TWI905090B - Mcl-1抑制劑之新結晶型, 其製備方法及包含其之醫藥組合物 - Google Patents

Mcl-1抑制劑之新結晶型, 其製備方法及包含其之醫藥組合物

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Publication number
TWI905090B
TWI905090B TW108144437A TW108144437A TWI905090B TW I905090 B TWI905090 B TW I905090B TW 108144437 A TW108144437 A TW 108144437A TW 108144437 A TW108144437 A TW 108144437A TW I905090 B TWI905090 B TW I905090B
Authority
TW
Taiwan
Prior art keywords
compound
cancer
crystalline form
expressed
ray powder
Prior art date
Application number
TW108144437A
Other languages
English (en)
Chinese (zh)
Other versions
TW202039511A (zh
Inventor
貝特斯 艾米莉 德
朱利恩 奧夫雷
麥可 林曲
尼古拉斯 勒布朗
Original Assignee
法商施維雅藥廠
英商佛納利斯(Ｒ&Ｄ)股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 法商施維雅藥廠, 英商佛納利斯(Ｒ&Ｄ)股份有限公司 filed Critical 法商施維雅藥廠
Publication of TW202039511A publication Critical patent/TW202039511A/zh
Application granted granted Critical
Publication of TWI905090B publication Critical patent/TWI905090B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW108144437A 2018-12-06 2019-12-05 Mcl-1抑制劑之新結晶型, 其製備方法及包含其之醫藥組合物 TWI905090B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18306634.9 2018-12-06
EP18306634 2018-12-06

Publications (2)

Publication Number Publication Date
TW202039511A TW202039511A (zh) 2020-11-01
TWI905090B true TWI905090B (zh) 2025-11-21

Family

ID=64665802

Family Applications (1)

Application Number Title Priority Date Filing Date
TW108144437A TWI905090B (zh) 2018-12-06 2019-12-05 Mcl-1抑制劑之新結晶型, 其製備方法及包含其之醫藥組合物

Country Status (26)

Country Link
US (2) US12129261B2 (https=)
EP (1) EP3891156B1 (https=)
JP (1) JP7649241B2 (https=)
KR (1) KR102855345B1 (https=)
CN (1) CN113166169A (https=)
AR (1) AR117255A1 (https=)
AU (1) AU2019391329B2 (https=)
BR (1) BR112021010072A2 (https=)
CA (1) CA3121363A1 (https=)
DK (1) DK3891156T3 (https=)
EA (1) EA202191534A1 (https=)
ES (1) ES2971258T3 (https=)
FI (1) FI3891156T3 (https=)
HR (1) HRP20240211T1 (https=)
HU (1) HUE065266T2 (https=)
IL (1) IL283656B2 (https=)
LT (1) LT3891156T (https=)
MA (1) MA54379B1 (https=)
MD (1) MD3891156T2 (https=)
MX (1) MX2021006702A (https=)
PL (1) PL3891156T3 (https=)
PT (1) PT3891156T (https=)
RS (1) RS65047B1 (https=)
SI (1) SI3891156T1 (https=)
TW (1) TWI905090B (https=)
WO (1) WO2020115183A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI910028B (zh) 2021-06-11 2025-12-21 美商基利科學股份有限公司 Mcl-1抑制劑與抗癌劑之組合
US11931424B2 (en) 2021-06-11 2024-03-19 Gilead Sciences, Inc. Combination MCL-1 inhibitors with anti-body drug conjugates

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015097123A1 (en) * 2013-12-23 2015-07-02 Les Laboratoires Servier New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3008975A1 (fr) * 2013-07-23 2015-01-30 Servier Lab Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037957B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3046792B1 (fr) 2016-01-19 2018-02-02 Les Laboratoires Servier Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015097123A1 (en) * 2013-12-23 2015-07-02 Les Laboratoires Servier New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
WO2020115183A1 (en) 2020-06-11
SI3891156T1 (sl) 2024-03-29
KR20210100148A (ko) 2021-08-13
EA202191534A1 (ru) 2021-10-27
KR102855345B1 (ko) 2025-09-03
FI3891156T3 (fi) 2024-02-07
PL3891156T3 (pl) 2024-05-13
HRP20240211T1 (hr) 2024-04-26
MA54379A (fr) 2021-10-13
BR112021010072A2 (pt) 2021-08-24
CN113166169A (zh) 2021-07-23
JP7649241B2 (ja) 2025-03-19
US20220017533A1 (en) 2022-01-20
EP3891156B1 (en) 2023-11-15
MD3891156T2 (ro) 2024-06-30
AU2019391329A1 (en) 2021-07-01
LT3891156T (lt) 2023-12-27
DK3891156T3 (da) 2024-02-19
EP3891156A1 (en) 2021-10-13
IL283656B1 (en) 2025-06-01
TW202039511A (zh) 2020-11-01
IL283656B2 (en) 2025-10-01
ES2971258T3 (es) 2024-06-04
IL283656A (en) 2021-07-29
CA3121363A1 (en) 2020-06-11
JP2022511495A (ja) 2022-01-31
MX2021006702A (es) 2021-07-07
MA54379B1 (fr) 2023-12-29
HUE065266T2 (hu) 2024-05-28
NZ776907A (en) 2025-05-02
AU2019391329B2 (en) 2024-09-26
US20250011337A1 (en) 2025-01-09
RS65047B1 (sr) 2024-02-29
US12129261B2 (en) 2024-10-29
AR117255A1 (es) 2021-07-21
PT3891156T (pt) 2024-01-16

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