UA115523C2 - Тверді форми макроциклічних інгібіторів кінази - Google Patents

Тверді форми макроциклічних інгібіторів кінази

Info

Publication number
UA115523C2
UA115523C2 UAA201306799A UAA201306799A UA115523C2 UA 115523 C2 UA115523 C2 UA 115523C2 UA A201306799 A UAA201306799 A UA A201306799A UA A201306799 A UAA201306799 A UA A201306799A UA 115523 C2 UA115523 C2 UA 115523C2
Authority
UA
Ukraine
Prior art keywords
kinase inhibitors
solid state
state forms
macrocyclic
macrocyclic kinase
Prior art date
Application number
UAA201306799A
Other languages
English (en)
Inventor
Роберт К. Менсфілд
Трейсі Левон
Браян Даймок
Original Assignee
Общєство С Огранічєнной Отвєтствєнностью "Новамєдіка"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Общєство С Огранічєнной Отвєтствєнностью "Новамєдіка" filed Critical Общєство С Огранічєнной Отвєтствєнностью "Новамєдіка"
Publication of UA115523C2 publication Critical patent/UA115523C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

В даному документі запропоновано сольові форми макроциклічних інгібіторів протеїнкінази – кристалічний цитрат структури 1 та кристалічний фумарат структури 2 14-метил-20-окса-5,7,14,27-тетраазатетрацикло-[19.3.1.12,6.18,12]гептакоза-1(25),2,4,6,8,10,12(26),16,21,23-декаєну, фармацевтичні композиції, що їх містять, способи виготовлення та використання цих сполук і композицій для лікування проліферативного захворювання, опосередкованого активністю кінази.
UAA201306799A 2010-02-05 2011-02-04 Тверді форми макроциклічних інгібіторів кінази UA115523C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30177110P 2010-02-05 2010-02-05
PCT/US2011/023810 WO2011097525A1 (en) 2010-02-05 2011-02-04 Solid state forms of macrocyclic kinase inhibitors

Publications (1)

Publication Number Publication Date
UA115523C2 true UA115523C2 (uk) 2017-11-27

Family

ID=44355815

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201306799A UA115523C2 (uk) 2010-02-05 2011-02-04 Тверді форми макроциклічних інгібіторів кінази

Country Status (6)

Country Link
US (1) US9120815B2 (uk)
EP (1) EP2531197B1 (uk)
EA (1) EA027622B1 (uk)
ES (1) ES2632548T3 (uk)
UA (1) UA115523C2 (uk)
WO (1) WO2011097525A1 (uk)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105061467B (zh) * 2015-08-28 2017-08-25 苏州立新制药有限公司 一种帕克替尼的制备方法
SG11201808306PA (en) 2016-03-24 2018-10-30 Tragara Pharmaceuticals Inc Treatment of cancer with tg02
JP7250764B2 (ja) * 2017-08-18 2023-04-03 コセラ バイオサイエンス， インコーポレイテッド Ｔｇ０２の多形形態
CN108864145B (zh) * 2018-09-14 2021-03-30 兆科（广州）肿瘤药物有限公司 一种氧联嘧啶衍生物的纯化方法
EP3958854A4 (en) 2019-04-22 2023-02-01 University of Pittsburgh - of The Commonwealth System of Higher Education USE OF TG02 FOR THE TREATMENT OF GLIOMA IN PEDIATRIC SUBJECTS

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Also Published As

Publication number Publication date
EP2531197A1 (en) 2012-12-12
WO2011097525A1 (en) 2011-08-11
US20130150378A1 (en) 2013-06-13
EA201390636A1 (ru) 2014-08-29
US9120815B2 (en) 2015-09-01
EP2531197A4 (en) 2013-12-11
EA027622B1 (ru) 2017-08-31
ES2632548T3 (es) 2017-09-14
EP2531197B1 (en) 2017-05-17

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