genes 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14163442 | 2014-04-03 | ||
| EP14183823 | 2014-09-05 | ||
| PCT/EP2015/057401 WO2015150557A1 (en) | 2014-04-03 | 2015-04-02 | Macrocylic pyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA118120C2 true UA118120C2 (uk) | 2018-11-26 |
Family
ID=52781118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201611003A UA118120C2 (uk) | 2014-04-03 | 2015-04-02 | Макроциклічні похідні піридину |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20170022201A1 (enExample) |
| EP (1) | EP3126365B1 (enExample) |
| JP (1) | JP6420362B2 (enExample) |
| KR (1) | KR102390274B1 (enExample) |
| CN (1) | CN106132964B (enExample) |
| AU (1) | AU2015239100B2 (enExample) |
| BR (1) | BR112016022700B1 (enExample) |
| CA (1) | CA2942751C (enExample) |
| CL (1) | CL2016002495A1 (enExample) |
| EA (1) | EA029758B1 (enExample) |
| ES (1) | ES2665797T3 (enExample) |
| IL (1) | IL248001B (enExample) |
| MA (1) | MA39823A (enExample) |
| MX (1) | MX369799B (enExample) |
| MY (1) | MY185500A (enExample) |
| NZ (1) | NZ725406A (enExample) |
| PE (1) | PE20161365A1 (enExample) |
| PH (1) | PH12016501962B1 (enExample) |
| SG (1) | SG11201608241UA (enExample) |
| UA (1) | UA118120C2 (enExample) |
| WO (1) | WO2015150557A1 (enExample) |
| ZA (1) | ZA201606768B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10407442B2 (en) | 2015-09-24 | 2019-09-10 | Cyclenium Pharma Inc. | Libraries of heteroaryl-containing macrocyclic compounds and methods of making and using the same |
| AU2017219846B2 (en) | 2016-02-19 | 2021-05-13 | Sprint Bioscience Ab | 6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes |
| LT3416957T (lt) | 2016-02-19 | 2020-11-25 | Sprint Bioscience Ab | 6-heterociklil-4-morfolin-4-ilpiridin-2-ono junginiai, tinkami vėžio ir diabeto gydymui |
| IL316954A (en) | 2017-02-28 | 2025-01-01 | Morphic Therapeutic Inc | (Alpha-V)(beta-6)integrin inhibitors |
| EP3760202A1 (en) | 2017-02-28 | 2021-01-06 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| ES2900199T3 (es) | 2017-03-28 | 2022-03-16 | Bayer Ag | Novedosos compuestos macrocíclicos inhibidores de PTEFB |
| WO2018177889A1 (en) | 2017-03-28 | 2018-10-04 | Bayer Aktiengesellschaft | Novel ptefb inhibiting macrocyclic compounds |
| US20200190083A1 (en) * | 2017-06-22 | 2020-06-18 | Cyclenium Pharma Inc. | Libraries of pyridine-containing macrocyclic compounds and methods of making and using the same |
| CN116589461A (zh) | 2017-08-23 | 2023-08-15 | 思普瑞特生物科学公司 | 氮杂吲哚基吡啶酮化合物和二氮杂吲哚基吡啶酮化合物 |
| IL302293A (en) | 2017-08-23 | 2023-06-01 | Sprint Bioscience Ab | Pyridinamine-pyridone and pyrimidinamine-pyridone compounds |
| IL302077A (en) | 2017-08-23 | 2023-06-01 | Sprint Bioscience Ab | Morpholinylpyridone compounds |
| EP4056556A1 (en) | 2017-08-23 | 2022-09-14 | Sprint Bioscience AB | Pyridylpyridone compounds |
| WO2020047208A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| UY38352A (es) | 2018-08-29 | 2020-03-31 | Morphic Therapeutic Inc | Inhibidores de integrina alfavbeta6 |
| UY38353A (es) | 2018-08-29 | 2020-03-31 | Morphic Therapeutic Inc | Inhibición de integrina alfavbeta6 |
| EP4013762A1 (en) * | 2019-08-16 | 2022-06-22 | Inflazome Limited | Macrocyclic sulfonylamide derivatives useful as nlrp3 inhibitors |
| CN113845521B (zh) * | 2021-08-31 | 2024-06-18 | 中原工学院 | 水相中光催化一锅法合成咪唑并含氮杂环肼类衍生物的方法 |
| CN115260128B (zh) * | 2022-09-21 | 2022-12-09 | 苏州凯瑞医药科技有限公司 | 一种新型jak抑制剂关键中间体的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001051125A1 (en) * | 2000-01-12 | 2001-07-19 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| WO2004078682A2 (en) * | 2003-03-05 | 2004-09-16 | Irm Llc | Cyclic compounds and compositions as protein kinase inhibitors |
| PA8603801A1 (es) | 2003-05-27 | 2004-12-16 | Janssen Pharmaceutica Nv | Derivados de la quinazolina |
| EP1697384B1 (en) | 2003-12-18 | 2008-04-02 | Janssen Pharmaceutica N.V. | Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents |
| ES2335216T3 (es) | 2003-12-18 | 2010-03-23 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-quinolina con actividad antiproliferativa. |
| MY169441A (en) | 2004-12-08 | 2019-04-11 | Janssen Pharmaceutica Nv | 2,4, (4,6) pyrimidine derivatives |
| JO3088B1 (ar) | 2004-12-08 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف |
| US8778919B2 (en) * | 2005-06-30 | 2014-07-15 | Janssen Pharmaceutica Nv | Cyclic anilino—pyridinotriazines |
| EP1951729B1 (en) * | 2005-11-16 | 2014-06-25 | Cell Therapeutics, Inc. | Oxygen linked pyrimidine derivatives |
| CA2687909C (en) | 2007-06-21 | 2015-09-15 | Janssen Pharmaceutica Nv | Indolin-2-ones and aza-indolin-2-ones |
| US8318731B2 (en) | 2007-07-27 | 2012-11-27 | Janssen Pharmaceutica Nv | Pyrrolopyrimidines |
| EP2283024B1 (en) * | 2008-03-10 | 2013-05-15 | Janssen Pharmaceutica, N.V. | 4-aryl-2-anilino-pyrimidines as plk kinase inhibitors |
| KR20110031318A (ko) | 2008-06-13 | 2011-03-25 | 노파르티스 아게 | Ｉａ 심부전 및 암 치료에 유용한 단백질 키나제 ｄ 억제제로서의 2,4'-비피리디닐 화합물 |
-
2015
- 2015-04-01 MA MA039823A patent/MA39823A/fr unknown
- 2015-04-02 NZ NZ725406A patent/NZ725406A/en not_active IP Right Cessation
- 2015-04-02 EA EA201692000A patent/EA029758B1/ru not_active IP Right Cessation
- 2015-04-02 MY MYPI2016001776A patent/MY185500A/en unknown
- 2015-04-02 ES ES15713523.7T patent/ES2665797T3/es active Active
- 2015-04-02 SG SG11201608241UA patent/SG11201608241UA/en unknown
- 2015-04-02 WO PCT/EP2015/057401 patent/WO2015150557A1/en not_active Ceased
- 2015-04-02 EP EP15713523.7A patent/EP3126365B1/en active Active
- 2015-04-02 BR BR112016022700-0A patent/BR112016022700B1/pt not_active IP Right Cessation
- 2015-04-02 UA UAA201611003A patent/UA118120C2/uk unknown
- 2015-04-02 AU AU2015239100A patent/AU2015239100B2/en not_active Ceased
- 2015-04-02 CN CN201580018081.0A patent/CN106132964B/zh active Active
- 2015-04-02 JP JP2016560816A patent/JP6420362B2/ja active Active
- 2015-04-02 PE PE2016001843A patent/PE20161365A1/es active IP Right Grant
- 2015-04-02 CA CA2942751A patent/CA2942751C/en active Active
- 2015-04-02 US US15/300,907 patent/US20170022201A1/en not_active Abandoned
- 2015-04-02 KR KR1020167028761A patent/KR102390274B1/ko not_active Expired - Fee Related
- 2015-04-02 MX MX2016012994A patent/MX369799B/es active IP Right Grant
-
2016
- 2016-09-25 IL IL248001A patent/IL248001B/en active IP Right Grant
- 2016-09-30 ZA ZA2016/06768A patent/ZA201606768B/en unknown
- 2016-09-30 CL CL2016002495A patent/CL2016002495A1/es unknown
- 2016-10-03 PH PH12016501962A patent/PH12016501962B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017509685A (ja) | 2017-04-06 |
| SG11201608241UA (en) | 2016-10-28 |
| ES2665797T3 (es) | 2018-04-27 |
| BR112016022700B1 (pt) | 2022-01-11 |
| PE20161365A1 (es) | 2016-12-17 |
| JP6420362B2 (ja) | 2018-11-07 |
| MY185500A (en) | 2021-05-19 |
| PH12016501962A1 (en) | 2017-01-09 |
| EP3126365B1 (en) | 2018-01-10 |
| KR102390274B1 (ko) | 2022-04-22 |
| MX2016012994A (es) | 2016-12-07 |
| AU2015239100A1 (en) | 2016-09-29 |
| MX369799B (es) | 2019-11-21 |
| EA201692000A1 (ru) | 2017-01-30 |
| IL248001B (en) | 2018-11-29 |
| CA2942751A1 (en) | 2015-10-08 |
| US20170022201A1 (en) | 2017-01-26 |
| CA2942751C (en) | 2023-03-21 |
| BR112016022700A2 (enExample) | 2017-08-15 |
| MA39823A (fr) | 2018-01-09 |
| CN106132964B (zh) | 2019-07-19 |
| ZA201606768B (en) | 2018-11-28 |
| NZ725406A (en) | 2022-08-26 |
| AU2015239100B2 (en) | 2019-06-27 |
| EA029758B1 (ru) | 2018-05-31 |
| KR20160140739A (ko) | 2016-12-07 |
| EP3126365A1 (en) | 2017-02-08 |
| PH12016501962B1 (en) | 2017-01-09 |
| KR102390274B9 (ko) | 2023-03-03 |
| WO2015150557A1 (en) | 2015-10-08 |
| CL2016002495A1 (es) | 2017-02-24 |
| CN106132964A (zh) | 2016-11-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX369799B (es) | Derivados de piridina macrociclicos. | |
| PH12016501963B1 (en) | Macrocyclic pyrimidine derivatives | |
| MX2017008518A (es) | Compuestos de isoquinolina para el tratamiento de virus de inmunodeficiencia humana (vih). | |
| PH12017501191B1 (en) | Quinazoline derivatives used to treat hiv | |
| PH12017501921A1 (en) | Novel compounds | |
| MY198472A (en) | Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as prmt5 inhibitors | |
| MD20170016A2 (ro) | Compuşi aminopirimidinici ca inhibitori JAK | |
| PH12018500610B1 (en) | Isoindolinone inhibitors of the mdm2-p53 interaction having anticancer activity | |
| PH12019500731A1 (en) | Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors | |
| PH12016501462A1 (en) | Neprilysin inhibitors | |
| PH12018500626A1 (en) | Isoindolinone inhibitors of the mdm2-p53 interaction having anticancer activity | |
| MX2016009794A (es) | Derivado de sulfonamida heterociclico y medicina que comprende el mismo. | |
| MX367914B (es) | Derivados de 4,5,6,7-tetrahidro-pirazolo[1,5-a]pirazina sustituidos y derivados de 5,6,7,8-tetrahidro-4h-pirazolo[1,5-a][1 ,4]diazepina como inhibidores de ros1. | |
| MX367913B (es) | Derivados de 4,5,6,7-tetrahidro-pirazolo[1,5-a]pirimidina y 2,3-dihidro-1h-imidazo[1,2-b]pirazol sustituidos como inhibidores de ros1. | |
| EA032927B1 (ru) | Производные гидроксиалкилпиперазина в качестве модуляторов cxcr3 рецептора | |
| MX2017008074A (es) | DERIVADOS DE IMIDAZOPIRIDAZINA COMO INHIBIDORES DE FOSFOINOSITIDA-3-QUINASAS BETA (PI3Kß). | |
| MX2017008076A (es) | DERIVADOS DE IMIDAZOPIRIDAZINA ENLAZADOS A HETEROCICLILO COMO INHIBIDORES DE PI3Kß. |