UA102225C2 - Соли производных пиперазина как як d3/d2-антагонисты - Google Patents

Соли производных пиперазина как як d3/d2-антагонисты

Info

Publication number
UA102225C2
UA102225C2 UAA200912891A UAA200912891A UA102225C2 UA 102225 C2 UA102225 C2 UA 102225C2 UA A200912891 A UAA200912891 A UA A200912891A UA A200912891 A UAA200912891 A UA A200912891A UA 102225 C2 UA102225 C2 UA 102225C2
Authority
UA
Ukraine
Prior art keywords
salts
antagonists
piperazine derivatives
solvates
hydrates
Prior art date
Application number
UAA200912891A
Other languages
English (en)
Ukrainian (uk)
Inventor
Чонгор Эва Агаине
Ласло Цибула
Ференц Шебек
Дьйордь Домань
Иштван Грейнер
Original Assignee
Рихтер Гедеон Нирт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рихтер Гедеон Нирт. filed Critical Рихтер Гедеон Нирт.
Publication of UA102225C2 publication Critical patent/UA102225C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)

Abstract

Данное изобретение касается солей моногидрохлорида, дигидрохлорида, моногидробромида, малеата и метансульфоната-4-{2-[4-(2,3-дихлорфенил)-пиперазин-1-ил]-этил}-N,N-диметилкарбамоил-циклогексиламина и/или их гидратов, и/или сольватов. Изобретение также относится к способу получения солей и их гидратов и/или сольватов, к их применению для лечения и/или предотвращения состояний, которые требуют модуляции дофаминового рецептора, и к фармацевтическим композициям, которые их включают.
UAA200912891A 2007-05-11 2008-05-13 Соли производных пиперазина как як d3/d2-антагонисты UA102225C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0700339A HU230748B1 (hu) 2007-05-11 2007-05-11 Új piperazin só és előállítási eljárása
PCT/HU2008/000044 WO2008139235A2 (en) 2007-05-11 2008-05-13 Novel piperazine salts as d3/d2 antagonists

Publications (1)

Publication Number Publication Date
UA102225C2 true UA102225C2 (ru) 2013-06-25

Family

ID=89987512

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200912891A UA102225C2 (ru) 2007-05-11 2008-05-13 Соли производных пиперазина как як d3/d2-антагонисты

Country Status (35)

Country Link
US (1) US7943621B2 (ru)
EP (1) EP2155696B1 (ru)
JP (1) JP2010526861A (ru)
KR (2) KR101668973B1 (ru)
CN (1) CN101679315B (ru)
AP (1) AP2009005012A0 (ru)
AU (1) AU2008249772B2 (ru)
BR (1) BRPI0811199A2 (ru)
CA (1) CA2684404C (ru)
CO (1) CO6241112A2 (ru)
CY (1) CY1119076T1 (ru)
DK (1) DK2155696T3 (ru)
EA (1) EA017270B1 (ru)
EC (1) ECSP099772A (ru)
ES (1) ES2628025T3 (ru)
GE (1) GEP20125522B (ru)
HK (1) HK1140473A1 (ru)
HR (1) HRP20170918T1 (ru)
HU (2) HU230748B1 (ru)
IL (1) IL201533A0 (ru)
LT (1) LT2155696T (ru)
MA (1) MA31434B1 (ru)
MX (1) MX2009012182A (ru)
MY (1) MY148078A (ru)
NI (1) NI200900203A (ru)
NZ (1) NZ580642A (ru)
PL (1) PL2155696T3 (ru)
PT (1) PT2155696T (ru)
RS (1) RS56036B1 (ru)
SI (1) SI2155696T1 (ru)
TN (1) TN2009000458A1 (ru)
TW (1) TWI424846B (ru)
UA (1) UA102225C2 (ru)
WO (1) WO2008139235A2 (ru)
ZA (1) ZA200907511B (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008141135A1 (en) * 2007-05-11 2008-11-20 Forest Laboratories Holdings Limited Novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
HUP0700369A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia
EP2185155B1 (en) * 2007-08-03 2017-10-04 Richter Gedeon Nyrt. Pharmaceutical compositions containing dopamine receptor ligands and methods of treatment using dopamine recptor ligands
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
KR101563383B1 (ko) * 2008-02-21 2015-10-26 미쓰비시 타나베 파마 코퍼레이션 경구 투여용 고형 제제
ES2532636T3 (es) 2008-07-16 2015-03-30 Richter Gedeon Nyrt. Formulaciones farmacéuticas que contienen ligandos de receptores de dopamina
HU230067B1 (hu) * 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
WO2014031162A1 (en) * 2012-08-20 2014-02-27 Forest Laboratories Holdings Limited Crystalline form of carbamoyl-cyclohexane derivatives
HU231227B1 (hu) 2012-11-29 2022-03-28 Richter Gedeon Nyrt. Transz-4-{2-[4-(2,3-diklórfenil)-piperazin-1-il]-etil}N,N-dimetilkarbamoil-ciklohexilamin skizofrénia negatív tüneteinek kezelésére
CN105218484B (zh) * 2015-09-14 2018-02-23 安徽省逸欣铭医药科技有限公司 酒石酸卡利拉嗪及其制备方法和医药用途
CN106543105B (zh) * 2015-09-22 2019-10-11 江苏恩华药业股份有限公司 一种盐酸卡利拉嗪晶型ⅳ及其制备方法
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
WO2018229794A1 (en) 2017-06-13 2018-12-20 Cipla Limited Amorphous form of cariprazine
WO2019016828A1 (en) * 2017-07-15 2019-01-24 Msn Laboratories Private Limited, R&D Center NOVEL PROCESSES FOR THE PREPARATION OF TRANS-N- {4- [2- [4- (2,3-DICHLOROPHENYL) PIPERAZIN-1-YL] ETHYL] CYCLOHEXYL} -N ', N'-DIMETHYLUMED HYDROCHLORIDE AND POLYMORPHS THIS ONE
CN111712486A (zh) * 2018-09-21 2020-09-25 上海诚妙医药科技有限公司 卡利拉嗪盐酸盐的新晶型及其制备方法及其用途
HU231500B1 (hu) 2019-04-10 2024-04-28 Richter Gedeon Nyrt Karbamoil-ciklohexán származékok autizmus spektrum betegség kezelésére
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
CN116139080A (zh) * 2020-08-26 2023-05-23 上海云晟研新生物科技有限公司 卡利拉嗪药物组合物、制备方法及应用
IL312456A (en) * 2021-10-28 2024-06-01 Richter Gedeon Nyrt Treatment of major depressive disorder
WO2024072930A1 (en) * 2022-09-30 2024-04-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dopamine d3/d2 receptor partial agonists for the treatment of neuropsychiatric disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227543B1 (en) * 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
HU227534B1 (en) 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
HUP0500170A3 (en) * 2005-02-03 2007-11-28 Richter Gedeon Nyrt Piperazine derivatives, process for producing them and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
KR101668973B1 (ko) 2016-10-24
IL201533A0 (en) 2010-05-31
CN101679315B (zh) 2013-06-12
CY1119076T1 (el) 2018-01-10
HUP0700339A2 (en) 2009-04-28
MY148078A (en) 2013-02-28
HU230748B1 (hu) 2018-02-28
AU2008249772B2 (en) 2013-09-05
JP2010526861A (ja) 2010-08-05
CN101679315A (zh) 2010-03-24
WO2008139235A8 (en) 2009-12-03
AP2009005012A0 (en) 2009-10-31
HRP20170918T1 (hr) 2017-09-22
ECSP099772A (es) 2009-12-28
ZA200907511B (en) 2010-07-28
PT2155696T (pt) 2017-06-02
RS56036B1 (sr) 2017-09-29
WO2008139235A3 (en) 2009-03-12
DK2155696T3 (en) 2017-07-10
GEP20125522B (en) 2012-05-25
BRPI0811199A2 (pt) 2014-10-29
TN2009000458A1 (en) 2011-03-31
EA200971046A1 (ru) 2010-04-30
CO6241112A2 (es) 2011-01-20
HUP0700339A3 (en) 2010-01-28
ES2628025T3 (es) 2017-08-01
US20090023750A1 (en) 2009-01-22
CA2684404C (en) 2013-02-05
US7943621B2 (en) 2011-05-17
MX2009012182A (es) 2009-12-09
WO2008139235A2 (en) 2008-11-20
HUE034796T2 (en) 2018-03-28
SI2155696T1 (sl) 2017-08-31
MA31434B1 (fr) 2010-06-01
HK1140473A1 (en) 2010-10-15
KR20100018493A (ko) 2010-02-17
NZ580642A (en) 2012-02-24
AU2008249772A1 (en) 2008-11-20
EP2155696B1 (en) 2017-03-22
EP2155696A2 (en) 2010-02-24
KR20150090264A (ko) 2015-08-05
PL2155696T3 (pl) 2017-10-31
NI200900203A (es) 2010-03-11
TW201002323A (en) 2010-01-16
TWI424846B (zh) 2014-02-01
LT2155696T (lt) 2017-06-12
CA2684404A1 (en) 2008-11-20
EA017270B1 (ru) 2012-11-30
HU0700339D0 (en) 2007-07-30

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