NI200900203A - Sales novedosas de piperazina como antagonistas d3/d2. - Google Patents
Sales novedosas de piperazina como antagonistas d3/d2.Info
- Publication number
- NI200900203A NI200900203A NI200900203A NI200900203A NI200900203A NI 200900203 A NI200900203 A NI 200900203A NI 200900203 A NI200900203 A NI 200900203A NI 200900203 A NI200900203 A NI 200900203A NI 200900203 A NI200900203 A NI 200900203A
- Authority
- NI
- Nicaragua
- Prior art keywords
- antagonists
- salts
- piperazine salts
- novel piperazine
- solvates
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000004677 hydrates Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- GIAOVZPOOUDJDR-UHFFFAOYSA-N 4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]-1-(dimethylamino)cyclohexane-1-carboxamide Chemical compound C1CC(N(C)C)(C(N)=O)CCC1CCN1CCN(C=2C(=C(Cl)C=CC=2)Cl)CC1 GIAOVZPOOUDJDR-UHFFFAOYSA-N 0.000 abstract 1
- 102000015554 Dopamine receptor Human genes 0.000 abstract 1
- 108050004812 Dopamine receptor Proteins 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Otolaryngology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
Abstract
La presente invención se refiere a sales novedosas monohidrocloruro, dihidrocloruro, monohidrobromuro, maleato y metanosulfanato de trans 4 - { 2 - [ 4 - ( 2, 3 - diclorofenil ) - piperazin - 1 - il ] - etil } - N, N - dimetilcarbamoil - ciclohexilamina y/o sus hidratos y/o solvatos. Además, la invención se refiere al proceso de preparación de sales y sus hidratos y/o solvatos, a su uso en el tratamiento y/o prevención de trastornos que requieren la modulación de receptores de dopamina y a composiciones farmacéuticas que las contienen.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0700339A HU230748B1 (hu) | 2007-05-11 | 2007-05-11 | Új piperazin só és előállítási eljárása |
Publications (1)
Publication Number | Publication Date |
---|---|
NI200900203A true NI200900203A (es) | 2010-03-11 |
Family
ID=89987512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NI200900203A NI200900203A (es) | 2007-05-11 | 2009-11-09 | Sales novedosas de piperazina como antagonistas d3/d2. |
Country Status (35)
Country | Link |
---|---|
US (1) | US7943621B2 (es) |
EP (1) | EP2155696B1 (es) |
JP (1) | JP2010526861A (es) |
KR (2) | KR101668973B1 (es) |
CN (1) | CN101679315B (es) |
AP (1) | AP2009005012A0 (es) |
AU (1) | AU2008249772B2 (es) |
BR (1) | BRPI0811199A2 (es) |
CA (1) | CA2684404C (es) |
CO (1) | CO6241112A2 (es) |
CY (1) | CY1119076T1 (es) |
DK (1) | DK2155696T3 (es) |
EA (1) | EA017270B1 (es) |
EC (1) | ECSP099772A (es) |
ES (1) | ES2628025T3 (es) |
GE (1) | GEP20125522B (es) |
HK (1) | HK1140473A1 (es) |
HR (1) | HRP20170918T1 (es) |
HU (2) | HU230748B1 (es) |
IL (1) | IL201533A0 (es) |
LT (1) | LT2155696T (es) |
MA (1) | MA31434B1 (es) |
MX (1) | MX2009012182A (es) |
MY (1) | MY148078A (es) |
NI (1) | NI200900203A (es) |
NZ (1) | NZ580642A (es) |
PL (1) | PL2155696T3 (es) |
PT (1) | PT2155696T (es) |
RS (1) | RS56036B1 (es) |
SI (1) | SI2155696T1 (es) |
TN (1) | TN2009000458A1 (es) |
TW (1) | TWI424846B (es) |
UA (1) | UA102225C2 (es) |
WO (1) | WO2008139235A2 (es) |
ZA (1) | ZA200907511B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2155200T (pt) * | 2007-05-11 | 2017-02-21 | Richter Gedeon Nyrt | Forma cristalina de um derivado de carbamoil-ciclohexano |
HUP0700353A2 (en) | 2007-05-18 | 2008-12-29 | Richter Gedeon Nyrt | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
HUP0700369A2 (en) | 2007-05-24 | 2009-04-28 | Richter Gedeon Nyrt | Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia |
WO2009020897A1 (en) * | 2007-08-03 | 2009-02-12 | Forest Laboratories Holdings Limited | Pharmaceutical compositions containing dopamine receptor ligands and methods of treatment using dopamine recptor ligands |
US7875610B2 (en) * | 2007-12-03 | 2011-01-25 | Richter Gedeon Nyrt. | Pyrimidinyl-piperazines useful as D3/D2 receptor ligands |
ATE552002T1 (de) * | 2008-02-21 | 2012-04-15 | Richter Gedeon Nyrt | Feste zubereitung zur oralen verabreichung |
AP2975A (en) | 2008-07-16 | 2014-09-30 | Richter Gedeon Nyrt | Pharmaceutical formulations containing dopamine receptor ligands |
HU230067B1 (hu) * | 2008-12-17 | 2015-06-29 | Richter Gedeon Nyrt | Új piperazin só és eljárás előállítására |
HUP0800765A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Nyrt | A new process for the preparation of piperazine derivatives and their hydrochloric salts |
HUP0800766A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Vegyeszet | Process for the preparation of piperazine derivatives |
US8912197B2 (en) | 2012-08-20 | 2014-12-16 | Forest Laboratories Holdings Ltd. | Crystalline form of carbamoyl-cyclohexane derivatives |
HU231227B1 (hu) | 2012-11-29 | 2022-03-28 | Richter Gedeon Nyrt. | Transz-4-{2-[4-(2,3-diklórfenil)-piperazin-1-il]-etil}N,N-dimetilkarbamoil-ciklohexilamin skizofrénia negatív tüneteinek kezelésére |
CN105218484B (zh) * | 2015-09-14 | 2018-02-23 | 安徽省逸欣铭医药科技有限公司 | 酒石酸卡利拉嗪及其制备方法和医药用途 |
CN106543105B (zh) * | 2015-09-22 | 2019-10-11 | 江苏恩华药业股份有限公司 | 一种盐酸卡利拉嗪晶型ⅳ及其制备方法 |
US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
WO2018229794A1 (en) | 2017-06-13 | 2018-12-20 | Cipla Limited | Amorphous form of cariprazine |
WO2019016828A1 (en) * | 2017-07-15 | 2019-01-24 | Msn Laboratories Private Limited, R&D Center | NOVEL PROCESSES FOR THE PREPARATION OF TRANS-N- {4- [2- [4- (2,3-DICHLOROPHENYL) PIPERAZIN-1-YL] ETHYL] CYCLOHEXYL} -N ', N'-DIMETHYLUMED HYDROCHLORIDE AND POLYMORPHS THIS ONE |
WO2020056929A1 (zh) * | 2018-09-21 | 2020-03-26 | 上海诚妙医药科技有限公司 | 卡利拉嗪盐酸盐的新晶型及其制备方法及其用途 |
HU231500B1 (hu) | 2019-04-10 | 2024-04-28 | Richter Gedeon Nyrt | Karbamoil-ciklohexán származékok autizmus spektrum betegség kezelésére |
US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
EP4206191A1 (en) * | 2020-08-26 | 2023-07-05 | Shanghai Bocimed Pharmaceutical Co., Ltd. | Pharmaceutically acceptable salt of cariprazine and crystal form thereof, and preparation method therefor and use thereof |
WO2023077094A1 (en) * | 2021-10-28 | 2023-05-04 | Abbvie Inc. | Treatment of major depressive disorder |
WO2024072930A1 (en) * | 2022-09-30 | 2024-04-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dopamine d3/d2 receptor partial agonists for the treatment of neuropsychiatric disorders |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU227543B1 (en) * | 2001-09-28 | 2011-08-29 | Richter Gedeon Nyrt | N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them |
HU227534B1 (en) * | 2003-08-04 | 2011-08-29 | Richter Gedeon Nyrt | (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them |
HUP0500170A3 (en) * | 2005-02-03 | 2007-11-28 | Richter Gedeon Nyrt | Piperazine derivatives, process for producing them and pharmaceutical compositions containing them |
-
2007
- 2007-05-11 HU HU0700339A patent/HU230748B1/hu not_active IP Right Cessation
-
2008
- 2008-05-09 US US12/118,437 patent/US7943621B2/en active Active
- 2008-05-13 CA CA2684404A patent/CA2684404C/en not_active Expired - Fee Related
- 2008-05-13 RS RS20170549A patent/RS56036B1/sr unknown
- 2008-05-13 HU HUE08750834A patent/HUE034796T2/en unknown
- 2008-05-13 UA UAA200912891A patent/UA102225C2/ru unknown
- 2008-05-13 WO PCT/HU2008/000044 patent/WO2008139235A2/en active Application Filing
- 2008-05-13 AU AU2008249772A patent/AU2008249772B2/en active Active
- 2008-05-13 SI SI200831816T patent/SI2155696T1/sl unknown
- 2008-05-13 MY MYPI20094708A patent/MY148078A/en unknown
- 2008-05-13 GE GEAP200811599A patent/GEP20125522B/en unknown
- 2008-05-13 LT LTEP08750834.7T patent/LT2155696T/lt unknown
- 2008-05-13 ES ES08750834.7T patent/ES2628025T3/es active Active
- 2008-05-13 BR BRPI0811199-5A2A patent/BRPI0811199A2/pt not_active Application Discontinuation
- 2008-05-13 AP AP2009005012A patent/AP2009005012A0/xx unknown
- 2008-05-13 EP EP08750834.7A patent/EP2155696B1/en active Active
- 2008-05-13 MX MX2009012182A patent/MX2009012182A/es active IP Right Grant
- 2008-05-13 NZ NZ580642A patent/NZ580642A/en unknown
- 2008-05-13 DK DK08750834.7T patent/DK2155696T3/en active
- 2008-05-13 KR KR1020157019598A patent/KR101668973B1/ko active IP Right Grant
- 2008-05-13 CN CN2008800156277A patent/CN101679315B/zh active Active
- 2008-05-13 EA EA200971046A patent/EA017270B1/ru unknown
- 2008-05-13 PT PT87508347T patent/PT2155696T/pt unknown
- 2008-05-13 PL PL08750834T patent/PL2155696T3/pl unknown
- 2008-05-13 KR KR1020097022188A patent/KR20100018493A/ko active Application Filing
- 2008-05-13 JP JP2010507992A patent/JP2010526861A/ja not_active Withdrawn
- 2008-07-08 TW TW097125707A patent/TWI424846B/zh active
-
2009
- 2009-10-15 IL IL201533A patent/IL201533A0/en active IP Right Grant
- 2009-10-26 ZA ZA200907511A patent/ZA200907511B/xx unknown
- 2009-10-30 TN TNP2009000458A patent/TN2009000458A1/fr unknown
- 2009-11-09 NI NI200900203A patent/NI200900203A/es unknown
- 2009-11-30 EC EC2009009772A patent/ECSP099772A/es unknown
- 2009-12-07 MA MA32405A patent/MA31434B1/fr unknown
- 2009-12-07 CO CO09139912A patent/CO6241112A2/es not_active Application Discontinuation
-
2010
- 2010-07-08 HK HK10106638.3A patent/HK1140473A1/xx unknown
-
2017
- 2017-05-12 CY CY20171100512T patent/CY1119076T1/el unknown
- 2017-06-16 HR HRP20170918TT patent/HRP20170918T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NI200900203A (es) | Sales novedosas de piperazina como antagonistas d3/d2. | |
NI200900202A (es) | Metabolitos de derivados del (tio) - carbamoil - ciclohexano. | |
MY148643A (en) | Solvate and crystalline forms of carbamoyl-cyclohexane derivatives | |
SG170785A1 (en) | Benzothiazoles having histamine h3 receptor activity | |
UY28765A1 (es) | Compuestos de piperazina acetilínica y su uso como antagonistas del receptor de glutamato metabotrópico | |
HRP20210486T1 (hr) | Trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-n,n-dimetilkarbamoil-cikloheksilamin za liječenje primarnih negativnih simptoma shizofrenije | |
CY1117638T1 (el) | Παραγωγα του 2-(1,2,3-τριαζολ-2-υλο)βενζαμιδιου και του 3-(1,2,3-τριαζολ-2-υλο)πικολιναμιδιου ως ανταγωνιστες του υποδοχεα της ορεξινης | |
ATE449090T1 (de) | Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren | |
HRP20120263T1 (hr) | Trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-n,n-dimetilkarbamoil-cikloheksilamin za liječenje shizofrenije | |
ECSP11011468A (es) | Compuestos de n-fenil-(piperazinil u homopiperazinil)-bencensulfonamida o bencensulfonil-fenil-(piperazina u homopiperazina) adecuados para tratar trastornos que responden a la modulación del receptor de serotonina 5-ht6 | |
AR072242A1 (es) | Derivados de imidazopiridina, una composicion farmaceutica que los comprende y su uso en el tratamiento de trastornos neuromusculares. | |
MX2021002111A (es) | Sales de adición de ácido de succinato y fumarato de derivados de piperazina útiles como inhibidores de glucosidasa. | |
MX2018014298A (es) | Nueva forma cristalina de n-[5-(3,5-difluoro-bencilo)-1h-indazol-3 -il]-4-(4-metilo-piperazina-1-il)-2-(tetrahidro-pirano-4-ilamino) -benzamida. | |
AR063345A1 (es) | N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)-piperidin-4-iliden)metil) benzamida para el tratamiento del dolor, ansiedad y depresion | |
EA202191620A1 (ru) | Твердые формы, содержащие (s)-4-(4-(4-(((2-(2,6-диоксопиперидин-3-ил)-1-оксоизоиндолин-4-ил)окси)метил)бензил)пиперазин-1-ил)-3-фторбензонитрил и его соли, и содержащие их композиции и способы их применения | |
CU20090190A7 (es) | Sales novedosas de piperazina como antagonistas d3/d2 | |
EA202091737A1 (ru) | Производные индола и бензимидазола в качестве двойных антагонистов рецепторов 5-ht2a и 5-ht6 | |
ATE496891T1 (de) | Für die behandlung von neuropsychiatrischen störungen geeignete arylpiperazinderivate | |
ATE433444T1 (de) | Pyroglutamatsalze und deren verwendung bei der optischen trennung von zwischenprodukten für die synthese von dextrocetirizin und levocetirizin | |
PL407397A1 (pl) | 1,1-ditlenek 3-(4-bromobenzoilo)-4-hydroksy-2-{2-[4-(2-pirymidylo)piperazyn-1-ylo]-2-oksoetylo}-2H-1,2-benzotiazyny o aktywności przeciwzapalnej i przeciwbólowej oraz sposób jego wytwarzania | |
PL431466A1 (pl) | Zastosowanie długołańcuchowej pochodnej arylopiperazyn JJ-AR-2 jako inhibitora nitryfikacji | |
PL431467A1 (pl) | Zastosowanie długołańcuchowej pochodnej arylopiperazyn JJ-AR-12 jako inhibitora nitryfikacji | |
PL407396A1 (pl) | 1,1-ditlenek 3-benzoilo-4-hydroksy-2-{2-[4-(2-metoksyfenylo)piperazyn-1-ylo]2-oksoetylo}-2H-1,2-benzotiazyny o aktywności przeciwzapalnej i przeciwbólowej oraz sposób jego wytwarzania | |
PL407398A1 (pl) | 1,1-ditlenek 2-[2-(4-fenylopiperazyn-1-ylo)-2-oksoetylo]-4-hydroksy-3-(4-metylobenzoilo)-2H-1,2-benzotiazyny o aktywności przeciwbólowej i przeciwzapalnej oraz sposób jego wytwarzania | |
TH131527A (th) | เกลือไพเพอราซีนชนิดใหม่ซึ่งเป็น d3/d2 แอนทาโกนิสต์ |