HRP20120263T1 - Trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-n,n-dimetilkarbamoil-cikloheksilamin za liječenje shizofrenije - Google Patents

Trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-n,n-dimetilkarbamoil-cikloheksilamin za liječenje shizofrenije Download PDF

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HRP20120263T1
HRP20120263T1 HR20120263T HRP20120263T HRP20120263T1 HR P20120263 T1 HRP20120263 T1 HR P20120263T1 HR 20120263 T HR20120263 T HR 20120263T HR P20120263 T HRP20120263 T HR P20120263T HR P20120263 T1 HRP20120263 T1 HR P20120263T1
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Croatia
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dimethylcarbamoyl
piperazin
dichlorophenyl
cyclohexylamine
trans
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HR20120263T
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Laszlovszky Istv�n
N�meth Gy�rgy
Andor Gy�rgy
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Richter Gedeon Nyrt.
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Publication of HRP20120263T1 publication Critical patent/HRP20120263T1/hr

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Abstract

Spoj, naznačen time, da je to trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-N,N-dimetilkarbamoil-cikloheksilamin i/ili njegove soli i/ili njegovi hidrati i/ili solvati i/ili polimorfi, koji su za uporabu u postupku liječenja shizofrenije s terapeutski učinkovitom količinom od 1,5; 3,0 ili 4,5 mg na dan. Patent sadrži još 8 patentnih zahtjeva.

Claims (9)

1. Spoj, naznačen time, da je to trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-N,N-dimetilkarbamoil-cikloheksilamin i/ili njegove soli i/ili njegovi hidrati i/ili solvati i/ili polimorfi, koji su za uporabu u postupku liječenja shizofrenije s terapeutski učinkovitom količinom od 1,5; 3,0 ili 4,5 mg na dan.
2. Trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-N,N-dimetilkarbamoil-cikloheksilamin za uporabu prema zahtjevu 1, naznačen time, da je u obliku trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-N,N-dimetilkarbamoil-cikloheksilamin hidroklorida i/ili njegovih hidrata i/ili solvata i/ili polimorfa.
3. Trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-N,N-dimetilkarbamoil-cikloheksilamin za uporabu prema zahtjevu 1 ili 2, naznačen time, da je terapeutski učinkovita količina podijeljena u jednu, dvije, tri ili četiri dnevne doze.
4. Trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-N,N-dimetilkarbamoil-cikloheksilamin za uporabu prema bilo kojem od zahtjeva 1 do 3, naznačen time, da je za uporabu u postupku liječenja kognitivnih simptoma shizofrenije.
5. Trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-N,N-dimetilkarbamoil-cikloheksilamin za uporabu prema bilo kojem od zahtjeva 1 do 3, naznačen time, da je za uporabu u postupku liječenja negativnih simptoma shizofrenije.
6. Trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-N,N-dimetilkarbamoil-cikloheksilamin za uporabu prema bilo kojem od zahtjeva 1 do 3, naznačen time, da je za uporabu u postupku liječenja pozitivnih simptoma shizofrenije.
7. Trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-N,N-dimetilkarbamoil-cikloheksilamin za uporabu prema bilo kojem od zahtjeva 1 do 3, naznačen time, da je za uporabu u postupku liječenja afektivnih i rezidualnih simptoma shizofrenije.
8. Trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-N,N-dimetilkarbamoil-cikloheksilamin za uporabu prema bilo kojem od zahtjeva 1 do 3, naznačen time, da je za uporabu u postupku liječenja sekundarnih socijalnih i profesionalnih disfunkcija shizofrenije.
9. Trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-N,N-dimetilkarbamoil-cikloheksilamin za uporabu prema bilo kojem od zahtjeva 1 do 3, naznačen time, da je za uporabu u postupku liječenja shizofreniformnog i shizoafektivnih poremećaja.
HR20120263T 2007-05-24 2012-03-22 Trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-n,n-dimetilkarbamoil-cikloheksilamin za liječenje shizofrenije HRP20120263T1 (hr)

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HU0700369A HUP0700369A2 (en) 2007-05-24 2007-05-24 Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia
PCT/HU2008/000051 WO2008142462A1 (en) 2007-05-24 2008-05-19 (thio) -carbamoyl-cyclohexane derivatives and method for treating schizophrenia

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HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
US20110059980A1 (en) * 2008-02-21 2011-03-10 Yasuaki Oobayashi Solid preparation for oral administration
SI2317852T1 (sl) 2008-07-16 2015-04-30 Richter Gedeon Nyrt. Farmacevtske formulacije, ki vsebujejo ligande dopaminskega receptorja
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP1200001A2 (en) 2012-01-02 2013-07-29 Gabor Dr Havas Wind motor with rotation axis substantially at right angle to wind direction with a multistage acceleration system
WO2014031162A1 (en) 2012-08-20 2014-02-27 Forest Laboratories Holdings Limited Crystalline form of carbamoyl-cyclohexane derivatives
HU231227B1 (hu) * 2012-11-29 2022-03-28 Richter Gedeon Nyrt. Transz-4-{2-[4-(2,3-diklórfenil)-piperazin-1-il]-etil}N,N-dimetilkarbamoil-ciklohexilamin skizofrénia negatív tüneteinek kezelésére
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder

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US6489341B1 (en) * 1999-06-02 2002-12-03 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using sertindole derivatives
HU227543B1 (en) * 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
HU227534B1 (en) * 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
HU230748B1 (hu) 2007-05-11 2018-02-28 Richter Gedeon Nyrt Új piperazin só és előállítási eljárása
EP2155200B1 (en) * 2007-05-11 2016-12-07 Richter Gedeon Nyrt. Crystalline form of a carbamoyl-cyclohexane derivative

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MY148257A (en) 2013-03-29
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MX2009012751A (es) 2010-03-15
EP2164492B1 (en) 2012-01-04
AU2008252620B2 (en) 2014-06-05
AU2008252620A1 (en) 2008-11-27
DK2164492T3 (da) 2012-04-02
EA200971086A1 (ru) 2010-04-30
EA021962B1 (ru) 2015-10-30
TWI426906B (zh) 2014-02-21
IL202047A0 (en) 2010-06-16
US20100197666A1 (en) 2010-08-05
UA101322C2 (en) 2013-03-25
NZ582281A (en) 2012-05-25
PL2164492T3 (pl) 2012-06-29
CA2687521C (en) 2015-06-23
ATE539750T1 (de) 2012-01-15
IL202047A (en) 2015-02-26
JP2010527984A (ja) 2010-08-19
HUP0700369D0 (en) 2007-07-30
CA2687521A1 (en) 2008-11-27
TW201002325A (en) 2010-01-16
CY1113996T1 (el) 2016-07-27
CN101678018A (zh) 2010-03-24
PT2164492E (pt) 2012-04-10
SI2164492T1 (sl) 2012-04-30
HK1137943A1 (en) 2010-08-13
ZA200908282B (en) 2011-04-28
HUP0700369A2 (en) 2009-04-28
CN104546852A (zh) 2015-04-29
KR20150080016A (ko) 2015-07-08
ES2380083T3 (es) 2012-05-08

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