JP7442141B2 - Ｃｃｒ２アンタゴニストによる固形腫瘍の治療方法 - Google Patents

Ｃｃｒ２アンタゴニストによる固形腫瘍の治療方法 Download PDF

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JP7442141B2
JP7442141B2 JP2020537565A JP2020537565A JP7442141B2 JP 7442141 B2 JP7442141 B2 JP 7442141B2 JP 2020537565 A JP2020537565 A JP 2020537565A JP 2020537565 A JP2020537565 A JP 2020537565A JP 7442141 B2 JP7442141 B2 JP 7442141B2
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alkyl
group
compound
tumor
heteroaryl
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JP2021509678A5 (https=
JP2021509678A (ja
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ジェイ．キャンベル ジェイムズ
シン ラジンダー
ファン サミュエル
ウー シュエソン
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University of California San Diego UCSD
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2020537565A 2018-01-08 2019-01-07 Ｃｃｒ２アンタゴニストによる固形腫瘍の治療方法 Active JP7442141B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862614923P 2018-01-08 2018-01-08
US62/614,923 2018-01-08
PCT/US2019/012515 WO2019136368A2 (en) 2018-01-08 2019-01-07 Methods of treating solid tumors with ccr2 antagonists

Publications (3)

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JP2021509678A JP2021509678A (ja) 2021-04-01
JP2021509678A5 JP2021509678A5 (https=) 2022-01-18
JP7442141B2 true JP7442141B2 (ja) 2024-03-04

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JP2020537565A Active JP7442141B2 (ja) 2018-01-08 2019-01-07 Ｃｃｒ２アンタゴニストによる固形腫瘍の治療方法

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US (2) US11154556B2 (https=)
EP (1) EP3737367B1 (https=)
JP (1) JP7442141B2 (https=)
CN (1) CN112105353B (https=)
AU (1) AU2019205784B2 (https=)
CA (1) CA3087765A1 (https=)
ES (1) ES2991280T3 (https=)
IL (1) IL275898B2 (https=)
MA (1) MA50423A (https=)
TW (1) TWI882953B (https=)
WO (1) WO2019136368A2 (https=)

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CA3293051A1 (en) 2017-09-25 2026-03-02 Chemocentryx, Inc. Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
CN111334575A (zh) * 2020-02-18 2020-06-26 至本医疗科技（上海）有限公司 Notch家族基因变异在预测实体瘤患者对免疫检查点抑制剂疗法敏感性中的应用

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Also Published As

Publication number Publication date
TW201938160A (zh) 2019-10-01
CA3087765A1 (en) 2019-07-11
TWI882953B (zh) 2025-05-11
WO2019136368A2 (en) 2019-07-11
US20220241290A1 (en) 2022-08-04
AU2019205784A1 (en) 2020-07-30
IL275898B2 (en) 2025-05-01
AU2019205784B2 (en) 2024-07-25
ES2991280T3 (es) 2024-12-03
US20190209573A1 (en) 2019-07-11
EP3737367A2 (en) 2020-11-18
IL275898B1 (en) 2025-01-01
IL275898A (en) 2020-08-31
MA50423A (fr) 2020-08-26
CN112105353A (zh) 2020-12-18
CN112105353B (zh) 2024-04-19
US11154556B2 (en) 2021-10-26
EP3737367A4 (en) 2022-11-09
JP2021509678A (ja) 2021-04-01
WO2019136368A3 (en) 2020-04-16
EP3737367B1 (en) 2024-10-02

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