UA115866C2 - Спосіб лікування остеопорозу - Google Patents

Спосіб лікування остеопорозу

Info

Publication number
UA115866C2
UA115866C2 UAA201404224A UAA201404224A UA115866C2 UA 115866 C2 UA115866 C2 UA 115866C2 UA A201404224 A UAA201404224 A UA A201404224A UA A201404224 A UAA201404224 A UA A201404224A UA 115866 C2 UA115866 C2 UA 115866C2
Authority
UA
Ukraine
Prior art keywords
treating osteoporosis
osteoporosis
tluorophenyl
dicarboxamide
methyloxy
Prior art date
Application number
UAA201404224A
Other languages
English (en)
Inventor
Дана Т. Афтаб
Дуглас Кларі
Original Assignee
Екселіксіс, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Екселіксіс, Інк. filed Critical Екселіксіс, Інк.
Publication of UA115866C2 publication Critical patent/UA115866C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Даний винахід стосується лікування остеопорозу із застосуванням N-(4-{[6,7-біс(метилокси)хінолін-4-іл]окси}феніл)-N'-(4-фторфеніл)циклопропан-1,1-дикарбоксаміду.
UAA201404224A 2011-09-22 2012-09-20 Спосіб лікування остеопорозу UA115866C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161538039P 2011-09-22 2011-09-22
PCT/US2012/056281 WO2013043840A1 (en) 2011-09-22 2012-09-20 Method for treating osteoporosis

Publications (1)

Publication Number Publication Date
UA115866C2 true UA115866C2 (uk) 2018-01-10

Family

ID=47010756

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201404224A UA115866C2 (uk) 2011-09-22 2012-09-20 Спосіб лікування остеопорозу

Country Status (19)

Country Link
US (1) US10166225B2 (uk)
EP (2) EP3275443A1 (uk)
JP (1) JP6240075B2 (uk)
KR (1) KR20140069133A (uk)
CN (1) CN103957915A (uk)
AR (1) AR087995A1 (uk)
AU (1) AU2012312364B2 (uk)
BR (1) BR112014006702A2 (uk)
CA (1) CA2848512A1 (uk)
EA (1) EA201490676A1 (uk)
ES (1) ES2639093T3 (uk)
GE (1) GEP201606523B (uk)
HK (1) HK1201040A1 (uk)
IL (1) IL231495B (uk)
MX (1) MX351133B (uk)
TW (1) TWI564009B (uk)
UA (1) UA115866C2 (uk)
WO (1) WO2013043840A1 (uk)
ZA (1) ZA201401728B (uk)

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JP2015515988A (ja) 2012-05-02 2015-06-04 エクセリクシス， インク． 溶骨性骨転移を治療するためのｍｅｔ−ｖｅｇｆ二重調節剤
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Also Published As

Publication number Publication date
EP2758057B1 (en) 2017-05-31
NZ622722A (en) 2016-09-30
CN103957915A (zh) 2014-07-30
JP2014527984A (ja) 2014-10-23
EA201490676A1 (ru) 2015-02-27
JP6240075B2 (ja) 2017-11-29
MX351133B (es) 2017-10-03
US20140228401A1 (en) 2014-08-14
AU2012312364A1 (en) 2014-04-10
AR087995A1 (es) 2014-04-30
HK1201040A1 (en) 2015-08-21
BR112014006702A2 (pt) 2017-06-13
KR20140069133A (ko) 2014-06-09
IL231495B (en) 2019-03-31
US10166225B2 (en) 2019-01-01
ZA201401728B (en) 2016-01-27
TWI564009B (zh) 2017-01-01
IL231495A0 (en) 2014-04-30
GEP201606523B (en) 2016-08-10
EP3275443A1 (en) 2018-01-31
CA2848512A1 (en) 2013-03-28
ES2639093T3 (es) 2017-10-25
MX2014003027A (es) 2014-10-24
WO2013043840A1 (en) 2013-03-28
EP2758057A1 (en) 2014-07-30
AU2012312364B2 (en) 2017-11-09
TW201313232A (zh) 2013-04-01

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