TWI882953B - 以ccr2拮抗劑治療實體腫瘤的方法 - Google Patents

以ccr2拮抗劑治療實體腫瘤的方法 Download PDF

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Publication number
TWI882953B
TWI882953B TW108100692A TW108100692A TWI882953B TW I882953 B TWI882953 B TW I882953B TW 108100692 A TW108100692 A TW 108100692A TW 108100692 A TW108100692 A TW 108100692A TW I882953 B TWI882953 B TW I882953B
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Taiwan
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group
alkyl
tumor
compound
ccr2
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TW108100692A
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English (en)
Chinese (zh)
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TW201938160A (zh
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詹姆士 Ｊ 坎貝爾
羅瑾德 斯穎
震宇 黃
吳雪松
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美商卡默森屈有限公司
美國加利福尼亞大學董事會
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW108100692A 2018-01-08 2019-01-08 以ccr2拮抗劑治療實體腫瘤的方法 TWI882953B (zh)

Applications Claiming Priority (2)

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US201862614923P 2018-01-08 2018-01-08
US62/614,923 2018-01-08

Publications (2)

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TW201938160A TW201938160A (zh) 2019-10-01
TWI882953B true TWI882953B (zh) 2025-05-11

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US (2) US11154556B2 (https=)
EP (1) EP3737367B1 (https=)
JP (1) JP7442141B2 (https=)
CN (1) CN112105353B (https=)
AU (1) AU2019205784B2 (https=)
CA (1) CA3087765A1 (https=)
ES (1) ES2991280T3 (https=)
IL (1) IL275898B2 (https=)
MA (1) MA50423A (https=)
TW (1) TWI882953B (https=)
WO (1) WO2019136368A2 (https=)

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US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
CN111334575A (zh) * 2020-02-18 2020-06-26 至本医疗科技（上海）有限公司 Notch家族基因变异在预测实体瘤患者对免疫检查点抑制剂疗法敏感性中的应用

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TW201706266A (zh) * 2015-05-21 2017-02-16 卡默森屈有限公司 Ｃｃｒ２調節劑

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TW201938160A (zh) 2019-10-01
CA3087765A1 (en) 2019-07-11
WO2019136368A2 (en) 2019-07-11
US20220241290A1 (en) 2022-08-04
AU2019205784A1 (en) 2020-07-30
JP7442141B2 (ja) 2024-03-04
IL275898B2 (en) 2025-05-01
AU2019205784B2 (en) 2024-07-25
ES2991280T3 (es) 2024-12-03
US20190209573A1 (en) 2019-07-11
EP3737367A2 (en) 2020-11-18
IL275898B1 (en) 2025-01-01
IL275898A (en) 2020-08-31
MA50423A (fr) 2020-08-26
CN112105353A (zh) 2020-12-18
CN112105353B (zh) 2024-04-19
US11154556B2 (en) 2021-10-26
EP3737367A4 (en) 2022-11-09
JP2021509678A (ja) 2021-04-01
WO2019136368A3 (en) 2020-04-16
EP3737367B1 (en) 2024-10-02

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