UA105170C2 - 1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 AND p40 - Google Patents
1-BENZYL-3-HYDROXYMETHYLINDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 AND p40 Download PDFInfo
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- UA105170C2 UA105170C2 UAA201008570A UAA201008570A UA105170C2 UA 105170 C2 UA105170 C2 UA 105170C2 UA A201008570 A UAA201008570 A UA A201008570A UA A201008570 A UAA201008570 A UA A201008570A UA 105170 C2 UA105170 C2 UA 105170C2
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- benzyl
- indazol
- mixture
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Abstract
Данное изобретение касается новых производных 1-бензил-3-гидроксиметилиндазола согласно формулы (I):, (I)где значения радикалов приведены в пунктах формулы изобретения, и фармацевтической композиции, которая содержит их, вместе с фармацевтически приемлемым носителем.Кроме того, данное изобретение касается применения производных 1-бензил-3-гидроксиметилиндазола для получения фармацевтической композиции, которая является активной в лечении болезней, основанных на экспрессии МСР-1, CX3CR1 и р40, и их применения в способе лечения или профилактики болезней, основанных на экспрессии МСР-1, CX3CR1 и р40.
Applications Claiming Priority (2)
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| EP08425139 | 2008-03-07 | ||
| PCT/EP2009/052585 WO2009109613A2 (en) | 2008-03-07 | 2009-03-05 | Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40 |
Publications (1)
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| UA105170C2 true UA105170C2 (en) | 2014-04-25 |
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| ES2569330T3 (es) * | 2008-03-07 | 2016-05-10 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Derivados del 1-bencil-3-hidroximetilindazol y su utilización en el tratamiento de enfermedades basadas en la expresión de MCP-1, CX3CR1 |
| SI2262778T1 (sl) * | 2008-03-07 | 2019-12-31 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | 1-benzil-3-hidroksimetilindazolni derivati in njihova uporaba pri zdravljenju bolezni, na osnovi izražanja MCP-1, CXCR1 in P40 |
| SG176885A1 (en) * | 2009-08-03 | 2012-01-30 | Acraf | Process for the preparation of 1-benzyl-3-hydr0xymethyl-1h-indaz0le and its derivatives and required magnesium intermediates |
| UA108742C2 (uk) * | 2009-09-23 | 2015-06-10 | Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1 | |
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| WO2015173786A1 (en) * | 2014-05-15 | 2015-11-19 | Boyd Shelley Romayne | Compositions and methods for treating and diagnosing ocular disorders |
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| CN113929627A (zh) * | 2021-10-19 | 2022-01-14 | 吕梁学院 | 一种宾达利的合成方法 |
| WO2024108386A1 (zh) * | 2022-11-22 | 2024-05-30 | 中国科学院深圳先进技术研究院 | 抗mcp1中和抗体在制备治疗神经退行性疾病引起的系统性炎症药物中的应用 |
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