ECSP11011468A - Compuestos de n-fenil-(piperazinil u homopiperazinil)-bencensulfonamida o bencensulfonil-fenil-(piperazina u homopiperazina) adecuados para tratar trastornos que responden a la modulación del receptor de serotonina 5-ht6 - Google Patents
Compuestos de n-fenil-(piperazinil u homopiperazinil)-bencensulfonamida o bencensulfonil-fenil-(piperazina u homopiperazina) adecuados para tratar trastornos que responden a la modulación del receptor de serotonina 5-ht6Info
- Publication number
- ECSP11011468A ECSP11011468A EC2011011468A ECSP11011468A ECSP11011468A EC SP11011468 A ECSP11011468 A EC SP11011468A EC 2011011468 A EC2011011468 A EC 2011011468A EC SP11011468 A ECSP11011468 A EC SP11011468A EC SP11011468 A ECSP11011468 A EC SP11011468A
- Authority
- EC
- Ecuador
- Prior art keywords
- phenyl
- hydrogen
- homopiperazine
- homopiperazinyl
- piperazine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compuestos de N-fenil-(piperazinil u homopiperazinil)-bencensulfonamida o bencensulfonil-fenil-(piperazina u homopiperazina), con composiciones farmacéuticas que contienen a los mismos y su uso en terapias. Los compuestos tienen propiedades terapéuticas valiosas y son apropiados, en particular, para tratar enfermedades que responden a la modulación del receptor de serotonina 5-HT6. Consta gráfico en dondeX es un enlace o un grupo N-R4;R1 es hidrógeno o metilo;R2 es hidrógeno o metilo;R3 es hidrógeno, C1-C3 alquilo, flúor, C1-C2 alcoxi o C1-C2 alcoxi fluorado;R4 es hidrógeno, C1-C4 alquilo, C3-C4 cicloalquilo o C3-C4 cicloalquil-CH2-;R5 es hidrógeno, flúor, cloro, C1-C2 alquilo, C1-C2 alquilo fluorado, C1-C2 alcoxi o C1-C2 alcoxi fluorado;R6 es hidrógeno, flúor o cloro; yn es 1 ó 2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17405409P | 2009-04-30 | 2009-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP11011468A true ECSP11011468A (es) | 2011-12-30 |
Family
ID=42236832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2011011468A ECSP11011468A (es) | 2009-04-30 | 2011-11-21 | Compuestos de n-fenil-(piperazinil u homopiperazinil)-bencensulfonamida o bencensulfonil-fenil-(piperazina u homopiperazina) adecuados para tratar trastornos que responden a la modulación del receptor de serotonina 5-ht6 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8076326B2 (es) |
| EP (1) | EP2432769B1 (es) |
| JP (1) | JP5718898B2 (es) |
| KR (1) | KR20120016639A (es) |
| CN (1) | CN102459197B (es) |
| AR (1) | AR076507A1 (es) |
| AU (1) | AU2010243585B2 (es) |
| BR (1) | BRPI1011875A2 (es) |
| CA (1) | CA2759482A1 (es) |
| CL (1) | CL2011002653A1 (es) |
| CO (1) | CO6450637A2 (es) |
| CR (1) | CR20110604A (es) |
| DO (1) | DOP2011000326A (es) |
| EC (1) | ECSP11011468A (es) |
| ES (1) | ES2536779T3 (es) |
| HK (1) | HK1163104A1 (es) |
| IL (1) | IL215642A (es) |
| MX (1) | MX2011011520A (es) |
| NZ (1) | NZ595698A (es) |
| PE (1) | PE20120881A1 (es) |
| RU (1) | RU2535200C2 (es) |
| SG (1) | SG175187A1 (es) |
| TW (1) | TWI465438B (es) |
| UA (1) | UA107080C2 (es) |
| UY (1) | UY32604A (es) |
| WO (1) | WO2010125134A1 (es) |
| ZA (1) | ZA201107569B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE552255T1 (de) | 2008-06-05 | 2012-04-15 | Glaxo Group Ltd | 4-aminoindazole |
| ES2526966T3 (es) | 2008-06-05 | 2015-01-19 | Glaxo Group Limited | Compuestos novedosos |
| WO2009147188A1 (en) | 2008-06-05 | 2009-12-10 | Glaxo Group Limited | Benzpyrazol derivatives as inhibitors of pi3 kinases |
| JP5656880B2 (ja) | 2009-03-09 | 2015-01-21 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | Ｐｉ３キナーゼの阻害剤としての４−オキサジアゾール−２−イル−インダゾール |
| AU2010243613B2 (en) | 2009-04-30 | 2015-05-07 | Glaxo Group Limited | Oxazole substituted indazoles as PI3-kinase inhibitors |
| US8343959B2 (en) * | 2009-04-30 | 2013-01-01 | Abbott Gmbh & Co. Kg | N-phenyl-(piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds suitable for treating disorders that respond to modulation of the serotonin 5-HT6 receptor |
| GB201018124D0 (en) | 2010-10-27 | 2010-12-08 | Glaxo Group Ltd | Polymorphs and salts |
| WO2012059432A1 (en) * | 2010-11-01 | 2012-05-10 | Abbott Gmbh & Co. Kg | N-phenyl-(homo)piperazinyl-benzenesulfonyl or benzenesulfonamide compounds suitable for treating disorders that respond to the modulation of the 5-ht6 receptor |
| US20140120036A1 (en) * | 2012-01-06 | 2014-05-01 | Abbvie Inc. | Radiolabeled 5-ht6 ligands |
| KR20150092764A (ko) * | 2012-12-10 | 2015-08-13 | 에프. 호프만-라 로슈 아게 | RORc 조절인자로서의 벤질 설폰아마이드 유도체 |
| JP2016510781A (ja) * | 2013-03-15 | 2016-04-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ＲＯＲｃモジュレーターとしてのアリールスルファミド及びスルファミン酸誘導体 |
| WO2015090233A1 (en) | 2013-12-20 | 2015-06-25 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
| CN105085436B (zh) * | 2014-04-19 | 2019-08-16 | 广东东阳光药业有限公司 | 磺酰胺类衍生物及其在药物上的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK55192D0 (da) * | 1992-04-28 | 1992-04-28 | Lundbeck & Co As H | 1-piperazino-1,2-dihydroindenderivater |
| DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| US6316450B1 (en) * | 1997-07-11 | 2001-11-13 | Smithkline Beecham P.L.C. | Compounds |
| GB9818916D0 (en) | 1998-08-28 | 1998-10-21 | Smithkline Beecham Plc | Use |
| GB9818914D0 (en) | 1998-08-28 | 1998-10-21 | Smithkline Beecham Plc | Use |
| SE0002739D0 (sv) | 2000-07-21 | 2000-07-21 | Pharmacia & Upjohn Ab | New use |
| AU2002303061B2 (en) | 2001-05-11 | 2009-01-29 | Biovitrum Ab (Publ) | Novel, arylsulfonamide compounds for the treatment of obesity, type II diabetes and CNS-disorders |
| JP4731114B2 (ja) * | 2001-06-11 | 2011-07-20 | プロキシマゲン・リミテッド | 置換スルホンアミド化合物、ｃｎｓ障害、肥満およびｉｉ型糖尿病の処置のための医薬としてのそれらの使用方法 |
| KR100608417B1 (ko) * | 2001-08-10 | 2006-08-02 | 에프. 호프만-라 로슈 아게 | 5-ｈｔ6 수용체 친화성을 갖는 아릴설포닐 유도체 |
| JP4467307B2 (ja) * | 2002-02-22 | 2010-05-26 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | ５−ｈｔ受容体アンタゴニストとしてのピリジルスルホン誘導体 |
| GB0305575D0 (en) | 2003-03-11 | 2003-04-16 | Glaxo Group Ltd | Novel compounds |
| CA2575359A1 (en) | 2004-07-28 | 2006-02-02 | Glaxo Group Limited | Piperazine derivatives useful for the treatment of gastrointestinal disorders |
| GB0419192D0 (en) * | 2004-08-27 | 2004-09-29 | Merck Sharp & Dohme | Therapeutic agents |
| JP2009533325A (ja) * | 2006-03-17 | 2009-09-17 | アストラゼネカ・アクチエボラーグ | ５−ｈｔ６調節剤としての新規なテトラリン |
| TW200812961A (en) * | 2006-04-19 | 2008-03-16 | Abbott Gmbh & Co Kg | Heterocyclic compounds suitable for treating disorders that respond to modulation of the serotonin 5HT6 receptor |
| WO2008087123A2 (en) | 2007-01-16 | 2008-07-24 | Solvay Pharmaceuticals B.V. | Use of 5-ht6 antagonists to prevent relapse into addiction |
-
2010
- 2010-04-29 PE PE2011001879A patent/PE20120881A1/es not_active Application Discontinuation
- 2010-04-29 AU AU2010243585A patent/AU2010243585B2/en not_active Ceased
- 2010-04-29 SG SG2011074325A patent/SG175187A1/en unknown
- 2010-04-29 CA CA2759482A patent/CA2759482A1/en not_active Abandoned
- 2010-04-29 JP JP2012507761A patent/JP5718898B2/ja not_active Expired - Fee Related
- 2010-04-29 EP EP10719748.5A patent/EP2432769B1/en active Active
- 2010-04-29 KR KR1020117028393A patent/KR20120016639A/ko not_active Application Discontinuation
- 2010-04-29 WO PCT/EP2010/055789 patent/WO2010125134A1/en active Application Filing
- 2010-04-29 ES ES10719748.5T patent/ES2536779T3/es active Active
- 2010-04-29 NZ NZ595698A patent/NZ595698A/en not_active IP Right Cessation
- 2010-04-29 UA UAA201114123A patent/UA107080C2/ru unknown
- 2010-04-29 CN CN201080030335.8A patent/CN102459197B/zh not_active Expired - Fee Related
- 2010-04-29 BR BRPI1011875A patent/BRPI1011875A2/pt not_active IP Right Cessation
- 2010-04-29 MX MX2011011520A patent/MX2011011520A/es active IP Right Grant
- 2010-04-29 RU RU2011148583/04A patent/RU2535200C2/ru not_active IP Right Cessation
- 2010-04-30 TW TW099113996A patent/TWI465438B/zh not_active IP Right Cessation
- 2010-04-30 UY UY0001032604A patent/UY32604A/es not_active Application Discontinuation
- 2010-04-30 US US12/770,837 patent/US8076326B2/en not_active Expired - Fee Related
- 2010-04-30 AR ARP100101465A patent/AR076507A1/es not_active Application Discontinuation
-
2011
- 2011-10-09 IL IL215642A patent/IL215642A/en not_active IP Right Cessation
- 2011-10-14 ZA ZA2011/07569A patent/ZA201107569B/en unknown
- 2011-10-25 DO DO2011000326A patent/DOP2011000326A/es unknown
- 2011-10-25 CL CL2011002653A patent/CL2011002653A1/es unknown
- 2011-11-03 CO CO11149288A patent/CO6450637A2/es active IP Right Grant
- 2011-11-15 CR CR20110604A patent/CR20110604A/es unknown
- 2011-11-21 EC EC2011011468A patent/ECSP11011468A/es unknown
-
2012
- 2012-04-20 HK HK12103943.8A patent/HK1163104A1/zh not_active IP Right Cessation
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