TWI851747B - 介導酪氨酸激酶2活性的雜環化合物 - Google Patents

介導酪氨酸激酶2活性的雜環化合物 Download PDF

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TWI851747B
TWI851747B TW109121616A TW109121616A TWI851747B TW I851747 B TWI851747 B TW I851747B TW 109121616 A TW109121616 A TW 109121616A TW 109121616 A TW109121616 A TW 109121616A TW I851747 B TWI851747 B TW I851747B
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alkyl
mmol
methyl
pyrazol
pyrrol
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TW109121616A
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TW202115034A (zh
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向陽 陳
育成 龐
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大陸商廣州諾誠健華醫藥科技有限公司
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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TW109121616A 2019-06-28 2020-06-24 介導酪氨酸激酶2活性的雜環化合物 TWI851747B (zh)

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Application Number Priority Date Filing Date Title
CN201910572091.9A CN112142743A (zh) 2019-06-28 2019-06-28 杂环类化合物、其制备方法及其在医药学上的应用
CN201910572091.9 2019-06-28

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TW202115034A TW202115034A (zh) 2021-04-16
TWI851747B true TWI851747B (zh) 2024-08-11

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EP (1) EP3990449A4 (enExample)
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KR (1) KR102926602B1 (enExample)
CN (2) CN112142743A (enExample)
AU (1) AU2020301437B2 (enExample)
BR (1) BR112021026531A2 (enExample)
CA (1) CA3144799A1 (enExample)
MX (1) MX2021015969A (enExample)
PH (1) PH12021553257A1 (enExample)
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CN112142743A (zh) 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用
TWI782599B (zh) * 2020-07-02 2022-11-01 美商輝瑞股份有限公司 胺基嘧啶基衍生物
CN113234081A (zh) * 2021-05-27 2021-08-10 东南大学 一种吡咯并吡唑衍生物与dmpeda做脲的制备方法
KR20240111312A (ko) 2021-10-25 2024-07-16 카이메라 쎄라퓨틱스 인코포레이티드 Tyk2 분해제 및 이의 용도
CN122421968A (zh) * 2023-12-15 2026-07-17 北京诺诚健华医药科技有限公司 特应性皮炎的治疗方法
WO2026086809A1 (en) * 2024-10-25 2026-04-30 Beijing Innocare Pharma Tech Co., Ltd. Process for preparing 3- [ (3as, 6ar) -5- {5-chloro-2- [ (1-methyl-1h-pyrazol-4-yl) amino] pyrimidin-4-yl} -3a-methyl-octahydropyrrolo [3, 4-c] pyrrole-2-yl] -3-oxopropionitrile

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN108137559A (zh) * 2015-07-09 2018-06-08 默克专利有限公司 用作btk抑制剂的嘧啶衍生物及其用途

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AU2011328237A1 (en) * 2010-11-09 2013-05-23 Cellzome Limited Pyridine compounds and aza analogues thereof as TYK2 inhibitors
WO2012145581A1 (en) * 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
EP2832734A4 (en) * 2012-03-28 2015-08-26 Takeda Pharmaceutical HETEROCYCLIC COMPOUND
CN105622638B (zh) 2014-10-29 2018-10-02 广州必贝特医药技术有限公司 嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用
TW201920170A (zh) * 2017-09-20 2019-06-01 美商庫拉腫瘤技術股份有限公司 經取代之menin-mll 抑制劑及使用方法
CN112142743A (zh) * 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108137559A (zh) * 2015-07-09 2018-06-08 默克专利有限公司 用作btk抑制剂的嘧啶衍生物及其用途

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JP7560136B2 (ja) 2024-10-02
JP2022540353A (ja) 2022-09-15
KR102926602B1 (ko) 2026-02-11
CN114096532A (zh) 2022-02-25
BR112021026531A2 (pt) 2022-02-15
US20220112200A1 (en) 2022-04-14
EP3990449A4 (en) 2023-07-26
US12448382B2 (en) 2025-10-21
AU2020301437A1 (en) 2022-02-17
CN112142743A (zh) 2020-12-29
AU2020301437B2 (en) 2026-02-26
WO2020259584A1 (en) 2020-12-30
PH12021553257A1 (en) 2022-08-08
CN114096532B (zh) 2023-12-01
MX2021015969A (es) 2022-04-18
TW202115034A (zh) 2021-04-16
US20260116887A1 (en) 2026-04-30
KR20220042344A (ko) 2022-04-05
EP3990449A1 (en) 2022-05-04
CA3144799A1 (en) 2020-12-30

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