AU2019205784B2 - Methods of treating solid tumors with CCR2 antagonists - Google Patents

Methods of treating solid tumors with CCR2 antagonists Download PDF

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Publication number
AU2019205784B2
AU2019205784B2 AU2019205784A AU2019205784A AU2019205784B2 AU 2019205784 B2 AU2019205784 B2 AU 2019205784B2 AU 2019205784 A AU2019205784 A AU 2019205784A AU 2019205784 A AU2019205784 A AU 2019205784A AU 2019205784 B2 AU2019205784 B2 AU 2019205784B2
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AU2019205784A1 (en
Inventor
James J. Campbell
Samuel HWANG
Rajinder Singh
Xuesong Wu
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Chemocentryx Inc
University of California San Diego UCSD
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Chemocentryx Inc
University of California Berkeley
University of California San Diego UCSD
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2019205784A 2018-01-08 2019-01-07 Methods of treating solid tumors with CCR2 antagonists Active AU2019205784B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862614923P 2018-01-08 2018-01-08
US62/614,923 2018-01-08
PCT/US2019/012515 WO2019136368A2 (en) 2018-01-08 2019-01-07 Methods of treating solid tumors with ccr2 antagonists

Publications (2)

Publication Number Publication Date
AU2019205784A1 AU2019205784A1 (en) 2020-07-30
AU2019205784B2 true AU2019205784B2 (en) 2024-07-25

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AU2019205784A Active AU2019205784B2 (en) 2018-01-08 2019-01-07 Methods of treating solid tumors with CCR2 antagonists

Country Status (11)

Country Link
US (2) US11154556B2 (https=)
EP (1) EP3737367B1 (https=)
JP (1) JP7442141B2 (https=)
CN (1) CN112105353B (https=)
AU (1) AU2019205784B2 (https=)
CA (1) CA3087765A1 (https=)
ES (1) ES2991280T3 (https=)
IL (1) IL275898B2 (https=)
MA (1) MA50423A (https=)
TW (1) TWI882953B (https=)
WO (1) WO2019136368A2 (https=)

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CN111334575A (zh) * 2020-02-18 2020-06-26 至本医疗科技（上海）有限公司 Notch家族基因变异在预测实体瘤患者对免疫检查点抑制剂疗法敏感性中的应用

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Also Published As

Publication number Publication date
TW201938160A (zh) 2019-10-01
CA3087765A1 (en) 2019-07-11
TWI882953B (zh) 2025-05-11
WO2019136368A2 (en) 2019-07-11
US20220241290A1 (en) 2022-08-04
AU2019205784A1 (en) 2020-07-30
JP7442141B2 (ja) 2024-03-04
IL275898B2 (en) 2025-05-01
ES2991280T3 (es) 2024-12-03
US20190209573A1 (en) 2019-07-11
EP3737367A2 (en) 2020-11-18
IL275898B1 (en) 2025-01-01
IL275898A (en) 2020-08-31
MA50423A (fr) 2020-08-26
CN112105353A (zh) 2020-12-18
CN112105353B (zh) 2024-04-19
US11154556B2 (en) 2021-10-26
EP3737367A4 (en) 2022-11-09
JP2021509678A (ja) 2021-04-01
WO2019136368A3 (en) 2020-04-16
EP3737367B1 (en) 2024-10-02

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