AR072242A1 - Derivados de imidazopiridina, una composicion farmaceutica que los comprende y su uso en el tratamiento de trastornos neuromusculares. - Google Patents
Derivados de imidazopiridina, una composicion farmaceutica que los comprende y su uso en el tratamiento de trastornos neuromusculares.Info
- Publication number
- AR072242A1 AR072242A1 ARP090100372A ARP090100372A AR072242A1 AR 072242 A1 AR072242 A1 AR 072242A1 AR P090100372 A ARP090100372 A AR P090100372A AR P090100372 A ARP090100372 A AR P090100372A AR 072242 A1 AR072242 A1 AR 072242A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- skeletal
- treatment
- troponin
- muscle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se proporcionan ciertas entidades químicas, y su uso para modular miosina esquelética, actina esquelética, tropomiosina esquelética, troponina C esquelética, troponina I esquelética, troponina T esquelética y musculo esquelético, que incluyen sus fragmentos e isoformas, así como el sarcomero esquelético, y los métodos de uso en el tratamiento de trastornos neuromusculares, enfermedades que presentan debilitamiento muscular, claudicacion, debilidad, síndrome metabolico, atrofia muscular por falta de actividad, y fatiga muscular, y otras indicaciones Reivindicacion 1: Al menos una entidad química seleccionada de los compuestos de formula (1) y sus sales y tautomeros aceptables para uso farmacéutico, en donde R3 se selecciona de alquilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, y heterocicloalquilo opcionalmente sustituido; R4 se selecciona de arilo opcionalmente sustituido y heteroarilo opcionalmente sustituido; R5 se selecciona de hidrogeno, halo, hidroxi, alquilo opcionalmente sustituido, amino opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, alcoxi opcionalmente sustituido, sulfanilo, y sulfinilo; y R6 se selecciona de hidrogeno, halo, hidroxi, alquilo inferior, y haloalquilo inferior.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2606708P | 2008-02-04 | 2008-02-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR072242A1 true AR072242A1 (es) | 2010-08-18 |
Family
ID=40952391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100372A AR072242A1 (es) | 2008-02-04 | 2009-02-04 | Derivados de imidazopiridina, una composicion farmaceutica que los comprende y su uso en el tratamiento de trastornos neuromusculares. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7989469B2 (es) |
| EP (1) | EP2244711A4 (es) |
| JP (1) | JP2011510985A (es) |
| KR (1) | KR20100119773A (es) |
| CN (1) | CN101983061A (es) |
| AR (1) | AR072242A1 (es) |
| AU (1) | AU2009210787A1 (es) |
| BR (1) | BRPI0907502A2 (es) |
| CA (1) | CA2713864A1 (es) |
| CL (1) | CL2009000246A1 (es) |
| CO (1) | CO6290673A2 (es) |
| EA (1) | EA201001224A1 (es) |
| EC (2) | ECSP10010430A (es) |
| IL (1) | IL207367A0 (es) |
| MX (1) | MX2010008518A (es) |
| TW (1) | TW200946524A (es) |
| WO (1) | WO2009099594A1 (es) |
| ZA (1) | ZA201005780B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| US7989469B2 (en) * | 2008-02-04 | 2011-08-02 | Cytokinetics, Incorporated | Certain chemical entities, compositions, and methods |
| CN102127070A (zh) * | 2010-01-15 | 2011-07-20 | 山东轩竹医药科技有限公司 | 吡啶并环衍生物 |
| ES2547687T3 (es) | 2011-07-09 | 2015-10-08 | Xuanzhu Pharma Co., Ltd. | Forma cristalina I de sal de un inhibidor de dipeptidil-peptidasa IV y procedimiento de preparación y uso de la misma |
| IN2014DN00200A (es) | 2011-07-13 | 2015-06-05 | Cytokinetics Inc | |
| KR102163931B1 (ko) * | 2012-04-11 | 2020-10-12 | 싸이토키네틱스, 인코포레이티드 | 골격근 피로에 대한 저항을 개선 |
| SI3137622T1 (sl) | 2014-04-29 | 2022-05-31 | Cytokinetics, Inc. | Postopki za zmanjšanje upada vitalne kapacitete |
| TW201927738A (zh) * | 2017-12-14 | 2019-07-16 | 丹麥商Ｎｍｄ藥品公司 | 用於治療神經肌肉病症的化合物 |
| TWI794369B (zh) * | 2017-12-14 | 2023-03-01 | 丹麥商Ｎｍｄ藥品公司 | 用於治療神經肌肉病症的化合物 |
| WO2020240586A1 (en) * | 2019-05-28 | 2020-12-03 | Mankind Pharma Ltd. | Novel compounds for inhibition of janus kinase 1 |
| WO2022234298A1 (en) * | 2021-05-06 | 2022-11-10 | Exscientia Ai Limited | Pkc-theta modulators |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0206860D0 (en) | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Compounds |
| GB0212048D0 (en) | 2002-05-24 | 2002-07-03 | Merck Sharp & Dohme | Therapeutic agents |
| WO2004043913A2 (en) | 2002-11-08 | 2004-05-27 | Trimeris, Inc. | Hetero-substituted benzimidazole compounds and antiviral uses thereof |
| WO2005002520A2 (en) | 2003-07-01 | 2005-01-13 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
| US20050250794A1 (en) | 2003-12-19 | 2005-11-10 | Andrew Napper | Methods of treating a disorder |
| AU2005208938A1 (en) | 2004-01-29 | 2005-08-11 | Elixir Pharmaceuticals, Inc | Anti-viral therapeutics |
| WO2005108374A1 (en) | 2004-04-29 | 2005-11-17 | Fmc Corporation | Insecticidal diazole and triazole derivatives |
| GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| US7718657B2 (en) | 2005-12-16 | 2010-05-18 | Cytokinetics, Inc. | Certain indanyl urea modulators of the cardiac sarcomere |
| US8227603B2 (en) | 2006-08-01 | 2012-07-24 | Cytokinetics, Inc. | Modulating skeletal muscle |
| ES2558517T3 (es) | 2006-08-02 | 2016-02-04 | Cytokinetics, Inc. | Ciertas entidades químicas, composiciones y métodos que comprenden imidazopirimidinas |
| ES2381215T3 (es) | 2006-10-19 | 2012-05-24 | Signal Pharmaceuticals Llc | Compuestos heteroarilo, sus composiciones y métodos de tratamiento con ellos |
| CL2007002994A1 (es) | 2006-10-19 | 2008-02-08 | Wyeth Corp | Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros. |
| WO2008075007A1 (en) * | 2006-12-21 | 2008-06-26 | Cancer Research Technology Limited | Morpholino-substituted bicycloheteroaryl compounds and their use as anti cancer agents |
| EP2139478A4 (en) * | 2007-03-30 | 2010-05-05 | Cytokinetics Inc | CHEMICAL ENTITIES, COMPOSITIONS AND METHODS |
| US7989469B2 (en) * | 2008-02-04 | 2011-08-02 | Cytokinetics, Incorporated | Certain chemical entities, compositions, and methods |
| US7998976B2 (en) | 2008-02-04 | 2011-08-16 | Cytokinetics, Inc. | Certain chemical entities, compositions and methods |
| JP5930278B2 (ja) | 2008-11-25 | 2016-06-08 | ユニバーシティー オブ ロチェスター | Ｍｌｋ阻害剤および使用方法 |
-
2009
- 2009-02-02 US US12/364,394 patent/US7989469B2/en not_active Expired - Fee Related
- 2009-02-02 KR KR1020107018611A patent/KR20100119773A/ko not_active Application Discontinuation
- 2009-02-02 CN CN2009801121602A patent/CN101983061A/zh active Pending
- 2009-02-02 WO PCT/US2009/000686 patent/WO2009099594A1/en active Application Filing
- 2009-02-02 EP EP09708594A patent/EP2244711A4/en not_active Withdrawn
- 2009-02-02 MX MX2010008518A patent/MX2010008518A/es not_active Application Discontinuation
- 2009-02-02 JP JP2010545031A patent/JP2011510985A/ja not_active Withdrawn
- 2009-02-02 CA CA2713864A patent/CA2713864A1/en not_active Abandoned
- 2009-02-02 AU AU2009210787A patent/AU2009210787A1/en not_active Abandoned
- 2009-02-02 BR BRPI0907502A patent/BRPI0907502A2/pt not_active Application Discontinuation
- 2009-02-02 EA EA201001224A patent/EA201001224A1/ru unknown
- 2009-02-03 TW TW098103382A patent/TW200946524A/zh unknown
- 2009-02-04 AR ARP090100372A patent/AR072242A1/es unknown
- 2009-02-04 CL CL2009000246A patent/CL2009000246A1/es unknown
-
2010
- 2010-08-02 IL IL207367A patent/IL207367A0/en unknown
- 2010-08-13 ZA ZA2010/05780A patent/ZA201005780B/en unknown
- 2010-08-27 EC EC2010010430A patent/ECSP10010430A/es unknown
- 2010-08-30 CO CO10106625A patent/CO6290673A2/es not_active Application Discontinuation
- 2010-08-30 EC EC2010010432A patent/ECSP10010432A/es unknown
-
2011
- 2011-06-21 US US13/165,281 patent/US20110312975A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EA201001224A1 (ru) | 2011-08-30 |
| CA2713864A1 (en) | 2009-08-13 |
| ECSP10010432A (es) | 2011-01-31 |
| WO2009099594A1 (en) | 2009-08-13 |
| CN101983061A (zh) | 2011-03-02 |
| CO6290673A2 (es) | 2011-06-20 |
| US20090253737A1 (en) | 2009-10-08 |
| US20110312975A1 (en) | 2011-12-22 |
| CL2009000246A1 (es) | 2009-06-26 |
| EP2244711A1 (en) | 2010-11-03 |
| MX2010008518A (es) | 2010-11-10 |
| BRPI0907502A2 (pt) | 2019-01-15 |
| ZA201005780B (en) | 2011-04-28 |
| ECSP10010430A (es) | 2011-02-28 |
| IL207367A0 (en) | 2010-12-30 |
| TW200946524A (en) | 2009-11-16 |
| EP2244711A4 (en) | 2011-08-24 |
| US7989469B2 (en) | 2011-08-02 |
| AU2009210787A1 (en) | 2009-08-13 |
| JP2011510985A (ja) | 2011-04-07 |
| KR20100119773A (ko) | 2010-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |