KR102855345B1 - Mcl-1 억제제의 신규 결정질 형태, 이들의 제조 방법 및 이들을 포함하는 약학적 조성물 - Google Patents

Mcl-1 억제제의 신규 결정질 형태, 이들의 제조 방법 및 이들을 포함하는 약학적 조성물

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Publication number
KR102855345B1
KR102855345B1 KR1020217020808A KR20217020808A KR102855345B1 KR 102855345 B1 KR102855345 B1 KR 102855345B1 KR 1020217020808 A KR1020217020808 A KR 1020217020808A KR 20217020808 A KR20217020808 A KR 20217020808A KR 102855345 B1 KR102855345 B1 KR 102855345B1
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South Korea
Prior art keywords
compound
crystalline form
cancer
expressed
theta
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English (en)
Korean (ko)
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KR20210100148A (ko
Inventor
에밀레 드 바에츠
줄리앙 오브레
미카엘 린치
니콜라스 르블랑
Original Assignee
르 라보레또레 쎄르비에르
베르날리스 (알 앤드 디) 리미티드
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Publication of KR20210100148A publication Critical patent/KR20210100148A/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020217020808A 2018-12-06 2019-12-05 Mcl-1 억제제의 신규 결정질 형태, 이들의 제조 방법 및 이들을 포함하는 약학적 조성물 Active KR102855345B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18306634.9 2018-12-06
EP18306634 2018-12-06
PCT/EP2019/083773 WO2020115183A1 (en) 2018-12-06 2019-12-05 New crystalline forms of a mcl-1 inhibitor, a process for their preparation and pharmaceutical compositions containing them.

Publications (2)

Publication Number Publication Date
KR20210100148A KR20210100148A (ko) 2021-08-13
KR102855345B1 true KR102855345B1 (ko) 2025-09-03

Family

ID=64665802

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217020808A Active KR102855345B1 (ko) 2018-12-06 2019-12-05 Mcl-1 억제제의 신규 결정질 형태, 이들의 제조 방법 및 이들을 포함하는 약학적 조성물

Country Status (26)

Country Link
US (2) US12129261B2 (https=)
EP (1) EP3891156B1 (https=)
JP (1) JP7649241B2 (https=)
KR (1) KR102855345B1 (https=)
CN (1) CN113166169A (https=)
AR (1) AR117255A1 (https=)
AU (1) AU2019391329B2 (https=)
BR (1) BR112021010072A2 (https=)
CA (1) CA3121363A1 (https=)
DK (1) DK3891156T3 (https=)
EA (1) EA202191534A1 (https=)
ES (1) ES2971258T3 (https=)
FI (1) FI3891156T3 (https=)
HR (1) HRP20240211T1 (https=)
HU (1) HUE065266T2 (https=)
IL (1) IL283656B2 (https=)
LT (1) LT3891156T (https=)
MA (1) MA54379B1 (https=)
MD (1) MD3891156T2 (https=)
MX (1) MX2021006702A (https=)
PL (1) PL3891156T3 (https=)
PT (1) PT3891156T (https=)
RS (1) RS65047B1 (https=)
SI (1) SI3891156T1 (https=)
TW (1) TWI905090B (https=)
WO (1) WO2020115183A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI910028B (zh) 2021-06-11 2025-12-21 美商基利科學股份有限公司 Mcl-1抑制劑與抗癌劑之組合
US11931424B2 (en) 2021-06-11 2024-03-19 Gilead Sciences, Inc. Combination MCL-1 inhibitors with anti-body drug conjugates

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015097123A1 (en) 2013-12-23 2015-07-02 Les Laboratoires Servier New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them
WO2016207225A1 (en) 2015-06-23 2016-12-29 Les Laboratoires Servier New hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3008975A1 (fr) * 2013-07-23 2015-01-30 Servier Lab Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3046792B1 (fr) 2016-01-19 2018-02-02 Les Laboratoires Servier Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015097123A1 (en) 2013-12-23 2015-07-02 Les Laboratoires Servier New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them
WO2016207225A1 (en) 2015-06-23 2016-12-29 Les Laboratoires Servier New hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
WO2020115183A1 (en) 2020-06-11
SI3891156T1 (sl) 2024-03-29
KR20210100148A (ko) 2021-08-13
EA202191534A1 (ru) 2021-10-27
FI3891156T3 (fi) 2024-02-07
PL3891156T3 (pl) 2024-05-13
TWI905090B (zh) 2025-11-21
HRP20240211T1 (hr) 2024-04-26
MA54379A (fr) 2021-10-13
BR112021010072A2 (pt) 2021-08-24
CN113166169A (zh) 2021-07-23
JP7649241B2 (ja) 2025-03-19
US20220017533A1 (en) 2022-01-20
EP3891156B1 (en) 2023-11-15
MD3891156T2 (ro) 2024-06-30
AU2019391329A1 (en) 2021-07-01
LT3891156T (lt) 2023-12-27
DK3891156T3 (da) 2024-02-19
EP3891156A1 (en) 2021-10-13
IL283656B1 (en) 2025-06-01
TW202039511A (zh) 2020-11-01
IL283656B2 (en) 2025-10-01
ES2971258T3 (es) 2024-06-04
IL283656A (en) 2021-07-29
CA3121363A1 (en) 2020-06-11
JP2022511495A (ja) 2022-01-31
MX2021006702A (es) 2021-07-07
MA54379B1 (fr) 2023-12-29
HUE065266T2 (hu) 2024-05-28
NZ776907A (en) 2025-05-02
AU2019391329B2 (en) 2024-09-26
US20250011337A1 (en) 2025-01-09
RS65047B1 (sr) 2024-02-29
US12129261B2 (en) 2024-10-29
AR117255A1 (es) 2021-07-21
PT3891156T (pt) 2024-01-16

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